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NO20044618L - Dedifferensierte, programmerbare stamceller av monocyttisk opprinnelse og deres fremstilling og anvendelse - Google Patents

Dedifferensierte, programmerbare stamceller av monocyttisk opprinnelse og deres fremstilling og anvendelse

Info

Publication number
NO20044618L
NO20044618L NO20044618A NO20044618A NO20044618L NO 20044618 L NO20044618 L NO 20044618L NO 20044618 A NO20044618 A NO 20044618A NO 20044618 A NO20044618 A NO 20044618A NO 20044618 L NO20044618 L NO 20044618L
Authority
NO
Norway
Prior art keywords
stem cells
programmable
dedifferentiated
preparation
monocytic stem
Prior art date
Application number
NO20044618A
Other languages
English (en)
Other versions
NO337668B1 (no
Inventor
Bernd Karl Friedrich Kremer
Fred Fandrich
Maren Ruhnke
Original Assignee
Blasticon Biotech Forschung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=30116586&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20044618(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE10214095A external-priority patent/DE10214095C1/de
Application filed by Blasticon Biotech Forschung filed Critical Blasticon Biotech Forschung
Publication of NO20044618L publication Critical patent/NO20044618L/no
Publication of NO337668B1 publication Critical patent/NO337668B1/no

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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
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Abstract

Oppfinnelsen vedrører produksjonen av voksne dedifferensierte, programmerbare stamceller fra humane monocytter ved å dyrke monocyttene i et dyrkingsmedium som inneholder M-CSF og IL-3. Oppfinnelsen vedrører videre farmasøytiske preparater som inneholder de dedifferensierte, programmerbare stamcellene og anvendelsen av disse stamcellene for produksjonen av målceller og målvev.
NO20044618A 2002-03-28 2004-10-26 Fremgangsmåte for produksjon av dedifferensierte programmerbare stamceller av monocyttisk opprinnelse, anvendelse derav, farmasøytisk sammensetning og implanterbare materialer. NO337668B1 (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10214095A DE10214095C1 (de) 2002-03-28 2002-03-28 Dedifferenzierte, programmierbare Stammzellen monozytären Ursprungs, sowie deren Herstellung und Verwendung
US10/372,657 US20040101962A1 (en) 2002-03-28 2003-02-25 Dedifferentiated, programmable stem cells of monocytic origin, and their production and use
PCT/EP2003/002121 WO2003083091A1 (de) 2002-03-28 2003-02-25 Dedifferenzierte, programmierbare stammzellen monozytären ursprungs, sowie deren herstellung und verwendung
PCT/EP2003/003279 WO2003083092A1 (en) 2002-03-28 2003-03-28 Dedifferentiated, programmable stem cells of monocytic origin, and their production and use

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NO337668B1 NO337668B1 (no) 2016-05-30

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Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9502022D0 (en) * 1995-02-02 1995-03-22 Abuljadayel Ilham M S A method for preparing lymphohaematopoietic progenitor cells
TWI288779B (en) * 2002-03-28 2007-10-21 Blasticon Biotech Forschung Dedifferentiated, programmable stem cells of monocytic origin, and their production and use
DE10231655A1 (de) * 2002-07-12 2004-02-26 Blasticon Biotechnologische Forschung Gmbh Transplantat-Akzeptanz induzierende Zellen monozytären Ursprungs, sowie deren Herstellung und Verwendung
WO2004043990A2 (en) * 2002-11-07 2004-05-27 University Of Chicago Human stem cell materials and methods
US20040136973A1 (en) * 2002-11-07 2004-07-15 Eliezer Huberman Human stem cell materials and methods
BRPI0412506A (pt) * 2003-07-11 2006-09-05 Blasticon Biotech Forschung células autólogas que induzem à autotoleráncia de origem monocìtica e seu uso em preparações farmacêuticos
ITRM20030376A1 (it) 2003-07-31 2005-02-01 Univ Roma Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia.
WO2005071065A1 (en) * 2004-01-26 2005-08-04 Cognis France S.A.S Method for studying functional interactions between sensory neurons and keratinocytes or melanocytes
EP1600500A1 (en) * 2004-05-27 2005-11-30 Georg-August-Universität Göttingen Method for producing pluripotent cells from monocytes
CN101437938B (zh) * 2004-11-08 2015-05-13 约翰霍普金斯大学 心脏干细胞
US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
WO2006096931A1 (en) * 2005-03-18 2006-09-21 The University Of Queensland Renal repair and regeneration
US9388382B2 (en) 2005-10-05 2016-07-12 The Board Of Trustees Of The University Of Illinois Isolation of CD14 negative, CD45 positive and CD117 positive embryonic-like stem cells free of monocytes from human umbilical cord blood mononuclear cells
ITTO20050819A1 (it) 2005-11-18 2007-05-19 Univ Degli Studi Torino Linea cellulare staminale pluripotente, linee cellulari derivate, procedimenti per la loro produzione e relativi usi
CA2651326A1 (en) * 2006-05-05 2007-11-15 Opexa Therapeutics Pancreatic islet-like cells
CA2651331A1 (en) * 2006-05-05 2007-11-15 Opexa Therapeutics Monocyte-derived stem cells
WO2007146106A2 (en) * 2006-06-05 2007-12-21 Cryo- Cell International, Inc. Procurement, isolation and cryopreservation of maternal placental cells
US20080050814A1 (en) * 2006-06-05 2008-02-28 Cryo-Cell International, Inc. Procurement, isolation and cryopreservation of fetal placental cells
ITRM20060498A1 (it) * 2006-09-20 2008-03-21 Alessandra Gambacurta Metodo di espansione di cellule staminali adulte da sangue periferico e relativi usi in campo medico
US8835163B2 (en) 2006-10-18 2014-09-16 The Board Of Trustees Of The University Of Illinois Embryonic-like stem cells derived from adult human peripheral blood and methods of use
KR101240487B1 (ko) * 2006-11-09 2013-03-08 더 존스 홉킨스 유니버시티 성체 포유동물 심근세포의 심장 줄기 세포로의 역분화
ITTO20060937A1 (it) * 2006-12-29 2008-06-30 Medestea Biotech S R L Linee cellulari immortali differenziate atte a produrre albumina e fattori di crescita, procedimenti per la loro preparazione da una linea cellulare leucemica e loro usi.
ATE479741T1 (de) * 2007-09-21 2010-09-15 Univ Leipzig Zellkulturenmedium und verfahren zur kultivierung von stammzellen und vorläuferzellen
ITUD20080058A1 (it) 2008-03-18 2009-09-19 Thankstem S R L Kit per la raccolta di sangue, preferibilmente periferico, per la produzione di cellule staminali
WO2009157610A1 (en) * 2008-06-26 2009-12-30 Pusan National University Industry-University Cooperation Foundation Selenium dedifferentiated cell, preparation method and usage thereof
MX336067B (es) * 2008-11-25 2016-01-06 Otsuka Pharma Co Ltd Celula madre para uso terapeutico, la cual se deriva de monocito humano y metodo para inducir la misma.
KR100950195B1 (ko) * 2009-03-20 2010-03-29 서울대학교산학협력단 Ｚｎｆ281을 발현하는 제대혈 유래 만능 줄기세포의 분리방법
US20110091433A1 (en) * 2009-10-19 2011-04-21 Ilham Mohamed Saleh Saeed Abuljadayel Treatment using reprogrammed mature adult cells
CN102647989A (zh) * 2009-10-19 2012-08-22 特里施泰姆贸易(塞浦路斯)有限公司 采用重编程序的成熟成体细胞的治疗
CN101760446B (zh) * 2009-12-31 2012-09-12 浙江中赢控股集团有限公司 制备单核细胞型干细胞的方法及应用
US9249392B2 (en) 2010-04-30 2016-02-02 Cedars-Sinai Medical Center Methods and compositions for maintaining genomic stability in cultured stem cells
US9845457B2 (en) 2010-04-30 2017-12-19 Cedars-Sinai Medical Center Maintenance of genomic stability in cultured stem cells
US8858934B2 (en) * 2010-08-12 2014-10-14 Abag Verwaltungs Gmbh Method for producing cells having characteristics of hepatocytes
US9809798B2 (en) 2011-03-11 2017-11-07 National University Of Singapore Pericyte progenitors from peripheral blood
EP2749639B1 (en) * 2012-02-10 2016-10-12 Hakushinkouseikai Foundation Proliferating agent for monocyte, culture medium for proliferating monocyte, method for producing monocyte, method for producing dendritic cell, and method for producing dendritic cell vaccine
WO2013180395A1 (ko) * 2012-05-29 2013-12-05 한국생명공학연구원 다능성 줄기세포의 제작, 유지, 증식을 증진하는 대사산물 및 이를 포함하는 조성물과 배양방법
JP2015521054A (ja) 2012-06-05 2015-07-27 カプリコール，インコーポレイテッド 心臓組織から心臓幹細胞を作製するための最適化方法および心臓治療におけるそれらの使用
US9828603B2 (en) 2012-08-13 2017-11-28 Cedars Sinai Medical Center Exosomes and micro-ribonucleic acids for tissue regeneration
SG11201504376SA (en) * 2012-12-06 2015-07-30 Fuwan Pty Ltd A method of generating multilineage potential cells
EP2862926B1 (en) 2013-10-17 2018-12-05 Centre National de la Recherche Scientifique (CNRS) Method for in vitro differentiation of blood circulating cells into neuronal-like cells and applications thereof
JP2016540770A (ja) * 2013-12-06 2016-12-28 フワン・ピーティーワイ・リミテッド 新生物の処置方法
KR20170002568A (ko) 2014-05-09 2017-01-06 땡스템 에스알엘 전혈로부터의 성체 줄기세포 증대 방법
WO2016054591A1 (en) 2014-10-03 2016-04-07 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy
US10233466B2 (en) 2014-12-31 2019-03-19 Poet Research, Inc. Economic ethanol fermentation sugar stream, processes and systems of producing same
EP3344755A4 (en) * 2015-08-31 2019-05-22 I Peace, Inc. PREPARATION SYSTEM FOR PLURIPOTENTE STEM CELLS AND METHOD FOR THE PRODUCTION OF INDUCED PLURIPOTENTAL STEM CELLS
US11253551B2 (en) 2016-01-11 2022-02-22 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction
US11351200B2 (en) 2016-06-03 2022-06-07 Cedars-Sinai Medical Center CDC-derived exosomes for treatment of ventricular tachyarrythmias
US11541078B2 (en) 2016-09-20 2023-01-03 Cedars-Sinai Medical Center Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders
US11759482B2 (en) 2017-04-19 2023-09-19 Cedars-Sinai Medical Center Methods and compositions for treating skeletal muscular dystrophy
CN107904202B (zh) * 2017-11-22 2018-11-20 北京恩诺生物科技有限公司 一种制备多能干细胞样细胞的方法、组合物和应用
CA3083354A1 (en) 2017-11-29 2019-06-06 Figene, Llc Interaction of fibroblasts and immune cells for activation and uses thereof
EP3727351A4 (en) 2017-12-20 2021-10-06 Cedars-Sinai Medical Center MODIFIED EXTRACELLULAR VESICLES FOR IMPROVED TISSUE DELIVERY
US12146137B2 (en) 2018-02-05 2024-11-19 Cedars-Sinai Medical Center Methods for therapeutic use of exosomes and Y-RNAS
MX2022011245A (es) 2020-03-11 2023-01-11 Bit Bio Ltd Método de generación de células hepáticas.
JP6826744B1 (ja) * 2020-07-17 2021-02-10 医療法人Ｙａｎａｇａ ＣＬｉｎｉｃ 成熟脂肪細胞含有組成物の製造方法
WO2022192967A1 (en) * 2021-03-18 2022-09-22 The University Of Sydney Bioengineered endothelial constructs

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4281061A (en) * 1979-07-27 1981-07-28 Syva Company Double antibody for enhanced sensitivity in immunoassay
US4761421A (en) * 1985-05-08 1988-08-02 Merck & Co., Inc. Use of certain compounds in livestock food as growth promotants for better feed utilization and improved carcass composition
US4783220A (en) * 1986-12-18 1988-11-08 Xerox Corporation Vesicle ink compositions
US5605835A (en) * 1988-05-23 1997-02-25 Regents Of The University Of Minnesota Bioreactor device with application as a bioartificial liver
IL105324A0 (en) * 1992-04-06 1993-08-18 Univ Florida Stem cell proliferation factor
US5866373A (en) * 1995-04-21 1999-02-02 Human Genome Sciences, Inc. Polynucleotide encoding a human chemotactic protein
EP0785803A4 (en) * 1994-09-23 2000-08-02 Gen Hospital Corp USE OF A NON-MAMMALIAN DNA VIRUS FOR EXPRESSION OF AN EXOGENOUS GENE IN A MAMMALIAN CELL
US5871986A (en) * 1994-09-23 1999-02-16 The General Hospital Corporation Use of a baculovirus to express and exogenous gene in a mammalian cell
GB9502022D0 (en) * 1995-02-02 1995-03-22 Abuljadayel Ilham M S A method for preparing lymphohaematopoietic progenitor cells
US7410773B2 (en) 1995-02-02 2008-08-12 Ghazi Jaswinder Dhoot Method of preparing an undifferentiated cell
US9068164B1 (en) 1995-02-02 2015-06-30 Tristem Trading (Cyprus) Limited Method of preparing an undifferentiated cell
US7112440B2 (en) * 1995-02-02 2006-09-26 Ghazi Jaswinder Dhoot Method of increasing the relative number of CD45 low cells in a cell population
US5650309A (en) * 1995-05-16 1997-07-22 The Regents Of The University Of California Viral vectors
US6043092A (en) * 1996-03-18 2000-03-28 University Of Pittsburgh Cell culture media for mammalian cells
US5827740A (en) * 1996-07-30 1998-10-27 Osiris Therapeutics, Inc. Adipogenic differentiation of human mesenchymal stem cells
WO1998014561A1 (en) * 1996-10-04 1998-04-09 Becton Dickinson And Company Identification of a cd34+ bone marrow precursor for dendritic cells in blood and lymphoid tissues
EP0983345A1 (en) * 1997-05-21 2000-03-08 THE UNITED STATES OF AMERICA, as represented by the Secretary of the Department of Health and Human Services Methods and compositions for making dendritic cells from expanded populations of monocytes and for activating t cells
US6336098B1 (en) * 1997-12-11 2002-01-01 International Business Machines Corp. Method for electronic distribution and redemption of coupons on the world wide web
IL146397A0 (en) 1999-05-14 2002-07-25 Hope City Ex vivo expansion of mammalian hematopoietic stem cells
US20010032130A1 (en) * 1999-12-28 2001-10-18 Gabos John S. Marketing information system for remote computing platforms
AU2001243464B2 (en) * 2000-03-09 2006-04-13 Saneron Ccel Therapeutics, Inc. Human cord blood as a source of neural tissue for repair of the brain and spinal cord
US20010049139A1 (en) * 2000-03-23 2001-12-06 Eric Lagasse Hepatic regeneration from hematopoietic stem cells
NL1017973C2 (nl) * 2000-05-10 2002-11-08 Tristem Trading Cyprus Ltd Inrichting.
AU2001284923A1 (en) * 2000-08-15 2002-02-25 Geron Corporation Reprogramming cells for enhanced differentiation capacity using pluripotent stemcells
US20040064365A1 (en) * 2001-02-17 2004-04-01 Sjoblom Johan Sjobl Electronic coupons
TWI288779B (en) * 2002-03-28 2007-10-21 Blasticon Biotech Forschung Dedifferentiated, programmable stem cells of monocytic origin, and their production and use
US7617122B2 (en) * 2002-08-28 2009-11-10 International Business Machines Corporation Targeted online marketing
US20040088218A1 (en) * 2002-11-04 2004-05-06 Abraham Daniel M. Coupon discounts redemption/cash back program
US20040136973A1 (en) * 2002-11-07 2004-07-15 Eliezer Huberman Human stem cell materials and methods
US20050003534A1 (en) * 2002-11-07 2005-01-06 Eliezer Huberman Human stem cell materials and methods
WO2004043990A2 (en) 2002-11-07 2004-05-27 University Of Chicago Human stem cell materials and methods
US8271320B2 (en) * 2002-12-12 2012-09-18 International Business Machines Corporation Method and system for enabling unregistered users to manage electronic items across sessions
US20050260158A1 (en) * 2003-11-07 2005-11-24 Eliezer Huberman Human stem cell materials and methods

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TWI288779B (en) 2007-10-21
BR0308919A (pt) 2005-01-04
US20090239295A1 (en) 2009-09-24
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WO2003083092A1 (en) 2003-10-09
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CN100347293C (zh) 2007-11-07
EP1436381A1 (en) 2004-07-14
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