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NL9201716A - Buitenmembraanvesikel dat voorzien is van een groep polypeptiden welke ten minste de immuunwerking van aan membraan gebonden buitenmembraaneiwitten (OMP's) hebben, werkwijze ter bereiding ervan alsmede een vaccin dat een dergelijk buitenmembraanvesikel omvat. - Google Patents

Buitenmembraanvesikel dat voorzien is van een groep polypeptiden welke ten minste de immuunwerking van aan membraan gebonden buitenmembraaneiwitten (OMP's) hebben, werkwijze ter bereiding ervan alsmede een vaccin dat een dergelijk buitenmembraanvesikel omvat. Download PDF

Info

Publication number
NL9201716A
NL9201716A NL9201716A NL9201716A NL9201716A NL 9201716 A NL9201716 A NL 9201716A NL 9201716 A NL9201716 A NL 9201716A NL 9201716 A NL9201716 A NL 9201716A NL 9201716 A NL9201716 A NL 9201716A
Authority
NL
Netherlands
Prior art keywords
omp
outer membrane
saccharide
polypeptide
membrane vesicle
Prior art date
Application number
NL9201716A
Other languages
English (en)
Dutch (nl)
Original Assignee
Nederlanden Staat
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nederlanden Staat filed Critical Nederlanden Staat
Priority to NL9201716A priority Critical patent/NL9201716A/nl
Priority to DE69334147T priority patent/DE69334147T2/de
Priority to CA002146145A priority patent/CA2146145C/en
Priority to JP6508917A priority patent/JPH08501940A/ja
Priority to EP93921120A priority patent/EP0680512B1/de
Priority to PCT/NL1993/000163 priority patent/WO1994008021A1/en
Priority to PT93921120T priority patent/PT680512E/pt
Priority to ES93921120T priority patent/ES2289739T3/es
Priority to US08/411,727 priority patent/US5705161A/en
Priority to DK93921120T priority patent/DK0680512T3/da
Priority to AT93921120T priority patent/ATE364702T1/de
Priority to AU48351/93A priority patent/AU684720B2/en
Publication of NL9201716A publication Critical patent/NL9201716A/nl
Priority to NO19951181A priority patent/NO321651B1/no
Priority to FI951535A priority patent/FI951535L/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
NL9201716A 1992-10-02 1992-10-02 Buitenmembraanvesikel dat voorzien is van een groep polypeptiden welke ten minste de immuunwerking van aan membraan gebonden buitenmembraaneiwitten (OMP's) hebben, werkwijze ter bereiding ervan alsmede een vaccin dat een dergelijk buitenmembraanvesikel omvat. NL9201716A (nl)

Priority Applications (14)

Application Number Priority Date Filing Date Title
NL9201716A NL9201716A (nl) 1992-10-02 1992-10-02 Buitenmembraanvesikel dat voorzien is van een groep polypeptiden welke ten minste de immuunwerking van aan membraan gebonden buitenmembraaneiwitten (OMP's) hebben, werkwijze ter bereiding ervan alsmede een vaccin dat een dergelijk buitenmembraanvesikel omvat.
ES93921120T ES2289739T3 (es) 1992-10-02 1993-07-30 Liposacarido meningococico inmunogenico y vesiculas de membrana externa y vacunas de los mismos.
US08/411,727 US5705161A (en) 1992-10-02 1993-07-30 Immunogenic meningococcal LPS and other membrane vesicles and vaccine therefrom
JP6508917A JPH08501940A (ja) 1992-10-02 1993-07-30 免疫原性髄膜炎菌のｌｐｓと外膜小胞とそれからのワクチン
EP93921120A EP0680512B1 (de) 1992-10-02 1993-07-30 Immunogene meningococcale lps und aussenmembranvesikel und impstoff daraus
PCT/NL1993/000163 WO1994008021A1 (en) 1992-10-02 1993-07-30 Immunogenic meningococcal lps and outer membrane vesicles and vaccine therefrom
PT93921120T PT680512E (pt) 1992-10-02 1993-07-30 Uma molécula provida de imunidade activadora das células e derivada de um lipopolissacarídeo meningocócico, métodos para a sua preparação, uma vesícula de membrana externa provida com grupo de polipepetídeos
DE69334147T DE69334147T2 (de) 1992-10-02 1993-07-30 Immunogene meningococcale lps und aussenmembranvesikel und impstoff daraus
CA002146145A CA2146145C (en) 1992-10-02 1993-07-30 Immunogenic meningococcal lps and outer membrane vesicles and vaccine therefrom
DK93921120T DK0680512T3 (da) 1992-10-02 1993-07-30 Immunogent meningokok LPS og ydermembranvesikler og vaccine deraf
AT93921120T ATE364702T1 (de) 1992-10-02 1993-07-30 Immunogene meningococcale lps und aussenmembranvesikel und impstoff daraus
AU48351/93A AU684720B2 (en) 1992-10-02 1993-07-30 Immunogenic meningococcal LPS and outer membrane vesicles and vaccine therefrom
NO19951181A NO321651B1 (no) 1992-10-02 1995-03-28 Immunogent meningokokk-lipopoly-sakkarid, ytter-membranvesikler, samt vaksine fremstilt derav.
FI951535A FI951535L (fi) 1992-10-02 1995-03-31 Immunogeeninen meningokokki -LPS ja siitä saadut ulkomembraanirakkulat ja rokote

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL9201716 1992-10-02
NL9201716A NL9201716A (nl) 1992-10-02 1992-10-02 Buitenmembraanvesikel dat voorzien is van een groep polypeptiden welke ten minste de immuunwerking van aan membraan gebonden buitenmembraaneiwitten (OMP's) hebben, werkwijze ter bereiding ervan alsmede een vaccin dat een dergelijk buitenmembraanvesikel omvat.

Publications (1)

Publication Number Publication Date
NL9201716A true NL9201716A (nl) 1994-05-02

Family

ID=19861338

Family Applications (1)

Application Number Title Priority Date Filing Date
NL9201716A NL9201716A (nl) 1992-10-02 1992-10-02 Buitenmembraanvesikel dat voorzien is van een groep polypeptiden welke ten minste de immuunwerking van aan membraan gebonden buitenmembraaneiwitten (OMP's) hebben, werkwijze ter bereiding ervan alsmede een vaccin dat een dergelijk buitenmembraanvesikel omvat.

Country Status (14)

Country Link
US (1) US5705161A (de)
EP (1) EP0680512B1 (de)
JP (1) JPH08501940A (de)
AT (1) ATE364702T1 (de)
AU (1) AU684720B2 (de)
CA (1) CA2146145C (de)
DE (1) DE69334147T2 (de)
DK (1) DK0680512T3 (de)
ES (1) ES2289739T3 (de)
FI (1) FI951535L (de)
NL (1) NL9201716A (de)
NO (1) NO321651B1 (de)
PT (1) PT680512E (de)
WO (1) WO1994008021A1 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
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US7118757B1 (en) * 1988-12-19 2006-10-10 Wyeth Holdings Corporation Meningococcal class 1 outer-membrane protein vaccine
AU707131B2 (en) * 1995-08-04 1999-07-01 University Of Guelph Novel vaccines and pharmaceutical compositions using membrane vesicles of microorganisms, and methods for preparing same
US20020028215A1 (en) 1999-08-09 2002-03-07 Jagath L. Kadurugamuwa Novel vaccines and pharmaceutical compositions using membrane vesicles of microorganisms, and methods for preparing same
US6872398B2 (en) * 1995-12-22 2005-03-29 The United States Of America As Represented By The Secretary Of The Army Conjugate vaccine against gram-negative bacterial infections
US6645503B1 (en) * 1998-03-10 2003-11-11 Wyeth Holdings Corporation Antigenic conjugates of conserved lipopolysaccharides of gram negative bacteria
US10967045B2 (en) 1998-11-02 2021-04-06 Secretary of State for Health and Social Care Multicomponent meningococcal vaccine
GB9823978D0 (en) * 1998-11-02 1998-12-30 Microbiological Res Authority Multicomponent meningococcal vaccine
US6514948B1 (en) * 1999-07-02 2003-02-04 The Regents Of The University Of California Method for enhancing an immune response
US6531131B1 (en) 1999-08-10 2003-03-11 The United States Of America As Represented By The Department Of Health And Human Services Conjugate vaccine for Neisseria meningitidis
US7585510B1 (en) 1999-09-30 2009-09-08 Isis Innovation Limited Vaccine
AU2001280883A1 (en) * 2000-07-27 2002-02-13 The Children's Hospital & Research Center At Oakland Vaccines for broad spectrum protection against diseases caused by neisseria meningitidis
CA2479879A1 (en) * 2002-03-20 2003-10-02 Emory University Neisseria mutants, lipooligosaccharides and immunogenic compositions
MY149591A (en) 2002-08-02 2013-09-13 Glaxosmithkline Biolog Sa Vaccines comprising l2 and/or l3 los from neisseria
GB0220194D0 (en) 2002-08-30 2002-10-09 Chiron Spa Improved vesicles
SI2351579T1 (sl) 2002-10-11 2017-05-31 Glaxosmithkline Biologicals Sa Polipeptidna cepiva za široko zaščito proti hipervirulentnim meningokoknim linijam
ATE466875T1 (de) 2002-11-15 2010-05-15 Novartis Vaccines & Diagnostic Unerwartete oberflächenproteine in neisseria meningitidis
GB0227346D0 (en) 2002-11-22 2002-12-31 Chiron Spa 741
CA2514328C (en) 2003-01-30 2020-01-14 Chiron Srl Injectable vaccines against multiple meningococcal serogroups
GB0323103D0 (en) 2003-10-02 2003-11-05 Chiron Srl De-acetylated saccharides
GB0408977D0 (en) 2004-04-22 2004-05-26 Chiron Srl Immunising against meningococcal serogroup Y using proteins
US7537766B2 (en) * 2004-08-30 2009-05-26 Wyeth Neisseria meningitidis inner core lipo-oligosaccharide epitopes, multivalent conjugates thereof and immunogenic compositions thereof
GB0424092D0 (en) 2004-10-29 2004-12-01 Chiron Srl Immunogenic bacterial vesicles with outer membrane proteins
NZ555937A (en) 2005-01-27 2009-05-31 Childrens Hosp & Res Ct Oak GNA1870-based vesicle vaccines for broad spectrum protection against diseases caused by Neisseria meningitidis
GB0524066D0 (en) 2005-11-25 2006-01-04 Chiron Srl 741 ii
US20090246224A1 (en) 2006-06-12 2009-10-01 Nathalie Devos Vaccine
WO2009104097A2 (en) 2008-02-21 2009-08-27 Novartis Ag Meningococcal fhbp polypeptides
MX2010012999A (es) * 2008-05-30 2012-03-07 U S A As Represented By The Secretary Of The Army On Behalf Of Walter Reed Army Vacuna de vesícula de membrana externa nativa multivalente del meningococo, método para su fabricación y uso.
CA2756533A1 (en) 2009-03-24 2010-09-30 Novartis Ag Combinations of meningococcal factor h binding protein and pneumococcal saccharide conjugates
HUE049695T2 (hu) 2009-03-24 2020-10-28 Glaxosmithkline Biologicals Sa Adjuváló H meningococcus faktort kötõ fehérje
AU2010247254A1 (en) * 2009-05-14 2012-01-12 Sanofi Pasteur Menigococcus vaccine containing lipooligosaccharide (LOS) from modified strains of L6 immunotype Neisseria meningitidis
JP5536765B2 (ja) * 2009-05-20 2014-07-02 国立大学法人鳥取大学 部分糖鎖エピトープを用いた、病原性ナイセリア属細菌感染の検出方法およびそれら細菌に対するワクチン
US20110076300A1 (en) 2009-08-27 2011-03-31 Mariagrazia Pizza Hybrid Polypeptides Including Meningococcal fHBP Sequences
CN102740882A (zh) 2009-08-27 2012-10-17 诺华有限公司 含有铝、寡核苷酸和聚阳离子的佐剂
AU2010302344A1 (en) 2009-09-30 2012-04-26 Novartis Ag Expression of meningococcal fhbp polypeptides
JP5960055B2 (ja) 2009-10-27 2016-08-02 ノバルティス アーゲー 改変髄膜炎菌ｆＨＢＰポリペプチド
EP2547357A1 (de) 2010-03-18 2013-01-23 Novartis AG Adjuvierte impfstoffe für serogruppen-b-meningokokken
US10478483B2 (en) 2010-06-25 2019-11-19 Glaxosmithkline Biologicals Sa Combinations of meningococcal factor H binding proteins
BR112014016223A8 (pt) 2011-12-29 2017-07-04 Novartis Ag combinações adjuvantes de proteínas de ligação de fator h meningocócico
KR20160127104A (ko) 2014-02-28 2016-11-02 글락소스미스클라인 바이오로지칼즈 에스.에이. 변형된 수막구균 fhbp 폴리펩티드
GB201712824D0 (en) 2017-08-10 2017-09-27 Glaxosmithkline Biologicals Sa Multi-functionalized nOMV Conjugates
JP2021533834A (ja) * 2018-08-14 2021-12-09 エバーサイト・ゲーエムベーハー 標的特異的細胞外小胞
EP4277654A1 (de) 2021-01-18 2023-11-22 Conserv Bioscience Limited Immunogene coronavirus-zusammensetzungen, verfahren und verwendungen davon

Family Cites Families (2)

* Cited by examiner, † Cited by third party
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WO1990006696A2 (en) * 1988-12-19 1990-06-28 Praxis Biologics, Inc. Meningococcal class 1 outer-membrane protein vaccine
NL9101359A (nl) * 1991-08-07 1993-03-01 Nederlanden Staat Nieuw saccharide-peptide-conjugaat, werkwijze ter bereiding ervan alsmede een vaccin dat een dergelijk saccharide-peptide-conjugaat omvat.

Also Published As

Publication number Publication date
WO1994008021A1 (en) 1994-04-14
DE69334147D1 (de) 2007-07-26
NO321651B1 (no) 2006-06-19
NO951181D0 (no) 1995-03-28
AU684720B2 (en) 1998-01-08
JPH08501940A (ja) 1996-03-05
ATE364702T1 (de) 2007-07-15
CA2146145A1 (en) 1994-04-14
FI951535A0 (fi) 1995-03-31
NO951181L (no) 1995-06-01
PT680512E (pt) 2007-09-25
EP0680512A1 (de) 1995-11-08
ES2289739T3 (es) 2008-02-01
CA2146145C (en) 2009-10-27
AU4835193A (en) 1994-04-26
DE69334147T2 (de) 2008-02-14
FI951535L (fi) 1995-06-01
DK0680512T3 (da) 2007-10-01
US5705161A (en) 1998-01-06
EP0680512B1 (de) 2007-06-13

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