NL8204067A - Platina-diaminecomplexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijk platinadiaminecomplex voor de behandeling van kanker, alsmede aldus verkregen gevormd geneesmiddel. - Google Patents

Platina-diaminecomplexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijk platinadiaminecomplex voor de behandeling van kanker, alsmede aldus verkregen gevormd geneesmiddel. Download PDF

Info

Publication number: NL8204067A
Authority: NL; Netherlands
Prior art keywords: formula; platinum; compound; process according; sheet
Prior art date: 1982-10-21

Application number

NL8204067A

Other languages

English (en)

Dutch (nl)

Original Assignee

Tno

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-10-21

Filing date

1982-10-21

Publication date

1984-05-16

1982-10-21 Application filed by Tno filed Critical Tno

1982-10-21 Priority to NL8204067A priority Critical patent/NL8204067A/nl

1983-10-13 Priority to DE19833337333 priority patent/DE3337333A1/de

1983-10-18 Priority to AU20275/83A priority patent/AU562964B2/en

1983-10-19 Priority to IL7000983A priority patent/IL70009A/xx

1983-10-19 Priority to CA000439308A priority patent/CA1229618A/en

1983-10-19 Priority to IT23359/83A priority patent/IT1169858B/it

1983-10-20 Priority to IE2459/83A priority patent/IE56124B1/en

1983-10-20 Priority to HU833623A priority patent/HU188035B/hu

1983-10-20 Priority to LU85054A priority patent/LU85054A1/xx

1983-10-20 Priority to YU2107/83A priority patent/YU43554B/xx

1983-10-20 Priority to FR8316715A priority patent/FR2534907B1/fr

1983-10-20 Priority to NZ206018A priority patent/NZ206018A/en

1983-10-20 Priority to DK483083A priority patent/DK483083A/da

1983-10-20 Priority to NO833825A priority patent/NO171276C/no

1983-10-20 Priority to DD83255826A priority patent/DD217522A5/de

1983-10-20 Priority to GR72754A priority patent/GR79652B/el

1983-10-20 Priority to GB08328084A priority patent/GB2128615B/en

1983-10-20 Priority to SE8305783A priority patent/SE8305783L/

1983-10-20 Priority to FI833842A priority patent/FI76351C/fi

1983-10-20 Priority to PT77542A priority patent/PT77542B/pt

1983-10-20 Priority to CH5718/83A priority patent/CH658244A5/de

1983-10-20 Priority to AT0373083A priority patent/AT390610B/de

1983-10-21 Priority to PH29726A priority patent/PH24077A/en

1983-10-21 Priority to ES526670A priority patent/ES526670A0/es

1983-10-21 Priority to ZA837857A priority patent/ZA837857B/xx

1983-10-21 Priority to BE0/211755A priority patent/BE898058A/nl

1983-10-21 Priority to JP58196286A priority patent/JPS5993091A/ja

1983-10-21 Priority to CS837752A priority patent/CS242888B2/cs

1983-10-21 Priority to KR1019830004987A priority patent/KR910002536B1/ko

1984-05-16 Publication of NL8204067A publication Critical patent/NL8204067A/nl

1992-06-09 Priority to DK075592A priority patent/DK75592A/da

Links

238000000034 method Methods 0.000 title claims description 42
BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Substances [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 title claims description 33
229910052697 platinum Inorganic materials 0.000 title claims description 25
-1 PLATINUM DIAMINE Chemical class 0.000 title claims description 23
206010028980 Neoplasm Diseases 0.000 title claims description 15
201000011510 cancer Diseases 0.000 title claims description 14
229940126601 medicinal product Drugs 0.000 title 1
150000001875 compounds Chemical class 0.000 claims description 43
HRGDZIGMBDGFTC-UHFFFAOYSA-N platinum(2+) Chemical compound [Pt+2] HRGDZIGMBDGFTC-UHFFFAOYSA-N 0.000 claims description 15
239000003814 drug Substances 0.000 claims description 7
238000002360 preparation method Methods 0.000 claims description 5
OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical group OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 4
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 4
ROBFUDYVXSDBQM-UHFFFAOYSA-N hydroxymalonic acid Chemical group OC(=O)C(O)C(O)=O ROBFUDYVXSDBQM-UHFFFAOYSA-N 0.000 claims description 4
159000000000 sodium salts Chemical class 0.000 claims description 4
CCQPAEQGAVNNIA-UHFFFAOYSA-N cyclobutane-1,1-dicarboxylic acid Chemical group OC(=O)C1(C(O)=O)CCC1 CCQPAEQGAVNNIA-UHFFFAOYSA-N 0.000 claims description 3
DDRVFRXYTKAZHH-UHFFFAOYSA-N 2-carboxyoxycarbonylbenzoic acid Chemical group OC(=O)OC(=O)C1=CC=CC=C1C(O)=O DDRVFRXYTKAZHH-UHFFFAOYSA-N 0.000 claims description 2
HGINADPHJQTSKN-UHFFFAOYSA-N Monoethyl malonic acid Chemical group CCOC(=O)CC(O)=O HGINADPHJQTSKN-UHFFFAOYSA-N 0.000 claims description 2
229910052799 carbon Inorganic materials 0.000 claims description 2
125000004432 carbon atom Chemical group C* 0.000 claims description 2
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 2
MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical group OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 1
150000004985 diamines Chemical class 0.000 claims 1
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 32
238000004458 analytical method Methods 0.000 description 13
239000000243 solution Substances 0.000 description 13
239000000203 mixture Substances 0.000 description 10
238000003756 stirring Methods 0.000 description 10
239000000706 filtrate Substances 0.000 description 8
229910021607 Silver chloride Inorganic materials 0.000 description 7
239000002244 precipitate Substances 0.000 description 7
HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 7
101710134784 Agnoprotein Proteins 0.000 description 6
231100000417 nephrotoxicity Toxicity 0.000 description 6
239000012153 distilled water Substances 0.000 description 5
231100000331 toxic Toxicity 0.000 description 5
230000002588 toxic effect Effects 0.000 description 5
208000028018 Lymphocytic leukaemia Diseases 0.000 description 4
241000699666 Mus <mouse, genus> Species 0.000 description 4
125000003963 dichloro group Chemical group Cl* 0.000 description 4
208000003747 lymphoid leukemia Diseases 0.000 description 4
230000001225 therapeutic effect Effects 0.000 description 4
241000699670 Mus sp. Species 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
PNNCWTXUWKENPE-UHFFFAOYSA-N [N].NC(N)=O Chemical compound [N].NC(N)=O PNNCWTXUWKENPE-UHFFFAOYSA-N 0.000 description 3
210000003734 kidney Anatomy 0.000 description 3
150000003057 platinum Chemical class 0.000 description 3
239000007787 solid Substances 0.000 description 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
230000001093 anti-cancer Effects 0.000 description 2
230000000259 anti-tumor effect Effects 0.000 description 2
125000003710 aryl alkyl group Chemical group 0.000 description 2
125000003118 aryl group Chemical group 0.000 description 2
239000008280 blood Substances 0.000 description 2
210000004369 blood Anatomy 0.000 description 2
239000004202 carbamide Substances 0.000 description 2
125000000753 cycloalkyl group Chemical group 0.000 description 2
KMEQMZMYKYCLMS-UHFFFAOYSA-N cyclohexane platinum(2+) Chemical compound [Pt+2].C1CCCCC1 KMEQMZMYKYCLMS-UHFFFAOYSA-N 0.000 description 2
230000006378 damage Effects 0.000 description 2
229940079593 drug Drugs 0.000 description 2
230000007717 exclusion Effects 0.000 description 2
238000002844 melting Methods 0.000 description 2
230000008018 melting Effects 0.000 description 2
230000008520 organization Effects 0.000 description 2
238000001228 spectrum Methods 0.000 description 2
125000000547 substituted alkyl group Chemical group 0.000 description 2
ARCGXLSVLAOJQL-UHFFFAOYSA-N trimellitic acid Chemical compound OC(=O)C1=CC=C(C(O)=O)C(C(O)=O)=C1 ARCGXLSVLAOJQL-UHFFFAOYSA-N 0.000 description 2
238000005160 1H NMR spectroscopy Methods 0.000 description 1
YMWLQHWZSKQTIJ-UHFFFAOYSA-L C(C(=O)[O-])(=O)[O-].[Pt+2].C1CCCCC1 Chemical compound C(C(=O)[O-])(=O)[O-].[Pt+2].C1CCCCC1 YMWLQHWZSKQTIJ-UHFFFAOYSA-L 0.000 description 1
201000009030 Carcinoma Diseases 0.000 description 1
229910020427 K2PtCl4 Inorganic materials 0.000 description 1
241000700159 Rattus Species 0.000 description 1
XZAHJRZBUWYCBM-UHFFFAOYSA-N [1-(aminomethyl)cyclohexyl]methanamine Chemical compound NCC1(CN)CCCCC1 XZAHJRZBUWYCBM-UHFFFAOYSA-N 0.000 description 1
PTGRNMGGKQUEGN-UHFFFAOYSA-N [Pt+2].NCC1CCCCC1 Chemical compound [Pt+2].NCC1CCCCC1 PTGRNMGGKQUEGN-UHFFFAOYSA-N 0.000 description 1
239000013543 active substance Substances 0.000 description 1
230000002411 adverse Effects 0.000 description 1
150000001412 amines Chemical class 0.000 description 1
125000000129 anionic group Chemical group 0.000 description 1
229940045985 antineoplastic platinum compound Drugs 0.000 description 1
230000036765 blood level Effects 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
230000000973 chemotherapeutic effect Effects 0.000 description 1
238000002512 chemotherapy Methods 0.000 description 1
FOCAUTSVDIKZOP-UHFFFAOYSA-N chloroacetic acid Chemical compound OC(=O)CCl FOCAUTSVDIKZOP-UHFFFAOYSA-N 0.000 description 1
DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 1
238000001816 cooling Methods 0.000 description 1
AVKNGPAMCBSNSO-UHFFFAOYSA-N cyclohexylmethanamine Chemical compound NCC1CCCCC1 AVKNGPAMCBSNSO-UHFFFAOYSA-N 0.000 description 1
238000000354 decomposition reaction Methods 0.000 description 1
229910003460 diamond Inorganic materials 0.000 description 1
239000010432 diamond Substances 0.000 description 1
IRXRGVFLQOSHOH-UHFFFAOYSA-L dipotassium;oxalate Chemical compound [K+].[K+].[O-]C(=O)C([O-])=O IRXRGVFLQOSHOH-UHFFFAOYSA-L 0.000 description 1
230000000694 effects Effects 0.000 description 1
235000019441 ethanol Nutrition 0.000 description 1
239000012530 fluid Substances 0.000 description 1
231100000086 high toxicity Toxicity 0.000 description 1
238000010562 histological examination Methods 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
230000036210 malignancy Effects 0.000 description 1
NHNBFGGVMKEFGY-UHFFFAOYSA-N nitrate group Chemical group [N+](=O)([O-])[O-] NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
125000004433 nitrogen atom Chemical group N* 0.000 description 1
229940026778 other chemotherapeutics in atc Drugs 0.000 description 1
150000003891 oxalate salts Chemical group 0.000 description 1
150000003058 platinum compounds Chemical class 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
238000012216 screening Methods 0.000 description 1
210000000952 spleen Anatomy 0.000 description 1
239000000126 substance Substances 0.000 description 1
230000004083 survival effect Effects 0.000 description 1
238000010998 test method Methods 0.000 description 1
231100001274 therapeutic index Toxicity 0.000 description 1
231100000816 toxic dose Toxicity 0.000 description 1
239000003053 toxin Substances 0.000 description 1
231100000765 toxin Toxicity 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NL8204067A 1979-07-04 1982-10-21 Platina-diaminecomplexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijk platinadiaminecomplex voor de behandeling van kanker, alsmede aldus verkregen gevormd geneesmiddel. NL8204067A (nl)

Priority Applications (30)

Application Number	Priority Date	Filing Date	Title
NL8204067A NL8204067A (nl)	1982-10-21	1982-10-21	Platina-diaminecomplexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijk platinadiaminecomplex voor de behandeling van kanker, alsmede aldus verkregen gevormd geneesmiddel.
DE19833337333 DE3337333A1 (de)	1982-10-21	1983-10-13	Neue platinverbindungen, verfahren zu ihrer herstellung und pharmazeutische mittel, welche diese verbindungen enthalten
AU20275/83A AU562964B2 (en)	1982-10-21	1983-10-18	Platinum-diamine complexes, a process for the preparation thereof, a process for the preparation of a medical composition using a such platinum-diamine complex for the treatment of cancer, as well as the thus shaped composition
IL7000983A IL70009A (en)	1979-07-04	1983-10-19	Platinum-diamine complexes,anti cancer pharmaceutical compositions containing them and methods for their preparation
CA000439308A CA1229618A (en)	1982-10-21	1983-10-19	Platinum-diamine complexes, a process for the preparation thereof, a process for the preparation of medical composition using a such platinum-diamine complex for the treatment of cancer, as well as the thus shaped composition
IT23359/83A IT1169858B (it)	1982-10-21	1983-10-19	Complessi platino-diamminici, procedtimento per la loro prreparazione,procedimento per la preparazione di una compossizione medica contenente tali complessi platino-diamminici per il trattamento del cancro,nonche' composizione cosi' realizzata
GR72754A GR79652B (da)	1982-10-21	1983-10-20
PT77542A PT77542B (en)	1982-10-21	1983-10-20	Process for preparing platinum-(ii)-diamine complexes and medi-cal compositions containing them
LU85054A LU85054A1 (da)	1982-10-21	1983-10-20
YU2107/83A YU43554B (en)	1982-10-21	1983-10-20	Process for obtaining new platinum-(ii)-diaminic complex
FR8316715A FR2534907B1 (fr)	1982-10-21	1983-10-20	Complexes diamine-platine, un procede pour leur preparation, un procede pour la preparation d'une composition medicinale utilisant un tel complexe diamine platine pour le traitement du cancer ainsi que la composition ainsi formee
NZ206018A NZ206018A (en)	1982-10-21	1983-10-20	Platinum-diamine complexes and compositions for treating cancer
DK483083A DK483083A (da)	1982-10-21	1983-10-20	Platin-diamin komplekser og fremgangsmaade til fremstilling deraf
NO833825A NO171276C (no)	1982-10-21	1983-10-20	Analogifremgangsmaate for fremstilling av terapeutisk virksomme platina-(ii)-diaminkomplekser
DD83255826A DD217522A5 (de)	1982-10-21	1983-10-20	Verfahren zur herstellung einer medizinischen zubereitung zur behandlung von krebs
IE2459/83A IE56124B1 (en)	1982-10-21	1983-10-20	Platinum diamine complexes
GB08328084A GB2128615B (en)	1982-10-21	1983-10-20	Platinum 1,3-propane diamine complexes
SE8305783A SE8305783L (sv)	1982-10-21	1983-10-20	Platina-diamin-komplex, ett forfarande for framstellning derav, ett forfarande for framstellning av en medicinsk komposition under anvendning av ett dylikt platina-diamin-komplex for behandling av cancer samt den pa det
FI833842A FI76351C (fi)	1982-10-21	1983-10-20	Foerfarande foer framstaellning av 2,2-substituerade 1,3-alkandiaminplatina(ii)komplexer med antitumoeraktivitet.
HU833623A HU188035B (en)	1982-10-21	1983-10-20	Process for producing new plantinum-diamine complex
CH5718/83A CH658244A5 (de)	1982-10-21	1983-10-20	Neue platinverbindungen und verfahren zu ihrer herstellung sowie verfahren zur herstellung von sie enthaltenden medizinischen zubereitungen zur behandlung von krebs.
AT0373083A AT390610B (de)	1982-10-21	1983-10-20	Verfahren zur herstellung von neuen platin-(ii) -diaminkomplexen
PH29726A PH24077A (en)	1982-10-21	1983-10-21	Platinum diamine complexes
ES526670A ES526670A0 (es)	1982-10-21	1983-10-21	Procedimiento de obtencion de complejos de platino (ii)-diamina
ZA837857A ZA837857B (en)	1982-10-21	1983-10-21	Platinum-diamine complexes,a process for the preparation thereof and a process for the preparation of a medical composition using such a complex for the treatment of cancer
BE0/211755A BE898058A (nl)	1982-10-21	1983-10-21	Platina-diaminecomplexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijk platina-diamine complex voor de behandeling van kanker, alsmede aldus verkregen gevormd geneesmiddel.
JP58196286A JPS5993091A (ja)	1982-10-21	1983-10-21	白金（２）ジアミン錯体
CS837752A CS242888B2 (en)	1982-10-21	1983-10-21	Method of diamminoplatinous complexes production
KR1019830004987A KR910002536B1 (ko)	1982-10-21	1983-10-21	플라티늄-디아민 착화물의 제조방법
DK075592A DK75592A (da)	1982-10-21	1992-06-09	Analogifremgangsmaade til fremstilling af platin-diamin komplekser

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
NL8204067		1982-10-21
NL8204067A NL8204067A (nl)	1982-10-21	1982-10-21	Platina-diaminecomplexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijk platinadiaminecomplex voor de behandeling van kanker, alsmede aldus verkregen gevormd geneesmiddel.

Publications (1)

Publication Number	Publication Date
NL8204067A true NL8204067A (nl)	1984-05-16

Family

ID=19840444

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL8204067A NL8204067A (nl)	1979-07-04	1982-10-21	Platina-diaminecomplexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijk platinadiaminecomplex voor de behandeling van kanker, alsmede aldus verkregen gevormd geneesmiddel.

Country Status (28)

Country	Link
JP (1)	JPS5993091A (da)
KR (1)	KR910002536B1 (da)
AT (1)	AT390610B (da)
AU (1)	AU562964B2 (da)
BE (1)	BE898058A (da)
CA (1)	CA1229618A (da)
CH (1)	CH658244A5 (da)
CS (1)	CS242888B2 (da)
DD (1)	DD217522A5 (da)
DE (1)	DE3337333A1 (da)
DK (2)	DK483083A (da)
ES (1)	ES526670A0 (da)
FI (1)	FI76351C (da)
FR (1)	FR2534907B1 (da)
GB (1)	GB2128615B (da)
GR (1)	GR79652B (da)
HU (1)	HU188035B (da)
IE (1)	IE56124B1 (da)
IT (1)	IT1169858B (da)
LU (1)	LU85054A1 (da)
NL (1)	NL8204067A (da)
NO (1)	NO171276C (da)
NZ (1)	NZ206018A (da)
PH (1)	PH24077A (da)
PT (1)	PT77542B (da)
SE (1)	SE8305783L (da)
YU (1)	YU43554B (da)
ZA (1)	ZA837857B (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4786725A (en) *	1982-06-28	1988-11-22	Engelhard Corporation	Solubilized platinum (II) complexes
US4661516A (en) *	1983-06-20	1987-04-28	Research Corporation	Diaminocyclohexane platinum complexes
US4758588A (en) *	1983-06-20	1988-07-19	Research Corporation Technologies	Diaminocyclohexane platinum complexes
EP0169645A1 (en) *	1984-06-27	1986-01-29	Johnson Matthey Public Limited Company	Platinum co-ordination compounds
DE3432320A1 (de) *	1984-09-03	1986-03-13	Behringwerke Ag, 3550 Marburg	Cis-platin-komplexe mit einem pentaerythritderivat als liganden, verfahren zu ihrer herstellung und diese verbindungen enthaltendes pharmazeutisches mittel
HU193809B (en) *	1984-09-12	1987-12-28	Chugai Pharmaceutical Co Ltd	Process for producing new platinum complexes
US4737589A (en) *	1985-08-27	1988-04-12	Nippon Kayaku Kabushiki Kaisha	Platinum Complexes
US4760157A (en) *	1986-01-31	1988-07-26	American Cyanamid Company	(2,2,-bis(aminomethyl)-1,3-propanediol-N,N')platinum complexes
US4880790A (en) *	1986-01-31	1989-11-14	American Cyanamid Company	(Gem-heterocyclodimethanamine-N,N')platinum complexes
DE3630497A1 (de) *	1986-09-08	1988-03-10	Behringwerke Ag	Cis-platin-komplexe, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel
ATE53217T1 (de) *	1986-10-03	1990-06-15	Asta Pharma Ag	Diamin-platin (ii)-komplexverbindungen mit einem hydroxylierten 2-phenyl-indolring.
JPS63203692A (ja) *	1987-02-19	1988-08-23	Nippon Kayaku Co Ltd	新規白金錯体
AT390065B (de) *	1987-10-08	1990-03-12	Behringwerke Ag	Cis-platin-komplexe, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel
NL8802149A (nl) *	1988-08-31	1990-03-16	Tno	Platina-(iv)diaminecomplex, werkwijze voor het bereiden van deze verbinding, preparaat met anti-tumor werking, dat ten minste een platinaverbinding bevat, alsmede gevormde preparaten met anti-tumor werking.
NL8802150A (nl) *	1988-08-31	1990-03-16	Tno	Platina-(ii)-diaminecomplex, werkwijze voor het bereiden van deze verbinding, preparaat met anti-tumor werking, dat deze verbinding bevat, alsmede gevormde preparaten met anti-tumor werking.
CN102924528B (zh) *	2012-10-29	2015-04-15	东南大学	抗肿瘤二价铂配合物以及该配合物和其配体的制备方法

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US4115418A (en) *	1976-09-02	1978-09-19	Government Of The United States Of America	1,2-diaminocyclohexane platinum (ii) complexes having antineoplastic activity
US4206226A (en) *	1977-08-29	1980-06-03	The United States Of America As Represented By The Department Of Health, Education And Welfare	Use of 4-carboxy-phthalato-(1,2-diaminocyclohexane)-platinum(II) and alkali metal salts thereof in alleviating L1210 murine leukemia
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NZ197104A (en) *	1980-05-27	1984-05-31	Bristol Myers Co	Soluble ammonium and sodium salts of 2-hydroxymalonato platinum ii derivatives

1982
- 1982-10-21 NL NL8204067A patent/NL8204067A/nl not_active Application Discontinuation
1983
- 1983-10-13 DE DE19833337333 patent/DE3337333A1/de not_active Ceased
- 1983-10-18 AU AU20275/83A patent/AU562964B2/en not_active Ceased
- 1983-10-19 CA CA000439308A patent/CA1229618A/en not_active Expired
- 1983-10-19 IT IT23359/83A patent/IT1169858B/it active
- 1983-10-20 YU YU2107/83A patent/YU43554B/xx unknown
- 1983-10-20 DK DK483083A patent/DK483083A/da not_active Application Discontinuation
- 1983-10-20 AT AT0373083A patent/AT390610B/de not_active IP Right Cessation
- 1983-10-20 IE IE2459/83A patent/IE56124B1/en not_active IP Right Cessation
- 1983-10-20 GR GR72754A patent/GR79652B/el unknown
- 1983-10-20 SE SE8305783A patent/SE8305783L/ not_active Application Discontinuation
- 1983-10-20 GB GB08328084A patent/GB2128615B/en not_active Expired
- 1983-10-20 DD DD83255826A patent/DD217522A5/de not_active IP Right Cessation
- 1983-10-20 NZ NZ206018A patent/NZ206018A/en unknown
- 1983-10-20 FR FR8316715A patent/FR2534907B1/fr not_active Expired
- 1983-10-20 PT PT77542A patent/PT77542B/pt unknown
- 1983-10-20 FI FI833842A patent/FI76351C/fi not_active IP Right Cessation
- 1983-10-20 LU LU85054A patent/LU85054A1/xx unknown
- 1983-10-20 CH CH5718/83A patent/CH658244A5/de not_active IP Right Cessation
- 1983-10-20 HU HU833623A patent/HU188035B/hu not_active IP Right Cessation
- 1983-10-20 NO NO833825A patent/NO171276C/no unknown
- 1983-10-21 JP JP58196286A patent/JPS5993091A/ja active Granted
- 1983-10-21 PH PH29726A patent/PH24077A/en unknown
- 1983-10-21 KR KR1019830004987A patent/KR910002536B1/ko not_active IP Right Cessation
- 1983-10-21 ES ES526670A patent/ES526670A0/es active Granted
- 1983-10-21 BE BE0/211755A patent/BE898058A/nl not_active IP Right Cessation
- 1983-10-21 CS CS837752A patent/CS242888B2/cs unknown
- 1983-10-21 ZA ZA837857A patent/ZA837857B/xx unknown
1992
- 1992-06-09 DK DK075592A patent/DK75592A/da not_active Application Discontinuation

Also Published As

Publication number	Publication date
FR2534907A1 (fr)	1984-04-27
IE832459L (en)	1984-04-21
IE56124B1 (en)	1991-04-24
GB8328084D0 (en)	1983-11-23
LU85054A1 (da)	1984-03-22
JPS5993091A (ja)	1984-05-29
NO171276C (no)	1993-02-17
DD217522A5 (de)	1985-01-16
AU562964B2 (en)	1987-06-25
GR79652B (da)	1984-10-31
FR2534907B1 (fr)	1988-08-19
SE8305783D0 (sv)	1983-10-20
DE3337333A1 (de)	1984-04-26
SE8305783L (sv)	1984-04-22
NZ206018A (en)	1986-02-21
ATA373083A (de)	1989-11-15
FI833842A0 (fi)	1983-10-20
FI833842A (fi)	1984-04-22
ES8406498A1 (es)	1984-07-01
PT77542A (en)	1983-11-01
IT1169858B (it)	1987-06-03
DK75592D0 (da)	1992-06-09
IT8323359A0 (it)	1983-10-19
HU188035B (en)	1986-03-28
PH24077A (en)	1990-03-05
FI76351B (fi)	1988-06-30
JPH0244479B2 (da)	1990-10-04
CA1229618A (en)	1987-11-24
KR840006492A (ko)	1984-11-30
KR910002536B1 (ko)	1991-04-23
FI76351C (fi)	1988-10-10
ZA837857B (en)	1984-06-27
ES526670A0 (es)	1984-07-01
CH658244A5 (de)	1986-10-31
YU43554B (en)	1989-08-31
PT77542B (en)	1986-02-12
YU210783A (en)	1986-08-31
NO171276B (no)	1992-11-09
AT390610B (de)	1990-06-11
DK483083D0 (da)	1983-10-20
NO833825L (no)	1984-04-24
CS775283A2 (en)	1985-08-15
DK75592A (da)	1992-06-09
DK483083A (da)	1984-04-22
CS242888B2 (en)	1986-05-15
AU2027583A (en)	1984-05-03
GB2128615A (en)	1984-05-02
GB2128615B (en)	1986-07-16
BE898058A (nl)	1984-04-24

Publication	Publication Date	Title
US4410544A (en)	1983-10-18	Platinum-diamine complexes, a method for the preparation of a medicine using such a platinum-diamine complex for the treatment of malignant tumor in mice
NL8204067A (nl)	1984-05-16	Platina-diaminecomplexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijk platinadiaminecomplex voor de behandeling van kanker, alsmede aldus verkregen gevormd geneesmiddel.
US4431666A (en)	1984-02-14	Platinum(IV)-diamine complexes, a process for the preparation thereof, a process for the preparation of a medicine using such a platinum(IV)-diamine complex for the treatment of malignant tumors in mice
US4466924A (en)	1984-08-21	Platinum-diamine complexes, a process for the preparation thereof, a process for the preparation of a medicine using such a platinum-diamine complex for the treatment of malignant tumors in mice as well as a medicine thus formed
CA1261864A (en)	1989-09-26	Liposoluble platinum (ii) complex and preparation thereof
JPS61171494A (ja)	1986-08-02	抗腫瘍性白金錯体
US4739087A (en)	1988-04-19	Antineoplastic platinum complexes
GB2055377A (en)	1981-03-04	Cis-platinum(II) amine ascorbate complexes
CA1196004A (en)	1985-10-29	Platinum-diamine complexes, a method for the preparation thereof, a method for the preparation of a medicine using such a platinum-diamine complex for the treatment of cancer as well as a medicine thus formed
NL8302115A (nl)	1985-01-02	Platina-diamine complexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijk platina-diamine complex voor de behandeling van kanker, alsmede aldus verkregen gevormd geneesmiddel.
NL7904740A (nl)	1980-01-08	Platina-diaminecomplexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmid- del met toepassing van een dergelijk platina-diamine- complex voor de behandeling van kanker, alsmede aldus verkregen gevormd geneesmiddel.
KR840000777B1 (ko)	1984-06-09	백금 디아민 착염의 제조방법
WO1989009598A1 (en)	1989-10-19	Platinum-amine-sulfoxides as anti-tumor agents
CA1219876A (en)	1987-03-31	Bis(thiocyanato)palladium(ii) complexes
JPS5988499A (ja)	1984-05-22	白金−ジアミン錯体
CS235311B2 (cs)	1985-05-15	Způsob výroby komplexního 2,2-disubstituovaného 1,3-alkandiaminu platnatého
Walker Jr et al.	1976	Antileukemic Properties of Organoplatinum Complexes 1, 2

Legal Events

Date	Code	Title
1984-05-16	A1B	A search report has been drawn up
1984-08-01	BT	A notification was added to the application dossier and made available to the public
1985-01-01	A85	Still pending on 85-01-01
1988-09-01	BT	A notification was added to the application dossier and made available to the public
1989-07-03	BC	A request for examination has been filed
1994-06-01	BV	The patent application has lapsed