[go: up one dir, main page]

NL301250I2 - piflufolastat (18F) of een farmaceutisch aanvaardbaar zout daarvan - Google Patents

piflufolastat (18F) of een farmaceutisch aanvaardbaar zout daarvan

Info

Publication number
NL301250I2
NL301250I2 NL301250C NL301250C NL301250I2 NL 301250 I2 NL301250 I2 NL 301250I2 NL 301250 C NL301250 C NL 301250C NL 301250 C NL301250 C NL 301250C NL 301250 I2 NL301250 I2 NL 301250I2
Authority
NL
Netherlands
Prior art keywords
piflufolastat
pharmaceutically acceptable
acceptable salt
salt
pharmaceutically
Prior art date
Application number
NL301250C
Other languages
English (en)
Original Assignee
Univ Johns Hopkins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins filed Critical Univ Johns Hopkins
Publication of NL301250I2 publication Critical patent/NL301250I2/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/16—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/18—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nuclear Medicine (AREA)
NL301250C 2008-08-01 2023-11-15 piflufolastat (18F) of een farmaceutisch aanvaardbaar zout daarvan NL301250I2 (nl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8546208P 2008-08-01 2008-08-01
US11179108P 2008-11-06 2008-11-06
PCT/US2009/052456 WO2010014933A2 (en) 2008-08-01 2009-07-31 Psma-binding agents and uses thereof

Publications (1)

Publication Number Publication Date
NL301250I2 true NL301250I2 (nl) 2023-11-23

Family

ID=41610978

Family Applications (1)

Application Number Title Priority Date Filing Date
NL301250C NL301250I2 (nl) 2008-08-01 2023-11-15 piflufolastat (18F) of een farmaceutisch aanvaardbaar zout daarvan

Country Status (24)

Country Link
US (6) US8778305B2 (nl)
EP (3) EP4089074A1 (nl)
JP (6) JP5588441B2 (nl)
KR (1) KR101664855B1 (nl)
CN (3) CN107382846B (nl)
AU (1) AU2009276423B2 (nl)
CA (2) CA2987744C (nl)
CY (2) CY1119367T1 (nl)
DK (2) DK2318366T3 (nl)
ES (2) ES2914593T3 (nl)
FI (1) FIC20230033I1 (nl)
FR (1) FR23C1044I2 (nl)
HK (1) HK1247197A1 (nl)
HR (2) HRP20220742T1 (nl)
HU (3) HUE034027T2 (nl)
LT (2) LT2318366T (nl)
NL (1) NL301250I2 (nl)
NO (1) NO2024006I1 (nl)
PL (2) PL2318366T3 (nl)
PT (2) PT3222615T (nl)
RU (1) RU2494096C2 (nl)
SI (2) SI3222615T1 (nl)
SM (1) SMT201700371T1 (nl)
WO (1) WO2010014933A2 (nl)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2187965T1 (sl) 2007-08-17 2020-03-31 Purdue Research Foundation Office Of Technology Commercialization Konjugati vezalca ligand-veznika PSMA in metode za uporabo
WO2009070302A1 (en) * 2007-11-30 2009-06-04 The Johns Hopkins University Prostate specific membrane antigen (psma) targeted nanoparticles for therapy of prostate cancer
USRE47609E1 (en) 2007-12-28 2019-09-17 Exini Diagnostics Ab System for detecting bone cancer metastases
CA2987744C (en) * 2008-08-01 2022-11-15 The Johns Hopkins University Psma-binding agents and uses thereof
CA2769444A1 (en) 2009-05-19 2010-11-25 Aic Blab Company Composite current collector and methods therefor
US9951324B2 (en) 2010-02-25 2018-04-24 Purdue Research Foundation PSMA binding ligand-linker conjugates and methods for using
WO2013028664A1 (en) * 2011-08-22 2013-02-28 Siemens Medical Solutions Usa, Inc. Psma imaging agents
US20130116404A1 (en) 2011-11-08 2013-05-09 Case Western Reserve University Targeted non-invasive imaging probes of egfr expressing cells
WO2013082338A1 (en) * 2011-11-30 2013-06-06 The Johns Hopkins University Homomultivalent and heteromultivalent inhibitors of prostate specific membrane antigen (pmsa) and uses thereof
US20140065070A1 (en) * 2012-08-28 2014-03-06 Mcmaster University Methods of preparing triazole-containing radioiodinated compounds
EA201590783A1 (ru) * 2012-11-15 2015-11-30 Эндосайт, Инк. Конъюгаты для доставки лекарственных средств и способы лечения заболеваний, вызванных клетками, экспрессирующими psma
PL3560937T3 (pl) * 2013-03-15 2023-03-27 Cancer Targeted Technology Llc Znakowane 18F środki do obrazowania PET ukierunkowane na PSMA i metody diagnostyczne je wykorzystujące
WO2015057692A1 (en) 2013-10-14 2015-04-23 The Johns Hopkins University Prostate-specific membrane antigen-targeted photosensitizers for photodynamic therapy
DE202014011593U1 (de) 2013-10-18 2023-08-23 Novartis Ag Markierte Inhibitoren des prostataspezifischen Membranantigens (PSMA), deren Verwendung als bildgebende Mittel und pharmazeutische Wirkstoffe für die Behandlung von Prostatakrebs
JP6292568B2 (ja) * 2013-11-06 2018-03-14 国立大学法人京都大学 ウレア誘導体化合物、これを含有する放射性医薬
EP3777898B1 (en) 2013-11-14 2025-01-01 Endocyte, Inc. Compounds for positron emission tomography
US9713649B2 (en) 2014-01-24 2017-07-25 The Cleveland Clinic Foundation PSMA-targeting imaging agents
WO2015153772A2 (en) * 2014-04-01 2015-10-08 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Zirconium-89 oxine complex as a cell labeling agent for positron emission tomography
EP2993171A1 (en) * 2014-09-04 2016-03-09 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Method for the production of 18F-labeled PSMA-specific PET-tracers
PL3183236T3 (pl) * 2014-08-24 2022-07-18 Max-Planck-Gesellschaft Zur Förderung Der Wissenschaften Sposób wytwarzania 18f-znakowanych aktywnych estrów i ich zastosowanie na przykładzie wytwarzania znacznika pet specyficznego dla psma
EP3209336B1 (en) 2014-10-20 2019-12-11 Deutsches Krebsforschungszentrum 18f-tagged inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer
EP3011976A1 (en) * 2014-10-20 2016-04-27 Deutsches Krebsforschungszentrum 18F-tagged inhibitors of prostate specific membrane antigen (PSMA), their use as imaging agents
WO2016065142A2 (en) * 2014-10-22 2016-04-28 The Johns Hopkins University New scaffolds and multifunctional intermediates for imaging psma and cancer therapy
US10188759B2 (en) 2015-01-07 2019-01-29 Endocyte, Inc. Conjugates for imaging
WO2016112382A2 (en) * 2015-01-09 2016-07-14 The Johns Hopkins University Intranasal administration of glutamate carboxypeptidase (gcp-ii) inhibitors
US10869940B2 (en) 2015-06-12 2020-12-22 The Board Of Trustees Of The Leland Stanford Junior University Targeted photoacoustic compounds, formulations, and uses thereof
EP3337520A1 (en) * 2015-08-20 2018-06-27 Universität zu Köln Pain tracking by pet-imaging (pain-trap)
PE20181350A1 (es) 2015-09-30 2018-08-22 Deutsches Krebsforsch Inhibidores marcados con 18f mejorados de antigeno de membrana especifico de prostata (psma) y su uso como agentes de diagnostico por imagenes para el cancer de prostata
US20200231614A1 (en) * 2015-10-22 2020-07-23 The Johns Hopkins University Psma targeted radiohalogenated ureas for cancer radiotherapy
KR101639599B1 (ko) 2015-11-09 2016-07-14 서울대학교산학협력단 펩타이드 싸이오우레아 유도체, 이를 포함하는 방사성 동위원소 표지 화합물 및 이를 유효 성분으로 함유하는 전립선암 치료 또는 진단용 약학적 조성물
AU2017204979B2 (en) 2016-01-10 2020-11-19 Provincial Health Services Authority 18/19F-labelled compounds which target the prostate specific membrane antigen
CA3026889A1 (en) 2016-06-10 2017-12-14 The Johns Hopkins University Improved synthesis of the radiolabeled prostate-specific membrane antigen (psma) inhibitor [18f]dcfpyl
US10806806B2 (en) 2016-06-23 2020-10-20 Cornell University Trifunctional constructs with tunable pharmacokinetics useful in imaging and anti-tumor therapies
CA3028978A1 (en) * 2016-06-23 2017-12-28 Cornell University Double targeted constructs to affect tumor kill
CN109844865B (zh) 2016-10-27 2021-03-30 普罗热尼奇制药公司 用于医学图像分析的网络、决策支持系统和相关图形用户界面(gui)应用
CN110167554B (zh) * 2016-11-17 2023-05-23 思路迪（北京）医药科技有限公司 一种具有抗癌作用的化合物及其制备方法和应用
DE102016122273B4 (de) * 2016-11-18 2018-06-21 Abx Advanced Biochemical Compounds Gmbh Präkursoren für die Radiofluorierung
CA3058663A1 (en) 2017-04-05 2018-10-11 Cornell University Trifunctional constructs with tunable pharmacokinetics useful in imaging and anti-tumor therapies
WO2018187791A1 (en) 2017-04-07 2018-10-11 Juno Therapeutics, Inc Engineered cells expressing prostate-specific membrane antigen (psma) or a modified form thereof and related methods
JP7373998B2 (ja) 2017-05-02 2023-11-06 コーネル・ユニバーシティー 有効性がより大きくかつ毒性がより少ない腫瘍標的指向方法及び試薬
WO2018236115A1 (ko) 2017-06-19 2018-12-27 (주)퓨쳐켐 전립선암 진단을 위한 18f-표지된 화합물 및 그의 용도
MX2019015616A (es) 2017-06-19 2020-02-26 Futurechem Co Ltd Compuesto marcado con 18f para diagnostico de cancer de prostata y uso de este.
WO2019083990A2 (en) 2017-10-23 2019-05-02 The Johns Hopkins University IMAGING AND RADIATION THERAPY AGENTS TARGETING α-FIBROBLAST ACTIVATION PROTEIN α (FAP-α)
PT3723815T (pt) * 2017-12-11 2022-05-30 Univ Muenchen Tech Ligandos psma para imagiologia e endorradioterapia
EP3738097B1 (en) 2018-01-08 2025-03-05 Progenics Pharmaceuticals, Inc. System and method for rapid neural network-based image segmentation
US10973486B2 (en) 2018-01-08 2021-04-13 Progenics Pharmaceuticals, Inc. Systems and methods for rapid neural network-based image segmentation and radiopharmaceutical uptake determination
EP3749653A4 (en) * 2018-02-06 2021-12-15 The Johns Hopkins University RADIOHALOGENATED UREA POLYAMINOCARBOXYLATES TARGETING PSMA FOR ANTI-CANCER RADIOTHERAPY
WO2019183633A1 (en) 2018-03-23 2019-09-26 Case Western Reserve Univeristy Psma targeted conjugate compounds and uses thereof
CA3097381A1 (en) 2018-04-17 2019-10-24 Endocyte, Inc. Methods of treating cancer
CN109160898B (zh) * 2018-05-16 2021-06-04 上海如絮生物科技有限公司 一种亲水性吡啶类化合物中间体及其制备方法
CN109160896B (zh) * 2018-05-16 2021-06-25 上海如絮生物科技有限公司 一种亲水性吡啶类化合物中间体及其制备方法
CN109160899B (zh) * 2018-05-16 2021-06-04 上海如絮生物科技有限公司 一种亲水性吡啶类化合物、中间体、其制备方法及应用
WO2020028323A1 (en) * 2018-07-30 2020-02-06 The Johns Hopkins Universtiy Competitive prostate-specific membrane antigen (psma) binding agents for the reduction of non-target organ uptake of radiolabeled psma inhibitors for psma positive tumor imaging and radiopharmaceutical therapy
CN113164450A (zh) 2018-10-11 2021-07-23 普罗热尼奇制药公司 用于治疗转移性前列腺癌的组合治疗
RU2697519C1 (ru) * 2018-10-15 2019-08-15 Общество с ограниченной ответственностью "Изварино Фарма" Средство пептидной природы, включающее псма-связывающий лиганд на основе производного мочевины, способ его получения и применение для получения конъюгата с лекарственным и диагностическим агентом
KR102403970B1 (ko) 2018-12-27 2022-05-31 (주)퓨쳐켐 카르복시산이 도입된 psma-표적 화합물 및 그의 용도
TWI851646B (zh) 2019-01-07 2024-08-11 瑞典商艾西尼診斷公司 用於平台中立性全身影像分段之系統及方法
PL239934B1 (pl) 2019-04-12 2022-01-31 Narodowe Centrum Badan Jadrowych Osrodek Radioizotopow Polatom Pochodne inhibitorów PSMA do znakowania ⁹⁹ᵐTc poprzez HYNIC, zestaw radiofarmaceutyczny, preparat radiofarmaceutyczny oraz ich zastosowanie w diagnostyce raka prostaty
US11534125B2 (en) 2019-04-24 2022-12-27 Progenies Pharmaceuticals, Inc. Systems and methods for automated and interactive analysis of bone scan images for detection of metastases
WO2020219619A1 (en) 2019-04-24 2020-10-29 Progenics Pharmaceuticals, Inc. Systems and methods for interactive adjustment of intensity windowing in nuclear medicine images
CA3144094A1 (en) 2019-06-21 2020-12-24 Provincial Health Services Authority Radiolabeled compounds targeting the prostate-specific membrane antigen
RU2713151C1 (ru) * 2019-07-02 2020-02-04 Общество с ограниченной ответственностью "Изварино Фарма" Конъюгат флуоресцентного красителя с веществом пептидной природы, включающим псма-связывающий лиганд на основе производного мочевины для визуализации клеток, экспрессирующих псма, способ его получения и применения
WO2021041896A1 (en) * 2019-08-30 2021-03-04 Memorial Sloan Kettering Cancer Center Novel theranostic agents for psma positive cancers
US11900597B2 (en) 2019-09-27 2024-02-13 Progenics Pharmaceuticals, Inc. Systems and methods for artificial intelligence-based image analysis for cancer assessment
US11544407B1 (en) 2019-09-27 2023-01-03 Progenics Pharmaceuticals, Inc. Systems and methods for secure cloud-based medical image upload and processing
US11564621B2 (en) 2019-09-27 2023-01-31 Progenies Pharmacenticals, Inc. Systems and methods for artificial intelligence-based image analysis for cancer assessment
US11386988B2 (en) 2020-04-23 2022-07-12 Exini Diagnostics Ab Systems and methods for deep-learning-based segmentation of composite images
US11321844B2 (en) 2020-04-23 2022-05-03 Exini Diagnostics Ab Systems and methods for deep-learning-based segmentation of composite images
CN111548305B (zh) * 2020-05-12 2021-08-31 北京师范大学 一种可用于靶向psma的喹啉类化合物及其制备方法
TW202207241A (zh) 2020-07-06 2022-02-16 瑞典商艾西尼診斷公司 用於偵測及表徵化病變之基於人工智慧的影像分析系統與方法
US11721428B2 (en) 2020-07-06 2023-08-08 Exini Diagnostics Ab Systems and methods for artificial intelligence-based image analysis for detection and characterization of lesions
US20230406847A1 (en) 2020-11-12 2023-12-21 Abx Advanced Biochemical Compounds Gmbh Ligands of prostate specific membrane antigen (psma) containing heteroaromatic linker building blocks
CN114685599A (zh) * 2020-12-30 2022-07-01 南京江原安迪科正电子研究发展有限公司 一种psma靶向抑制剂及放射性核素标记的psma靶向抑制剂、制备方法和用途
CA3227534A1 (en) 2021-07-30 2023-02-02 Yoshifumi Shirakami Radiolabeled compound and use thereof
WO2023057411A1 (en) 2021-10-08 2023-04-13 Exini Diagnostics Ab Systems and methods for automated identification and classification of lesions in local lymph and distant metastases
EP4429654A1 (en) 2021-11-09 2024-09-18 Case Western Reserve University Psma targeted conjugate compounds and uses thereof
CN119325617A (zh) 2022-06-08 2025-01-17 普罗热尼奇制药公司 评估疾病负荷和进展的系统和方法
WO2024150132A1 (en) 2023-01-10 2024-07-18 Sun Pharma Advanced Research Company Limited Ligand-drug conjugates
US20240285248A1 (en) 2023-02-13 2024-08-29 Progenics Pharmaceuticals, Inc. Systems and methods for predicting biochemical progression free survival in prostate cancer patients
CN116217505B (zh) * 2023-03-17 2024-10-01 南京医科大学 用于诊断或治疗表达前列腺特异性膜抗原癌症的新型标记靶向剂
WO2024211651A1 (en) 2023-04-07 2024-10-10 Progenics Pharmaceuticals, Inc. Systems and methods for facilitating lesion inspection and analysis
CN117670883B (zh) * 2024-01-31 2024-05-07 中国医学科学院北京协和医院 一种鉴别高低级别膀胱癌的方法、设备和系统

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2233269C2 (ru) * 1998-11-02 2004-07-27 Авентис Фарма Лимитед Замещенные анилиды, фармацевтическая композиция и способ лечения
JP3750494B2 (ja) 1999-08-31 2006-03-01 松下電器産業株式会社 半導体装置
WO2006093991A1 (en) * 2005-03-02 2006-09-08 The Cleveland Clinic Foundation Compounds which bind psma and uses thereof
EP2942065B1 (en) * 2006-11-08 2018-06-27 Molecular Insight Pharmaceuticals, Inc. Heterodimers of glutamic acid
CN104774175B (zh) * 2007-06-26 2019-04-16 约翰·霍普金斯大学 标记的前列腺特异性膜抗原(psma)的抑制子、生物学评估及作为成像试剂的用途
HUE034775T2 (hu) * 2007-09-28 2018-02-28 Pfizer Rákos sejt célzása nanorészecskék alkalmazásával
CA2987744C (en) * 2008-08-01 2022-11-15 The Johns Hopkins University Psma-binding agents and uses thereof
GB0905438D0 (en) 2009-03-30 2009-05-13 Ge Healthcare Ltd Radiolabelling reagents and methods
CA3026889A1 (en) * 2016-06-10 2017-12-14 The Johns Hopkins University Improved synthesis of the radiolabeled prostate-specific membrane antigen (psma) inhibitor [18f]dcfpyl

Also Published As

Publication number Publication date
JP5806765B2 (ja) 2015-11-10
CA2732632C (en) 2018-01-09
CA2987744C (en) 2022-11-15
JP2016053025A (ja) 2016-04-14
JP7219497B2 (ja) 2023-02-08
US20220088229A1 (en) 2022-03-24
AU2009276423A1 (en) 2010-02-04
JP2017048204A (ja) 2017-03-09
ES2914593T3 (es) 2022-06-14
PL3222615T3 (pl) 2022-09-26
FIC20230033I1 (fi) 2023-11-02
CN107382846A (zh) 2017-11-24
EP2318366B1 (en) 2017-05-03
US20180236110A1 (en) 2018-08-23
DK3222615T3 (da) 2022-06-20
NO2024006I1 (no) 2024-02-01
PL2318366T3 (pl) 2017-10-31
HRP20220742T1 (hr) 2022-10-28
JP7277113B2 (ja) 2023-05-18
CY2023024I1 (el) 2024-02-16
LT2318366T (lt) 2017-10-25
CA2987744A1 (en) 2010-02-04
CN102171187A (zh) 2011-08-31
CN113563262A (zh) 2021-10-29
EP4089074A1 (en) 2022-11-16
SI2318366T1 (sl) 2017-10-30
LT3222615T (lt) 2022-08-25
AU2009276423B2 (en) 2014-10-30
JP2011529919A (ja) 2011-12-15
US12070513B2 (en) 2024-08-27
ES2634894T3 (es) 2017-09-29
EP2318366A4 (en) 2011-12-14
CN102171187B (zh) 2017-07-28
FR23C1044I1 (fr) 2023-12-29
PT3222615T (pt) 2022-06-20
US20110142760A1 (en) 2011-06-16
HK1247197A1 (zh) 2018-09-21
US20160114060A1 (en) 2016-04-28
KR20110038725A (ko) 2011-04-14
CY2023024I2 (el) 2024-12-13
RU2494096C2 (ru) 2013-09-27
HRP20171133T1 (hr) 2017-10-20
KR101664855B1 (ko) 2016-10-11
US10500292B2 (en) 2019-12-10
CN107382846B (zh) 2021-07-06
WO2010014933A2 (en) 2010-02-04
FR23C1044I2 (fr) 2024-08-23
EP2318366A2 (en) 2011-05-11
JP6524046B2 (ja) 2019-06-05
DK2318366T3 (en) 2017-08-21
WO2010014933A3 (en) 2010-05-20
EP3222615B1 (en) 2022-05-04
JP5588441B2 (ja) 2014-09-10
CA2732632A1 (en) 2010-02-04
US20140369931A1 (en) 2014-12-18
HUE034027T2 (en) 2018-01-29
CY1119367T1 (el) 2018-02-14
US20200282083A1 (en) 2020-09-10
RU2011107752A (ru) 2012-09-10
EP3222615A1 (en) 2017-09-27
HUS2300039I1 (hu) 2023-12-28
JP2021095407A (ja) 2021-06-24
US9226981B2 (en) 2016-01-05
HUE059436T2 (hu) 2022-11-28
JP2019055973A (ja) 2019-04-11
JP2015007058A (ja) 2015-01-15
US9861713B2 (en) 2018-01-09
SMT201700371T1 (it) 2017-09-07
US8778305B2 (en) 2014-07-15
PT2318366T (pt) 2017-08-02
SI3222615T1 (sl) 2022-11-30
JP6030724B2 (ja) 2016-11-24

Similar Documents

Publication Publication Date Title
NL301250I2 (nl) piflufolastat (18F) of een farmaceutisch aanvaardbaar zout daarvan
NL301305I2 (nl) Vibegron of een farmaceutisch aanvaardbaar zout daarvan
NL301166I2 (nl) Avacopan of een farmaceutisch aanvaardbaar zout daarvan
NL301071I2 (nl) alpelisib of een farmaceutisch aanvaardbaar zout ervan
NL301291I2 (nl) sparsentan of een farmaceutisch aanvaardbaar zout daarvan
NL301256I2 (nl) cedazuridine, of een farmaceutisch aanvaardbaar zout daarvan
NL301209I2 (nl) capmatinib of een farmaceutisch aanvaardbaar zout daarvan
NL301187I2 (nl) Rimegepant of een farmaceutisch aanvaardbaar zout daarvan
NL301035I2 (nl) upadacitinib of een farmaceutisch aanvaardbaar zout daarvan
NL301284I2 (nl) Etrasimod, of een farmaceutisch aanvaardbaar zout daarvan, zoals etrasimod arginine
NL301003I2 (nl) Sotagliflozin of een farmaceutisch aanvaardbaar zout daarvan
NL300993I2 (nl) Apalutamide of een farmaceutisch aanvaardbaar zout daarvan
NL300886I2 (nl) baricitinib, of een farmaceutisch aanvaardbaar zout daarvan
NL301157I2 (nl) odevixibat of een farmaceutisch aanvaardbaar zout daarvan
NL301248I2 (nl) atogepant of een farmaceutisch aanvaardbaar zout daarvan
NL301304I2 (nl) aprocitentan of een farmaceutisch aanvaardbaar zout daarvan
NL301096I2 (nl) Filgotinib of een zout daarvan
NL301106I1 (nl) Cenobamaat of een farmaceutisch aanvaardbaar zout daarvan
NL301028I2 (nl) Gilteritinib of een zout ervan
NL301065I2 (nl) Ozanimod of een farmaceutisch aanvaardbaar zout daarvan, in het bijzonder ozanimodhydrochloride
FIC20190029I1 (fi) Brigatinibi tai sen farmaseuttisesti hyväksyttävä suola
NL300901I2 (nl) pibrentasvir of een farmaceutisch aanvaardbaar zout daarvan
NL301084I2 (nl) remdesivir of een farmaceutisch aanvaardbaar zout of ester daarvan
NO2017059I2 (no) ribosiklib eller et farmasøytisk akseptabelt salt derav
NL300900I2 (nl) glecaprevir of een farmaceutisch aanvaardbaar zout of ester daarvan