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MXPA04003976A - Agentes antiarritmicos de administracion vaginal para tratamiento de dolor pelvico e infertilidad. - Google Patents

Agentes antiarritmicos de administracion vaginal para tratamiento de dolor pelvico e infertilidad.

Info

Publication number
MXPA04003976A
MXPA04003976A MXPA04003976A MXPA04003976A MXPA04003976A MX PA04003976 A MXPA04003976 A MX PA04003976A MX PA04003976 A MXPA04003976 A MX PA04003976A MX PA04003976 A MXPA04003976 A MX PA04003976A MX PA04003976 A MXPA04003976 A MX PA04003976A
Authority
MX
Mexico
Prior art keywords
infertility
pelvic pain
dysrhythmic
treating
bioadhesive
Prior art date
Application number
MXPA04003976A
Other languages
English (en)
Inventor
L Levine Howard
Original Assignee
Columbia Lab Bermuda Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Columbia Lab Bermuda Ltd filed Critical Columbia Lab Bermuda Ltd
Publication of MXPA04003976A publication Critical patent/MXPA04003976A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Inorganic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pregnancy & Childbirth (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La presente invencion se refiere a una composicion farmaceutica para aliviar el dolor pelvico o la infertilidad asociados con arritmia uterina. La composicion comprende un agente para el tratamiento de arritmia de administracion local y un portador bioadhesivo de liberacion prolongada. La composicion puede estar disponible como formulacion de liberacion lenta incluyendo un polimero de acido policarboxilico reticulado bioadhesivo, expandible en agua, insoluble en agua, tal como policarbofilo. El agente del tratamiento puede ser un anestesico local, tal como lidocaina. La invencion se refiere tambien a un metodo para el tratamiento o la prevencion de dolor pelvico, o el tratamiento o la mejoria de infertilidad, insertando una mezcla de un agente de tratamiento antiarritmico y un portador bioadhesivo en la vagina de la paciente que debe someterse a tratamiento.
MXPA04003976A 2001-10-29 2002-10-28 Agentes antiarritmicos de administracion vaginal para tratamiento de dolor pelvico e infertilidad. MXPA04003976A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33068401P 2001-10-29 2001-10-29
US10/278,912 US20030114394A1 (en) 2001-10-29 2002-10-24 Vaginally administered anti-dysrhythmic agents for treating pelvic pain
PCT/EP2002/012042 WO2003037381A1 (en) 2001-10-29 2002-10-28 Vaginally administerd anti-dysrhythmic agents for treating pelvic pain and infertility

Publications (1)

Publication Number Publication Date
MXPA04003976A true MXPA04003976A (es) 2004-07-08

Family

ID=26959337

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04003976A MXPA04003976A (es) 2001-10-29 2002-10-28 Agentes antiarritmicos de administracion vaginal para tratamiento de dolor pelvico e infertilidad.

Country Status (33)

Country Link
US (1) US20030114394A1 (es)
EP (2) EP1441770B1 (es)
JP (2) JP2005511564A (es)
KR (2) KR20050040820A (es)
CN (1) CN100404072C (es)
AR (1) AR037048A1 (es)
AT (2) ATE451123T1 (es)
AU (1) AU2002350644B2 (es)
BR (1) BR0213585A (es)
CA (1) CA2465132C (es)
CY (2) CY1106000T1 (es)
DE (2) DE60234725D1 (es)
DK (2) DK1764111T3 (es)
ES (2) ES2275928T3 (es)
GE (1) GEP20094614B (es)
HR (1) HRP20040479B1 (es)
HU (1) HUP0402389A3 (es)
IL (3) IL161513A0 (es)
MA (1) MA26230A1 (es)
ME (1) ME00255B (es)
MX (1) MXPA04003976A (es)
MY (2) MY149482A (es)
NO (1) NO333544B1 (es)
NZ (1) NZ532295A (es)
PE (1) PE20030692A1 (es)
PL (2) PL369790A1 (es)
PT (2) PT1764111E (es)
RS (1) RS51414B (es)
RU (2) RU2345758C2 (es)
SI (2) SI1764111T1 (es)
UA (1) UA90077C2 (es)
WO (1) WO2003037381A1 (es)
ZA (1) ZA200402944B (es)

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Also Published As

Publication number Publication date
DE60216495D1 (de) 2007-01-11
BR0213585A (pt) 2004-08-24
MA26230A1 (fr) 2004-07-01
RU2476212C2 (ru) 2013-02-27
KR20100088718A (ko) 2010-08-10
EP1441770A1 (en) 2004-08-04
NO20042208L (no) 2004-07-29
HRP20040479A2 (en) 2004-10-31
HUP0402389A2 (hu) 2005-03-29
US20030114394A1 (en) 2003-06-19
MY145215A (en) 2012-01-13
UA90077C2 (uk) 2010-04-12
HK1102221A1 (en) 2007-11-09
GEP20094614B (en) 2009-02-25
NZ532295A (en) 2006-12-22
NO333544B1 (no) 2013-07-08
ME00255B (me) 2011-05-10
JP2011201909A (ja) 2011-10-13
HUP0402389A3 (en) 2012-09-28
CY1110288T1 (el) 2015-01-14
AU2002350644B2 (en) 2008-05-08
PL402549A1 (pl) 2013-08-05
IL161513A (en) 2011-12-29
PT1441770E (pt) 2007-01-31
DE60216495T2 (de) 2007-07-26
IL161513A0 (en) 2004-09-27
PE20030692A1 (es) 2003-08-28
CN1578675A (zh) 2005-02-09
RU2345758C2 (ru) 2009-02-10
DE60234725D1 (de) 2010-01-21
ES2336238T3 (es) 2010-04-09
HRP20040479B1 (en) 2009-02-28
EP1441770B1 (en) 2006-11-29
CA2465132C (en) 2012-04-24
AR037048A1 (es) 2004-10-20
DK1441770T3 (da) 2007-03-19
EP1764111A1 (en) 2007-03-21
SI1441770T1 (sl) 2007-02-28
WO2003037381A1 (en) 2003-05-08
ES2275928T3 (es) 2007-06-16
RU2004116346A (ru) 2005-03-10
RU2008133235A (ru) 2010-02-20
CN100404072C (zh) 2008-07-23
IL211288A0 (en) 2011-04-28
DK1764111T3 (da) 2010-04-06
IL211288A (en) 2014-02-27
CA2465132A1 (en) 2003-05-08
CY1106000T1 (el) 2011-04-06
EP1764111B1 (en) 2009-12-09
KR20050040820A (ko) 2005-05-03
MEP34908A (en) 2011-02-10
JP2005511564A (ja) 2005-04-28
MY149482A (en) 2013-08-30
SI1764111T1 (sl) 2010-04-30
HK1063293A1 (en) 2004-12-24
PT1764111E (pt) 2010-01-29
RS36704A (en) 2006-10-27
ATE346614T1 (de) 2006-12-15
PL369790A1 (en) 2005-05-02
ATE451123T1 (de) 2009-12-15
ZA200402944B (en) 2005-03-30
RS51414B (en) 2011-02-28

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