[go: up one dir, main page]

MX9806341A - Derivados de ergolina heterociclica. - Google Patents

Derivados de ergolina heterociclica.

Info

Publication number
MX9806341A
MX9806341A MX9806341A MX9806341A MX9806341A MX 9806341 A MX9806341 A MX 9806341A MX 9806341 A MX9806341 A MX 9806341A MX 9806341 A MX9806341 A MX 9806341A MX 9806341 A MX9806341 A MX 9806341A
Authority
MX
Mexico
Prior art keywords
hydrogen
atom
heterocyclyl
receptor ligands
chlorine
Prior art date
Application number
MX9806341A
Other languages
English (en)
Inventor
Sergio Mantegani
Tiziano Bandiera
Maurizio Meroni
Mario Varasi
Carla Caccia
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Publication of MX9806341A publication Critical patent/MX9806341A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

El derivado ergolina que tiene la formula (I) en donde R1 es un átomo de hidrogeno o un grupo alquilo C1-4; R2 es un átomo de hidrogeno, cloro o bromo, metilo o un grupo alquiltio C1-4; n es 0.1 o 2; el substituyente a la posicion 8 en una configuracion alfa o beta, Het representa un anillo heterocíclico aromático de 5 miembros, dicho anillo tiene 3 heteroátomos, el cual es el mismo o diferente y el cual se selecciona a partir del grupo que consiste de átomos de azufre, oxígeno y nitrogeno y X es un átomo de hidrogeno, cloro, bromo o fluor, o una sal de adicion farmacéuticamente aceptable del mismo, se activa al nivel del sistema nervioso central. También se describe un proceso para su preparacion, así como sus composiciones farmacéuticas del mismo.
MX9806341A 1996-02-15 1998-08-06 Derivados de ergolina heterociclica. MX9806341A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9603226.3A GB9603226D0 (en) 1996-02-15 1996-02-15 Heterocyclyl-ergoline derivatives

Publications (1)

Publication Number Publication Date
MX9806341A true MX9806341A (es) 1998-10-31

Family

ID=10788832

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9806341A MX9806341A (es) 1996-02-15 1998-08-06 Derivados de ergolina heterociclica.

Country Status (26)

Country Link
US (1) US6087371A (es)
EP (1) EP0885222B1 (es)
JP (1) JP2000504700A (es)
KR (1) KR19990082680A (es)
CN (1) CN1211253A (es)
AR (1) AR005820A1 (es)
AT (1) ATE201683T1 (es)
AU (1) AU1767797A (es)
BR (1) BR9707463A (es)
CA (1) CA2243992A1 (es)
DE (1) DE69705032T2 (es)
DK (1) DK0885222T3 (es)
EA (1) EA199800720A1 (es)
ES (1) ES2159838T3 (es)
GB (1) GB9603226D0 (es)
GR (1) GR3036390T3 (es)
HU (1) HUP9900572A3 (es)
IL (1) IL125344A0 (es)
MX (1) MX9806341A (es)
NO (1) NO983656L (es)
NZ (1) NZ331087A (es)
PL (1) PL328373A1 (es)
PT (1) PT885222E (es)
TW (1) TW360655B (es)
WO (1) WO1997030050A1 (es)
ZA (1) ZA971167B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03001472A (es) * 2000-08-16 2003-06-06 Upjohn Co Compuestos para el tratamiento de trastornos adictivos.
EP1685838A1 (en) * 2000-08-16 2006-08-02 Pharmacia & Upjohn Company LLC Compounds for the treatment of addictive disorders
US8106074B2 (en) 2001-07-13 2012-01-31 Pierre Fabre Medicament Pyridin-2-yl-methylamine derivatives for treating opiate dependence
BR122018010510B1 (pt) 2008-07-17 2019-01-02 Bayer Ip Gmbh compostos heterocíclicos, seu uso, composição, e processo para combater parasitas
CN106866656A (zh) * 2017-02-28 2017-06-20 西南交通大学 一类麦角碱衍生物及其在预防和治疗精神疾病的用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU39278B (en) * 1976-12-22 1984-10-31 Lek Tovarna Farmacevtskih Process for preparing 5-bromo nicotinic acid esters
GB8714767D0 (en) * 1987-06-24 1987-07-29 Erba Farmitalia Egoline derivatives
AU553809B2 (en) * 1981-07-21 1986-07-31 Farmitalia Carlo Erba S.P.A. Ergoline derivatives
HU190105B (en) * 1983-06-03 1986-08-28 Gyogyszerkutato Intezet Process for production of pirazolyl-methyl-ergolin- derivatives and their acid additional salts
HU193781B (en) * 1985-06-21 1987-11-30 Richter Gedeon Vegyeszet Process for producing 10alpha-methoxy-6-methylergoline derivatives and acid additional salts thereof
GB8612366D0 (en) * 1986-05-21 1986-06-25 Erba Farmitalia Ergoline esters
GB8702364D0 (en) * 1987-02-03 1987-03-11 Erba Farmitalia Ergolinyl heterocycles
DE3868866D1 (de) * 1987-11-20 1992-04-09 Erba Carlo Spa Ergolinderivate mit antiparkinsonwirkung.
US5210194A (en) * 1990-01-25 1993-05-11 Farmitalia Carlo Erba S.R.L. An Italian Body Corporate Process for preparing ergoline derivatives
JP2888648B2 (ja) * 1990-12-28 1999-05-10 出光興産株式会社 スチレン系重合体の製造方法及びその触媒

Also Published As

Publication number Publication date
CA2243992A1 (en) 1997-08-21
DE69705032D1 (de) 2001-07-05
EA199800720A1 (ru) 1999-02-25
CN1211253A (zh) 1999-03-17
EP0885222A1 (en) 1998-12-23
GB9603226D0 (en) 1996-04-17
ATE201683T1 (de) 2001-06-15
EP0885222B1 (en) 2001-05-30
GR3036390T3 (en) 2001-11-30
HUP9900572A3 (en) 2000-10-30
TW360655B (en) 1999-06-11
AR005820A1 (es) 1999-07-14
DK0885222T3 (da) 2001-08-27
HUP9900572A2 (hu) 1999-06-28
JP2000504700A (ja) 2000-04-18
AU1767797A (en) 1997-09-02
NO983656D0 (no) 1998-08-10
KR19990082680A (ko) 1999-11-25
PT885222E (pt) 2001-10-31
PL328373A1 (en) 1999-01-18
NO983656L (no) 1998-10-12
ZA971167B (en) 1997-08-25
ES2159838T3 (es) 2001-10-16
WO1997030050A1 (en) 1997-08-21
NZ331087A (en) 1999-08-30
BR9707463A (pt) 1999-07-20
DE69705032T2 (de) 2001-11-22
IL125344A0 (en) 1999-03-12
US6087371A (en) 2000-07-11

Similar Documents

Publication Publication Date Title
GR3030969T3 (en) Benzo and pyrido pyridazinone and pyridazinthione compounds with pde iv inhibiting activity.
CA2311742A1 (en) 6-amino-9-benzyl-8-hydroxypurine derivatives
IL111959A (en) N-(polysubstituted pyrimidin-4-yl) benzenesulfonamide derivatives their preparation and pharmaceutical compositions containing them
IL109395A0 (en) Heterocyclic derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
EP1259487B8 (en) 2-amino-nicotinamide derivatives and their use as vegf-receptor tyrosine kinase inhibitors
NO940737L (es)
IL98872A0 (en) Pyrazolopyridine derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
ATE79380T1 (de) 2-substituierte-e-kondensierte(1,2,4>triazolo(1,5-c>pyrimidine, pharmazeutische zubereitungen und ihre verwendung.
IL103944A0 (en) Piperazine derivatives,their preparation and pharmaceutical compositions containing them
NZ330078A (en) Active oxygen carriers containing pterin derivatives and salts thereof for use as cosmetic agents and feed
ES8500247A1 (es) Un procedimiento para la preparacion de un isomero optico en su forma (-) de un derivado de triazina.
NZ232283A (en) Substituted imidazo(1,2-b)pyridazine derivatives; pharmaceutical compositions and preparatory processes
NZ516100A (en) Streptogramin derivatives, preparation and compositions containing them
NZ240180A (en) 4-IMINOPYRROLO[2,3-d]PYRIMIDINE DERIVATIVES; PHARMACEUTICAL COMPOSITIONS.
MX9806341A (es) Derivados de ergolina heterociclica.
GB2264492B (en) Benzodiazepine derivatives
AU4458793A (en) Novel 3-oxadiazolyl-1,6-naphthyridine derivatives
CA2238723A1 (en) Arylethenesulfonamide derivatives and drug composition containing the same
DK0434982T3 (da) 5-(Amino)-triazolylcarbothioamidderivater, fremgangsmåde til deres fremstilling, lægemiddel, hvori de er indeholdt, og anvendelse af dem
GR860739B (en) Process for the preparation of benzene fused heterocyclic compounds
MX9710378A (es) Derivados de 4-finilaminotiazol, su proceso de preparacion y las composiciones farmaceuticas que los contienen.