TW360655B - Heterocyclyl-ergoline derivatives - Google Patents

Heterocyclyl-ergoline derivatives

Info

Publication number: TW360655B
Authority: TW; Taiwan
Prior art keywords: hydrogen; atom; chlorine; bromine; group
Prior art date: 1996-02-15

Application number

TW086100411A

Other languages

English (en)

Inventor

Sergio Mantegani

Tiziano Bandiera

Maurizio Meroni

Mario Varasi

Carla Caccia

Original Assignee

Pharmacia & Upjohn Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-15

Filing date

1997-01-16

Publication date

1999-06-11

1997-01-16 Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa

1999-06-11 Application granted granted Critical

1999-06-11 Publication of TW360655B publication Critical patent/TW360655B/zh

Links

125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
239000000460 chlorine Chemical group 0.000 abstract 2
229910052801 chlorine Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
AWFDCTXCTHGORH-HGHGUNKESA-N 6-[4-[(6ar,9r,10ar)-5-bromo-7-methyl-6,6a,8,9,10,10a-hexahydro-4h-indolo[4,3-fg]quinoline-9-carbonyl]piperazin-1-yl]-1-methylpyridin-2-one Chemical class O=C([C@H]1CN([C@H]2[C@@H](C=3C=CC=C4NC(Br)=C(C=34)C2)C1)C)N(CC1)CCN1C1=CC=CC(=O)N1C AWFDCTXCTHGORH-HGHGUNKESA-N 0.000 abstract 1
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical group ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
229910052794 bromium Chemical group 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
229910052731 fluorine Chemical group 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

TW086100411A 1996-02-15 1997-01-16 Heterocyclyl-ergoline derivatives TW360655B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB9603226.3A GB9603226D0 (en)	1996-02-15	1996-02-15	Heterocyclyl-ergoline derivatives

Publications (1)

Publication Number	Publication Date
TW360655B true TW360655B (en)	1999-06-11

Family

ID=10788832

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW086100411A TW360655B (en)	1996-02-15	1997-01-16	Heterocyclyl-ergoline derivatives

Country Status (26)

Country	Link
US (1)	US6087371A (zh)
EP (1)	EP0885222B1 (zh)
JP (1)	JP2000504700A (zh)
KR (1)	KR19990082680A (zh)
CN (1)	CN1211253A (zh)
AR (1)	AR005820A1 (zh)
AT (1)	ATE201683T1 (zh)
AU (1)	AU1767797A (zh)
BR (1)	BR9707463A (zh)
CA (1)	CA2243992A1 (zh)
DE (1)	DE69705032T2 (zh)
DK (1)	DK0885222T3 (zh)
EA (1)	EA199800720A1 (zh)
ES (1)	ES2159838T3 (zh)
GB (1)	GB9603226D0 (zh)
GR (1)	GR3036390T3 (zh)
HU (1)	HUP9900572A3 (zh)
IL (1)	IL125344A0 (zh)
MX (1)	MX9806341A (zh)
NO (1)	NO983656L (zh)
NZ (1)	NZ331087A (zh)
PL (1)	PL328373A1 (zh)
PT (1)	PT885222E (zh)
TW (1)	TW360655B (zh)
WO (1)	WO1997030050A1 (zh)
ZA (1)	ZA971167B (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CZ200380A3 (cs) *	2000-08-16	2004-01-14	Pharmacia & Upjohn Company	Sloučeniny pro léčbu poruch spojených se závislostmi
EP1685838A1 (en) *	2000-08-16	2006-08-02	Pharmacia & Upjohn Company LLC	Compounds for the treatment of addictive disorders
US8106074B2 (en)	2001-07-13	2012-01-31	Pierre Fabre Medicament	Pyridin-2-yl-methylamine derivatives for treating opiate dependence
EP2309857B1 (de) *	2008-07-17	2013-07-03	Bayer CropScience AG	Heterocyclische verbindungen als schädlingsbekämpfungsmittel
CN106866656A (zh) *	2017-02-28	2017-06-20	西南交通大学	一类麦角碱衍生物及其在预防和治疗精神疾病的用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
YU39278B (en) *	1976-12-22	1984-10-31	Lek Tovarna Farmacevtskih	Process for preparing 5-bromo nicotinic acid esters
GB8714767D0 (en) *	1987-06-24	1987-07-29	Erba Farmitalia	Egoline derivatives
AU553809B2 (en) *	1981-07-21	1986-07-31	Farmitalia Carlo Erba S.P.A.	Ergoline derivatives
HU190105B (en) *	1983-06-03	1986-08-28	Gyogyszerkutato Intezet	Process for production of pirazolyl-methyl-ergolin- derivatives and their acid additional salts
HU193781B (en) *	1985-06-21	1987-11-30	Richter Gedeon Vegyeszet	Process for producing 10alpha-methoxy-6-methylergoline derivatives and acid additional salts thereof
GB8612366D0 (en) *	1986-05-21	1986-06-25	Erba Farmitalia	Ergoline esters
GB8702364D0 (en) *	1987-02-03	1987-03-11	Erba Farmitalia	Ergolinyl heterocycles
ES2032570T3 (es) *	1987-11-20	1993-02-16	Farmitalia Carlo Erba S.R.L.	Derivados antiparkinson de ergolina. (reserva del art. 167.2 cpe).
EP0464178B1 (en) *	1990-01-25	1995-12-06	PHARMACIA S.p.A.	Process for preparing ergoline derivatives
JP2888648B2 (ja) *	1990-12-28	1999-05-10	出光興産株式会社	スチレン系重合体の製造方法及びその触媒

1996
- 1996-02-15 GB GBGB9603226.3A patent/GB9603226D0/en active Pending
1997
- 1997-01-16 TW TW086100411A patent/TW360655B/zh active
- 1997-02-07 ES ES97903245T patent/ES2159838T3/es not_active Expired - Lifetime
- 1997-02-07 KR KR1019980706426A patent/KR19990082680A/ko not_active Application Discontinuation
- 1997-02-07 EP EP97903245A patent/EP0885222B1/en not_active Expired - Lifetime
- 1997-02-07 BR BR9707463A patent/BR9707463A/pt not_active Application Discontinuation
- 1997-02-07 US US09/125,108 patent/US6087371A/en not_active Expired - Fee Related
- 1997-02-07 CN CN97192277A patent/CN1211253A/zh active Pending
- 1997-02-07 WO PCT/EP1997/000582 patent/WO1997030050A1/en not_active Application Discontinuation
- 1997-02-07 HU HU9900572A patent/HUP9900572A3/hu unknown
- 1997-02-07 EA EA199800720A patent/EA199800720A1/ru unknown
- 1997-02-07 JP JP9528958A patent/JP2000504700A/ja not_active Withdrawn
- 1997-02-07 AU AU17677/97A patent/AU1767797A/en not_active Abandoned
- 1997-02-07 PL PL97328373A patent/PL328373A1/xx unknown
- 1997-02-07 DK DK97903245T patent/DK0885222T3/da active
- 1997-02-07 IL IL12534497A patent/IL125344A0/xx unknown
- 1997-02-07 PT PT97903245T patent/PT885222E/pt unknown
- 1997-02-07 DE DE69705032T patent/DE69705032T2/de not_active Expired - Fee Related
- 1997-02-07 CA CA002243992A patent/CA2243992A1/en not_active Abandoned
- 1997-02-07 AT AT97903245T patent/ATE201683T1/de not_active IP Right Cessation
- 1997-02-07 NZ NZ331087A patent/NZ331087A/xx unknown
- 1997-02-12 ZA ZA9701167A patent/ZA971167B/xx unknown
- 1997-02-14 AR ARP970100586A patent/AR005820A1/es unknown
1998
- 1998-08-06 MX MX9806341A patent/MX9806341A/es unknown
- 1998-08-10 NO NO983656A patent/NO983656L/no unknown
2001
- 2001-08-14 GR GR20010401246T patent/GR3036390T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
BR9707463A (pt)	1999-07-20
NO983656D0 (no)	1998-08-10
GR3036390T3 (en)	2001-11-30
HUP9900572A3 (en)	2000-10-30
NZ331087A (en)	1999-08-30
WO1997030050A1 (en)	1997-08-21
IL125344A0 (en)	1999-03-12
HUP9900572A2 (hu)	1999-06-28
DK0885222T3 (da)	2001-08-27
GB9603226D0 (en)	1996-04-17
EA199800720A1 (ru)	1999-02-25
KR19990082680A (ko)	1999-11-25
EP0885222B1 (en)	2001-05-30
DE69705032D1 (de)	2001-07-05
US6087371A (en)	2000-07-11
AR005820A1 (es)	1999-07-14
MX9806341A (es)	1998-10-31
PT885222E (pt)	2001-10-31
AU1767797A (en)	1997-09-02
NO983656L (no)	1998-10-12
CN1211253A (zh)	1999-03-17
EP0885222A1 (en)	1998-12-23
JP2000504700A (ja)	2000-04-18
ES2159838T3 (es)	2001-10-16
PL328373A1 (en)	1999-01-18
ZA971167B (en)	1997-08-25
DE69705032T2 (de)	2001-11-22
CA2243992A1 (en)	1997-08-21
ATE201683T1 (de)	2001-06-15

Publication	Publication Date	Title
IL109395A0 (en)	1994-07-31	Heterocyclic derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
GR3030969T3 (en)	1999-11-30	Benzo and pyrido pyridazinone and pyridazinthione compounds with pde iv inhibiting activity.
EP1259487B8 (en)	2014-04-23	2-amino-nicotinamide derivatives and their use as vegf-receptor tyrosine kinase inhibitors
CA2311742A1 (en)	1999-06-10	6-amino-9-benzyl-8-hydroxypurine derivatives
IL98872A0 (en)	1992-07-15	Pyrazolopyridine derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
IL111959A (en)	2000-07-16	N-(polysubstituted pyrimidin-4-yl) benzenesulfonamide derivatives their preparation and pharmaceutical compositions containing them
NO940737L (zh)	1994-05-03
NZ330078A (en)	2000-01-28	Active oxygen carriers containing pterin derivatives and salts thereof for use as cosmetic agents and feed
NZ232283A (en)	1991-08-27	Substituted imidazo(1,2-b)pyridazine derivatives; pharmaceutical compositions and preparatory processes
NZ516100A (en)	2004-01-30	Streptogramin derivatives, preparation and compositions containing them
GB9022644D0 (en)	1990-11-28	Heterocyclic compounds
TW360655B (en)	1999-06-11	Heterocyclyl-ergoline derivatives
HU9201033D0 (en)	1992-06-29	Tiazolidinone- and oxazolidinone derivatives, process for their production, and for the production of medical preparations containing them as active agents
NZ517315A (en)	2004-02-27	New derivatives of A-500359
NO894325D0 (no)	1989-10-30	Fremgangsmaate for fremstilling av terapeutisk aktive pyrrolidin-derivater.
GB2264492B (en)	1996-09-25	Benzodiazepine derivatives
AU4458793A (en)	1994-03-10	Novel 3-oxadiazolyl-1,6-naphthyridine derivatives
TW360630B (en)	1999-06-11	A secoaporphine compounds on arrhythmia