EA199800720A1 - Гетероциклические производные эрголина в качестве лигандов 5-htia рецептора - Google Patents
Гетероциклические производные эрголина в качестве лигандов 5-htia рецептораInfo
- Publication number
- EA199800720A1 EA199800720A1 EA199800720A EA199800720A EA199800720A1 EA 199800720 A1 EA199800720 A1 EA 199800720A1 EA 199800720 A EA199800720 A EA 199800720A EA 199800720 A EA199800720 A EA 199800720A EA 199800720 A1 EA199800720 A1 EA 199800720A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- ergoline
- hydrogen
- heterocyclic derivatives
- bromine
- chlorine
- Prior art date
Links
- AWFDCTXCTHGORH-HGHGUNKESA-N 6-[4-[(6ar,9r,10ar)-5-bromo-7-methyl-6,6a,8,9,10,10a-hexahydro-4h-indolo[4,3-fg]quinoline-9-carbonyl]piperazin-1-yl]-1-methylpyridin-2-one Chemical class O=C([C@H]1CN([C@H]2[C@@H](C=3C=CC=C4NC(Br)=C(C=34)C2)C1)C)N(CC1)CCN1C1=CC=CC(=O)N1C AWFDCTXCTHGORH-HGHGUNKESA-N 0.000 title abstract 2
- 239000003446 ligand Substances 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 229910052794 bromium Inorganic materials 0.000 abstract 2
- 239000000460 chlorine Substances 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000011737 fluorine Chemical group 0.000 abstract 1
- 229910052731 fluorine Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Производное эрголина, имеющее формулу (I), в которой Rявляется атомом водорода или Салкильной группой; Rявляется атомом водорода, хлора или брома, метильной или C-алкилтиогруппой; n равно 0, 1 или 2; заместитель в положении 8 имеет α- или β-конфигурацию; Het представляет собой ароматическое 5-членное гетероциклическое кольцо, упомянутое кольцо имеет три гетероатома, которые являются одинаковыми или разными и которые выбирают из группы, состоящей из атома серы, кислорода и азота, и Х является атомом водорода, хлора или брома или фтора, или его фармацевтически приемлемая соль с кислотой являются активными в отношении центральной нервной системы. Описан также способ их получения и содержащие их лекарственные препараты.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9603226.3A GB9603226D0 (en) | 1996-02-15 | 1996-02-15 | Heterocyclyl-ergoline derivatives |
| PCT/EP1997/000582 WO1997030050A1 (en) | 1996-02-15 | 1997-02-07 | Heterocyclyl-ergoline derivatives as 5-ht1a receptor ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA199800720A1 true EA199800720A1 (ru) | 1999-02-25 |
Family
ID=10788832
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA199800720A EA199800720A1 (ru) | 1996-02-15 | 1997-02-07 | Гетероциклические производные эрголина в качестве лигандов 5-htia рецептора |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6087371A (ru) |
| EP (1) | EP0885222B1 (ru) |
| JP (1) | JP2000504700A (ru) |
| KR (1) | KR19990082680A (ru) |
| CN (1) | CN1211253A (ru) |
| AR (1) | AR005820A1 (ru) |
| AT (1) | ATE201683T1 (ru) |
| AU (1) | AU1767797A (ru) |
| BR (1) | BR9707463A (ru) |
| CA (1) | CA2243992A1 (ru) |
| DE (1) | DE69705032T2 (ru) |
| DK (1) | DK0885222T3 (ru) |
| EA (1) | EA199800720A1 (ru) |
| ES (1) | ES2159838T3 (ru) |
| GB (1) | GB9603226D0 (ru) |
| GR (1) | GR3036390T3 (ru) |
| HU (1) | HUP9900572A3 (ru) |
| IL (1) | IL125344A0 (ru) |
| MX (1) | MX9806341A (ru) |
| NO (1) | NO983656L (ru) |
| NZ (1) | NZ331087A (ru) |
| PL (1) | PL328373A1 (ru) |
| PT (1) | PT885222E (ru) |
| TW (1) | TW360655B (ru) |
| WO (1) | WO1997030050A1 (ru) |
| ZA (1) | ZA971167B (ru) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1363634A2 (en) * | 2000-08-16 | 2003-11-26 | PHARMACIA & UPJOHN COMPANY | Compounds for the treatment of addictive disorders |
| EP1685838A1 (en) * | 2000-08-16 | 2006-08-02 | Pharmacia & Upjohn Company LLC | Compounds for the treatment of addictive disorders |
| US8106074B2 (en) | 2001-07-13 | 2012-01-31 | Pierre Fabre Medicament | Pyridin-2-yl-methylamine derivatives for treating opiate dependence |
| ES2579085T3 (es) * | 2008-07-17 | 2016-08-04 | Bayer Cropscience Ag | Compuestos heterocíclicos como pesticidas |
| CN106866656A (zh) * | 2017-02-28 | 2017-06-20 | 西南交通大学 | 一类麦角碱衍生物及其在预防和治疗精神疾病的用途 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU39278B (en) * | 1976-12-22 | 1984-10-31 | Lek Tovarna Farmacevtskih | Process for preparing 5-bromo nicotinic acid esters |
| GB8714767D0 (en) * | 1987-06-24 | 1987-07-29 | Erba Farmitalia | Egoline derivatives |
| AU553809B2 (en) * | 1981-07-21 | 1986-07-31 | Farmitalia Carlo Erba S.P.A. | Ergoline derivatives |
| HU190105B (en) * | 1983-06-03 | 1986-08-28 | Gyogyszerkutato Intezet | Process for production of pirazolyl-methyl-ergolin- derivatives and their acid additional salts |
| HU193781B (en) * | 1985-06-21 | 1987-11-30 | Richter Gedeon Vegyeszet | Process for producing 10alpha-methoxy-6-methylergoline derivatives and acid additional salts thereof |
| GB8612366D0 (en) * | 1986-05-21 | 1986-06-25 | Erba Farmitalia | Ergoline esters |
| GB8702364D0 (en) * | 1987-02-03 | 1987-03-11 | Erba Farmitalia | Ergolinyl heterocycles |
| ES2032570T3 (es) * | 1987-11-20 | 1993-02-16 | Farmitalia Carlo Erba S.R.L. | Derivados antiparkinson de ergolina. (reserva del art. 167.2 cpe). |
| KR920701205A (ko) * | 1990-01-25 | 1992-08-11 | 비토리노 페라리오 | 에르골린 유도체의 제조방법 |
| JP2888648B2 (ja) * | 1990-12-28 | 1999-05-10 | 出光興産株式会社 | スチレン系重合体の製造方法及びその触媒 |
-
1996
- 1996-02-15 GB GBGB9603226.3A patent/GB9603226D0/en active Pending
-
1997
- 1997-01-16 TW TW086100411A patent/TW360655B/zh active
- 1997-02-07 CN CN97192277A patent/CN1211253A/zh active Pending
- 1997-02-07 US US09/125,108 patent/US6087371A/en not_active Expired - Fee Related
- 1997-02-07 KR KR1019980706426A patent/KR19990082680A/ko not_active Withdrawn
- 1997-02-07 DE DE69705032T patent/DE69705032T2/de not_active Expired - Fee Related
- 1997-02-07 NZ NZ331087A patent/NZ331087A/xx unknown
- 1997-02-07 BR BR9707463A patent/BR9707463A/pt not_active Application Discontinuation
- 1997-02-07 EA EA199800720A patent/EA199800720A1/ru unknown
- 1997-02-07 AT AT97903245T patent/ATE201683T1/de not_active IP Right Cessation
- 1997-02-07 EP EP97903245A patent/EP0885222B1/en not_active Expired - Lifetime
- 1997-02-07 ES ES97903245T patent/ES2159838T3/es not_active Expired - Lifetime
- 1997-02-07 IL IL12534497A patent/IL125344A0/xx unknown
- 1997-02-07 PL PL97328373A patent/PL328373A1/xx unknown
- 1997-02-07 AU AU17677/97A patent/AU1767797A/en not_active Abandoned
- 1997-02-07 JP JP9528958A patent/JP2000504700A/ja not_active Withdrawn
- 1997-02-07 HU HU9900572A patent/HUP9900572A3/hu unknown
- 1997-02-07 CA CA002243992A patent/CA2243992A1/en not_active Abandoned
- 1997-02-07 DK DK97903245T patent/DK0885222T3/da active
- 1997-02-07 PT PT97903245T patent/PT885222E/pt unknown
- 1997-02-07 WO PCT/EP1997/000582 patent/WO1997030050A1/en not_active Application Discontinuation
- 1997-02-12 ZA ZA9701167A patent/ZA971167B/xx unknown
- 1997-02-14 AR ARP970100586A patent/AR005820A1/es unknown
-
1998
- 1998-08-06 MX MX9806341A patent/MX9806341A/es unknown
- 1998-08-10 NO NO983656A patent/NO983656L/no unknown
-
2001
- 2001-08-14 GR GR20010401246T patent/GR3036390T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP9900572A2 (hu) | 1999-06-28 |
| DK0885222T3 (da) | 2001-08-27 |
| GB9603226D0 (en) | 1996-04-17 |
| GR3036390T3 (en) | 2001-11-30 |
| TW360655B (en) | 1999-06-11 |
| PT885222E (pt) | 2001-10-31 |
| AR005820A1 (es) | 1999-07-14 |
| ZA971167B (en) | 1997-08-25 |
| JP2000504700A (ja) | 2000-04-18 |
| ATE201683T1 (de) | 2001-06-15 |
| PL328373A1 (en) | 1999-01-18 |
| CN1211253A (zh) | 1999-03-17 |
| WO1997030050A1 (en) | 1997-08-21 |
| NZ331087A (en) | 1999-08-30 |
| AU1767797A (en) | 1997-09-02 |
| US6087371A (en) | 2000-07-11 |
| HUP9900572A3 (en) | 2000-10-30 |
| EP0885222B1 (en) | 2001-05-30 |
| NO983656D0 (no) | 1998-08-10 |
| EP0885222A1 (en) | 1998-12-23 |
| CA2243992A1 (en) | 1997-08-21 |
| KR19990082680A (ko) | 1999-11-25 |
| MX9806341A (es) | 1998-10-31 |
| IL125344A0 (en) | 1999-03-12 |
| DE69705032D1 (de) | 2001-07-05 |
| NO983656L (no) | 1998-10-12 |
| BR9707463A (pt) | 1999-07-20 |
| ES2159838T3 (es) | 2001-10-16 |
| DE69705032T2 (de) | 2001-11-22 |
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