[go: up one dir, main page]

ES8500247A1 - Un procedimiento para la preparacion de un isomero optico en su forma (-) de un derivado de triazina. - Google Patents

Un procedimiento para la preparacion de un isomero optico en su forma (-) de un derivado de triazina.

Info

Publication number
ES8500247A1
ES8500247A1 ES523300A ES523300A ES8500247A1 ES 8500247 A1 ES8500247 A1 ES 8500247A1 ES 523300 A ES523300 A ES 523300A ES 523300 A ES523300 A ES 523300A ES 8500247 A1 ES8500247 A1 ES 8500247A1
Authority
ES
Spain
Prior art keywords
processes
preparation
pharmaceutical compositions
same
triazine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES523300A
Other languages
English (en)
Other versions
ES523300A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of ES8500247A1 publication Critical patent/ES8500247A1/es
Publication of ES523300A0 publication Critical patent/ES523300A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UN ISOMERO OPTICO EN SU FORMA (-) DE UN DERIVADO DE TRIAZINA, DE FORMULA GENERAL (I), Y SUS SALES FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN ISOMERO OPTICO DE FORMULA: RB2NCO. A CONTINUACION SE AISLA EL ISOMERO OPTICO OBTENIDO DE FORMULA GENERAL (III) Y SE ELIMINA EL GRUPO CARBAMOILO.DE APLICACION EN TERAPEUTICA, EN EL TRATAMIENTO DE LA HIPERTENSION Y DE LA TROMBOSIS.
ES523300A 1981-10-22 1983-06-15 Un procedimiento para la preparacion de un isomero optico en su forma (-) de un derivado de triazina. Granted ES523300A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8131900 1981-10-22
GB8224151 1982-08-23

Publications (2)

Publication Number Publication Date
ES8500247A1 true ES8500247A1 (es) 1984-10-01
ES523300A0 ES523300A0 (es) 1984-10-01

Family

ID=26281042

Family Applications (3)

Application Number Title Priority Date Filing Date
ES516724A Granted ES516724A0 (es) 1981-10-22 1982-10-21 Un procedimiento para la preparacion de nuevos derivados de triazina.
ES523299A Expired ES8601934A1 (es) 1981-10-22 1983-06-15 Un procedimiento para la preparacion de nuevos derivados de triazina.
ES523300A Granted ES523300A0 (es) 1981-10-22 1983-06-15 Un procedimiento para la preparacion de un isomero optico en su forma (-) de un derivado de triazina.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES516724A Granted ES516724A0 (es) 1981-10-22 1982-10-21 Un procedimiento para la preparacion de nuevos derivados de triazina.
ES523299A Expired ES8601934A1 (es) 1981-10-22 1983-06-15 Un procedimiento para la preparacion de nuevos derivados de triazina.

Country Status (11)

Country Link
US (1) US4616014A (es)
EP (1) EP0077983B1 (es)
JP (1) JPS5899468A (es)
AU (1) AU8926982A (es)
DE (1) DE3276164D1 (es)
DK (1) DK453882A (es)
ES (3) ES516724A0 (es)
FI (1) FI823544L (es)
GR (1) GR76714B (es)
NO (1) NO823506L (es)
OA (1) OA07236A (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1199027A (en) * 1981-11-12 1986-01-07 Stuart D. Mills Heterocyclic derivatives of pyridazinone, thiadiazinone, oxadiazinone and triazinone
US4581356A (en) * 1983-03-22 1986-04-08 Fujisawa Pharmaceutical Co., Ltd. Triazine derivatives, and pharmaceutical compositions comprising the same
JPS59196874A (ja) * 1983-04-22 1984-11-08 Fujisawa Pharmaceut Co Ltd トリアジン誘導体
GB8328757D0 (en) * 1983-10-27 1983-11-30 Wellcome Found Chemical compounds
GB8612796D0 (en) * 1986-05-27 1986-07-02 Fbc Ltd Fungicides
US4970210A (en) * 1987-07-17 1990-11-13 Abbott Laboratories Triazinone lipoxygenase compounds
CN1038249C (zh) * 1991-08-28 1998-05-06 罗姆和哈斯公司 含有二氢哒嗪酮及其相关化合物的杀菌组合物
IT1318392B1 (it) * 2000-03-15 2003-08-25 Getters Spa Composizione getter di idrogeno.
CA2427134A1 (en) 2000-10-27 2002-07-25 Dow Agrosciences Llc Substituted 4,5-dihydro-1,2,4-triazin-3-ones, 1,2,4-triazin-3-ones, and their use as fungicides and insecticides
EP1340743A4 (en) * 2000-11-09 2007-04-25 Mitsui Chemicals Inc OPTICALLY ACTIVE AMINO DERIVATIVE AND METHOD OF SYNTHESIS
US20030236259A1 (en) * 2002-02-05 2003-12-25 Rolf Hohlweg Novel aryl- and heteroarylpiperazines
JP4498133B2 (ja) * 2002-07-02 2010-07-07 シェーリング コーポレイション 新規神経ペプチドｙｙ５レセプターアンタゴニスト
US7323455B2 (en) 2004-03-24 2008-01-29 Wyeth 7-aryl 1,5-dihydro-4,1-benzoxazepin-2(3H)-one derivatives and their use as progesterone receptor modulators
RU2442775C2 (ru) * 2005-07-04 2012-02-20 Хай Пойнт Фармасьютикалс, ЛЛС Антагонисты гистаминовых н3-рецепторов
JP5121707B2 (ja) * 2005-07-04 2013-01-16 ハイ ポイント ファーマシューティカルズ，エルエルシー 新規医薬
CA2653062A1 (en) * 2006-05-23 2007-11-29 Transtech Pharma, Inc. 6- (4-cyclopropylpiperazin-1-yl) -2 ' -methyl- [3, 4 ' ] -bipyridine and its use as a medicament
CN102295606A (zh) * 2006-05-29 2011-12-28 高点制药有限责任公司 合成3-（1，3-苯并间二氧杂环戊烯-5-基）-6-（4-环丙基哌嗪-1-基）-哒嗪的方法及其适用的中间体
EP2014656A3 (en) * 2007-06-11 2011-08-24 High Point Pharmaceuticals, LLC New heteocyclic h3 antagonists

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4157392A (en) * 1977-05-17 1979-06-05 Diamond Shamrock Corporation Pharmacologically active substituted 1,2,4-triazines
CH633541A5 (en) * 1977-05-17 1982-12-15 Diamond Shamrock Corp Pharmacologically active substituted 1,2,4-triazines and medicaments containing these triazines
EP0052442B1 (en) * 1980-11-14 1985-09-11 Imperial Chemical Industries Plc Heterocyclic compounds
US4495185A (en) * 1981-11-12 1985-01-22 Imperial Chemical Industries, Plc 1,2,4-Triazin-3(2H) ones
US4581356A (en) * 1983-03-22 1986-04-08 Fujisawa Pharmaceutical Co., Ltd. Triazine derivatives, and pharmaceutical compositions comprising the same

Also Published As

Publication number Publication date
OA07236A (fr) 1984-04-30
GR76714B (es) 1984-08-29
DK453882A (da) 1983-04-23
ES523299A0 (es) 1985-04-16
EP0077983A1 (en) 1983-05-04
EP0077983B1 (en) 1987-04-29
AU8926982A (en) 1983-04-28
NO823506L (no) 1983-04-25
FI823544L (fi) 1983-04-23
ES523300A0 (es) 1984-10-01
DE3276164D1 (en) 1987-06-04
JPS5899468A (ja) 1983-06-13
US4616014A (en) 1986-10-07
ES8601934A1 (es) 1985-04-16
ES8401042A1 (es) 1983-11-16
FI823544A0 (fi) 1982-10-18
ES516724A0 (es) 1983-11-16

Similar Documents

Publication Publication Date Title
ES8500247A1 (es) Un procedimiento para la preparacion de un isomero optico en su forma (-) de un derivado de triazina.
ES480542A1 (es) Metodo para producir derivados de imidazol.
IE831568L (en) Heterocyclic compounds
ES8404990A1 (es) Un procedimiento para la preparacion de derivados de prolina.
CA1251209A (en) DISHYDROPYRIDAZINONE DERIVATIVES
ATE18765T1 (de) Pharmazeutische zusammenstellungen.
ES8704924A1 (es) Un procedimiento para la preparacion de derivados de benzotiazol y benzotiofeno
FI870421A (fi) Analogiamenetelmä alkueläintenvastaisesti vaikuttavien 5,6-dihydro-2-(substituoitu fenyyli)-1,2,4-triatsiini-3,5(2H,4H)-dionijohdannaisten valmistamiseksi
ES481729A1 (es) Procedimiento para la preparacion de derivados de 1,2-dihi- droquinolein-2-onas.
IE811250L (en) Imidazole derivatives
ES8706664A1 (es) Procedimiento para preparar compuestos carbostirilicos
IE780515L (en) Morphine derivatives
ES8801230A1 (es) Un procedimiento para preparar un derivado de 1,5-benzotiazepina
MY101801A (en) Novel phenoxyacetic acid derivatives, process for preparing the same and pharmaceutical composition having the same as an active ingredient.
AU552908B2 (en) 4 n-phenyl benzyl-aminomethyl-imidazole
IE780514L (en) Morphine derivatives
ES8705410A1 (es) Un procedimiento para preparar un derivado de 1,5 beurotiarepina.
ES8303393A1 (es) Un procedimiento para preparar derivados del acido ascorbico.
IE811212L (en) Substituted phenoxy-aminopropanol derivatives
GB1323325A (en) Indolo 1,2-d 1,4 benzodiazepin-6-ones
ES8304091A1 (es) Procedimiento para preparar derivados de imidazol.
ES442149A1 (es) Procedimiento para preparar derivados de 1,2,4-benzotiadia- zino-1,1-dioxido.
ES8406442A1 (es) Un procedimiento para preparar compuestos de acido quinolilacetico
ES8401952A1 (es) Un procedimiento para preparar nuevos derivados de 1,4-benzotiazina.
ES8801652A1 (es) Un procedimiento para la preparacion de un derivado de tiazolidina.

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000403