[go: up one dir, main page]

MX9405152A - Proceso para la sintesis de azetidinonas. - Google Patents

Proceso para la sintesis de azetidinonas.

Info

Publication number
MX9405152A
MX9405152A MX9405152A MX9405152A MX9405152A MX 9405152 A MX9405152 A MX 9405152A MX 9405152 A MX9405152 A MX 9405152A MX 9405152 A MX9405152 A MX 9405152A MX 9405152 A MX9405152 A MX 9405152A
Authority
MX
Mexico
Prior art keywords
substituted
azetidinones
amino
synthesis
ester
Prior art date
Application number
MX9405152A
Other languages
English (en)
Inventor
Tiruvettipuram K Thiruvengadam
Timothy Mcallister
Chou-Hong Tann
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22217215&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX9405152(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of MX9405152A publication Critical patent/MX9405152A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Esta invención proporciona un proceso para preparar azetidinonas útilescomo intermediarios en la síntesis de penems y como agenteshipocolesterolémicos, particularmente para azetidinonas substituidas enlas posiciones C-3 y C-4, y opcionalmente substituidas en el nitrógeno delanillo, que comprende hacer reaccionar una ß-(amino-substituido)amida, unéster de ácido ß-(amino-substituido o un éster de ácidoß-(amino-substituido)tiolcarbónico, con un agente de sililación y unagente de ciclización.
MX9405152A 1993-07-09 1994-07-06 Proceso para la sintesis de azetidinonas. MX9405152A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8935793A 1993-07-09 1993-07-09

Publications (1)

Publication Number Publication Date
MX9405152A true MX9405152A (es) 1995-01-31

Family

ID=22217215

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9405152A MX9405152A (es) 1993-07-09 1994-07-06 Proceso para la sintesis de azetidinonas.

Country Status (21)

Country Link
US (1) US5728827A (es)
EP (1) EP0707567B1 (es)
JP (1) JP2840452B2 (es)
KR (1) KR0176001B1 (es)
CN (1) CN1071745C (es)
AT (1) ATE205475T1 (es)
AU (1) AU681419B2 (es)
CA (1) CA2166784C (es)
CZ (1) CZ7696A3 (es)
DE (1) DE69428280T2 (es)
DK (1) DK0707567T3 (es)
ES (1) ES2160125T3 (es)
FI (1) FI960095L (es)
HU (1) HUT73237A (es)
MX (1) MX9405152A (es)
NO (1) NO306294B1 (es)
NZ (1) NZ268798A (es)
PL (1) PL312502A1 (es)
PT (1) PT707567E (es)
SK (1) SK3796A3 (es)
WO (1) WO1995001961A1 (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5631365A (en) 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
AU2030100A (en) * 1998-12-07 2000-06-26 Schering Corporation Process for the synthesis of azetidinones
US6207822B1 (en) 1998-12-07 2001-03-27 Schering Corporation Process for the synthesis of azetidinones
AR023463A1 (es) * 1999-04-16 2002-09-04 Schering Corp Uso de compuestos de azetidinona
US6982251B2 (en) 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
US20060287254A1 (en) * 2001-01-26 2006-12-21 Schering Corporation Use of substituted azetidinone compounds for the treatment of sitosterolemia
US7071181B2 (en) 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
US7417039B2 (en) 2001-01-26 2008-08-26 Schering Corporation Use of substituted azetidinone compounds for the treatment of sitosterolemia
CN100509058C (zh) 2001-01-26 2009-07-08 先灵公司 过氧化物酶体增殖物激活受体(ppar)活化剂和甾醇吸收抑制剂的组合药以及对于血管适应症的治疗
SI1373230T1 (sl) * 2001-03-28 2005-12-31 Schering Corp Enantioselektivna sinteza azetidinonskih intermediatnih spojin
US7132415B2 (en) * 2001-09-21 2006-11-07 Schering Corporation Methods and therapeutic combinations for the treatment of xanthoma using sterol absorption inhibitors
US7053080B2 (en) 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
US20030204096A1 (en) * 2002-03-25 2003-10-30 Schering Corporation Enantioselective synthesis of azetidinone intermediate compounds
GB0215579D0 (en) 2002-07-05 2002-08-14 Astrazeneca Ab Chemical compounds
US7135556B2 (en) * 2002-07-19 2006-11-14 Schering Corporation NPC1L1 (NPC3) and methods of use thereof
CA2504878A1 (en) 2002-11-06 2004-05-27 Schering Corporation Cholesterol absorption inhibitors for the treatment of demyelination
MXPA05009501A (es) * 2003-03-07 2005-10-18 Schering Corp Compuestos de azetidinona sustituidos, formulaciones y usos de los mismos para el tratamiento de hipercolesterolemia.
JP2006519869A (ja) 2003-03-07 2006-08-31 シェーリング　コーポレイション 置換アゼチジノン化合物、置換アゼチジノン化合物を調製するためのプロセス、それらの処方物および使用
US7459442B2 (en) * 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
JP5137228B2 (ja) 2003-03-07 2013-02-06 メルク・シャープ・アンド・ドーム・コーポレーション 高コレステロール血症の処置のための置換アゼチジノン化合物、置換アゼチジノン処方物およびそれらの使用
WO2005062824A2 (en) * 2003-12-23 2005-07-14 Merck & Co., Inc. Anti-hypercholesterolemic compounds
US7871998B2 (en) 2003-12-23 2011-01-18 Astrazeneca Ab Diphenylazetidinone derivatives possessing cholesterol absorption inhibitory activity
EP1723414A4 (en) * 2004-01-16 2008-03-26 Merck & Co Inc NPC1L1 (NPC3) AND METHOD FOR IDENTIFYING ITS LIGANDS
JP2007538042A (ja) * 2004-05-21 2007-12-27 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング １，４−ジフェニルアゼチジノン誘導体の製造方法
DE102004025071B4 (de) * 2004-05-21 2006-12-21 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung von Diphenylazetidinon-Derivaten
SG158132A1 (en) 2004-12-20 2010-01-29 Schering Corp Process for the synthesis of azetidinones
JP2008546784A (ja) * 2005-06-20 2008-12-25 シェーリング コーポレイション ヒスタミンｈ３アンタゴニストとして有用なピペリジン誘導体
SA06270191B1 (ar) 2005-06-22 2010-03-29 استرازينيكا ايه بي مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم
EP1986489A2 (en) * 2006-02-24 2008-11-05 Schering Corporation Npc1l1 orthologues
AR060623A1 (es) 2006-04-27 2008-07-02 Astrazeneca Ab Compuestos derivados de 2-azetidinona y un metodo de preparacion
EP2059241A1 (en) * 2006-09-05 2009-05-20 Schering Corporation Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis
WO2008032338A2 (en) * 2006-09-11 2008-03-20 Manne Satyanarayana Reddy Improved process for the preparation of ezetimibe and its intermediates
EA017349B1 (ru) 2007-01-24 2012-11-30 Крка Способ получения эзетимиба и его производных
EP2414529A2 (en) 2009-04-01 2012-02-08 Matrix Laboratories Ltd Enzymatic process for the preparation of (s)-5-(4-fluoro-phenyl)-5-hydroxy- 1morpholin-4-yl-pentan-1-one, an intermediate of ezetimibe and further conversion to ezetimibe
CN104803858B (zh) * 2014-01-23 2019-03-01 东莞东阳光科研发有限公司 一种制备四丁基氟化铵三水合物的方法
ES2986788T3 (es) 2020-02-07 2024-11-12 Gasherbrum Bio Inc Agonistas heterocíclicos de GLP-1

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0333268A1 (en) * 1988-03-18 1989-09-20 Merck & Co. Inc. Process for synthesis of a chiral 3-beta hydrogen (3R) 4-aroyloxy azetidinone
US4876365A (en) * 1988-12-05 1989-10-24 Schering Corporation Intermediate compounds for preparing penems and carbapenems
US4983597A (en) * 1989-08-31 1991-01-08 Merck & Co., Inc. Beta-lactams as anticholesterolemic agents
US5085473A (en) * 1990-10-09 1992-02-04 Yuhe Yang Air actuated car curtain device
MY131273A (en) * 1991-07-23 2007-07-31 Schering Corp Substituted beta-lactam compounds useful as hypocholesterolemic agents and processes for the preparation thereof

Also Published As

Publication number Publication date
ES2160125T3 (es) 2001-11-01
DE69428280D1 (de) 2001-10-18
AU7214694A (en) 1995-02-06
FI960095A0 (fi) 1996-01-09
WO1995001961A1 (en) 1995-01-19
NO306294B1 (no) 1999-10-18
JPH08507085A (ja) 1996-07-30
CZ7696A3 (en) 1996-04-17
ATE205475T1 (de) 2001-09-15
AU681419B2 (en) 1997-08-28
FI960095L (fi) 1996-01-09
DK0707567T3 (da) 2001-11-26
DE69428280T2 (de) 2002-06-13
JP2840452B2 (ja) 1998-12-24
PL312502A1 (en) 1996-04-29
CA2166784A1 (en) 1995-01-19
NZ268798A (en) 1997-01-29
SK3796A3 (en) 1997-02-05
EP0707567B1 (en) 2001-09-12
HU9503748D0 (en) 1996-02-28
NO960083D0 (no) 1996-01-08
KR0176001B1 (ko) 1999-03-20
KR960703853A (ko) 1996-08-31
NO960083L (no) 1996-03-04
CN1071745C (zh) 2001-09-26
PT707567E (pt) 2002-01-30
US5728827A (en) 1998-03-17
HUT73237A (en) 1996-07-29
CN1126989A (zh) 1996-07-17
EP0707567A1 (en) 1996-04-24
CA2166784C (en) 2001-12-11

Similar Documents

Publication Publication Date Title
MX9405152A (es) Proceso para la sintesis de azetidinonas.
PT797439E (pt) Utilizacao de pramipexote como agente neuroprotector
DE59914996D1 (en) Heterocyclisch substituierte amide als calpainhemmer
MX9800625A (es) Marcfortinas y paraherquamidas antiparasitarias.
AU6613896A (en) Chemical compounds
PL354976A1 (en) Factor ix/factor ixa antibodies and antibody derivatives
DK0711140T3 (da) Antimykotisk opløsning til negle
MX9303376A (es) Utilizacion de metilhidroxietil- o metilhidroxipropil-(eteres de celulosa)carboximetilados.
BG104117A (en) Universally applicable blood plasma
BG102696A (en) Antipsoriasic nail varnish
SI1028950T1 (en) 7-substituted quinazolin-2,4-diones useful as antibacterial agents
HK1034523A1 (en) Hemiasterlin analogs
GB2331987B (en) Polycyclic sulphamate inhibitors of oestrone sulphatase
GB2380939B (en) Treatment or prevention of auto-immune diseases
AR022321A1 (es) Derivados de anticonvulsivo utiles para el tratamiento de la migrana transformada
MY125674A (en) Use of 1-hydroxy-2-pyridones for the treatment of seborrheic dermatitis
AU2003285485A1 (en) 5 ANDROSTEN-3Beta-OL STEROID INTERMEDIATES AND PROCESSES FOR THEIR PREPARATION
MXPA01011630A (es) Fluoracion incatalizada de 240fa.
TR200103219T2 (tr) Nöropatik ağrının iyileştirilmesinde kullanım için aroil aminoasil piroller
ES2115975T3 (es) Derivados de triariletileno utilizados terapeuticamente.
MXPA04010915A (es) Base y procedimiento de conocimiento de recursos humanos dinamicos.
BG102908A (en) Floor moulding
IL135516A0 (en) Process for n-desmethylating erythromycins and derivatives thereof
EP1351680B8 (fr) Utilisation de l'anethole-dithiolethione dans la prevention et le traitement de la tenotoxicite induite par un medicament
AR003452A1 (es) Dimaleato de n,n-dietil-8,8-dipropil-2-azaspiro [4.5]decano-2-propanamina y una composicion farmaceutica que lo comprende.

Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees