FI960095A0 - Menetelmä atsetidinonien syntetitoimiseksi - Google Patents
Menetelmä atsetidinonien syntetitoimiseksiInfo
- Publication number
- FI960095A0 FI960095A0 FI960095A FI960095A FI960095A0 FI 960095 A0 FI960095 A0 FI 960095A0 FI 960095 A FI960095 A FI 960095A FI 960095 A FI960095 A FI 960095A FI 960095 A0 FI960095 A0 FI 960095A0
- Authority
- FI
- Finland
- Prior art keywords
- substituted
- pct
- beta
- azetidinones
- amino
- Prior art date
Links
- MNFORVFSTILPAW-UHFFFAOYSA-N azetidin-2-one Chemical class O=C1CCN1 MNFORVFSTILPAW-UHFFFAOYSA-N 0.000 title abstract 3
- 230000002194 synthesizing effect Effects 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 150000001408 amides Chemical class 0.000 abstract 1
- 239000003529 anticholesteremic agent Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 150000002961 penems Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8935793A | 1993-07-09 | 1993-07-09 | |
| PCT/US1994/007291 WO1995001961A1 (en) | 1993-07-09 | 1994-07-01 | Process for the synthesis of azetidinones |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI960095L FI960095L (fi) | 1996-01-09 |
| FI960095A0 true FI960095A0 (fi) | 1996-01-09 |
Family
ID=22217215
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI960095A FI960095A0 (fi) | 1993-07-09 | 1996-01-09 | Menetelmä atsetidinonien syntetitoimiseksi |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5728827A (fi) |
| EP (1) | EP0707567B1 (fi) |
| JP (1) | JP2840452B2 (fi) |
| KR (1) | KR0176001B1 (fi) |
| CN (1) | CN1071745C (fi) |
| AT (1) | ATE205475T1 (fi) |
| AU (1) | AU681419B2 (fi) |
| CA (1) | CA2166784C (fi) |
| CZ (1) | CZ7696A3 (fi) |
| DE (1) | DE69428280T2 (fi) |
| DK (1) | DK0707567T3 (fi) |
| ES (1) | ES2160125T3 (fi) |
| FI (1) | FI960095A0 (fi) |
| HU (1) | HUT73237A (fi) |
| MX (1) | MX9405152A (fi) |
| NO (1) | NO306294B1 (fi) |
| NZ (1) | NZ268798A (fi) |
| PL (1) | PL312502A1 (fi) |
| PT (1) | PT707567E (fi) |
| SK (1) | SK3796A3 (fi) |
| WO (1) | WO1995001961A1 (fi) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5631365A (en) | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
| US6207822B1 (en) | 1998-12-07 | 2001-03-27 | Schering Corporation | Process for the synthesis of azetidinones |
| CA2353981C (en) * | 1998-12-07 | 2005-04-26 | Schering Corporation | Process for the synthesis of azetidinones |
| AU4343500A (en) | 1999-04-16 | 2000-11-02 | Schering Corporation | Use of azetidinone compounds |
| US6982251B2 (en) | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
| ATE331512T1 (de) | 2001-01-26 | 2006-07-15 | Schering Corp | Verwendung azetidinone-substituierter verbindungen zur behandlung der sitosterolhämie |
| US20060287254A1 (en) * | 2001-01-26 | 2006-12-21 | Schering Corporation | Use of substituted azetidinone compounds for the treatment of sitosterolemia |
| DK1413331T3 (da) | 2001-01-26 | 2007-12-10 | Schering Corp | Kombinationer af peroxisomproliferatoraktiveret receptor (PPAR)-aktivatoren fenofibrat og sterolabsorptionsinhibitoren ezetimib til vaskulære indikationer |
| US7071181B2 (en) | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
| RS50386B (sr) * | 2001-03-28 | 2009-12-31 | Schering Corporation, | Enantioselektivna sinteza intermedijarnih jedinjenja azetidinona |
| JP2005504091A (ja) | 2001-09-21 | 2005-02-10 | シェーリング コーポレイション | ステロール吸収阻害剤としてアゼチジノンを用いる黄色腫の処置 |
| US7053080B2 (en) | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
| US20030204096A1 (en) * | 2002-03-25 | 2003-10-30 | Schering Corporation | Enantioselective synthesis of azetidinone intermediate compounds |
| GB0215579D0 (en) | 2002-07-05 | 2002-08-14 | Astrazeneca Ab | Chemical compounds |
| US7135556B2 (en) * | 2002-07-19 | 2006-11-14 | Schering Corporation | NPC1L1 (NPC3) and methods of use thereof |
| US20040092499A1 (en) | 2002-11-06 | 2004-05-13 | Schering Corporation | Methods and therapeutic combinations for the treatment of autoimmune disorders |
| ES2311806T3 (es) * | 2003-03-07 | 2009-02-16 | Schering Corporation | Compuesto de azetidinona sustituidos, fornulaciones y usos de los mismos para el tratamiento de hipercolesterolemia. |
| WO2004081004A1 (en) | 2003-03-07 | 2004-09-23 | Schering Corporation | Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia |
| US7459442B2 (en) * | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
| EP1601669B1 (en) * | 2003-03-07 | 2008-12-24 | Schering Corporation | Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia |
| AU2004308332B2 (en) * | 2003-12-23 | 2008-04-10 | Merck Sharp & Dohme Corp. | Anti-hypercholesterolemic compounds |
| SA04250427A (ar) | 2003-12-23 | 2005-12-03 | استرازينيكا ايه بي | مشتقات ثاني فينيل أزيتيدون |
| CA2553769C (en) * | 2004-01-16 | 2011-01-04 | Merck & Co., Inc. | Npc1l1 (npc3) and methods of identifying ligands thereof |
| WO2005113496A1 (de) * | 2004-05-21 | 2005-12-01 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur herstellung von 1,4-diphenylazetidinon-derivaten |
| DE102004025071B4 (de) * | 2004-05-21 | 2006-12-21 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Herstellung von Diphenylazetidinon-Derivaten |
| CN101119966B (zh) * | 2004-12-20 | 2014-08-13 | 默沙东公司 | 合成2-吖丁啶酮的方法 |
| ES2337727T3 (es) * | 2005-06-20 | 2010-04-28 | Schering Corporation | Derivados de piperidina utiles como antagonistas de histamina h3. |
| SA06270191B1 (ar) | 2005-06-22 | 2010-03-29 | استرازينيكا ايه بي | مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم |
| EP1986489A2 (en) * | 2006-02-24 | 2008-11-05 | Schering Corporation | Npc1l1 orthologues |
| AR060623A1 (es) | 2006-04-27 | 2008-07-02 | Astrazeneca Ab | Compuestos derivados de 2-azetidinona y un metodo de preparacion |
| JP2010502702A (ja) * | 2006-09-05 | 2010-01-28 | シェーリング コーポレイション | 脂質管理およびアテローム性動脈硬化症および脂肪肝の治療治療において使用される医薬組成物 |
| WO2008032338A2 (en) * | 2006-09-11 | 2008-03-20 | Manne Satyanarayana Reddy | Improved process for the preparation of ezetimibe and its intermediates |
| EA017349B1 (ru) | 2007-01-24 | 2012-11-30 | Крка | Способ получения эзетимиба и его производных |
| WO2010113175A2 (en) | 2009-04-01 | 2010-10-07 | Matrix Laboratories Ltd | Enzymatic process for the preparation of (s)-5-(4-fluoro-phenyl)-5-hydroxy- 1morpholin-4-yl-pentan-1-one, an intermediate of ezetimibe and further conversion to ezetimibe |
| CN104803858B (zh) * | 2014-01-23 | 2019-03-01 | 东莞东阳光科研发有限公司 | 一种制备四丁基氟化铵三水合物的方法 |
| ES2986788T3 (es) | 2020-02-07 | 2024-11-12 | Gasherbrum Bio Inc | Agonistas heterocíclicos de GLP-1 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0333268A1 (en) * | 1988-03-18 | 1989-09-20 | Merck & Co. Inc. | Process for synthesis of a chiral 3-beta hydrogen (3R) 4-aroyloxy azetidinone |
| US4876365A (en) * | 1988-12-05 | 1989-10-24 | Schering Corporation | Intermediate compounds for preparing penems and carbapenems |
| US4983597A (en) * | 1989-08-31 | 1991-01-08 | Merck & Co., Inc. | Beta-lactams as anticholesterolemic agents |
| US5085473A (en) * | 1990-10-09 | 1992-02-04 | Yuhe Yang | Air actuated car curtain device |
| EP0596015B1 (en) * | 1991-07-23 | 1997-10-01 | Schering Corporation | Substituted beta-lactam compounds useful as hypocholesterolemic agents and processes for the preparation thereof |
-
1994
- 1994-07-01 CN CN94192732A patent/CN1071745C/zh not_active Expired - Fee Related
- 1994-07-01 JP JP7504054A patent/JP2840452B2/ja not_active Expired - Fee Related
- 1994-07-01 AU AU72146/94A patent/AU681419B2/en not_active Ceased
- 1994-07-01 HU HU9503748A patent/HUT73237A/hu unknown
- 1994-07-01 CZ CZ9676A patent/CZ7696A3/cs unknown
- 1994-07-01 AT AT94921407T patent/ATE205475T1/de active
- 1994-07-01 KR KR1019960700068A patent/KR0176001B1/ko not_active Expired - Fee Related
- 1994-07-01 EP EP94921407A patent/EP0707567B1/en not_active Expired - Lifetime
- 1994-07-01 SK SK37-96A patent/SK3796A3/sk unknown
- 1994-07-01 DK DK94921407T patent/DK0707567T3/da active
- 1994-07-01 PL PL94312502A patent/PL312502A1/xx unknown
- 1994-07-01 CA CA002166784A patent/CA2166784C/en not_active Expired - Fee Related
- 1994-07-01 DE DE69428280T patent/DE69428280T2/de not_active Expired - Lifetime
- 1994-07-01 US US08/578,594 patent/US5728827A/en not_active Expired - Lifetime
- 1994-07-01 ES ES94921407T patent/ES2160125T3/es not_active Expired - Lifetime
- 1994-07-01 PT PT94921407T patent/PT707567E/pt unknown
- 1994-07-01 NZ NZ268798A patent/NZ268798A/en unknown
- 1994-07-01 WO PCT/US1994/007291 patent/WO1995001961A1/en active IP Right Grant
- 1994-07-06 MX MX9405152A patent/MX9405152A/es not_active IP Right Cessation
-
1996
- 1996-01-08 NO NO960083A patent/NO306294B1/no not_active IP Right Cessation
- 1996-01-09 FI FI960095A patent/FI960095A0/fi unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO1995001961A1 (en) | 1995-01-19 |
| ES2160125T3 (es) | 2001-11-01 |
| CZ7696A3 (en) | 1996-04-17 |
| KR0176001B1 (ko) | 1999-03-20 |
| CA2166784C (en) | 2001-12-11 |
| NO306294B1 (no) | 1999-10-18 |
| SK3796A3 (en) | 1997-02-05 |
| FI960095L (fi) | 1996-01-09 |
| AU681419B2 (en) | 1997-08-28 |
| HU9503748D0 (en) | 1996-02-28 |
| JPH08507085A (ja) | 1996-07-30 |
| NZ268798A (en) | 1997-01-29 |
| NO960083D0 (no) | 1996-01-08 |
| MX9405152A (es) | 1995-01-31 |
| DE69428280D1 (de) | 2001-10-18 |
| DE69428280T2 (de) | 2002-06-13 |
| CN1126989A (zh) | 1996-07-17 |
| PT707567E (pt) | 2002-01-30 |
| AU7214694A (en) | 1995-02-06 |
| EP0707567A1 (en) | 1996-04-24 |
| ATE205475T1 (de) | 2001-09-15 |
| DK0707567T3 (da) | 2001-11-26 |
| PL312502A1 (en) | 1996-04-29 |
| US5728827A (en) | 1998-03-17 |
| KR960703853A (ko) | 1996-08-31 |
| JP2840452B2 (ja) | 1998-12-24 |
| HUT73237A (en) | 1996-07-29 |
| NO960083L (no) | 1996-03-04 |
| CN1071745C (zh) | 2001-09-26 |
| EP0707567B1 (en) | 2001-09-12 |
| CA2166784A1 (en) | 1995-01-19 |
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