DK0707567T3 - Fremgangsmåde til syntese af azetidinoner - Google Patents
Fremgangsmåde til syntese af azetidinonerInfo
- Publication number
- DK0707567T3 DK0707567T3 DK94921407T DK94921407T DK0707567T3 DK 0707567 T3 DK0707567 T3 DK 0707567T3 DK 94921407 T DK94921407 T DK 94921407T DK 94921407 T DK94921407 T DK 94921407T DK 0707567 T3 DK0707567 T3 DK 0707567T3
- Authority
- DK
- Denmark
- Prior art keywords
- substituted
- pct
- beta
- amino
- azetidinones
- Prior art date
Links
- MNFORVFSTILPAW-UHFFFAOYSA-N azetidin-2-one Chemical class O=C1CCN1 MNFORVFSTILPAW-UHFFFAOYSA-N 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 150000001408 amides Chemical class 0.000 abstract 1
- 239000003529 anticholesteremic agent Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 150000002961 penems Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Steroid Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8935793A | 1993-07-09 | 1993-07-09 | |
| PCT/US1994/007291 WO1995001961A1 (en) | 1993-07-09 | 1994-07-01 | Process for the synthesis of azetidinones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0707567T3 true DK0707567T3 (da) | 2001-11-26 |
Family
ID=22217215
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94921407T DK0707567T3 (da) | 1993-07-09 | 1994-07-01 | Fremgangsmåde til syntese af azetidinoner |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5728827A (da) |
| EP (1) | EP0707567B1 (da) |
| JP (1) | JP2840452B2 (da) |
| KR (1) | KR0176001B1 (da) |
| CN (1) | CN1071745C (da) |
| AT (1) | ATE205475T1 (da) |
| AU (1) | AU681419B2 (da) |
| CA (1) | CA2166784C (da) |
| CZ (1) | CZ7696A3 (da) |
| DE (1) | DE69428280T2 (da) |
| DK (1) | DK0707567T3 (da) |
| ES (1) | ES2160125T3 (da) |
| FI (1) | FI960095L (da) |
| HU (1) | HUT73237A (da) |
| MX (1) | MX9405152A (da) |
| NO (1) | NO306294B1 (da) |
| NZ (1) | NZ268798A (da) |
| PL (1) | PL312502A1 (da) |
| PT (1) | PT707567E (da) |
| SK (1) | SK3796A3 (da) |
| WO (1) | WO1995001961A1 (da) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5631365A (en) | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
| AU2030100A (en) * | 1998-12-07 | 2000-06-26 | Schering Corporation | Process for the synthesis of azetidinones |
| US6207822B1 (en) | 1998-12-07 | 2001-03-27 | Schering Corporation | Process for the synthesis of azetidinones |
| AR023463A1 (es) * | 1999-04-16 | 2002-09-04 | Schering Corp | Uso de compuestos de azetidinona |
| US6982251B2 (en) | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
| US20060287254A1 (en) * | 2001-01-26 | 2006-12-21 | Schering Corporation | Use of substituted azetidinone compounds for the treatment of sitosterolemia |
| US7071181B2 (en) | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
| US7417039B2 (en) | 2001-01-26 | 2008-08-26 | Schering Corporation | Use of substituted azetidinone compounds for the treatment of sitosterolemia |
| CN100509058C (zh) | 2001-01-26 | 2009-07-08 | 先灵公司 | 过氧化物酶体增殖物激活受体(ppar)活化剂和甾醇吸收抑制剂的组合药以及对于血管适应症的治疗 |
| SI1373230T1 (sl) * | 2001-03-28 | 2005-12-31 | Schering Corp | Enantioselektivna sinteza azetidinonskih intermediatnih spojin |
| US7132415B2 (en) * | 2001-09-21 | 2006-11-07 | Schering Corporation | Methods and therapeutic combinations for the treatment of xanthoma using sterol absorption inhibitors |
| US7053080B2 (en) | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
| US20030204096A1 (en) * | 2002-03-25 | 2003-10-30 | Schering Corporation | Enantioselective synthesis of azetidinone intermediate compounds |
| GB0215579D0 (en) | 2002-07-05 | 2002-08-14 | Astrazeneca Ab | Chemical compounds |
| US7135556B2 (en) * | 2002-07-19 | 2006-11-14 | Schering Corporation | NPC1L1 (NPC3) and methods of use thereof |
| CA2504878A1 (en) | 2002-11-06 | 2004-05-27 | Schering Corporation | Cholesterol absorption inhibitors for the treatment of demyelination |
| MXPA05009501A (es) * | 2003-03-07 | 2005-10-18 | Schering Corp | Compuestos de azetidinona sustituidos, formulaciones y usos de los mismos para el tratamiento de hipercolesterolemia. |
| JP2006519869A (ja) | 2003-03-07 | 2006-08-31 | シェーリング コーポレイション | 置換アゼチジノン化合物、置換アゼチジノン化合物を調製するためのプロセス、それらの処方物および使用 |
| US7459442B2 (en) * | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
| JP5137228B2 (ja) | 2003-03-07 | 2013-02-06 | メルク・シャープ・アンド・ドーム・コーポレーション | 高コレステロール血症の処置のための置換アゼチジノン化合物、置換アゼチジノン処方物およびそれらの使用 |
| WO2005062824A2 (en) * | 2003-12-23 | 2005-07-14 | Merck & Co., Inc. | Anti-hypercholesterolemic compounds |
| US7871998B2 (en) | 2003-12-23 | 2011-01-18 | Astrazeneca Ab | Diphenylazetidinone derivatives possessing cholesterol absorption inhibitory activity |
| EP1723414A4 (en) * | 2004-01-16 | 2008-03-26 | Merck & Co Inc | NPC1L1 (NPC3) AND METHOD FOR IDENTIFYING ITS LIGANDS |
| JP2007538042A (ja) * | 2004-05-21 | 2007-12-27 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | １，４−ジフェニルアゼチジノン誘導体の製造方法 |
| DE102004025071B4 (de) * | 2004-05-21 | 2006-12-21 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Herstellung von Diphenylazetidinon-Derivaten |
| SG158132A1 (en) | 2004-12-20 | 2010-01-29 | Schering Corp | Process for the synthesis of azetidinones |
| JP2008546784A (ja) * | 2005-06-20 | 2008-12-25 | シェーリング コーポレイション | ヒスタミンｈ３アンタゴニストとして有用なピペリジン誘導体 |
| SA06270191B1 (ar) | 2005-06-22 | 2010-03-29 | استرازينيكا ايه بي | مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم |
| EP1986489A2 (en) * | 2006-02-24 | 2008-11-05 | Schering Corporation | Npc1l1 orthologues |
| AR060623A1 (es) | 2006-04-27 | 2008-07-02 | Astrazeneca Ab | Compuestos derivados de 2-azetidinona y un metodo de preparacion |
| EP2059241A1 (en) * | 2006-09-05 | 2009-05-20 | Schering Corporation | Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis |
| WO2008032338A2 (en) * | 2006-09-11 | 2008-03-20 | Manne Satyanarayana Reddy | Improved process for the preparation of ezetimibe and its intermediates |
| EA017349B1 (ru) | 2007-01-24 | 2012-11-30 | Крка | Способ получения эзетимиба и его производных |
| EP2414529A2 (en) | 2009-04-01 | 2012-02-08 | Matrix Laboratories Ltd | Enzymatic process for the preparation of (s)-5-(4-fluoro-phenyl)-5-hydroxy- 1morpholin-4-yl-pentan-1-one, an intermediate of ezetimibe and further conversion to ezetimibe |
| CN104803858B (zh) * | 2014-01-23 | 2019-03-01 | 东莞东阳光科研发有限公司 | 一种制备四丁基氟化铵三水合物的方法 |
| ES2986788T3 (es) | 2020-02-07 | 2024-11-12 | Gasherbrum Bio Inc | Agonistas heterocíclicos de GLP-1 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0333268A1 (en) * | 1988-03-18 | 1989-09-20 | Merck & Co. Inc. | Process for synthesis of a chiral 3-beta hydrogen (3R) 4-aroyloxy azetidinone |
| US4876365A (en) * | 1988-12-05 | 1989-10-24 | Schering Corporation | Intermediate compounds for preparing penems and carbapenems |
| US4983597A (en) * | 1989-08-31 | 1991-01-08 | Merck & Co., Inc. | Beta-lactams as anticholesterolemic agents |
| US5085473A (en) * | 1990-10-09 | 1992-02-04 | Yuhe Yang | Air actuated car curtain device |
| MY131273A (en) * | 1991-07-23 | 2007-07-31 | Schering Corp | Substituted beta-lactam compounds useful as hypocholesterolemic agents and processes for the preparation thereof |
-
1994
- 1994-07-01 ES ES94921407T patent/ES2160125T3/es not_active Expired - Lifetime
- 1994-07-01 SK SK37-96A patent/SK3796A3/sk unknown
- 1994-07-01 AU AU72146/94A patent/AU681419B2/en not_active Ceased
- 1994-07-01 PL PL94312502A patent/PL312502A1/xx unknown
- 1994-07-01 NZ NZ268798A patent/NZ268798A/en unknown
- 1994-07-01 PT PT94921407T patent/PT707567E/pt unknown
- 1994-07-01 AT AT94921407T patent/ATE205475T1/de active
- 1994-07-01 DE DE69428280T patent/DE69428280T2/de not_active Expired - Lifetime
- 1994-07-01 JP JP7504054A patent/JP2840452B2/ja not_active Expired - Fee Related
- 1994-07-01 US US08/578,594 patent/US5728827A/en not_active Expired - Lifetime
- 1994-07-01 CZ CZ9676A patent/CZ7696A3/cs unknown
- 1994-07-01 KR KR1019960700068A patent/KR0176001B1/ko not_active Expired - Fee Related
- 1994-07-01 CA CA002166784A patent/CA2166784C/en not_active Expired - Fee Related
- 1994-07-01 DK DK94921407T patent/DK0707567T3/da active
- 1994-07-01 HU HU9503748A patent/HUT73237A/hu unknown
- 1994-07-01 EP EP94921407A patent/EP0707567B1/en not_active Expired - Lifetime
- 1994-07-01 WO PCT/US1994/007291 patent/WO1995001961A1/en active IP Right Grant
- 1994-07-01 CN CN94192732A patent/CN1071745C/zh not_active Expired - Fee Related
- 1994-07-06 MX MX9405152A patent/MX9405152A/es not_active IP Right Cessation
-
1996
- 1996-01-08 NO NO960083A patent/NO306294B1/no not_active IP Right Cessation
- 1996-01-09 FI FI960095A patent/FI960095L/fi unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2160125T3 (es) | 2001-11-01 |
| DE69428280D1 (de) | 2001-10-18 |
| AU7214694A (en) | 1995-02-06 |
| FI960095A0 (fi) | 1996-01-09 |
| WO1995001961A1 (en) | 1995-01-19 |
| NO306294B1 (no) | 1999-10-18 |
| JPH08507085A (ja) | 1996-07-30 |
| CZ7696A3 (en) | 1996-04-17 |
| ATE205475T1 (de) | 2001-09-15 |
| MX9405152A (es) | 1995-01-31 |
| AU681419B2 (en) | 1997-08-28 |
| FI960095L (fi) | 1996-01-09 |
| DE69428280T2 (de) | 2002-06-13 |
| JP2840452B2 (ja) | 1998-12-24 |
| PL312502A1 (en) | 1996-04-29 |
| CA2166784A1 (en) | 1995-01-19 |
| NZ268798A (en) | 1997-01-29 |
| SK3796A3 (en) | 1997-02-05 |
| EP0707567B1 (en) | 2001-09-12 |
| HU9503748D0 (en) | 1996-02-28 |
| NO960083D0 (no) | 1996-01-08 |
| KR0176001B1 (ko) | 1999-03-20 |
| KR960703853A (ko) | 1996-08-31 |
| NO960083L (no) | 1996-03-04 |
| CN1071745C (zh) | 2001-09-26 |
| PT707567E (pt) | 2002-01-30 |
| US5728827A (en) | 1998-03-17 |
| HUT73237A (en) | 1996-07-29 |
| CN1126989A (zh) | 1996-07-17 |
| EP0707567A1 (en) | 1996-04-24 |
| CA2166784C (en) | 2001-12-11 |
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