MX377930B - Proceso para fabricar compuestos de quinolona. - Google Patents
Proceso para fabricar compuestos de quinolona.Info
- Publication number
- MX377930B MX377930B MX2015000081A MX2015000081A MX377930B MX 377930 B MX377930 B MX 377930B MX 2015000081 A MX2015000081 A MX 2015000081A MX 2015000081 A MX2015000081 A MX 2015000081A MX 377930 B MX377930 B MX 377930B
- Authority
- MX
- Mexico
- Prior art keywords
- manufacturing
- quinolone
- quinolone compounds
- compounds
- synthesizing
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000007660 quinolones Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- 230000002194 synthesizing effect Effects 0.000 abstract 2
- 230000002924 anti-infective effect Effects 0.000 abstract 1
- 229960005475 antiinfective agent Drugs 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 abstract 1
- -1 quinolone compound Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16H—GEARING
- F16H57/00—General details of gearing
- F16H57/02—Gearboxes; Mounting gearing therein
- F16H57/027—Gearboxes; Mounting gearing therein characterised by means for venting gearboxes, e.g. air breathers
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16H—GEARING
- F16H57/00—General details of gearing
- F16H57/02—Gearboxes; Mounting gearing therein
- F16H57/037—Gearboxes for accommodating differential gearings
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16H—GEARING
- F16H48/00—Differential gearings
- F16H48/06—Differential gearings with gears having orbital motion
- F16H48/08—Differential gearings with gears having orbital motion comprising bevel gears
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16H—GEARING
- F16H57/00—General details of gearing
- F16H57/04—Features relating to lubrication or cooling or heating
- F16H57/0457—Splash lubrication
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16H—GEARING
- F16H57/00—General details of gearing
- F16H57/04—Features relating to lubrication or cooling or heating
- F16H57/048—Type of gearings to be lubricated, cooled or heated
- F16H57/0482—Gearings with gears having orbital motion
- F16H57/0483—Axle or inter-axle differentials
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T74/00—Machine element or mechanism
- Y10T74/19—Gearing
- Y10T74/19642—Directly cooperating gears
- Y10T74/19688—Bevel
- Y10T74/19693—Motor vehicle drive
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T74/00—Machine element or mechanism
- Y10T74/21—Elements
- Y10T74/2186—Gear casings
- Y10T74/2188—Axle and torque tubes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Mechanical Engineering (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención se refiere al campo de la sintetización de compuestos antiinfecciosos. Más particularmente, la invención se refiere a la sintetización de una familia de compuestos de quinolona útiles como agentes antinfecciosos. La invención incluye un proceso para preparar un compuesto de quinolona en donde menos de aproximadamente 0.40 % de la impureza dimérica de la quinolona es producida.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19408308P | 2008-09-24 | 2008-09-24 | |
| PCT/US2009/005276 WO2010036329A2 (en) | 2008-09-24 | 2009-09-23 | Process for making quinolone compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX377930B true MX377930B (es) | 2025-03-10 |
Family
ID=42060333
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2011003122A MX2011003122A (es) | 2008-09-24 | 2009-09-23 | Proceso para fabricar compuestos de quinolona. |
| MX2015000081A MX377930B (es) | 2008-09-24 | 2009-09-23 | Proceso para fabricar compuestos de quinolona. |
| MX2020009790A MX2020009790A (es) | 2008-09-24 | 2011-03-23 | Proceso para fabricar compuestos de quinolona. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2011003122A MX2011003122A (es) | 2008-09-24 | 2009-09-23 | Proceso para fabricar compuestos de quinolona. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020009790A MX2020009790A (es) | 2008-09-24 | 2011-03-23 | Proceso para fabricar compuestos de quinolona. |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US8497378B2 (es) |
| EP (3) | EP3766876B8 (es) |
| JP (2) | JP6013734B2 (es) |
| KR (3) | KR20110091504A (es) |
| CN (2) | CN105001207A (es) |
| AU (1) | AU2009297085B2 (es) |
| BR (1) | BRPI0919241B8 (es) |
| CA (1) | CA2738236C (es) |
| CY (2) | CY1123658T1 (es) |
| DK (2) | DK3214083T3 (es) |
| ES (3) | ES2629466T3 (es) |
| FI (2) | FI3766876T3 (es) |
| HK (1) | HK1214243A1 (es) |
| HR (1) | HRP20201879T1 (es) |
| HU (2) | HUE052219T2 (es) |
| IL (1) | IL211845A (es) |
| LT (3) | LT3214083T (es) |
| MX (3) | MX2011003122A (es) |
| NL (1) | NL301091I2 (es) |
| NO (1) | NO2021006I1 (es) |
| PL (2) | PL3214083T3 (es) |
| PT (1) | PT3214083T (es) |
| RS (1) | RS61194B1 (es) |
| RU (1) | RU2546667C2 (es) |
| SG (1) | SG10201605492YA (es) |
| SI (1) | SI3214083T1 (es) |
| SM (1) | SMT202000690T1 (es) |
| WO (1) | WO2010036329A2 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7576216B2 (en) * | 2004-07-30 | 2009-08-18 | Abbott Laboratories | Preparation of pyridonecarboxylic acid antibacterials |
| JP6013734B2 (ja) * | 2008-09-24 | 2016-10-25 | メリンタ セラピューティクス、インク | キノロン化合物の製造方法 |
| WO2014152317A2 (en) * | 2013-03-15 | 2014-09-25 | Melinta Therapeutics, Inc. | Methods of treating gonorrhea infections using quinolone antibiotics |
| CN104098548B (zh) * | 2013-04-11 | 2017-07-18 | 上海医药工业研究院 | 一种Delafloxacin的精制方法 |
| CN103709100A (zh) * | 2013-12-31 | 2014-04-09 | 南京工业大学 | 一种8-氯代喹诺酮衍生物的制备方法 |
| TW201605447A (zh) * | 2014-06-20 | 2016-02-16 | 美林塔治療學有限公司 | 處理感染的方法 |
| CN106256824B (zh) * | 2015-06-18 | 2020-10-27 | 重庆医药工业研究院有限责任公司 | 一种高纯度德拉沙星葡甲胺盐的制备方法 |
| CN105017224A (zh) * | 2015-07-10 | 2015-11-04 | 扬子江药业集团有限公司 | 一种德拉沙星葡甲胺晶型的制备方法 |
| CN107778293B (zh) * | 2016-08-29 | 2023-06-16 | 鲁南制药集团股份有限公司 | 一种改进的德拉沙星的制备方法 |
| JP6813665B2 (ja) | 2017-03-31 | 2021-01-13 | 富士フイルム株式会社 | ４−ピリドン化合物またはその塩、それを含む医薬組成物および剤 |
| WO2022240897A1 (en) | 2021-05-10 | 2022-11-17 | Sepelo Therapeutics, Llc | Pharmaceutical composition comprising delafloxacin for administration into the lung |
| CN113527262B (zh) * | 2021-06-22 | 2022-07-15 | 安徽普利药业有限公司 | 一种德拉沙星及其葡甲胺盐的精制方法 |
| CN114031607B (zh) * | 2021-11-16 | 2023-01-10 | 海南普利制药股份有限公司 | 一种德拉沙星及其中间体的精制方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| DE69617750T2 (de) | 1995-09-22 | 2002-08-08 | Wakunaga Pharma Co Ltd | Neue pyridoncarbonsäure-derivate oder ihre salze und antibakterielle mittel, die diese als aktiven wirkstoff enthalten |
| CN1157389C (zh) * | 1999-07-01 | 2004-07-14 | 涌永制药株式会社 | 喹啉羧酸衍生物或其盐 |
| JP2005097116A (ja) | 1999-11-11 | 2005-04-14 | Wakunaga Pharmaceut Co Ltd | キノリンカルボン酸誘導体アルカリ金属塩及びこれを用いたキノリンカルボン酸誘導体の精製法 |
| JP5274012B2 (ja) * | 2004-07-30 | 2013-08-28 | アボット・ラボラトリーズ | ピリドンカルボン酸抗菌薬の調製 |
| EP3056492B1 (en) | 2004-10-08 | 2021-09-22 | AbbVie Inc. | Meglumine salt and crystalline forms thereof of a drug (delafloxacin) |
| DK1868581T3 (da) | 2005-04-11 | 2012-07-09 | Abbott Lab | Farmaceutiske sammensætninger med forbedrede opløsningsprofiler til dårligt opløselige lægemidler |
| JP6013734B2 (ja) | 2008-09-24 | 2016-10-25 | メリンタ セラピューティクス、インク | キノロン化合物の製造方法 |
-
2009
- 2009-09-23 JP JP2011529013A patent/JP6013734B2/ja active Active
- 2009-09-23 ES ES09816565.7T patent/ES2629466T3/es active Active
- 2009-09-23 RU RU2011116052/04A patent/RU2546667C2/ru active
- 2009-09-23 US US13/120,278 patent/US8497378B2/en not_active Ceased
- 2009-09-23 KR KR1020117009326A patent/KR20110091504A/ko not_active Ceased
- 2009-09-23 MX MX2011003122A patent/MX2011003122A/es active IP Right Grant
- 2009-09-23 PL PL17163383T patent/PL3214083T3/pl unknown
- 2009-09-23 KR KR1020167026280A patent/KR101775304B1/ko active Active
- 2009-09-23 MX MX2015000081A patent/MX377930B/es unknown
- 2009-09-23 RS RS20201519A patent/RS61194B1/sr unknown
- 2009-09-23 DK DK17163383.7T patent/DK3214083T3/da active
- 2009-09-23 EP EP20191961.0A patent/EP3766876B8/en active Active
- 2009-09-23 SI SI200932102T patent/SI3214083T1/sl unknown
- 2009-09-23 WO PCT/US2009/005276 patent/WO2010036329A2/en not_active Ceased
- 2009-09-23 AU AU2009297085A patent/AU2009297085B2/en active Active
- 2009-09-23 LT LTEP17163383.7T patent/LT3214083T/lt unknown
- 2009-09-23 ES ES17163383T patent/ES2826273T3/es active Active
- 2009-09-23 HU HUE17163383A patent/HUE052219T2/hu unknown
- 2009-09-23 CN CN201510401546.2A patent/CN105001207A/zh active Pending
- 2009-09-23 PT PT171633837T patent/PT3214083T/pt unknown
- 2009-09-23 BR BRPI0919241A patent/BRPI0919241B8/pt active IP Right Grant
- 2009-09-23 LT LTEP20191961.0T patent/LT3766876T/lt unknown
- 2009-09-23 SG SG10201605492YA patent/SG10201605492YA/en unknown
- 2009-09-23 EP EP17163383.7A patent/EP3214083B1/en active Active
- 2009-09-23 CA CA2738236A patent/CA2738236C/en active Active
- 2009-09-23 DK DK09816565.7T patent/DK2346855T3/en active
- 2009-09-23 CN CN200980138280.XA patent/CN102164912B/zh active Active
- 2009-09-23 SM SM20200690T patent/SMT202000690T1/it unknown
- 2009-09-23 US US14/743,365 patent/USRE46617E1/en active Active
- 2009-09-23 FI FIEP20191961.0T patent/FI3766876T3/fi active
- 2009-09-23 ES ES20191961T patent/ES2966093T3/es active Active
- 2009-09-23 KR KR1020177008707A patent/KR20170039758A/ko not_active Ceased
- 2009-09-23 PL PL20191961.0T patent/PL3766876T3/pl unknown
- 2009-09-23 EP EP09816565.7A patent/EP2346855B1/en active Active
-
2011
- 2011-03-22 IL IL211845A patent/IL211845A/en active IP Right Grant
- 2011-03-23 MX MX2020009790A patent/MX2020009790A/es unknown
-
2013
- 2013-07-09 US US13/937,488 patent/US8871938B2/en active Active
-
2015
- 2015-05-19 JP JP2015101828A patent/JP2015178515A/ja active Pending
-
2016
- 2016-02-23 HK HK16101979.5A patent/HK1214243A1/zh unknown
-
2020
- 2020-11-25 HR HRP20201879TT patent/HRP20201879T1/hr unknown
- 2020-12-09 CY CY20201101168T patent/CY1123658T1/el unknown
-
2021
- 2021-02-04 NL NL301091C patent/NL301091I2/nl unknown
- 2021-02-10 HU HUS2100004C patent/HUS2100004I1/hu unknown
- 2021-02-10 CY CY2021004C patent/CY2021004I2/el unknown
- 2021-02-15 NO NO2021006C patent/NO2021006I1/no unknown
- 2021-02-16 FI FIC20210002C patent/FIC20210002I1/fi unknown
- 2021-02-17 LT LTPA2021002C patent/LTC3214083I2/lt unknown
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