IN2014MN01521A - - Google Patents
Info
- Publication number
- IN2014MN01521A IN2014MN01521A IN1521MUN2014A IN2014MN01521A IN 2014MN01521 A IN2014MN01521 A IN 2014MN01521A IN 1521MUN2014 A IN1521MUN2014 A IN 1521MUN2014A IN 2014MN01521 A IN2014MN01521 A IN 2014MN01521A
- Authority
- IN
- India
- Prior art keywords
- formula
- compound
- preparation
- disclosed
- eribulin
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229930195695 Halichondrin Natural products 0.000 abstract 1
- UFNVPOGXISZXJD-XJPMSQCNSA-N eribulin Chemical compound C([C@H]1CC[C@@H]2O[C@@H]3[C@H]4O[C@H]5C[C@](O[C@H]4[C@H]2O1)(O[C@@H]53)CC[C@@H]1O[C@H](C(C1)=C)CC1)C(=O)C[C@@H]2[C@@H](OC)[C@@H](C[C@H](O)CN)O[C@H]2C[C@@H]2C(=C)[C@H](C)C[C@H]1O2 UFNVPOGXISZXJD-XJPMSQCNSA-N 0.000 abstract 1
- 229960003649 eribulin Drugs 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/02—Acyclic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
- C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161581164P | 2011-12-29 | 2011-12-29 | |
| PCT/CA2012/050939 WO2013097042A1 (en) | 2011-12-29 | 2012-12-24 | 2-((2s,3s,4r,5r)-5-((s)-3-amino-2-hydroxyprop-1-yl)-4-methoxy-3-(phenylsulfonylmethyl)tetrahydrofuran-2-yl)acetaldehyde derivatives and process for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014MN01521A true IN2014MN01521A (es) | 2015-05-01 |
Family
ID=48696142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN1521MUN2014 IN2014MN01521A (es) | 2011-12-29 | 2012-12-24 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9062020B2 (es) |
| EP (1) | EP2797945B1 (es) |
| JP (1) | JP6300030B2 (es) |
| CN (1) | CN104080793B (es) |
| AU (1) | AU2012363334B2 (es) |
| CA (1) | CA2860446C (es) |
| IN (1) | IN2014MN01521A (es) |
| SI (1) | SI2797945T1 (es) |
| WO (1) | WO2013097042A1 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012344697A1 (en) | 2011-11-30 | 2014-07-10 | Alphora Research Inc. | Process for preparation of (3R)-2,4-di-leaving group-3-methylbut-1-ene |
| CA2857395A1 (en) | 2011-12-16 | 2013-06-20 | Alphora Research Inc. | Process for preparation of 3-((2s,5s)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propanol derivatives and intermediates useful thereof |
| AU2013239290B2 (en) * | 2012-03-30 | 2017-08-03 | Sandoz Ag | Synthetic process for preparation of macrocyclic C1-keto analogs of Halichondrin B and intermediates useful therein |
| TW201617326A (zh) | 2014-03-06 | 2016-05-16 | Ａｌｐｈｏｒａ研發股份有限公司 | （ｓ）－１－（（２ｒ，３ｒ，４ｓ，５ｓ）－５－烯丙－３－甲氧－４－（對甲苯磺醯甲基）四氫呋喃－２－基）－３－氨基丙－２－醇之結晶衍生物 |
| WO2016003975A1 (en) | 2014-06-30 | 2016-01-07 | President And Fellows Of Harvard College | Synthesis of halichondrin analogs and uses thereof |
| US10147463B2 (en) | 2014-12-10 | 2018-12-04 | Nxp Usa, Inc. | Video processing unit and method of buffering a source video stream |
| WO2016176560A1 (en) | 2015-04-30 | 2016-11-03 | President And Fellows Of Harvard College | Chromium-mediated coupling and application to the synthesis of halichondrins |
| ES2880402T3 (es) | 2016-03-02 | 2021-11-24 | Eisai R&D Man Co Ltd | Conjugados de anticuerpo-fármaco basados en eribulina y métodos de uso |
| JP6978758B2 (ja) | 2016-11-11 | 2021-12-08 | プレジデント アンド フェローズ オブ ハーバード カレッジ | パラジウム媒介ケトール化 |
| US9938288B1 (en) | 2017-04-05 | 2018-04-10 | President And Fellows Of Harvard College | Macrocyclic compound and uses thereof |
| UA124399C2 (uk) | 2017-04-05 | 2021-09-08 | Президент Енд Феллоуз Оф Гарвард Колледж | Макроциклічна сполука та її застосування |
| CN111433211B (zh) | 2017-07-06 | 2024-05-07 | 哈佛大学的校长及成员们 | 软海绵素的合成 |
| US11498892B2 (en) | 2017-07-06 | 2022-11-15 | President And Fellows Of Harvard College | Fe/Cu-mediated ketone synthesis |
| CN111566113B (zh) | 2017-11-15 | 2024-01-09 | 哈佛大学的校长及成员们 | 大环化合物及其用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5436238A (en) | 1992-03-12 | 1995-07-25 | President And Fellows Of Harvard College | Halichondrins and related compounds |
| US5338865A (en) | 1992-03-12 | 1994-08-16 | President And Fellows Of Harvard College | Synthesis of halichondrin B and norhalichondrin B |
| PT707566E (pt) | 1993-07-09 | 2000-09-29 | Theramex | Novos analogos estruturais da vitamina d |
| DE122011100031I1 (de) | 1998-06-17 | 2011-12-15 | Eisai R&D Man Co Ltd | Makrocyclische analoga und verfahren zu ihrer verwendung und herstellung. |
| US7001982B2 (en) | 2003-03-31 | 2006-02-21 | Council Of Scientific And Industrial Research | Non-natural C-linked carbo-β-peptides with robust secondary structures |
| CN1993342A (zh) * | 2004-06-03 | 2007-07-04 | 卫材株式会社 | 用于制备软海绵素b的中间体 |
| ES2748200T3 (es) * | 2004-06-03 | 2020-03-13 | Eisai R&D Man Co Ltd | Productos intermedios para la preparación de halicondrina B |
| CN102056930B (zh) * | 2008-04-04 | 2016-04-20 | 卫材R&D管理有限公司 | 软海绵素b类似物 |
| AU2012344697A1 (en) | 2011-11-30 | 2014-07-10 | Alphora Research Inc. | Process for preparation of (3R)-2,4-di-leaving group-3-methylbut-1-ene |
| CA2857395A1 (en) | 2011-12-16 | 2013-06-20 | Alphora Research Inc. | Process for preparation of 3-((2s,5s)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propanol derivatives and intermediates useful thereof |
| AU2013239290B2 (en) | 2012-03-30 | 2017-08-03 | Sandoz Ag | Synthetic process for preparation of macrocyclic C1-keto analogs of Halichondrin B and intermediates useful therein |
| EP2997017B1 (en) | 2013-05-15 | 2017-08-09 | Alphora Research Inc. | 3-((2s,5s)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propanol derivatives, their preparation and intermediates useful thereof |
-
2012
- 2012-12-24 WO PCT/CA2012/050939 patent/WO2013097042A1/en active Application Filing
- 2012-12-24 AU AU2012363334A patent/AU2012363334B2/en not_active Ceased
- 2012-12-24 US US14/369,442 patent/US9062020B2/en not_active Expired - Fee Related
- 2012-12-24 EP EP12863099.3A patent/EP2797945B1/en not_active Not-in-force
- 2012-12-24 CN CN201280064611.1A patent/CN104080793B/zh not_active Expired - Fee Related
- 2012-12-24 IN IN1521MUN2014 patent/IN2014MN01521A/en unknown
- 2012-12-24 SI SI201230582A patent/SI2797945T1/sl unknown
- 2012-12-24 CA CA2860446A patent/CA2860446C/en active Active
- 2012-12-24 JP JP2014549284A patent/JP6300030B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| SI2797945T1 (sl) | 2016-07-29 |
| US20150011776A1 (en) | 2015-01-08 |
| CN104080793A (zh) | 2014-10-01 |
| CA2860446A1 (en) | 2013-07-04 |
| EP2797945A1 (en) | 2014-11-05 |
| JP6300030B2 (ja) | 2018-03-28 |
| EP2797945A4 (en) | 2015-06-03 |
| CN104080793B (zh) | 2017-09-19 |
| AU2012363334A1 (en) | 2014-08-21 |
| AU2012363334B2 (en) | 2017-02-02 |
| EP2797945B1 (en) | 2016-03-16 |
| CA2860446C (en) | 2017-01-10 |
| WO2013097042A1 (en) | 2013-07-04 |
| JP2015503525A (ja) | 2015-02-02 |
| US9062020B2 (en) | 2015-06-23 |
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