MX373105B - Métodos de síntesis química de compuestos de diaminofenotiazinio que incluyen cloruro de metiltioninio (mtc). - Google Patents
Métodos de síntesis química de compuestos de diaminofenotiazinio que incluyen cloruro de metiltioninio (mtc).Info
- Publication number
- MX373105B MX373105B MX2019002620A MX2019002620A MX373105B MX 373105 B MX373105 B MX 373105B MX 2019002620 A MX2019002620 A MX 2019002620A MX 2019002620 A MX2019002620 A MX 2019002620A MX 373105 B MX373105 B MX 373105B
- Authority
- MX
- Mexico
- Prior art keywords
- mtc
- diaminophenethiazinium
- chemical synthesis
- synthesis methods
- compounds including
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- CXKWCBBOMKCUKX-UHFFFAOYSA-M methylene blue Chemical compound [Cl-].C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 CXKWCBBOMKCUKX-UHFFFAOYSA-M 0.000 title 2
- 238000003786 synthesis reaction Methods 0.000 title 1
- RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- 229960000907 methylthioninium chloride Drugs 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
- CBBMGBGDIPJEMI-UHFFFAOYSA-N thionine cation Chemical class C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 CBBMGBGDIPJEMI-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/30—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds
- C07C209/38—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
- C07C381/02—Thiosulfates
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Se proporcionan métodos para sintetizar y purificar ciertos compuestos de 3,7-diamino-fenotiazin-5-io (referidos en la presente como ``compuestos de diaminofenotiazinio´´) que incluyen cloruro de metiltioninio (MTC) / también conocido como Azul de Metileno).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1317702.7A GB201317702D0 (en) | 2013-10-07 | 2013-10-07 | Methods of chemical synthesis of diaminophenothiazinium compounds including methylthioninium chloride (MTC) |
| PCT/GB2014/053007 WO2015052496A1 (en) | 2013-10-07 | 2014-10-06 | Methods of chemical synthesis of diaminophenothiazinium compounds including methylthioninium chloride (mtc) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2019002620A MX2019002620A (es) | 2019-08-01 |
| MX373105B true MX373105B (es) | 2025-03-04 |
Family
ID=49630291
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020004348A MX2020004348A (es) | 2013-10-07 | 2014-10-06 | Métodos de síntesis química de compuestos de diaminofenotiazinio que incluyen cloruro de metiltioninio (mtc). |
| MX2016004229A MX363102B (es) | 2013-10-07 | 2014-10-06 | Metodos de sintesis quimica de compuestos de diaminofenotiazinio que incluyen cloruro de metiltioninio (mtc). |
| MX2019002620A MX373105B (es) | 2013-10-07 | 2016-04-01 | Métodos de síntesis química de compuestos de diaminofenotiazinio que incluyen cloruro de metiltioninio (mtc). |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020004348A MX2020004348A (es) | 2013-10-07 | 2014-10-06 | Métodos de síntesis química de compuestos de diaminofenotiazinio que incluyen cloruro de metiltioninio (mtc). |
| MX2016004229A MX363102B (es) | 2013-10-07 | 2014-10-06 | Metodos de sintesis quimica de compuestos de diaminofenotiazinio que incluyen cloruro de metiltioninio (mtc). |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US9765042B2 (es) |
| EP (3) | EP3415505B1 (es) |
| JP (1) | JP6505091B2 (es) |
| CN (3) | CN110092764B (es) |
| AU (3) | AU2014333610B2 (es) |
| CA (3) | CA3131803C (es) |
| DK (2) | DK3055291T3 (es) |
| ES (2) | ES2713324T3 (es) |
| GB (1) | GB201317702D0 (es) |
| HK (1) | HK1222175A1 (es) |
| HR (2) | HRP20220102T1 (es) |
| MX (3) | MX2020004348A (es) |
| MY (3) | MY177815A (es) |
| PL (2) | PL3415505T3 (es) |
| PT (2) | PT3055291T (es) |
| SG (3) | SG10201913293PA (es) |
| SI (2) | SI3415505T1 (es) |
| TR (1) | TR201902152T4 (es) |
| TW (2) | TWI675829B (es) |
| WO (1) | WO2015052496A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105130926B (zh) * | 2015-07-31 | 2018-02-13 | 江苏恒润制药有限公司 | 一种亚甲基蓝的制备方法 |
| GB201621817D0 (en) * | 2016-12-21 | 2017-02-01 | Wista Lab Ltd | Methods of chemical synthesis |
| US12215234B2 (en) * | 2019-09-21 | 2025-02-04 | RK Pharma Solutions LLC | Process for the purification of methylene blue |
| CN114989113A (zh) * | 2022-06-01 | 2022-09-02 | 山东科源制药股份有限公司 | 一种药用亚甲基蓝的精制方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US204796A (en) | 1878-06-11 | Improvement in the production of dye-stuffs from methyl-aniline | ||
| DE1886C (de) | 1877-12-15 | 1877-12-15 | Basf Ag | Verfahren zur darstellung blauer farbstoffe aus dimethylanilin und anderen tertiaeren aromatischen monaminen |
| US4212971A (en) * | 1979-03-08 | 1980-07-15 | American Cyanamid Company | Process for preparing methylene blue |
| CH640146A5 (de) * | 1979-05-14 | 1983-12-30 | Meyer Maschinenfabrik Ag | Filtrationsverfahren. |
| US5344928A (en) * | 1991-04-26 | 1994-09-06 | Takeda Chemical Industries, Ltd. | Phenothiazine derivatives, their production and use |
| GB9506197D0 (en) | 1995-03-27 | 1995-05-17 | Hoffmann La Roche | Inhibition of tau-tau association. |
| AU740547B2 (en) | 1997-01-21 | 2001-11-08 | American National Red Cross, The | Intracellular and extracellular decontamination of whole blood and blood components by amphiphilic phenothiazin-5-ium dyes plus light |
| FR2810318B1 (fr) | 2000-06-15 | 2005-09-23 | Laurent Galey | Derives de diamano-phenothiazine |
| GB0101049D0 (en) | 2001-01-15 | 2001-02-28 | Univ Aberdeen | Materials and methods relating to protein aggregation in neurodegenerative disease |
| GB2373787A (en) | 2001-03-08 | 2002-10-02 | Univ Central Lancashire | Phenothiazinium derivatives and their use to reduce pathogenic contaminants |
| SI1799662T1 (sl) | 2004-09-23 | 2013-08-30 | Wista Laboratories Ltd. | Postopki za kemijsko sintezo in čiščenje diaminofenotiazinijevih spojin, vključno metiltioninijevega klorida (MTC) |
| JP5186212B2 (ja) * | 2004-09-23 | 2013-04-17 | ウィスタ ラボラトリーズ リミテッド | メチルチオニニウム塩化物（ｍｔｃ）などのジアミノフェノチアジニウム化合物を化学合成および精製する方法 |
| US8263589B2 (en) * | 2006-03-29 | 2012-09-11 | Wista Laboratories Ltd. | Inhibitors of protein aggregation |
| ES2525001T3 (es) * | 2006-03-29 | 2014-12-16 | Wista Laboratories Ltd. | Compuestos de tioninio y su uso |
| CN101511803B (zh) * | 2006-07-11 | 2012-10-31 | 维斯塔实验室有限公司 | 二氨基吩噻嗪*化合物的合成和/或纯化方法 |
| CN100436431C (zh) * | 2006-12-15 | 2008-11-26 | 贵州同济堂制药有限公司 | 药用亚甲蓝的合成方法 |
| PL2430007T3 (pl) * | 2009-05-12 | 2014-07-31 | Wista Lab Ltd | Sposoby chemicznej syntezy związków diaminofenotiazyniowych z zastosowaniem nadsiarczanowych środków utleniających |
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2013
- 2013-10-07 GB GBGB1317702.7A patent/GB201317702D0/en not_active Ceased
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2014
- 2014-10-06 DK DK14789349.9T patent/DK3055291T3/en active
- 2014-10-06 HR HRP20220102TT patent/HRP20220102T1/hr unknown
- 2014-10-06 MY MYPI2016701234A patent/MY177815A/en unknown
- 2014-10-06 MX MX2020004348A patent/MX2020004348A/es unknown
- 2014-10-06 MX MX2016004229A patent/MX363102B/es unknown
- 2014-10-06 PL PL18181405T patent/PL3415505T3/pl unknown
- 2014-10-06 SG SG10201913293PA patent/SG10201913293PA/en unknown
- 2014-10-06 CN CN201910293813.7A patent/CN110092764B/zh active Active
- 2014-10-06 DK DK18181405.4T patent/DK3415505T3/da active
- 2014-10-06 CA CA3131803A patent/CA3131803C/en active Active
- 2014-10-06 CA CA2925801A patent/CA2925801C/en active Active
- 2014-10-06 PT PT14789349T patent/PT3055291T/pt unknown
- 2014-10-06 MY MYPI2020004693A patent/MY200570A/en unknown
- 2014-10-06 TR TR2019/02152T patent/TR201902152T4/tr unknown
- 2014-10-06 PL PL14789349T patent/PL3055291T3/pl unknown
- 2014-10-06 JP JP2016520050A patent/JP6505091B2/ja active Active
- 2014-10-06 CA CA3207522A patent/CA3207522A1/en active Pending
- 2014-10-06 CN CN201480054610.8A patent/CN105683171B/zh active Active
- 2014-10-06 SG SG10201907363Y patent/SG10201907363YA/en unknown
- 2014-10-06 MY MYPI2020004692A patent/MY200569A/en unknown
- 2014-10-06 US US15/027,400 patent/US9765042B2/en active Active
- 2014-10-06 SG SG11201602650XA patent/SG11201602650XA/en unknown
- 2014-10-06 PT PT181814054T patent/PT3415505T/pt unknown
- 2014-10-06 CN CN202310997777.9A patent/CN117209450A/zh active Pending
- 2014-10-06 EP EP18181405.4A patent/EP3415505B1/en active Active
- 2014-10-06 AU AU2014333610A patent/AU2014333610B2/en active Active
- 2014-10-06 TW TW107113518A patent/TWI675829B/zh active
- 2014-10-06 ES ES14789349T patent/ES2713324T3/es active Active
- 2014-10-06 WO PCT/GB2014/053007 patent/WO2015052496A1/en active Application Filing
- 2014-10-06 ES ES18181405T patent/ES2903529T3/es active Active
- 2014-10-06 EP EP21203620.6A patent/EP4032880A3/en active Pending
- 2014-10-06 SI SI201431945T patent/SI3415505T1/sl unknown
- 2014-10-06 TW TW103134782A patent/TWI626237B/zh active
- 2014-10-06 SI SI201431094T patent/SI3055291T1/sl unknown
- 2014-10-06 EP EP14789349.9A patent/EP3055291B1/en active Active
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2016
- 2016-04-01 MX MX2019002620A patent/MX373105B/es active IP Right Grant
- 2016-09-01 HK HK16110424.7A patent/HK1222175A1/zh unknown
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2017
- 2017-07-17 AU AU2017206141A patent/AU2017206141B2/en active Active
- 2017-08-10 US US15/674,229 patent/US10047062B2/en active Active
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2018
- 2018-07-20 US US16/040,964 patent/US10421733B2/en active Active
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2019
- 2019-02-27 HR HRP20190374TT patent/HRP20190374T1/hr unknown
- 2019-05-17 AU AU2019203490A patent/AU2019203490B2/en active Active
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| Date | Code | Title | Description |
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| FG | Grant or registration |