[go: up one dir, main page]

EA201590787A1 - Замещенные пиридопиразины в качестве ингибиторов syk - Google Patents

Замещенные пиридопиразины в качестве ингибиторов syk

Info

Publication number
EA201590787A1
EA201590787A1 EA201590787A EA201590787A EA201590787A1 EA 201590787 A1 EA201590787 A1 EA 201590787A1 EA 201590787 A EA201590787 A EA 201590787A EA 201590787 A EA201590787 A EA 201590787A EA 201590787 A1 EA201590787 A1 EA 201590787A1
Authority
EA
Eurasian Patent Office
Prior art keywords
syk inhibitors
pyridopyrazines
substituted
substituted pyridopyrazines
syk
Prior art date
Application number
EA201590787A
Other languages
English (en)
Inventor
Вэй-го Су
Вэй Дэн
Original Assignee
Хатчисон Медифарма Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50882786&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201590787(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Хатчисон Медифарма Лимитед filed Critical Хатчисон Медифарма Лимитед
Publication of EA201590787A1 publication Critical patent/EA201590787A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Otolaryngology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)

Abstract

Изобретение относится к пиридопиразиновым соединениям формулы (I), к содержащим их фармацевтическим композициям и к способам их применения, где R, R, R, L, m, p и W такие, как определено в описании.
EA201590787A 2012-12-07 2013-12-06 Замещенные пиридопиразины в качестве ингибиторов syk EA201590787A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/CN2012/086144 WO2014086032A1 (en) 2012-12-07 2012-12-07 Substituted pyridopyrazines as syk inhibitors
PCT/CN2013/088817 WO2014086316A1 (en) 2012-12-07 2013-12-06 Substituted pyridopyrazines as syk inhibitors

Publications (1)

Publication Number Publication Date
EA201590787A1 true EA201590787A1 (ru) 2015-11-30

Family

ID=50882786

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201590787A EA201590787A1 (ru) 2012-12-07 2013-12-06 Замещенные пиридопиразины в качестве ингибиторов syk

Country Status (17)

Country Link
US (2) US20150307491A1 (ru)
EP (1) EP2928888A4 (ru)
JP (1) JP6105745B2 (ru)
KR (1) KR20150091169A (ru)
AU (1) AU2013354552B2 (ru)
BR (1) BR112015012825A2 (ru)
CA (1) CA2891725A1 (ru)
CL (1) CL2015001516A1 (ru)
EA (1) EA201590787A1 (ru)
HK (1) HK1210178A1 (ru)
IL (1) IL239153A0 (ru)
MX (1) MX2015007126A (ru)
PE (1) PE20151145A1 (ru)
PH (1) PH12015501175A1 (ru)
SG (1) SG11201503848UA (ru)
TW (1) TW201422616A (ru)
WO (2) WO2014086032A1 (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10251565B2 (en) * 2015-04-30 2019-04-09 Dna Medicine Institute, Inc. Multi-channel vitals device
CA3036384A1 (en) 2016-09-14 2018-03-22 Gilead Sciences, Inc. Syk inhibitors
TW201822764A (zh) 2016-09-14 2018-07-01 美商基利科學股份有限公司 Syk抑制劑
WO2018195471A1 (en) 2017-04-21 2018-10-25 Gilead Sciences, Inc. Syk inhibitors in combination with hypomethylating agents
JP2022526713A (ja) 2019-03-21 2022-05-26 オンクセオ がんの処置のための、キナーゼ阻害剤と組み合わせたＤｂａｉｔ分子
US11464460B2 (en) 2019-10-21 2022-10-11 Pratyush Pavan Devarasetty Systems, devices, and methods for detecting physical distress in infant tracheostomy patients
CN115038700B (zh) 2019-11-08 2025-07-25 内尔维亚诺医疗科学公司 偕二取代的杂环化合物及其作为idh抑制剂的用途
JP2023500906A (ja) 2019-11-08 2023-01-11 インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル） キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
JP2025511779A (ja) * 2022-04-07 2025-04-16 ユニクエスト ピーティーワイ リミテッド 脾臓チロシンキナーゼ阻害剤

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101115479A (zh) * 2005-02-14 2008-01-30 默克公司 Akt活性抑制剂
TW200942537A (en) * 2008-02-01 2009-10-16 Irm Llc Compounds and compositions as kinase inhibitors
JP5754568B2 (ja) * 2008-08-05 2015-07-29 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ４−ジメチルアミノ−フェニルで置換されているナフチリジン、及び医薬としてのその使用
JP2011529932A (ja) * 2008-08-05 2011-12-15 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 置換ナフチリジン及び医薬としてのその使用
JP2013501002A (ja) * 2009-07-30 2013-01-10 アイアールエム・リミテッド・ライアビリティ・カンパニー Ｓｙｋキナーゼ阻害剤としての化合物および組成物
JP5629331B2 (ja) * 2010-01-29 2014-11-19 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 置換ナフチリジン及びｓｙｋキナーゼ阻害剤としてのその使用
EP2683716A1 (en) * 2011-03-11 2014-01-15 Glaxo Group Limited Pyrido[3,4-b]pyrazine derivatives as syk inhibitors
WO2012167423A1 (en) * 2011-06-08 2012-12-13 Hutchison Medipharma Limited Substituted pyridopyrazines as novel syk inhibitors

Also Published As

Publication number Publication date
HK1210178A1 (en) 2016-04-15
IL239153A0 (en) 2015-07-30
EP2928888A4 (en) 2016-04-20
US20150307491A1 (en) 2015-10-29
JP6105745B2 (ja) 2017-03-29
US20160002221A1 (en) 2016-01-07
WO2014086032A1 (en) 2014-06-12
PE20151145A1 (es) 2015-08-03
CA2891725A1 (en) 2014-06-12
SG11201503848UA (en) 2015-06-29
JP2016501237A (ja) 2016-01-18
PH12015501175A1 (en) 2015-08-17
KR20150091169A (ko) 2015-08-07
AU2013354552B2 (en) 2016-09-29
AU2013354552A1 (en) 2015-07-23
WO2014086316A1 (en) 2014-06-12
EP2928888A1 (en) 2015-10-14
TW201422616A (zh) 2014-06-16
CL2015001516A1 (es) 2015-10-23
US20170152258A9 (en) 2017-06-01
MX2015007126A (es) 2015-10-14
BR112015012825A2 (pt) 2017-07-11

Similar Documents

Publication Publication Date Title
JOP20180103A1 (ar) مركب صيدلاني
PH12017502141A1 (en) Compounds and their methods of use
UA111744C2 (uk) ЗАМІЩЕНІ ПІРИДОПІРАЗИНИ ЯК ІНГІБІТОРИ Syk
EA201590787A1 (ru) Замещенные пиридопиразины в качестве ингибиторов syk
EA201590534A1 (ru) Новые бициклические производные
EA201591527A1 (ru) Новые производные пиридина
NZ743274A (en) Substituted tricyclic compounds as fgfr inhibitors
EA201400833A1 (ru) Новые индолизиновые соединения, способ их получения и фармацевтические композиции, содержащие их
EA201391285A1 (ru) Производные тетрагидрохинолина, полезные в качестве ингибиторов бромодомена
EA201492287A1 (ru) Дейтерированные производные руксолитиниба
JO3515B1 (ar) مثبطات fgfr4 بيريميدين
EA201490567A1 (ru) Новые бициклические производные дигидрохинолин-2-она
TR201816379T4 (tr) DNA-PK inhibitörleri.
EA201591728A1 (ru) Гетероциклические соединения и способы их применения
EA201490846A1 (ru) Новые производные арилхинолина
EA201590887A1 (ru) Композиция
EA201490471A1 (ru) Пиридазиноновые соединения и их применение в качестве ингибиторов daao
EA201490037A1 (ru) Антагонисты trpv4
EA201500801A1 (ru) Бензохинолоновые ингибиторы vmat2
EA201600124A1 (ru) Новые индолизиновые соединения, способ их получения и фармацевтические композиции, содержащие их
MX373320B (es) Compuestos inhibidores de pde2.
EA201590552A1 (ru) Аминохинолины в качестве ингибиторов киназы
EA201890331A1 (ru) Пиридинондикарбоксамиды для применения в качестве ингибиторов бромодомена
EA201490599A1 (ru) Соединения триазолопиридина в качестве ингибиторов фосфодиэстеразы pde10a
EA201690561A1 (ru) Пептидилнитрильные соединения в качестве ингибиторов дипептидилпептидазы i