HRP20190374T1 - Postupci kemijske sinteze diaminofenotiazinskih spojeva uključujući metiltioninijev klorid (mtc) - Google Patents
Postupci kemijske sinteze diaminofenotiazinskih spojeva uključujući metiltioninijev klorid (mtc)Info
- Publication number
- HRP20190374T1 HRP20190374T1 HRP20190374TT HRP20190374T HRP20190374T1 HR P20190374 T1 HRP20190374 T1 HR P20190374T1 HR P20190374T T HRP20190374T T HR P20190374TT HR P20190374 T HRP20190374 T HR P20190374T HR P20190374 T1 HRP20190374 T1 HR P20190374T1
- Authority
- HR
- Croatia
- Prior art keywords
- methlionine
- diaminophenotiazine
- mtc
- procedures
- chloride
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/30—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds
- C07C209/38—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
- C07C381/02—Thiosulfates
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1317702.7A GB201317702D0 (en) | 2013-10-07 | 2013-10-07 | Methods of chemical synthesis of diaminophenothiazinium compounds including methylthioninium chloride (MTC) |
| PCT/GB2014/053007 WO2015052496A1 (en) | 2013-10-07 | 2014-10-06 | Methods of chemical synthesis of diaminophenothiazinium compounds including methylthioninium chloride (mtc) |
| EP14789349.9A EP3055291B1 (en) | 2013-10-07 | 2014-10-06 | Methods of chemical synthesis of diaminophenothiazinium compounds including methylthioninium chloride (mtc) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20190374T1 true HRP20190374T1 (hr) | 2019-04-19 |
Family
ID=49630291
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20190374TT HRP20190374T1 (hr) | 2013-10-07 | 2014-10-06 | Postupci kemijske sinteze diaminofenotiazinskih spojeva uključujući metiltioninijev klorid (mtc) |
| HRP20220102TT HRP20220102T1 (hr) | 2013-10-07 | 2014-10-06 | Postupci za kemijsku sintezu diaminofenotiazinskih spojeva uključujući metiltioninij klorid (mtc) |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20220102TT HRP20220102T1 (hr) | 2013-10-07 | 2014-10-06 | Postupci za kemijsku sintezu diaminofenotiazinskih spojeva uključujući metiltioninij klorid (mtc) |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US9765042B2 (hr) |
| EP (3) | EP3055291B1 (hr) |
| JP (1) | JP6505091B2 (hr) |
| CN (3) | CN110092764B (hr) |
| AU (3) | AU2014333610B2 (hr) |
| CA (3) | CA3207522A1 (hr) |
| DK (2) | DK3055291T3 (hr) |
| ES (2) | ES2903529T3 (hr) |
| GB (1) | GB201317702D0 (hr) |
| HR (2) | HRP20190374T1 (hr) |
| MX (3) | MX380797B (hr) |
| MY (3) | MY200570A (hr) |
| PL (2) | PL3415505T3 (hr) |
| PT (2) | PT3415505T (hr) |
| SG (3) | SG10201907363YA (hr) |
| SI (2) | SI3415505T1 (hr) |
| TR (1) | TR201902152T4 (hr) |
| TW (2) | TWI626237B (hr) |
| WO (1) | WO2015052496A1 (hr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105130926B (zh) * | 2015-07-31 | 2018-02-13 | 江苏恒润制药有限公司 | 一种亚甲基蓝的制备方法 |
| GB201621817D0 (en) | 2016-12-21 | 2017-02-01 | Wista Lab Ltd | Methods of chemical synthesis |
| US12215234B2 (en) * | 2019-09-21 | 2025-02-04 | RK Pharma Solutions LLC | Process for the purification of methylene blue |
| CN114989113A (zh) * | 2022-06-01 | 2022-09-02 | 山东科源制药股份有限公司 | 一种药用亚甲基蓝的精制方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US204796A (en) | 1878-06-11 | Improvement in the production of dye-stuffs from methyl-aniline | ||
| DE1886C (de) | 1877-12-15 | 1877-12-15 | Basf Ag | Verfahren zur darstellung blauer farbstoffe aus dimethylanilin und anderen tertiaeren aromatischen monaminen |
| US4212971A (en) * | 1979-03-08 | 1980-07-15 | American Cyanamid Company | Process for preparing methylene blue |
| CH640146A5 (de) * | 1979-05-14 | 1983-12-30 | Meyer Maschinenfabrik Ag | Filtrationsverfahren. |
| US5344928A (en) | 1991-04-26 | 1994-09-06 | Takeda Chemical Industries, Ltd. | Phenothiazine derivatives, their production and use |
| GB9506197D0 (en) | 1995-03-27 | 1995-05-17 | Hoffmann La Roche | Inhibition of tau-tau association. |
| JP2001514617A (ja) | 1997-01-21 | 2001-09-11 | ジ・アメリカン・ナショナル・レッド・クロス | 両親媒性フェノチアジン−５−イウム染料と光による全血および血液成分の細胞内および細胞外汚染除去 |
| FR2810318B1 (fr) | 2000-06-15 | 2005-09-23 | Laurent Galey | Derives de diamano-phenothiazine |
| GB0101049D0 (en) | 2001-01-15 | 2001-02-28 | Univ Aberdeen | Materials and methods relating to protein aggregation in neurodegenerative disease |
| GB2373787A (en) | 2001-03-08 | 2002-10-02 | Univ Central Lancashire | Phenothiazinium derivatives and their use to reduce pathogenic contaminants |
| ES2736160T3 (es) * | 2004-09-23 | 2019-12-26 | Wista Lab Ltd | Procedimientos de síntesis química y purificación de compuestos de diaminofenotiazinio que incluyen cloruro de metiltioninio (CMT) |
| CN101084204B (zh) * | 2004-09-23 | 2012-12-05 | 卫思道制药有限公司 | 包括亚甲蓝(mtc)在内的二氨基吩噻嗪鎓化合物的化学合成和纯化方法 |
| CA2645919C (en) * | 2006-03-29 | 2016-05-31 | Wista Laboratories Ltd. | Thioninium compounds and their use |
| ES2667002T3 (es) * | 2006-03-29 | 2018-05-09 | Wista Laboratories Ltd. | Inhibidores de la agregación de proteínas |
| CA2657352C (en) * | 2006-07-11 | 2019-06-11 | Wista Laboratories Ltd. | Methods of synthesis and/or purification of diaminophenothiazinium compounds |
| CN100436431C (zh) * | 2006-12-15 | 2008-11-26 | 贵州同济堂制药有限公司 | 药用亚甲蓝的合成方法 |
| DK2430007T3 (da) | 2009-05-12 | 2014-05-12 | Wista Lab Ltd | Fremgangsmåde for kemisk syntese af diaminophenothiazinium forbindelser ved anvendelse af persulfat oxidanter |
-
2013
- 2013-10-07 GB GBGB1317702.7A patent/GB201317702D0/en not_active Ceased
-
2014
- 2014-10-06 CN CN201910293813.7A patent/CN110092764B/zh active Active
- 2014-10-06 DK DK14789349.9T patent/DK3055291T3/en active
- 2014-10-06 PL PL18181405T patent/PL3415505T3/pl unknown
- 2014-10-06 HR HRP20190374TT patent/HRP20190374T1/hr unknown
- 2014-10-06 MY MYPI2020004693A patent/MY200570A/en unknown
- 2014-10-06 US US15/027,400 patent/US9765042B2/en active Active
- 2014-10-06 ES ES18181405T patent/ES2903529T3/es active Active
- 2014-10-06 CA CA3207522A patent/CA3207522A1/en active Pending
- 2014-10-06 EP EP14789349.9A patent/EP3055291B1/en active Active
- 2014-10-06 SI SI201431945T patent/SI3415505T1/sl unknown
- 2014-10-06 MY MYPI2020004692A patent/MY200569A/en unknown
- 2014-10-06 MY MYPI2016701234A patent/MY177815A/en unknown
- 2014-10-06 PT PT181814054T patent/PT3415505T/pt unknown
- 2014-10-06 SG SG10201907363Y patent/SG10201907363YA/en unknown
- 2014-10-06 SI SI201431094T patent/SI3055291T1/sl unknown
- 2014-10-06 TW TW103134782A patent/TWI626237B/zh active
- 2014-10-06 CN CN201480054610.8A patent/CN105683171B/zh active Active
- 2014-10-06 HR HRP20220102TT patent/HRP20220102T1/hr unknown
- 2014-10-06 JP JP2016520050A patent/JP6505091B2/ja active Active
- 2014-10-06 SG SG11201602650XA patent/SG11201602650XA/en unknown
- 2014-10-06 EP EP21203620.6A patent/EP4032880A3/en active Pending
- 2014-10-06 TR TR2019/02152T patent/TR201902152T4/tr unknown
- 2014-10-06 CA CA3131803A patent/CA3131803C/en active Active
- 2014-10-06 EP EP18181405.4A patent/EP3415505B1/en active Active
- 2014-10-06 PT PT14789349T patent/PT3055291T/pt unknown
- 2014-10-06 TW TW107113518A patent/TWI675829B/zh active
- 2014-10-06 PL PL14789349T patent/PL3055291T3/pl unknown
- 2014-10-06 DK DK18181405.4T patent/DK3415505T3/da active
- 2014-10-06 AU AU2014333610A patent/AU2014333610B2/en active Active
- 2014-10-06 WO PCT/GB2014/053007 patent/WO2015052496A1/en active Application Filing
- 2014-10-06 MX MX2020004348A patent/MX380797B/es unknown
- 2014-10-06 SG SG10201913293PA patent/SG10201913293PA/en unknown
- 2014-10-06 MX MX2019002620A patent/MX373105B/es active IP Right Grant
- 2014-10-06 ES ES14789349T patent/ES2713324T3/es active Active
- 2014-10-06 CN CN202310997777.9A patent/CN117209450A/zh active Pending
- 2014-10-06 MX MX2016004229A patent/MX363102B/es unknown
- 2014-10-06 CA CA2925801A patent/CA2925801C/en active Active
-
2017
- 2017-07-17 AU AU2017206141A patent/AU2017206141B2/en active Active
- 2017-08-10 US US15/674,229 patent/US10047062B2/en active Active
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2018
- 2018-07-20 US US16/040,964 patent/US10421733B2/en active Active
-
2019
- 2019-05-17 AU AU2019203490A patent/AU2019203490B2/en active Active
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