MX369525B - Métodos para mejorar la produccion de rebaudiosido d y rebaudiosido m. - Google Patents
Métodos para mejorar la produccion de rebaudiosido d y rebaudiosido m.Info
- Publication number
- MX369525B MX369525B MX2015010043A MX2015010043A MX369525B MX 369525 B MX369525 B MX 369525B MX 2015010043 A MX2015010043 A MX 2015010043A MX 2015010043 A MX2015010043 A MX 2015010043A MX 369525 B MX369525 B MX 369525B
- Authority
- MX
- Mexico
- Prior art keywords
- rebaudioside
- methods
- improved production
- relates
- compositions containing
- Prior art date
Links
- RPYRMTHVSUWHSV-CUZJHZIBSA-N rebaudioside D Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O RPYRMTHVSUWHSV-CUZJHZIBSA-N 0.000 title 2
- GSGVXNMGMKBGQU-PHESRWQRSA-N rebaudioside M Chemical compound C[C@@]12CCC[C@](C)([C@H]1CC[C@@]13CC(=C)[C@@](C1)(CC[C@@H]23)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H]1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H]1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O GSGVXNMGMKBGQU-PHESRWQRSA-N 0.000 title 1
- 239000004383 Steviol glycoside Substances 0.000 abstract 2
- 229930182488 steviol glycoside Natural products 0.000 abstract 2
- 235000019411 steviol glycoside Nutrition 0.000 abstract 2
- 150000008144 steviol glycosides Chemical class 0.000 abstract 2
- 235000019202 steviosides Nutrition 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
- A23L2/52—Adding ingredients
- A23L2/60—Sweeteners
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
- A23L27/33—Artificial sweetening agents containing sugars or derivatives
- A23L27/36—Terpene glycosides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1081—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
- Seasonings (AREA)
- Enzymes And Modification Thereof (AREA)
- Non-Alcoholic Beverages (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Peptides Or Proteins (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
La presente invención se refiere a métodos para la producción recombinante de glicósido de esteviol y composiciones que contienen glicósidos de esteviol.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361761490P | 2013-02-06 | 2013-02-06 | |
| US201361886442P | 2013-10-03 | 2013-10-03 | |
| PCT/EP2014/052363 WO2014122227A2 (en) | 2013-02-06 | 2014-02-06 | Methods for improved production of rebaudioside d and rebaudioside m |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015010043A MX2015010043A (es) | 2016-03-04 |
| MX369525B true MX369525B (es) | 2019-11-11 |
Family
ID=50064631
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015010043A MX369525B (es) | 2013-02-06 | 2014-02-06 | Métodos para mejorar la produccion de rebaudiosido d y rebaudiosido m. |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US9957540B2 (es) |
| EP (2) | EP2954058B1 (es) |
| JP (4) | JP6379112B2 (es) |
| KR (1) | KR20150115002A (es) |
| CN (2) | CN110551646B (es) |
| AU (4) | AU2014214004B2 (es) |
| CA (2) | CA3171770A1 (es) |
| MX (1) | MX369525B (es) |
| MY (2) | MY190346A (es) |
| SG (2) | SG10201705926YA (es) |
| WO (1) | WO2014122227A2 (es) |
Families Citing this family (110)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9107436B2 (en) | 2011-02-17 | 2015-08-18 | Purecircle Sdn Bhd | Glucosylated steviol glycoside as a flavor modifier |
| US10696706B2 (en) | 2010-03-12 | 2020-06-30 | Purecircle Usa Inc. | Methods of preparing steviol glycosides and uses of the same |
| MY167872A (en) | 2010-06-02 | 2018-09-26 | Evolva Inc | Recombinant production of steviol glycosides |
| US11690391B2 (en) | 2011-02-17 | 2023-07-04 | Purecircle Sdn Bhd | Glucosylated steviol glycoside as a flavor modifier |
| US9771434B2 (en) | 2011-06-23 | 2017-09-26 | Purecircle Sdn Bhd | Products from stevia rebaudiana |
| US9631215B2 (en) | 2011-08-08 | 2017-04-25 | Evolva Sa | Recombinant production of steviol glycosides |
| EP2826861B1 (en) | 2012-03-16 | 2020-04-29 | Suntory Holdings Limited | Steviol glycosyltransferase and gene encoding same |
| CA2867572C (en) | 2012-03-27 | 2023-02-21 | Suntory Holdings Limited | Method for producing steviol glycoside |
| US9752174B2 (en) | 2013-05-28 | 2017-09-05 | Purecircle Sdn Bhd | High-purity steviol glycosides |
| MX395285B (es) | 2012-05-22 | 2025-03-25 | Purecircle Sdn Bhd | Glucosidos de esteviol de alta pureza. |
| TW201402599A (zh) | 2012-05-30 | 2014-01-16 | Suntory Holdings Ltd | 甜菊糖苷糖苷轉化酵素及編碼該酵素之基因 |
| MX369525B (es) * | 2013-02-06 | 2019-11-11 | Evolva Sa | Métodos para mejorar la produccion de rebaudiosido d y rebaudiosido m. |
| CN105189771B (zh) | 2013-02-11 | 2019-11-05 | 埃沃尔瓦公司 | 在重组宿主中有效产生甜菊醇糖苷 |
| EP3502264A3 (en) * | 2013-05-31 | 2019-11-06 | DSM IP Assets B.V. | Microorganisms for diterpene production |
| US10952458B2 (en) | 2013-06-07 | 2021-03-23 | Purecircle Usa Inc | Stevia extract containing selected steviol glycosides as flavor, salty and sweetness profile modifier |
| ES2817049T5 (es) | 2013-06-07 | 2023-11-10 | Purecircle Usa Inc | Extracto de estevia que contiene glucósidos de esteviol seleccionados como modificador del perfil de gusto, sabor y dulzor |
| AU2014292150B2 (en) * | 2013-07-15 | 2019-04-04 | Dsm Ip Assets B.V. | Diterpene production |
| AU2014298420B2 (en) * | 2013-07-31 | 2018-10-04 | Dsm Ip Assets B.V. | Recovery of steviol glycosides |
| CN103397064B (zh) | 2013-08-14 | 2015-04-15 | 苏州汉酶生物技术有限公司 | 一种酶法制备瑞鲍迪甙m的方法 |
| US9522929B2 (en) * | 2014-05-05 | 2016-12-20 | Conagen Inc. | Non-caloric sweetener |
| SG11201700651RA (en) | 2014-08-11 | 2017-02-27 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| WO2016028899A1 (en) * | 2014-08-19 | 2016-02-25 | The Coca-Cola Company | Methods for preparing rebaudioside i and uses |
| EP3936513B1 (en) | 2014-09-02 | 2024-05-22 | PureCircle USA Inc. | Stevia extracts enriched in rebaudioside d, e, n and/or o and process for the preparation thereof |
| JP2017528134A (ja) * | 2014-09-09 | 2017-09-28 | エヴォルヴァ エスアー.Evolva Sa. | 組み換え宿主におけるステビオールグリコシドの生産 |
| EP3193636B1 (en) * | 2014-09-19 | 2022-07-06 | PureCircle SDN BHD | High-purity steviol glycosides |
| CN107105733B (zh) | 2014-09-26 | 2021-08-24 | 谱赛科美国股份有限公司 | 甜叶菊成分、生产方法和用途 |
| ES2693371T3 (es) * | 2014-10-03 | 2018-12-11 | Conagen Inc. | Edulcorantes no calóricos y métodos de síntesis |
| CN107109453A (zh) | 2014-11-05 | 2017-08-29 | 马努斯生物合成股份有限公司 | 甜菊醇糖苷的微生物产生 |
| MX2017008043A (es) * | 2014-12-17 | 2017-12-11 | Cargill Inc | Compuestos de glicósido de esteviol, composiciones para ingesta por vía oral o uso oral y metodo para mejorar la solubilidad del glicósido de esteviol. |
| WO2016120486A1 (en) | 2015-01-30 | 2016-08-04 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| CN107404911A (zh) | 2015-02-10 | 2017-11-28 | 谱赛科美国股份有限公司 | 莱鲍迪苷m生物合成生产和回收方法 |
| US10731195B2 (en) | 2015-03-10 | 2020-08-04 | Rijksuniversiteit Groningen | Methods for the enzymatic modification of steviol glycosides, modified steviol glycosides obtainable thereby, and the use thereof as sweeteners |
| EP3862426B1 (en) | 2015-03-16 | 2025-09-03 | DSM IP Assets B.V. | Udp-glycosyltransferases |
| BR112017021066B1 (pt) | 2015-04-03 | 2022-02-08 | Dsm Ip Assets B.V. | Glicosídeos de esteviol, método para a produção de um glicosídeo de esteviol, composição, usos relacionados, gênero alimentício, alimento para animais e bebida |
| JP6793957B2 (ja) | 2015-04-14 | 2020-12-02 | コナゲン インコーポレイテッド | 改変された全細胞触媒を用いたノンカロリー甘味料の生成 |
| US11332724B2 (en) * | 2015-04-21 | 2022-05-17 | Dsm Ip Assets B.V. | Microbial production of terpenoids |
| AU2016264732A1 (en) * | 2015-05-20 | 2017-11-30 | Cargill, Incorporated | Glycoside compositions |
| JP2018516081A (ja) | 2015-05-29 | 2018-06-21 | カーギル・インコーポレイテッド | 配糖体を産生するための熱処理 |
| BR112017025709B1 (pt) | 2015-05-29 | 2024-03-05 | Cargill, Incorporated | Método para produzir glicosídeos de esteviol |
| WO2016196321A1 (en) | 2015-05-29 | 2016-12-08 | Cargill, Incorporated | Fermentation methods for producing steviol glycosides using high ph and compositions obtained therefrom |
| JP2018521680A (ja) * | 2015-08-06 | 2018-08-09 | カーギル・インコーポレイテッド | ステビオール配糖体を生成するための発酵法 |
| CA2995067A1 (en) * | 2015-08-07 | 2017-02-16 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| WO2017031424A1 (en) * | 2015-08-20 | 2017-02-23 | Pepsico, Inc. | Preparation of rebaudioside m in a single reaction vessel |
| EP3352855A4 (en) * | 2015-09-22 | 2019-05-22 | Vitality Biopharma, Inc. | CANNABINOID GLYCOSIDE PRODRUGS AND SYNTHESIS METHOD |
| EP3359654B1 (en) | 2015-10-05 | 2022-01-05 | DSM IP Assets B.V. | Kaurenoic acid hydroxylases |
| MX2018005148A (es) | 2015-10-26 | 2018-08-01 | Purecircle Usa Inc | Composiciones de glicosido de esteviol. |
| CN108884484A (zh) * | 2015-11-30 | 2018-11-23 | 谱赛科有限责任公司 | 用于制备高纯度甜菊醇糖苷的方法 |
| EP3383201B1 (en) * | 2015-11-30 | 2022-11-30 | Cargill, Incorporated | Steviol glycoside compositions for oral ingestion or use |
| BR112018011611A2 (pt) * | 2015-12-10 | 2018-11-27 | Evolva Sa | produção de glicosídeos de esteviol em hospedeiros recombinantes |
| EP3389403A4 (en) | 2015-12-15 | 2019-09-04 | PureCircle USA Inc. | STEVIOLGLYCOSIDZUSAMMENSETZUNGEN |
| CN109154010A (zh) * | 2016-03-11 | 2019-01-04 | 埃沃尔瓦公司 | 在重组宿主中生产甜菊醇糖苷 |
| KR20180132696A (ko) * | 2016-04-13 | 2018-12-12 | 에볼바 에스아 | 재조합 숙주에서의 스테비올 글리코사이드의 생산 |
| CN109312378A (zh) * | 2016-05-16 | 2019-02-05 | 埃沃尔瓦公司 | 在重组宿主中产生甜菊醇糖苷 |
| JP2019519212A (ja) * | 2016-05-16 | 2019-07-11 | エヴォルヴァ エスアー.Evolva Sa. | 組換え宿主内でのステビオールグリコシドの産生 |
| MX2018015534A (es) | 2016-06-15 | 2019-03-14 | Codexis Inc | Beta-glucosidasas dise?adas y metodos de glucosilacion. |
| WO2017218036A1 (en) * | 2016-06-17 | 2017-12-21 | Cargill, Incorporated | Steviol glycoside compositions for oral ingestion or use |
| BR112018076294B1 (pt) * | 2016-06-17 | 2022-12-27 | Cargill, Incorporated | Bebida ou composição, método para modificar as características sensoriais de uma composição, e, produto alimentício |
| CN109804073B (zh) | 2016-08-12 | 2023-05-16 | 阿迈瑞斯公司 | 用于高效生成瑞鲍迪苷的udp依赖性糖基转移酶 |
| ES2964976T3 (es) * | 2016-10-14 | 2024-04-10 | Conagen Inc | Producción biosintética de glucósidos de esteviol y procesos para el mismo |
| CN116574775A (zh) | 2016-10-21 | 2023-08-11 | 百事可乐公司 | 一种酶法制备瑞鲍迪甙j的方法 |
| RU2736155C1 (ru) | 2016-10-21 | 2020-11-12 | Пепсико, Инк. | Способ получения ребаудиозида c с применением ферментативного способа |
| BR112019008048A2 (pt) | 2016-10-21 | 2019-07-02 | Pepsico Inc | método para preparar rebaudiosídeo n com o uso de método enzimático |
| EP3998337B1 (en) * | 2016-10-27 | 2024-11-20 | DSM IP Assets B.V. | Geranylgeranyl pyrophosphate synthases |
| WO2018083338A1 (en) | 2016-11-07 | 2018-05-11 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| CN106834389B (zh) * | 2016-12-13 | 2020-03-17 | 南京工业大学 | 一种重组菌催化莱鲍迪甙a制备莱鲍迪甙m2的方法 |
| EP3564369A4 (en) * | 2016-12-27 | 2020-07-29 | Suntory Holdings Limited | STEVIOL GLYCOSIDE HEXOSE TRANSFERASE AND CODING GENE FOR THIS |
| EP3577229A4 (en) | 2017-02-03 | 2020-12-23 | Codexis, Inc. | MODIFIED GLYCOSYL TRANSFERASES AND PROCESSES FOR GLUCOSYLATION OF STEVIOL GLYCOSIDES |
| AU2018225152A1 (en) | 2017-02-24 | 2019-09-19 | Corn Products Development, Inc. | Use of steviol glycoside in malting |
| WO2018165330A1 (en) * | 2017-03-08 | 2018-09-13 | Purecircle Usa Inc. | High rebaudioside m stevia plant cultivars and methods of producing the same |
| US11207291B2 (en) | 2017-05-09 | 2021-12-28 | Graphium Biosciences, Inc. | Antimicrobial compositions comprising cannabinoids and methods of using the same |
| WO2018211032A1 (en) | 2017-05-17 | 2018-11-22 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| MY204670A (en) | 2017-06-30 | 2024-09-07 | Conagen Inc | Hydrolysis of steviol glycosides by beta-glucosidase |
| CN107287264B (zh) * | 2017-07-11 | 2020-09-04 | 山东大学 | 糖基转移酶ugt71c3在催化合成水杨酸甲酯糖苷中的应用 |
| WO2019055325A2 (en) * | 2017-09-12 | 2019-03-21 | Biocapital Holdings, Llc | BIOOGICAL DEVICES AND METHODS OF USING THE SAME TO PRODUCE STEVIOL GLYCOSIDES |
| WO2019110684A1 (en) | 2017-12-05 | 2019-06-13 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| JP6981267B2 (ja) | 2018-01-17 | 2021-12-15 | 東京エレクトロン株式会社 | エッチング方法及びエッチング装置 |
| WO2019178116A1 (en) | 2018-03-12 | 2019-09-19 | Conagen Inc. | Biosynthetic production of steviol glycosides rebaudioside j and rebaudioside n |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| BR112021001661A8 (pt) | 2018-07-30 | 2022-08-09 | Codexis Inc | Glicosiltransferase modificada, polinucleotídeo modificado, vetor, célula hospedeira, métodos para produzir pelo menos uma glicosiltransferase modificada, para produzir pelo menos uma variante de sacarose sintase, para glicosilação de um substrato, para produzir rebaudiosídeo m, rebaudiosídeo a e/ou rebaudiosídeo i e rebaudiosídeo d, composição, sacarose sintase modificada, pelo menos um rebaudiosídeo, rebaudiosídeo m, rebaudiosídeo a, rebaudiosídeo i, e, rebaudiosídeo d. |
| WO2020062437A1 (zh) * | 2018-09-29 | 2020-04-02 | 四川盈嘉合生科技有限公司 | 复合甜味剂及其生产方法 |
| US11274328B2 (en) * | 2018-09-29 | 2022-03-15 | Sichuan Ingia Biosynthetic Co., Ltd. | Methods for producing rebaudioside D and rebaudioside M and compositions thereof |
| CN109393426A (zh) * | 2018-09-29 | 2019-03-01 | 四川盈嘉合生科技有限公司 | 一种复合甜味剂 |
| CN109234341A (zh) * | 2018-09-29 | 2019-01-18 | 四川盈嘉合生科技有限公司 | 全细胞催化合成甜味剂组合物的方法 |
| EP3877519A4 (en) | 2018-11-09 | 2022-08-24 | Ginkgo Bioworks, Inc. | BIOSYNTHESIS OF MOGROSIDS |
| CN113474464B (zh) * | 2018-12-12 | 2025-06-10 | 科纳根公司 | 变体甜菊醇糖苷的生物合成生产 |
| CN109750071A (zh) * | 2019-01-31 | 2019-05-14 | 南京工业大学 | 一种生物催化合成莱鲍迪苷m的方法 |
| CN112080480B (zh) * | 2019-06-14 | 2023-01-03 | 中国科学院分子植物科学卓越创新中心 | 糖基转移酶突变体及其应用 |
| CA3144658A1 (en) | 2019-06-25 | 2020-12-30 | Manus Bio, Inc. | Uridine diphosphate-dependent glycosyltransferase enzyme |
| CN110684813A (zh) * | 2019-09-18 | 2020-01-14 | 江苏施宇甜生物科技有限公司 | 在重组宿主中生产甜菊醇糖苷的方法 |
| CN112553175B (zh) * | 2019-09-26 | 2023-04-07 | 中国科学院分子植物科学卓越创新中心 | 糖基转移酶ugt76g1突变体的制备及其应用 |
| CN110734944B (zh) * | 2019-11-11 | 2023-02-21 | 中化健康产业发展有限公司 | 一步法合成莱鲍迪苷m的方法 |
| CN110872586B (zh) * | 2019-11-11 | 2024-01-30 | 天津大学 | 固定化葡萄糖基转移酶及制备方法及催化生产莱鲍迪苷d的方法 |
| CN111187316B (zh) * | 2020-02-14 | 2021-06-15 | 南京全凯生物基材料研究院有限公司 | 一种从甜菊糖母液中提取莱包迪苷d和莱包迪苷m的方法 |
| WO2023006179A1 (en) | 2020-07-27 | 2023-02-02 | Dsm Ip Assets B.V. | Method to produce retinyl acetate |
| WO2022072718A1 (en) | 2020-09-30 | 2022-04-07 | Nobell Foods, Inc. | Recombinant milk proteins and food compositions comprising the same |
| US10947552B1 (en) | 2020-09-30 | 2021-03-16 | Alpine Roads, Inc. | Recombinant fusion proteins for producing milk proteins in plants |
| US10894812B1 (en) | 2020-09-30 | 2021-01-19 | Alpine Roads, Inc. | Recombinant milk proteins |
| AU2021367159A1 (en) | 2020-10-22 | 2023-05-04 | Cargill, Incorporated | Microorganisms for diterpene production |
| CN112852653A (zh) * | 2021-01-26 | 2021-05-28 | 江南大学 | 从头合成莱鲍迪苷m的酿酒酵母工程菌及其应用 |
| US11299700B1 (en) | 2021-02-19 | 2022-04-12 | Acequia Biotechnology, Llc | Bioreactor containers and methods of growing hairy roots using the same |
| MX2023010079A (es) | 2021-03-01 | 2023-11-03 | Cargill Inc | Glicósidos de esteviol xilosilados y métodos enzimáticos para su producción. |
| WO2023006851A1 (en) | 2021-07-27 | 2023-02-02 | Dsm Ip Assets B.V. | Fermentative production of retinyl acetate in the presence of ethanol |
| CN113462670B (zh) * | 2021-08-23 | 2023-03-24 | 兴化格林生物制品有限公司 | 一种糖基转移酶突变体及其催化合成莱鲍迪苷m的方法 |
| WO2023044368A1 (en) * | 2021-09-17 | 2023-03-23 | Doublerainbow Biosciences Inc. | Method for producing glycosylated therapeutics by using an immobilized enzyme preparation |
| WO2023044365A1 (en) * | 2021-09-17 | 2023-03-23 | Doublerainbow Biosciences Inc. | Use of cyclodextrin to enhance solubility of substrates and increase enzymatic glycosylation reaction efficiency |
| CN114045273B (zh) * | 2021-11-15 | 2022-07-22 | 四川大学 | 糖基转移酶OsUGT91C1突变体及其应用 |
| CA3261258A1 (en) | 2022-07-07 | 2024-01-11 | Purecircle Sdn Bhd | HIGH PURITY STEVIOL GLYCOSIDES |
| WO2024121721A1 (en) * | 2022-12-05 | 2024-06-13 | Tate & Lyle Solutions Usa Llc | Methods for obtaining steviol glycosides |
| WO2025048633A2 (en) | 2023-08-29 | 2025-03-06 | Purecircle Sdn. Bhd. | High-purity steviol glycosides |
| CN120060187A (zh) * | 2025-04-29 | 2025-05-30 | 成都圆大生物科技有限公司 | 一种固定化酶组合物及其在高效制备瑞鲍迪苷m中的应用 |
Family Cites Families (133)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58149697A (ja) | 1982-02-27 | 1983-09-06 | Dainippon Ink & Chem Inc | β−1,3グリコシルステビオシドの製造方法 |
| US6946587B1 (en) | 1990-01-22 | 2005-09-20 | Dekalb Genetics Corporation | Method for preparing fertile transgenic corn plants |
| US5484956A (en) | 1990-01-22 | 1996-01-16 | Dekalb Genetics Corporation | Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin |
| JPH03277275A (ja) | 1990-03-28 | 1991-12-09 | Dainippon Ink & Chem Inc | 新規酵素及びその酵素を用いた配糖体の製造方法 |
| US5204253A (en) | 1990-05-29 | 1993-04-20 | E. I. Du Pont De Nemours And Company | Method and apparatus for introducing biological substances into living cells |
| US5306862A (en) | 1990-10-12 | 1994-04-26 | Amoco Corporation | Method and composition for increasing sterol accumulation in higher plants |
| US5460949A (en) | 1990-11-15 | 1995-10-24 | Amoco Corporation | Method and composition for increasing the accumulation of squalene and specific sterols in yeast |
| US5712112A (en) | 1992-11-04 | 1998-01-27 | National Science Council Of R.O.C. | Gene expression system comprising the promoter region of the alpha-amylase genes |
| EP0785988A1 (en) | 1993-07-15 | 1997-07-30 | Neose Pharmaceuticals, Inc | Method of synthesizing saccharide compositions |
| US7186891B1 (en) | 1996-04-12 | 2007-03-06 | University Of Kentucky, Research Foundation | Plant cells and plants expressing chimeric isoprenoid synthases |
| JPH10117776A (ja) | 1996-10-22 | 1998-05-12 | Japan Tobacco Inc | インディカイネの形質転換方法 |
| EP1021551A1 (en) | 1997-10-06 | 2000-07-26 | Centre National De La Recherche Scientifique | Plant fatty acid hydroxylase genes |
| US6255557B1 (en) | 1998-03-31 | 2001-07-03 | Her Majesty The Queen In Right Of Canada As Represented By The Ministerof Agriculture And Agri-Food Canada | Stevia rebaudiana with altered steviol glycoside composition |
| CA2325798C (en) | 1998-04-14 | 2008-08-26 | Kyowa Hakko Kogyo Co., Ltd. | A process for producing isoprenoid compounds by microorganisms and a method for screening compounds with antibiotic or weeding activity |
| EP0955363A3 (en) | 1998-05-06 | 2004-01-28 | F. Hoffmann-La Roche Ag | Dna sequences encoding enzymes involved in production of isoprenoids |
| TWI250210B (en) | 1998-05-06 | 2006-03-01 | Dsm Ip Assets Bv | An isolated DNA sequence coding for an enzyme involved in the mevalonate pathway or the pathway from isopentenyl pyrophosphate to farnesyl pyrophosphate |
| EP2305825B1 (en) | 1998-07-06 | 2015-01-14 | DCV Inc. doing business as Bio-Technical Resourses | Method of vitamin production |
| EP2100963B1 (en) | 1998-07-06 | 2011-12-14 | DCV Inc. doing business as Bio-Technical Resourses | Method of vitamin production |
| AR021636A1 (es) | 1998-12-17 | 2002-07-31 | Rubicon Forests Holdings Ltd | Materiales y metodos para la modificacion del contenido, la composicion y el metabolismo de los isoprenoides |
| JP2002533090A (ja) | 1998-12-23 | 2002-10-08 | ザ、サミュアル、ラバツ、ノゥブル、ファウンデイシャン、インク | 植物形質転換法 |
| BRPI0009763B8 (pt) | 1999-04-15 | 2020-03-10 | Calgene Llc | sequência de ácido nucléico codificando uma preniltransferase, construção compreendendo a mesma, bem como métodos para alteração do teor de tocoferol, produção de um composto de tocoferol,e aumento do fluxo biossintético em uma célula |
| AU4365200A (en) | 1999-04-21 | 2000-11-02 | Samuel Roberts Noble Foundation, Inc., The | Plant transformation process |
| AU6280300A (en) | 1999-08-04 | 2001-03-05 | Adelbert Bacher | Isoprenoid biosynthesis |
| WO2001012828A1 (en) | 1999-08-18 | 2001-02-22 | Paradigm Genetics, Inc. | Methods and apparatus for transformation of monocotyledenous plants using agrobacterium in combination with vacuum filtration |
| WO2001083769A2 (en) | 2000-05-03 | 2001-11-08 | The Salk Institute For Biological Studies | Crystallization of 4-diphosphocytidyl-2-c-methylerythritol synthesis |
| DE10027821A1 (de) | 2000-06-05 | 2001-12-06 | Adelbert Bacher | Der Mevalonat-unabhängige Isoprenoidbiosyntheseweg |
| EP2281890A1 (en) | 2000-07-31 | 2011-02-09 | Danisco US Inc. | Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms |
| AU2001286811B2 (en) | 2000-08-24 | 2007-03-01 | Syngenta Participations Ag | Stress-regulated genes of plants, transgenic plants containing same, and methods of use |
| US6660507B2 (en) | 2000-09-01 | 2003-12-09 | E. I. Du Pont De Nemours And Company | Genes involved in isoprenoid compound production |
| US6689601B2 (en) | 2000-09-01 | 2004-02-10 | E. I. Du Pont De Nemours And Company | High growth methanotropic bacterial strain |
| US6818424B2 (en) | 2000-09-01 | 2004-11-16 | E. I. Du Pont De Nemours And Company | Production of cyclic terpenoids |
| EP1409530A2 (en) | 2000-09-19 | 2004-04-21 | Microbia, Inc. | Modulation of secondary metabolite production by zinc binuclear cluster proteins |
| AU2001296359B2 (en) | 2000-09-29 | 2006-04-27 | Cargill Incorporated | Isoprenoid production |
| US6949362B2 (en) | 2000-12-12 | 2005-09-27 | E. I. Du Pont De Nemours And Company | Rhodococcus cloning and expression vectors |
| AU2002227883A1 (en) | 2001-01-25 | 2002-08-06 | Evolva Biotech A/S | A library of a collection of cells |
| US20050003474A1 (en) | 2001-01-26 | 2005-01-06 | Desouza Mervyn L. | Carotenoid biosynthesis |
| US20040078846A1 (en) | 2002-01-25 | 2004-04-22 | Desouza Mervyn L. | Carotenoid biosynthesis |
| DE10201458A1 (de) | 2001-04-11 | 2002-10-17 | Adelbert Bacher | Intermediate und Enzyme des Mevalonat-unabhängigen Isoprenoidbiosyntheseweg |
| US7034140B2 (en) | 2001-04-24 | 2006-04-25 | E.I. Du Pont De Nemours And Company | Genes involved in isoprenoid compound production |
| CA2449885A1 (en) | 2001-06-06 | 2002-12-12 | Roche Vitamins Ag | Improved isoprenoid production |
| AU2002341541A1 (en) | 2001-06-22 | 2003-03-03 | Syngenta Participations Ag | Abiotic stress responsive polynucleotides and polypeptides |
| NZ513755A (en) | 2001-08-24 | 2001-09-28 | Ann Rachel Holmes | Protein expression system in yeast comprising a vector encoding a heterologous membrane protein and its application in screening for drugs |
| US20040072311A1 (en) | 2001-08-28 | 2004-04-15 | Dicosimo Deana J. | Production of cyclic terpenoids |
| US20040010815A1 (en) | 2001-09-26 | 2004-01-15 | Lange B. Markus | Identification and characterization of plant genes |
| US7172886B2 (en) | 2001-12-06 | 2007-02-06 | The Regents Of The University Of California | Biosynthesis of isopentenyl pyrophosphate |
| WO2004018682A1 (ja) | 2002-08-20 | 2004-03-04 | Suntory Limited | 新規糖転移酵素遺伝子 |
| CA2498800C (en) | 2002-09-27 | 2012-01-03 | Dsm Ip Assets B.V. | Sqs gene |
| US7098000B2 (en) | 2003-06-04 | 2006-08-29 | E. I. Du Pont De Nemoure And Company | Method for production of C30-aldehyde carotenoids |
| WO2004111214A1 (en) | 2003-06-12 | 2004-12-23 | Dsm Ip Assets B.V. | Feedback-resistant mevalonate kinases |
| US7569389B2 (en) | 2004-09-30 | 2009-08-04 | Ceres, Inc. | Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics |
| CN101023181A (zh) | 2004-05-21 | 2007-08-22 | 加利福尼亚大学董事会 | 提高类异戊二烯化合物的产生的方法 |
| US20060014264A1 (en) | 2004-07-13 | 2006-01-19 | Stowers Institute For Medical Research | Cre/lox system with lox sites having an extended spacer region |
| JPWO2006016395A1 (ja) | 2004-08-09 | 2008-05-01 | 国立大学法人東北大学 | Udp−グルクロニル基転移酵素およびその遺伝子 |
| CN101044243B (zh) | 2004-08-19 | 2011-12-28 | 帝斯曼知识产权资产管理有限公司 | 类异戊二烯的生产方法 |
| US7923552B2 (en) | 2004-10-18 | 2011-04-12 | SGF Holdings, LLC | High yield method of producing pure rebaudioside A |
| DE602005026692D1 (de) | 2004-12-14 | 2011-04-14 | Dsm Ip Assets Bv | Verbesserte mevalonatkinase |
| WO2006092449A2 (en) | 2005-03-02 | 2006-09-08 | Metanomics Gmbh | Process for the production of fine chemicals |
| WO2006096392A2 (en) | 2005-03-04 | 2006-09-14 | Diversa Corporation | Enzymes involved in astaxanthin, carotenoid and isoprenoid biosynthetic pathways, genes encoding them and methods of making and using them |
| JP4284562B2 (ja) | 2005-03-04 | 2009-06-24 | 独立行政法人産業技術総合研究所 | Udp−キシロースの製造方法 |
| WO2007022318A2 (en) | 2005-08-17 | 2007-02-22 | Cornell Research Foundation | Nucleic acids and proteins associated with sucrose accumulation in coffee |
| US8293307B2 (en) | 2005-10-11 | 2012-10-23 | Purecircle Sdn Bhd | Process for manufacturing a sweetener and use thereof |
| EP2526783B1 (en) | 2005-11-23 | 2016-10-19 | The Coca-Cola Company | Natural high-potency sweetener compositions with improved temporal profile and/or flavor profile |
| KR100784261B1 (ko) | 2006-01-02 | 2007-12-11 | 한국과학기술원 | 탄저균의 포자외막 단백질을 이용한 목적단백질의 미생물표면발현방법 |
| US7927851B2 (en) | 2006-03-21 | 2011-04-19 | Vineland Research And Innovation Centre | Compositions having ent-kaurenoic acid 13-hydroxylase activity and methods for producing same |
| WO2008034648A1 (en) | 2006-04-05 | 2008-03-27 | Metanomics Gmbh | Process for the production of a fine chemical |
| US8114645B2 (en) | 2006-05-19 | 2012-02-14 | The Regents Of The University Of California | Methods for increasing isoprenoid and isoprenoid precursor production by modulating fatty acid levels |
| KR101440639B1 (ko) | 2006-06-19 | 2014-09-22 | 지보당 에스아 | 핵산, 폴리펩타이드 및 이의 용도 |
| WO2008008256A2 (en) | 2006-07-07 | 2008-01-17 | The Regents Of The University Of California | Methods for enhancing production of isoprenoid compounds by host cells |
| US8257957B2 (en) | 2006-09-26 | 2012-09-04 | The Regents Of The University Of California | Production of isoprenoids and isoprenoid precursors |
| US7741119B2 (en) | 2006-09-28 | 2010-06-22 | E. I. Du Pont De Nemours And Company | Xylitol synthesis mutant of xylose-utilizing zymomonas for ethanol production |
| US7629156B2 (en) | 2006-09-28 | 2009-12-08 | E.I. Du Pont De Nemours And Company | Ethanol production in fermentation of mixed sugars containing xylose |
| CN101200480B (zh) | 2006-12-15 | 2011-03-30 | 成都华高药业有限公司 | 莱鲍迪甙a的提取方法 |
| JP4915917B2 (ja) | 2006-12-22 | 2012-04-11 | 独立行政法人農業・食品産業技術総合研究機構 | ラクト−n−ビオースi及びガラクト−n−ビオースの製造方法 |
| WO2008091547A2 (en) | 2007-01-22 | 2008-07-31 | Cargill, Incorporated | Method of producing purified rebaudioside a compositions using solvent/antisolvent crystallization |
| JP2008237110A (ja) | 2007-03-27 | 2008-10-09 | Institute Of Physical & Chemical Research | ステビオール合成酵素遺伝子及びステビオールの製造方法 |
| WO2008144060A2 (en) | 2007-05-17 | 2008-11-27 | Tetravitae Bioscience, Inc. | Methods and compositions for producing solvents |
| US20080292775A1 (en) | 2007-05-22 | 2008-11-27 | The Coca-Cola Company | Delivery Systems for Natural High-Potency Sweetener Compositions, Methods for Their Formulation, and Uses |
| WO2009005704A1 (en) | 2007-07-03 | 2009-01-08 | The Regents Of The University Of California | Methods of increasing isoprenoid or isoprenoid precursor production |
| US7964232B2 (en) | 2007-09-17 | 2011-06-21 | Pepsico, Inc. | Steviol glycoside isomers |
| RU2519718C2 (ru) | 2007-12-03 | 2014-06-20 | ДСМ АйПи АССЕТС Б.В. | Новые нутрицевтические композиции, содержащие экстракт stevia или компоненты экстракта stevia, и их применения |
| WO2009086049A2 (en) | 2007-12-27 | 2009-07-09 | Mc Neil Nutritionals, Llc | Synergistic sweetening compositions |
| BRPI0907786B1 (pt) | 2008-02-20 | 2021-06-01 | Ceres, Inc. | Método de produção de uma planta e método de aumentar o nível de tolerância a baixo teor de nitrogênio em uma planta |
| TWI475963B (zh) | 2008-02-25 | 2015-03-11 | 可口可樂公司 | 甜菊糖苷a衍生性產物以及製造彼的方法 |
| US9005444B2 (en) | 2008-05-13 | 2015-04-14 | Cargill, Incorporated | Separation of rebaudioside A from stevia glycosides using chromatography |
| WO2010021001A2 (en) | 2008-08-19 | 2010-02-25 | Kaushik Ramakrishnan S | Process for preparing sweetener from stevia rebaudiana |
| KR20200000478A (ko) * | 2008-10-03 | 2020-01-02 | 모리타 가가쿠 고교 가부시키가이샤 | 신규 스테비올 배당체 |
| CN101720910B (zh) | 2008-10-23 | 2012-07-25 | 大闽食品(漳州)有限公司 | 一种甜菊糖甙的制备方法 |
| US8614085B2 (en) | 2009-02-27 | 2013-12-24 | Butamax(Tm) Advanced Biofuels Llc | Yeast with increased butanol tolerance involving a multidrug efflux pump gene |
| US20100297722A1 (en) * | 2009-05-20 | 2010-11-25 | Board Of Trustees Of Southern Illinois University | Transgenic moss producing terpenoids |
| PL2440661T3 (pl) | 2009-06-08 | 2018-06-29 | Jennewein Biotechnologie Gmbh | Synteza hmo |
| US9131718B2 (en) | 2009-06-16 | 2015-09-15 | Epc (Beijing) Natural Products Co., Ltd. | Process for rebaudioside D |
| EP2473064A1 (en) | 2009-09-04 | 2012-07-11 | Redpoint Bio Corporation | Sweetness enhancers including rebaudioside a or d |
| SG178920A1 (en) | 2009-09-22 | 2012-04-27 | Redpoint Bio Corp | Novel polymorphs of rebaudioside c and methods for making and using the same |
| KR101733515B1 (ko) * | 2009-10-15 | 2017-05-08 | 퓨어 써클 에스디엔 비에이치디 | 고순도 레바우디오사이드 d 및 적용 |
| US8299224B2 (en) | 2009-10-15 | 2012-10-30 | Purecircle Sdn Bhd | High-purity Rebaudioside D |
| US8703224B2 (en) | 2009-11-04 | 2014-04-22 | Pepsico, Inc. | Method to improve water solubility of Rebaudioside D |
| SG181422A1 (en) | 2009-11-10 | 2012-07-30 | Massachusetts Inst Technology | Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway |
| US8993840B2 (en) | 2009-11-23 | 2015-03-31 | E I du Pont de Nemours and Compay | Sucrose transporter genes for increasing plant seed lipids |
| DK2816112T3 (en) | 2009-12-10 | 2018-11-19 | Univ Minnesota | TAL effector-mediated DNA modification |
| MX2012007607A (es) | 2009-12-28 | 2012-07-20 | Coca Cola Co | Intensificadores de dulzor, composiciones de los mismos y metodos para su uso. |
| KR101244315B1 (ko) | 2010-10-19 | 2013-03-14 | 이화여자대학교 산학협력단 | 에탄올―저항성 효모 유전자 및 이의 용도 |
| WO2011140329A1 (en) | 2010-05-06 | 2011-11-10 | Ceres, Inc. | Transgenic plants having increased biomass |
| EP2571991A1 (en) | 2010-05-20 | 2013-03-27 | Evolva SA | Method of producing isoprenoid compounds in yeast |
| WO2011151326A2 (en) | 2010-05-31 | 2011-12-08 | Vib Vzw | The use of transporters to modulate flavor production by yeast |
| MY167872A (en) * | 2010-06-02 | 2018-09-26 | Evolva Inc | Recombinant production of steviol glycosides |
| US20120021111A1 (en) | 2010-07-23 | 2012-01-26 | Aexelon Therapeutics, Inc. | Natural Low Caloric Sweetener Compositions for Use in Beverages, Foods and Pharmaceuticals, and Their Methods of Manufacture |
| US20120083593A1 (en) | 2010-10-01 | 2012-04-05 | Shanghai Yongyou Bioscience Inc. | Separation and Purification of Stevioside and Rebaudioside A |
| WO2012075030A1 (en) | 2010-11-30 | 2012-06-07 | Massachusetts Institute Of Technology | Microbial production of natural sweeteners, diterpenoid steviol glycosides |
| KR20130014227A (ko) | 2011-07-29 | 2013-02-07 | 한국생명공학연구원 | 신규한 α-글루코실 스테비오사이드 및 이의 제조 방법 |
| KR101815063B1 (ko) | 2011-08-08 | 2018-01-05 | 에볼바 에스아 | 사프란 화합물의 재조합 생성을 위한 방법 및 물질 |
| US9631215B2 (en) * | 2011-08-08 | 2017-04-25 | Evolva Sa | Recombinant production of steviol glycosides |
| CN103159808B (zh) | 2011-12-09 | 2017-03-29 | 上海泓博智源医药股份有限公司 | 一种制备天然甜味剂的工艺方法 |
| BR112014014965B1 (pt) | 2011-12-19 | 2021-01-05 | The Coca-Cola Company | bebida compreendendo glicosídeos |
| WO2013110673A1 (en) | 2012-01-23 | 2013-08-01 | Dsm Ip Assets B.V. | Diterpene production |
| EP2826861B1 (en) | 2012-03-16 | 2020-04-29 | Suntory Holdings Limited | Steviol glycosyltransferase and gene encoding same |
| MX395285B (es) * | 2012-05-22 | 2025-03-25 | Purecircle Sdn Bhd | Glucosidos de esteviol de alta pureza. |
| EP2902410B1 (en) | 2012-09-29 | 2022-01-05 | Sichuan Ingia Biosynthetic Co., Ltd. | Method for producing stevioside compounds by microorganism |
| WO2014086890A1 (en) * | 2012-12-05 | 2014-06-12 | Evolva Sa | Steviol glycoside compositions sensory properties |
| MX369525B (es) | 2013-02-06 | 2019-11-11 | Evolva Sa | Métodos para mejorar la produccion de rebaudiosido d y rebaudiosido m. |
| CN105189771B (zh) | 2013-02-11 | 2019-11-05 | 埃沃尔瓦公司 | 在重组宿主中有效产生甜菊醇糖苷 |
| AU2014273054A1 (en) | 2013-05-31 | 2015-12-03 | Dsm Ip Assets B.V. | Extracellular diterpene production |
| EP3502264A3 (en) | 2013-05-31 | 2019-11-06 | DSM IP Assets B.V. | Microorganisms for diterpene production |
| KR101559478B1 (ko) | 2013-06-24 | 2015-10-13 | 한국생명공학연구원 | 효소전환법을 이용한 천연 고감미료의 제조방법 |
| US10273519B2 (en) | 2013-07-23 | 2019-04-30 | Dsm Ip Assets B.V. | Diterpene production in Yarrowia |
| AU2014298420B2 (en) | 2013-07-31 | 2018-10-04 | Dsm Ip Assets B.V. | Recovery of steviol glycosides |
| CN105658081A (zh) | 2013-07-31 | 2016-06-08 | 帝斯曼知识产权资产管理有限公司 | 甜菊糖苷 |
| WO2015016393A1 (ja) | 2013-08-02 | 2015-02-05 | サントリーホールディングス株式会社 | ヘキセノール配糖体化酵素の利用方法 |
| CN103397064B (zh) | 2013-08-14 | 2015-04-15 | 苏州汉酶生物技术有限公司 | 一种酶法制备瑞鲍迪甙m的方法 |
| SG11201700651RA (en) | 2014-08-11 | 2017-02-27 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| JP2017528134A (ja) | 2014-09-09 | 2017-09-28 | エヴォルヴァ エスアー.Evolva Sa. | 組み換え宿主におけるステビオールグリコシドの生産 |
| ES2693371T3 (es) | 2014-10-03 | 2018-12-11 | Conagen Inc. | Edulcorantes no calóricos y métodos de síntesis |
| EP3862426B1 (en) | 2015-03-16 | 2025-09-03 | DSM IP Assets B.V. | Udp-glycosyltransferases |
| JP2018521680A (ja) * | 2015-08-06 | 2018-08-09 | カーギル・インコーポレイテッド | ステビオール配糖体を生成するための発酵法 |
-
2014
- 2014-02-06 MX MX2015010043A patent/MX369525B/es active IP Right Grant
- 2014-02-06 SG SG10201705926YA patent/SG10201705926YA/en unknown
- 2014-02-06 EP EP14702889.8A patent/EP2954058B1/en active Active
- 2014-02-06 US US14/761,629 patent/US9957540B2/en active Active
- 2014-02-06 SG SG11201505597SA patent/SG11201505597SA/en unknown
- 2014-02-06 WO PCT/EP2014/052363 patent/WO2014122227A2/en not_active Ceased
- 2014-02-06 CN CN201910741874.5A patent/CN110551646B/zh active Active
- 2014-02-06 AU AU2014214004A patent/AU2014214004B2/en active Active
- 2014-02-06 CA CA3171770A patent/CA3171770A1/en active Pending
- 2014-02-06 JP JP2015556497A patent/JP6379112B2/ja active Active
- 2014-02-06 MY MYPI2015001861A patent/MY190346A/en unknown
- 2014-02-06 MY MYPI2020003959A patent/MY199452A/en unknown
- 2014-02-06 CN CN201480007742.5A patent/CN105051195B/zh active Active
- 2014-02-06 KR KR1020157024042A patent/KR20150115002A/ko not_active Abandoned
- 2014-02-06 CA CA2899276A patent/CA2899276C/en active Active
- 2014-02-06 EP EP21165720.0A patent/EP3892728A1/en active Pending
-
2018
- 2018-02-28 US US15/908,214 patent/US10612066B2/en active Active
- 2018-07-30 JP JP2018142038A patent/JP6660980B2/ja active Active
- 2018-08-22 AU AU2018220068A patent/AU2018220068B2/en active Active
-
2020
- 2020-02-10 JP JP2020020276A patent/JP7061145B2/ja active Active
- 2020-02-24 US US16/799,541 patent/US11530431B2/en active Active
- 2020-11-19 AU AU2020273296A patent/AU2020273296B2/en active Active
-
2021
- 2021-12-23 JP JP2021208879A patent/JP7465252B2/ja active Active
-
2022
- 2022-11-03 US US18/052,477 patent/US20230279459A1/en active Pending
- 2022-12-06 AU AU2022283672A patent/AU2022283672B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX369525B (es) | Métodos para mejorar la produccion de rebaudiosido d y rebaudiosido m. | |
| BR112018002564A2 (pt) | produção de glicosídeos de esteviol em hospedeiros recombinantes | |
| BR112017004712A2 (pt) | produção de glicosídeos de esteviol em hospedeiros recombinantes | |
| EP3063286A4 (en) | Recombinant production of steviol glycosides | |
| BR112017002783A2 (pt) | produção de glicosídeos de esteviol em hospedeiros recombinantes | |
| BR112018011611A2 (pt) | produção de glicosídeos de esteviol em hospedeiros recombinantes | |
| BR112014003037A2 (pt) | produção recombinante de glicosídeos de esteviol | |
| MX378831B (es) | Edulcorantes no caloricos y metodos para sintetizar | |
| EP3468385A4 (en) | STEVIOL GLYCOSIDE COMPOSITIONS, METHODS OF MAKING AND USES | |
| PL3464607T3 (pl) | Kompozycje glikozylowanych glikozydów stewiolowych | |
| BR112016012883A2 (pt) | Métodos e composições para aprimorar o rendimento de milho | |
| SG10201705993YA (en) | Efficient production of steviol glycosides in recombinant hosts | |
| EP3764810A4 (en) | HIGH PURITY STEVIOL GLYCOSIDES | |
| EP3052638A4 (en) | Glucosyl stevia composition | |
| MX2017006293A (es) | Composicion que comprende sal de glutamato de acilo como surfactante principal o surfactante anionico principal. | |
| BR112018071144A2 (pt) | produção de glicosídeos de esteviol em hospedeiros recombinantes | |
| BR112018000550A2 (pt) | composição de glicosídeo de esteviol | |
| HUE040000T2 (hu) | Glikozilált szteviol-glikozidokat tartalmazó készítmény | |
| EP3471559A4 (en) | STEVIOL GLYCOSIDE COMPOSITIONS FOR ORAL INGESTION OR USE | |
| BR112016006155A2 (pt) | glicosídeo de esteviol glicosilado como um modificador de sabor | |
| EP3367816C0 (en) | STEVIOL GLYCOSIDE COMPOSITIONS | |
| MX2016007813A (es) | Glucosido de esteviol estabilizado en jarabe concentrado. | |
| BR112018000298A2 (pt) | composição de glicosídeo de esteviol | |
| BR112015032388A2 (pt) | métodos e composições para as vacinas contra o vírus da dengue | |
| PH12016501201A1 (en) | Synthesis of ent-progesterone and intermediates thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |