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MX2022004631A - Metodos para la preparacion del acido 5-bromo-2-(3-cloropiridin-2- il)-2h-pirazol-3-carboxilico. - Google Patents

Metodos para la preparacion del acido 5-bromo-2-(3-cloropiridin-2- il)-2h-pirazol-3-carboxilico.

Info

Publication number
MX2022004631A
MX2022004631A MX2022004631A MX2022004631A MX2022004631A MX 2022004631 A MX2022004631 A MX 2022004631A MX 2022004631 A MX2022004631 A MX 2022004631A MX 2022004631 A MX2022004631 A MX 2022004631A MX 2022004631 A MX2022004631 A MX 2022004631A
Authority
MX
Mexico
Prior art keywords
pyrazole
chloropyridin
bromo
carboxylic acid
methods
Prior art date
Application number
MX2022004631A
Other languages
English (en)
Inventor
Xin Liu
Jianhua Mao
Yanchun Cao
Zhijian Xu
Original Assignee
Fmc Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fmc Corp filed Critical Fmc Corp
Publication of MX2022004631A publication Critical patent/MX2022004631A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

En la presente se describen métodos novedosos para sintetizar el ácido 5-bromo-2-(3-cloropiridin-2-il)-2H-pirazol-3-carboxílico a partir de pirazol o derivados de pirazol. En la presente también se describen intermedios de reacción novedosos.
MX2022004631A 2019-10-18 2020-10-16 Metodos para la preparacion del acido 5-bromo-2-(3-cloropiridin-2- il)-2h-pirazol-3-carboxilico. MX2022004631A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962916840P 2019-10-18 2019-10-18
US202062982248P 2020-02-27 2020-02-27
PCT/US2020/055888 WO2021076835A1 (en) 2019-10-18 2020-10-16 Methods for the preparation of 5-bromo-2-(3chloro-pyridin-2-yl)-2h-pyrazole-3-carboxylic acid

Publications (1)

Publication Number Publication Date
MX2022004631A true MX2022004631A (es) 2022-05-24

Family

ID=73198483

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2022004631A MX2022004631A (es) 2019-10-18 2020-10-16 Metodos para la preparacion del acido 5-bromo-2-(3-cloropiridin-2- il)-2h-pirazol-3-carboxilico.
MX2022004627A MX2022004627A (es) 2019-10-18 2020-10-16 Metodos para la preparacion del acido 5-bromo-2-(3-cloropiridin-2- il)-2h-pirazol-3-carboxilico.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2022004627A MX2022004627A (es) 2019-10-18 2020-10-16 Metodos para la preparacion del acido 5-bromo-2-(3-cloropiridin-2- il)-2h-pirazol-3-carboxilico.

Country Status (16)

Country Link
US (2) US20220396560A1 (es)
EP (5) EP3976591B1 (es)
JP (2) JP7667144B2 (es)
KR (2) KR20220084347A (es)
CN (3) CN114650987B (es)
AU (2) AU2020366212A1 (es)
BR (2) BR112022007215A2 (es)
HU (4) HUE062047T2 (es)
IL (5) IL291939B2 (es)
MA (2) MA56053A (es)
MX (2) MX2022004631A (es)
PL (4) PL3976589T3 (es)
TW (1) TWI875840B (es)
UY (1) UY38925A (es)
WO (2) WO2021076835A1 (es)
ZA (2) ZA202204278B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220259177A1 (en) * 2019-10-18 2022-08-18 Fmc Corporation Methods for the preparation of 5-bromo-2-(3-chloro-pyridin-2-yl)-2h-pyrazole-3-carboxylic acid
CN114650987B (zh) 2019-10-18 2024-09-06 Fmc公司 用于制备5-溴-2-(3-氯-吡啶-2-基)-2h-吡唑-3-甲酸的方法
CN115557931B (zh) * 2022-10-20 2024-05-14 浙江新安化工集团股份有限公司 一种3-溴-1-(3-氯-2-吡啶基)-1h-吡唑-5-甲酸的合成方法
CN117024374A (zh) * 2023-08-08 2023-11-10 安庆百谊生物科技有限公司 一种3-甲基-1，2，4-噻二唑-5-碳酰肼或其盐的合成方法

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CN114650987B (zh) 2019-10-18 2024-09-06 Fmc公司 用于制备5-溴-2-(3-氯-吡啶-2-基)-2h-吡唑-3-甲酸的方法

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EP4043451B1 (en) 2024-02-28
PL3976589T3 (pl) 2023-07-31
US20220259178A1 (en) 2022-08-18
EP3976591B1 (en) 2023-04-19
WO2021076835A8 (en) 2021-11-04
IL299818B2 (en) 2025-02-01
IL294551B1 (en) 2023-01-01
EP4219455A1 (en) 2023-08-02
IL291939B (en) 2022-12-01
US20220396560A1 (en) 2022-12-15
EP3976591A1 (en) 2022-04-06
CN114650987A (zh) 2022-06-21
IL298694B2 (en) 2025-05-01
CN119039270A (zh) 2024-11-29
BR112022007102A2 (pt) 2022-07-05
WO2021076839A1 (en) 2021-04-22
EP4253380A2 (en) 2023-10-04
IL299818A (en) 2023-03-01
IL294551A (en) 2022-09-01
IL291939B2 (en) 2023-04-01
HUE070680T2 (hu) 2025-06-28
CN114650987B (zh) 2024-09-06
KR20220084347A (ko) 2022-06-21
PL4219455T3 (pl) 2025-04-14
EP3976589A1 (en) 2022-04-06
MA56055A (fr) 2022-04-06
EP4219455B1 (en) 2024-12-11
IL292090B2 (en) 2023-06-01
IL298694A (en) 2023-02-01
ZA202204277B (en) 2024-08-28
JP2022552272A (ja) 2022-12-15
CN114641471B (zh) 2025-05-23
IL291939A (en) 2022-06-01
TWI875840B (zh) 2025-03-11
UY38925A (es) 2021-05-31
HUE066520T2 (hu) 2024-08-28
KR20220086612A (ko) 2022-06-23
TW202116748A (zh) 2021-05-01
IL294551B2 (en) 2023-05-01
CN114641471A (zh) 2022-06-17
PL4043451T3 (pl) 2024-06-10
AU2020366037A1 (en) 2022-04-21
EP4043451A1 (en) 2022-08-17
ZA202204278B (en) 2024-08-28
MA56053A (fr) 2022-04-20
MX2022004627A (es) 2022-05-26
IL298694B1 (en) 2025-01-01
WO2021076835A1 (en) 2021-04-22
BR112022007215A2 (pt) 2022-07-05
JP7667144B2 (ja) 2025-04-22
EP3976589B1 (en) 2023-04-12
HUE062237T2 (hu) 2023-10-28
IL299818B1 (en) 2024-10-01
JP2022552273A (ja) 2022-12-15
HUE062047T2 (hu) 2023-09-28
TW202128631A (zh) 2021-08-01
AU2020366212A1 (en) 2022-04-21
IL292090A (en) 2022-06-01
EP4253380A3 (en) 2023-11-15
PL3976591T3 (pl) 2023-07-31

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