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BR112022007102A2 - Métodos para a preparação de ácido 5-bromo-2-(3-cloro-piridin-2-il)-2h-pirazol-3-carboxílico - Google Patents

Métodos para a preparação de ácido 5-bromo-2-(3-cloro-piridin-2-il)-2h-pirazol-3-carboxílico

Info

Publication number
BR112022007102A2
BR112022007102A2 BR112022007102A BR112022007102A BR112022007102A2 BR 112022007102 A2 BR112022007102 A2 BR 112022007102A2 BR 112022007102 A BR112022007102 A BR 112022007102A BR 112022007102 A BR112022007102 A BR 112022007102A BR 112022007102 A2 BR112022007102 A2 BR 112022007102A2
Authority
BR
Brazil
Prior art keywords
pyridin
bromo
chloro
methods
carboxylic acid
Prior art date
Application number
BR112022007102A
Other languages
English (en)
Inventor
Cao Yanchun
Liu Xin
Mao Jianhua
Xu Zhijian
Original Assignee
Fmc Corp
Fmc Agro Singapore Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fmc Corp, Fmc Agro Singapore Pte Ltd filed Critical Fmc Corp
Publication of BR112022007102A2 publication Critical patent/BR112022007102A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

MÉTODOS PARA A PREPARAÇÃO DE ÁCIDO 5-BROMO-2-(3-CLORO-PIRIDIN-2- IL)-2H-PIRAZOL-3-CARBOXÍLICO. A presente invenção refere-se a métodos de síntese de ácido 5-bromo-2-(3-cloro-piridin-2-il)-2H-pirazol-3-carboxílico a partir de pirazol ou derivados de pirazol. A invenção também se refere a intermediários de reação.
BR112022007102A 2019-10-18 2020-10-16 Métodos para a preparação de ácido 5-bromo-2-(3-cloro-piridin-2-il)-2h-pirazol-3-carboxílico BR112022007102A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962916840P 2019-10-18 2019-10-18
US202062982248P 2020-02-27 2020-02-27
PCT/US2020/055897 WO2021076839A1 (en) 2019-10-18 2020-10-16 Methods for the preparation of 5-bromo-2-(3-chloro-pyridin-2-yl)-2h-pyrazole-3-carboxylic acid

Publications (1)

Publication Number Publication Date
BR112022007102A2 true BR112022007102A2 (pt) 2022-07-05

Family

ID=73198483

Family Applications (2)

Application Number Title Priority Date Filing Date
BR112022007215A BR112022007215A2 (pt) 2019-10-18 2020-10-16 Métodos para preparação de ácido 5-bromo-2-(3-cloro-piridin-2-il)-2h-pirazol-3-carboxílico
BR112022007102A BR112022007102A2 (pt) 2019-10-18 2020-10-16 Métodos para a preparação de ácido 5-bromo-2-(3-cloro-piridin-2-il)-2h-pirazol-3-carboxílico

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR112022007215A BR112022007215A2 (pt) 2019-10-18 2020-10-16 Métodos para preparação de ácido 5-bromo-2-(3-cloro-piridin-2-il)-2h-pirazol-3-carboxílico

Country Status (16)

Country Link
US (2) US20220396560A1 (pt)
EP (5) EP4043451B1 (pt)
JP (2) JP7667144B2 (pt)
KR (2) KR20220084347A (pt)
CN (3) CN114641471B (pt)
AU (2) AU2020366037A1 (pt)
BR (2) BR112022007215A2 (pt)
HU (4) HUE062047T2 (pt)
IL (5) IL294551B2 (pt)
MA (2) MA56055A (pt)
MX (2) MX2022004631A (pt)
PL (4) PL4043451T3 (pt)
TW (1) TWI875840B (pt)
UY (1) UY38925A (pt)
WO (2) WO2021076835A1 (pt)
ZA (2) ZA202204278B (pt)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7667144B2 (ja) 2019-10-18 2025-04-22 エフ エム シー コーポレーション ５－ブロモ－２－（３－クロロ－ピリジン－２－イル）－２ｈ－ピラゾール－３－カルボン酸の調製方法
EP4045487B1 (en) * 2019-10-18 2025-02-12 Fmc Corporation Methods for the preparation of 5-bromo-2-(3-chloro-pyridin-2-yl)-2h-pyrazole-3-carboxylic acid
CN115557931B (zh) * 2022-10-20 2024-05-14 浙江新安化工集团股份有限公司 一种3-溴-1-(3-氯-2-吡啶基)-1h-吡唑-5-甲酸的合成方法
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JP7667144B2 (ja) 2019-10-18 2025-04-22 エフ エム シー コーポレーション ５－ブロモ－２－（３－クロロ－ピリジン－２－イル）－２ｈ－ピラゾール－３－カルボン酸の調製方法

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IL299818A (en) 2023-03-01
EP3976589A1 (en) 2022-04-06
IL291939A (en) 2022-06-01
HUE066520T2 (hu) 2024-08-28
EP4043451A1 (en) 2022-08-17
ZA202204277B (en) 2024-08-28
KR20220084347A (ko) 2022-06-21
MA56053A (fr) 2022-04-20
EP4253380A3 (en) 2023-11-15
US20220396560A1 (en) 2022-12-15
JP2022552273A (ja) 2022-12-15
MA56055A (fr) 2022-04-06
TW202116748A (zh) 2021-05-01
IL292090B2 (en) 2023-06-01
EP4219455B1 (en) 2024-12-11
TWI875840B (zh) 2025-03-11
MX2022004627A (es) 2022-05-26
CN119039270A (zh) 2024-11-29
AU2020366212A1 (en) 2022-04-21
CN114641471A (zh) 2022-06-17
EP3976589B1 (en) 2023-04-12
EP4253380A2 (en) 2023-10-04
IL299818B1 (en) 2024-10-01
PL3976591T3 (pl) 2023-07-31
IL291939B2 (en) 2023-04-01
IL292090A (en) 2022-06-01
KR20220086612A (ko) 2022-06-23
BR112022007215A2 (pt) 2022-07-05
AU2020366037A1 (en) 2022-04-21
IL294551B1 (en) 2023-01-01
HUE070680T2 (hu) 2025-06-28
IL294551B2 (en) 2023-05-01
CN114650987A (zh) 2022-06-21
ZA202204278B (en) 2024-08-28
IL298694B1 (en) 2025-01-01
UY38925A (es) 2021-05-31
HUE062237T2 (hu) 2023-10-28
WO2021076835A1 (en) 2021-04-22
TW202128631A (zh) 2021-08-01
MX2022004631A (es) 2022-05-24
JP7667144B2 (ja) 2025-04-22
PL4219455T3 (pl) 2025-04-14
US20220259178A1 (en) 2022-08-18
IL298694A (en) 2023-02-01
EP3976591A1 (en) 2022-04-06
PL4043451T3 (pl) 2024-06-10
JP2022552272A (ja) 2022-12-15
WO2021076839A1 (en) 2021-04-22
EP4043451B1 (en) 2024-02-28
PL3976589T3 (pl) 2023-07-31
EP4219455A1 (en) 2023-08-02
IL299818B2 (en) 2025-02-01
EP3976591B1 (en) 2023-04-19
IL291939B (en) 2022-12-01
CN114641471B (zh) 2025-05-23
CN114650987B (zh) 2024-09-06
IL298694B2 (en) 2025-05-01
HUE062047T2 (hu) 2023-09-28
WO2021076835A8 (en) 2021-11-04
IL294551A (en) 2022-09-01

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Legal Events

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B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements