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MX2012012614A - Compuestos de 7-(1h-pirazol-4-il)-1, 6-naftiridina como inhibidores de syk. - Google Patents

Compuestos de 7-(1h-pirazol-4-il)-1, 6-naftiridina como inhibidores de syk.

Info

Publication number
MX2012012614A
MX2012012614A MX2012012614A MX2012012614A MX2012012614A MX 2012012614 A MX2012012614 A MX 2012012614A MX 2012012614 A MX2012012614 A MX 2012012614A MX 2012012614 A MX2012012614 A MX 2012012614A MX 2012012614 A MX2012012614 A MX 2012012614A
Authority
MX
Mexico
Prior art keywords
pyrazol
syk inhibitors
cells
naphthyridine compounds
syk
Prior art date
Application number
MX2012012614A
Other languages
English (en)
Inventor
David Matthew Wilson
Vipulkumar Kantibhai Patel
Michael David Barker
Francis Louis Atkinson
Clement Douault
Neil Stuart Garton
John Liddle
Alexander George Steven Preston
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of MX2012012614A publication Critical patent/MX2012012614A/es

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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61P17/04—Antipruritics
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
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  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Un compuesto de fórmula (I) o una sal del mismo: que es un inhibidor de la tirosina cinasa de bazo (Syk) y, por tanto, potencialmente útil en el tratamiento de enfermedades resultantes de la activación inadecuada de mastocitos y/o basófilos, macrófagos y linfocitos B, y respuestas inflamatorias y daños tisulares relacionados, por ejemplo enfermedad inflamatoria y/o trastornos alérgicos y en la terapia del cáncer, específicamente neoplasias malignas hematológicas, urticaria espontánea crónica y afecciones autoinmunes. (Ver Formula).
MX2012012614A 2010-04-29 2011-04-27 Compuestos de 7-(1h-pirazol-4-il)-1, 6-naftiridina como inhibidores de syk. MX2012012614A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1007203.1A GB201007203D0 (en) 2010-04-29 2010-04-29 Novel compounds
PCT/EP2011/056600 WO2011134971A1 (en) 2010-04-29 2011-04-27 7-(1h-pyrazol-4-yl)-1,6-naphthyridine compounds as syk inhibitors

Publications (1)

Publication Number Publication Date
MX2012012614A true MX2012012614A (es) 2012-12-17

Family

ID=42289852

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012012614A MX2012012614A (es) 2010-04-29 2011-04-27 Compuestos de 7-(1h-pirazol-4-il)-1, 6-naftiridina como inhibidores de syk.

Country Status (17)

Country Link
US (1) US8633319B2 (es)
EP (1) EP2563789B1 (es)
JP (1) JP2013525405A (es)
KR (1) KR20130069653A (es)
CN (1) CN102947306A (es)
AR (1) AR081138A1 (es)
BR (1) BR112012027198A2 (es)
CA (1) CA2796954A1 (es)
EA (1) EA201290910A1 (es)
ES (1) ES2543426T3 (es)
GB (1) GB201007203D0 (es)
MX (1) MX2012012614A (es)
SG (1) SG184513A1 (es)
TW (1) TW201206925A (es)
UY (1) UY33359A (es)
WO (1) WO2011134971A1 (es)
ZA (1) ZA201207859B (es)

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ES2543426T3 (es) 2015-08-19
GB201007203D0 (en) 2010-06-16
CA2796954A1 (en) 2011-11-03
AR081138A1 (es) 2012-06-27
UY33359A (es) 2011-12-01
KR20130069653A (ko) 2013-06-26
US8633319B2 (en) 2014-01-21
SG184513A1 (en) 2012-11-29
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