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EA201101497A1 - Имидазопираны для применения в качестве ингибиторов киназ - Google Patents

Имидазопираны для применения в качестве ингибиторов киназ

Info

Publication number
EA201101497A1
EA201101497A1 EA201101497A EA201101497A EA201101497A1 EA 201101497 A1 EA201101497 A1 EA 201101497A1 EA 201101497 A EA201101497 A EA 201101497A EA 201101497 A EA201101497 A EA 201101497A EA 201101497 A1 EA201101497 A1 EA 201101497A1
Authority
EA
Eurasian Patent Office
Prior art keywords
imidazopirana
treatment
kinaz
inhibitors
kinaz inhibitors
Prior art date
Application number
EA201101497A
Other languages
English (en)
Other versions
EA022629B1 (ru
Inventor
Хоакин Пастор Фернандес
Соня Мартинес Гонсалес
Хулен Ойарсабаль Сантамарина
Original Assignee
Сентро Насиональ Де Инвестигасьонес Онколохикас (Снио)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сентро Насиональ Де Инвестигасьонес Онколохикас (Снио) filed Critical Сентро Насиональ Де Инвестигасьонес Онколохикас (Снио)
Publication of EA201101497A1 publication Critical patent/EA201101497A1/ru
Publication of EA022629B1 publication Critical patent/EA022629B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

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Abstract

Описываются соединения формулы Iгде R, R, R, Rи Rимеют значения, указанные в описании, и их фармацевтически приемлемые сложные эфиры, амиды, сольваты или соли, применимые при лечении заболеваний, при которых желательно или требуется ингибирование протеин- или липидкиназы (например, PI3-K и/или mTOR), в частности, при лечении рака или пролиферативного заболевания.
EA201101497A 2009-04-16 2010-04-16 Имидазопираны для применения в качестве ингибиторов киназ EA022629B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09380079 2009-04-16
PCT/GB2010/000773 WO2010119264A1 (en) 2009-04-16 2010-04-16 Imidazopyrazines for use as kinase inhibitors

Publications (2)

Publication Number Publication Date
EA201101497A1 true EA201101497A1 (ru) 2012-04-30
EA022629B1 EA022629B1 (ru) 2016-02-29

Family

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EA201101497A EA022629B1 (ru) 2009-04-16 2010-04-16 Имидазопираны для применения в качестве ингибиторов киназ

Country Status (17)

Country Link
US (1) US8778935B2 (ru)
EP (1) EP2419429B1 (ru)
JP (1) JP5805623B2 (ru)
KR (2) KR101792837B1 (ru)
CN (1) CN102428087B (ru)
AU (1) AU2010238361B2 (ru)
BR (1) BRPI1014572B8 (ru)
CA (1) CA2756759C (ru)
DK (1) DK2419429T3 (ru)
EA (1) EA022629B1 (ru)
ES (1) ES2475091T3 (ru)
IL (1) IL215297A (ru)
MX (1) MX2011010915A (ru)
NZ (1) NZ596185A (ru)
SG (1) SG175195A1 (ru)
WO (1) WO2010119264A1 (ru)
ZA (1) ZA201107717B (ru)

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