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MA55206A - Polyribonucléotides circulaires et compositions pharmaceutiques associées - Google Patents

Polyribonucléotides circulaires et compositions pharmaceutiques associées

Info

Publication number
MA55206A
MA55206A MA055206A MA55206A MA55206A MA 55206 A MA55206 A MA 55206A MA 055206 A MA055206 A MA 055206A MA 55206 A MA55206 A MA 55206A MA 55206 A MA55206 A MA 55206A
Authority
MA
Morocco
Prior art keywords
pharmaceutical compositions
related pharmaceutical
circular polyribonucleotides
polyribonucleotides
circular
Prior art date
Application number
MA055206A
Other languages
English (en)
Inventor
Catherine Cifuentes-Rojas
Boer Alexandra Sophie De
Avak Kahvejian
Michael Donato Melfi
Ki Young Paek
Nicholas Mccartney Plugis
Original Assignee
Flagship Pioneering Innovations Vi Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Flagship Pioneering Innovations Vi Llc filed Critical Flagship Pioneering Innovations Vi Llc
Publication of MA55206A publication Critical patent/MA55206A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0091—Purification or manufacturing processes for gene therapy compositions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/532—Closed or circular

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Manufacturing & Machinery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MA055206A 2019-03-04 2020-03-04 Polyribonucléotides circulaires et compositions pharmaceutiques associées MA55206A (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962813666P 2019-03-04 2019-03-04
US201962825683P 2019-03-28 2019-03-28
US201962840174P 2019-04-29 2019-04-29
US202062967545P 2020-01-29 2020-01-29

Publications (1)

Publication Number Publication Date
MA55206A true MA55206A (fr) 2022-01-12

Family

ID=70110338

Family Applications (1)

Application Number Title Priority Date Filing Date
MA055206A MA55206A (fr) 2019-03-04 2020-03-04 Polyribonucléotides circulaires et compositions pharmaceutiques associées

Country Status (10)

Country Link
US (1) US20220143062A1 (fr)
EP (1) EP3935162A1 (fr)
JP (1) JP2022523794A (fr)
KR (1) KR20210135265A (fr)
CN (1) CN113544269A (fr)
AU (1) AU2020233404A1 (fr)
CA (1) CA3128626A1 (fr)
IL (1) IL285906A (fr)
MA (1) MA55206A (fr)
WO (1) WO2020181013A1 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3028682A1 (fr) 2016-06-20 2017-12-28 Howard Y. Chang Arn circulaires et leur utilisation dans l'immunomodulation
US20200306286A1 (en) 2017-12-15 2020-10-01 Flagship Pioneering Innovations Vi, Llc Compositions comprising circular polyribonucleotides and uses thereof
AU2021391823A1 (en) 2020-12-03 2023-06-29 Battelle Memorial Institute Polymer nanoparticle and dna nanostructure compositions and methods for non-viral delivery
TW202300650A (zh) * 2021-03-26 2023-01-01 美商旗艦先鋒創新有限責任（Ｖｉｉ）公司 真核系統中環狀多核糖核苷酸的產生
TW202305130A (zh) * 2021-03-26 2023-02-01 美商旗艦先鋒創新有限責任（Ｖｉｉ）公司 原核系統中環狀多核糖核苷酸之產生
AR125216A1 (es) * 2021-03-26 2023-06-28 Flagship Pioneering Innovations Vii Llc Producción de polirribonucleótidos circulares en un sistema eucariota
US12031128B2 (en) 2021-04-07 2024-07-09 Battelle Memorial Institute Rapid design, build, test, and learn technologies for identifying and using non-viral carriers
KR20240035752A (ko) * 2021-05-18 2024-03-18 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 원형 폴리리보뉴클레오티드의 농축 방법
CN117616133A (zh) * 2021-05-18 2024-02-27 旗舰创业创新第六有限责任公司 富集环状多核糖核苷酸的方法
EP4377454A1 (fr) 2021-07-27 2024-06-05 Flagship Pioneering Innovations VI, LLC Dispositifs, systèmes et procédés de traitement
MX2024003262A (es) * 2021-09-17 2024-06-19 Flagship Pioneering Innovations Vi Llc Composiciones y metodos para producir poliribonucleotidos circulares.
EP4422698A1 (fr) * 2021-10-29 2024-09-04 CureVac SE Arn circulaire amélioré pour exprimer des protéines thérapeutiques
KR102488280B1 (ko) * 2021-11-25 2023-01-16 주식회사 뉴클릭스바이오 신규한 부목 dna 및 이의 용도
CN114317684B (zh) * 2021-12-15 2023-12-26 南京大学 一种基于tna分子的细胞内镁离子成像的方法
US20240401024A1 (en) 2021-12-17 2024-12-05 Flagship Pioneering Innovations Vi, Llc Methods for enrichment of circular rna under denaturing conditions
CN118451182A (zh) * 2022-01-28 2024-08-06 北京昌平实验室 环状rna疫苗及其使用方法
WO2024097664A1 (fr) * 2022-10-31 2024-05-10 Flagship Pioneering Innovations Vi, Llc Compositions et procédés de purification de polyribonucléotides
TW202438673A (zh) 2023-01-09 2024-10-01 美商旗艦先鋒創新有限責任（Ｖｉｉ）公司 疫苗及相關方法
WO2024159172A1 (fr) 2023-01-27 2024-08-02 Senda Biosciences, Inc. Composition lipidique modifiée et ses utilisations
WO2024167885A1 (fr) 2023-02-06 2024-08-15 Flagship Pioneering Innovations Vii, Llc Compositions immunomodulatrices et procédés associés
WO2025002331A1 (fr) * 2023-06-28 2025-01-02 Ribox Therapeutics Hk Limited Polynucléotide d'arn modifié et son procédé de préparation
CN118688370B (zh) * 2024-08-27 2024-12-13 天津辰欣药物研究有限公司 一种抗病毒新药中间体的质量控制方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2087256A1 (fr) 1990-07-25 1992-01-26 Jerry L. Ruth Extension circulaire pour produire des complements multiples d'acides nucleiques
US5426180A (en) 1991-03-27 1995-06-20 Research Corporation Technologies, Inc. Methods of making single-stranded circular oligonucleotides
JPH07502898A (ja) 1992-01-13 1995-03-30 デューク・ユニバーシティー 酵素ｒｎａ分子
US5773244A (en) 1993-05-19 1998-06-30 Regents Of The University Of California Methods of making circular RNA
US5766903A (en) 1995-08-23 1998-06-16 University Technology Corporation Circular RNA and uses thereof
US6429301B1 (en) 1998-04-17 2002-08-06 Whitehead Institute For Biomedical Research Use of a ribozyme to join nucleic acids and peptides
US6693086B1 (en) 1998-06-25 2004-02-17 National Jewish Medical And Research Center Systemic immune activation method using nucleic acid-lipid complexes
US6210931B1 (en) 1998-11-30 2001-04-03 The United States Of America As Represented By The Secretary Of Agriculture Ribozyme-mediated synthesis of circular RNA
EP2224003B1 (fr) 2001-09-28 2018-04-18 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Molécules de micro ARN
US7683036B2 (en) 2003-07-31 2010-03-23 Regulus Therapeutics Inc. Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
JP5296328B2 (ja) 2007-05-09 2013-09-25 独立行政法人理化学研究所 １本鎖環状ｒｎａおよびその製造方法
WO2010084371A1 (fr) 2009-01-26 2010-07-29 Mitoprod Nouvelles molécules d'arn interférent circulaire
US20120315324A1 (en) 2010-02-05 2012-12-13 University Of Louisville Research Foundation, Inc. Exosomal compositions and methods for the treatment of disease
WO2013070324A1 (fr) 2011-11-07 2013-05-16 University Of Louisville Research Foundation, Inc. Compositions de microvésicules dérivées de plante comestible pour le diagnostic et le traitement d'une maladie
BR112016011195A2 (pt) 2013-11-18 2017-09-19 Rubius Therapeutics Inc Células eritroides enucleadas e seus métodos de fabricação, composição farmacêutica e seu uso, uso de uma população de células eritroides, biorreator, mistura de células e dispositivo médico
CA2944492A1 (fr) 2014-04-01 2015-10-08 Rubius Therapeutics, Inc. Methodes et compositions d'immunomodulation
WO2016183482A1 (fr) 2015-05-13 2016-11-17 Rubius Therapeutics, Inc. Agents thérapeutiques d'un complexe membrane-récepteur
AU2016271519B2 (en) 2015-06-05 2021-09-02 Dana-Farber Cancer Institute, Inc. Compositions and methods for transient gene therapy with enhanced stability
EP3316862A4 (fr) 2015-07-02 2019-02-06 University of Louisville Research Foundation, Inc. Compositions de microvésicules dérivées d'une plante comestible pour l'administration d'arnmi et méthodes de traitement du cancer
CA3010510A1 (fr) 2016-01-11 2017-07-20 Rubius Therapeutics, Inc. Compositions et procedes associes a des systemes cellulaires therapeutiques multimodaux pour indications immunitaires
WO2018009838A1 (fr) 2016-07-07 2018-01-11 Rubius Therapeutics, Inc. Compositions et procédés associés à des systèmes cellulaires thérapeutiques exprimant de l'arn exogène
KR20190091497A (ko) 2016-12-02 2019-08-06 루비우스 테라퓨틱스, 아이엔씨. 고형 종양으로의 침투를 위한 세포 시스템과 관련된 조성물 및 방법
KR20190117667A (ko) 2017-02-17 2019-10-16 루비우스 테라퓨틱스, 아이엔씨. 기능화된 적혈구 세포
KR102761577B1 (ko) 2017-05-08 2025-02-03 플래그쉽 파이어니어링 이노베이션스 브이, 인크. 막 융합을 촉진시키기 위한 조성물 및 그의 용도
US20200306286A1 (en) * 2017-12-15 2020-10-01 Flagship Pioneering Innovations Vi, Llc Compositions comprising circular polyribonucleotides and uses thereof
AR116016A1 (es) 2018-08-24 2021-03-25 Flagship Pioneering Innovations Vi Llc Métodos para fabricar paquetes mensajeros vegetales

Also Published As

Publication number Publication date
WO2020181013A1 (fr) 2020-09-10
US20220143062A1 (en) 2022-05-12
CA3128626A1 (fr) 2020-09-10
IL285906A (en) 2021-10-31
EP3935162A1 (fr) 2022-01-12
AU2020233404A1 (en) 2021-09-16
KR20210135265A (ko) 2021-11-12
CN113544269A (zh) 2021-10-22
JP2022523794A (ja) 2022-04-26

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