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LT2970487T - Citotoksiniai baltymai, apimantys tikslinių ląstelių rišimosi sritis ir shiga toksino subvienetų sritis, skirtas selektyviam tam tikrų rūšių ląstelių žudymui - Google Patents

Citotoksiniai baltymai, apimantys tikslinių ląstelių rišimosi sritis ir shiga toksino subvienetų sritis, skirtas selektyviam tam tikrų rūšių ląstelių žudymui

Info

Publication number
LT2970487T
LT2970487T LTEP14726015.2T LT14726015T LT2970487T LT 2970487 T LT2970487 T LT 2970487T LT 14726015 T LT14726015 T LT 14726015T LT 2970487 T LT2970487 T LT 2970487T
Authority
LT
Lithuania
Prior art keywords
regions
shiga toxin
selective killing
cytotoxic proteins
targeting binding
Prior art date
Application number
LTEP14726015.2T
Other languages
English (en)
Inventor
Eric POMA
Erin WILLERT
Jason Kim
Jack Higgins
Original Assignee
Molecular Templates, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Templates, Inc. filed Critical Molecular Templates, Inc.
Publication of LT2970487T publication Critical patent/LT2970487T/lt

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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/25—Shigella (G)
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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LTEP14726015.2T 2013-03-12 2014-03-11 Citotoksiniai baltymai, apimantys tikslinių ląstelių rišimosi sritis ir shiga toksino subvienetų sritis, skirtas selektyviam tam tikrų rūšių ląstelių žudymui LT2970487T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361777130P 2013-03-12 2013-03-12
PCT/US2014/023231 WO2014164693A2 (en) 2013-03-12 2014-03-11 Cytotoxic proteins comprising cell-targeting binding regions and shiga toxin a subunit regions for selective killing of specific cell types

Publications (1)

Publication Number Publication Date
LT2970487T true LT2970487T (lt) 2020-05-11

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LTEP14726015.2T LT2970487T (lt) 2013-03-12 2014-03-11 Citotoksiniai baltymai, apimantys tikslinių ląstelių rišimosi sritis ir shiga toksino subvienetų sritis, skirtas selektyviam tam tikrų rūšių ląstelių žudymui

Country Status (22)

Country Link
US (4) US10450354B2 (lt)
EP (4) EP3683240A1 (lt)
JP (6) JP6548630B2 (lt)
KR (2) KR102110127B1 (lt)
CN (2) CN105051067B (lt)
AU (1) AU2014249107C1 (lt)
CA (2) CA2902324A1 (lt)
CY (1) CY1123138T1 (lt)
DK (1) DK2970487T3 (lt)
ES (2) ES2808726T3 (lt)
HK (1) HK1215268A1 (lt)
HR (1) HRP20200553T1 (lt)
HU (1) HUE049470T2 (lt)
IL (3) IL240433B (lt)
LT (1) LT2970487T (lt)
MX (1) MX2015012808A (lt)
PL (1) PL2970487T3 (lt)
PT (1) PT2970487T (lt)
RS (1) RS60280B1 (lt)
SI (1) SI2970487T1 (lt)
SM (1) SMT202000266T1 (lt)
WO (2) WO2014164693A2 (lt)

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PT2789684T (pt) 2008-05-23 2017-02-14 Siwa Corp Métodos e composições para facilitar a regeneração
CN105051067B (zh) 2013-03-12 2020-04-17 分子模板公司 用于引起细胞内化的cd20结合免疫毒素及其使用方法
US20210138076A2 (en) * 2014-01-27 2021-05-13 Molecular Templates, Inc. Cell-targeting molecules comprising shiga toxin a subunit effectors and cd8+ t-cell epitopes
US20160340394A1 (en) 2014-01-27 2016-11-24 Molecular Templates, Inc. De-immunized shiga toxin a subunit effector polypeptides for applications in mammals
EP3102245B1 (en) * 2014-02-05 2021-09-08 Molecular Templates, Inc. Methods of screening, selecting, and identifying cytotoxic recombinant polypeptides based on an interim diminution of ribotoxicity
PT3604333T (pt) 2014-03-11 2021-06-07 Molecular Templates Inc Proteínas compreendendo regiões efetoras da subunidade a da toxina shiga próximas de amino-terminais e regiões de ligação do tipo imunoglobulina de direcionamento celular capazes de se ligarem especificamente a cd38
US11142584B2 (en) 2014-03-11 2021-10-12 Molecular Templates, Inc. CD20-binding proteins comprising Shiga toxin A subunit effector regions for inducing cellular internalization and methods using same
JP6935195B2 (ja) 2014-03-11 2021-09-15 モレキュラー テンプレーツ, インク.Molecular Templates, Inc. 結合領域、志賀毒素ａサブユニットのエフェクター領域、及びカルボキシ末端小胞体局在化シグナルモチーフを含むタンパク質
US20150328263A1 (en) * 2014-05-14 2015-11-19 University Of Maryland, Baltimore Cardiac stem cells for cardiac repair
MX2016016288A (es) 2014-06-11 2017-10-12 Molecular Templates Inc Polipeptidos efectores de la subunidad a de la toxina shiga resistentes a la disociacion por proteasa y moleculas dirigidas a las celulas que los comprenden.
AU2015318036B2 (en) 2014-09-19 2021-07-01 Siwa Corporation Anti-AGE antibodies for treating inflammation and auto-immune disorders
US10387178B2 (en) * 2014-10-29 2019-08-20 Red Hat Israel, Ltd. Idle based latency reduction for coalesced interrupts
US10358502B2 (en) 2014-12-18 2019-07-23 Siwa Corporation Product and method for treating sarcopenia
US9993535B2 (en) 2014-12-18 2018-06-12 Siwa Corporation Method and composition for treating sarcopenia
CA2972151C (en) * 2015-02-05 2022-10-11 Molecular Templates, Inc. Multivalent cd20-binding molecules comprising shiga toxin a subunit effector regions and enriched compositions thereof
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