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CY1123138T1 - Κυτταροτοξικες πρωτεϊνες που περιλαμβανουν περιοχες δεσμευσης στοχευσης-κυtταρων και περιοχες α υπομοναδας τοξινης shiga για επιλεκτικη θανατωση συγκεκριμενων κυτταρικων τυπων - Google Patents

Κυτταροτοξικες πρωτεϊνες που περιλαμβανουν περιοχες δεσμευσης στοχευσης-κυtταρων και περιοχες α υπομοναδας τοξινης shiga για επιλεκτικη θανατωση συγκεκριμενων κυτταρικων τυπων

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Publication number
CY1123138T1
CY1123138T1 CY20201100456T CY201100456T CY1123138T1 CY 1123138 T1 CY1123138 T1 CY 1123138T1 CY 20201100456 T CY20201100456 T CY 20201100456T CY 201100456 T CY201100456 T CY 201100456T CY 1123138 T1 CY1123138 T1 CY 1123138T1
Authority
CY
Cyprus
Prior art keywords
shiga toxin
regions
cytotoxic proteins
cell types
proteins containing
Prior art date
Application number
CY20201100456T
Other languages
English (en)
Inventor
Eric POMA
Erin WILLERT
Jason Kim
Jack Higgins
Original Assignee
Molecular Templates, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Templates, Inc. filed Critical Molecular Templates, Inc.
Publication of CY1123138T1 publication Critical patent/CY1123138T1/el

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    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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Abstract

Η παρούσα εφεύρεση παρέχει κυτταροτοξικές πρωτείνες που περιλαμβάνουν περιοχές δέσμευσης τύπου-ανοσοσφαιρίνης για τη διαμεσολάβηση ειδικής για-τον-κυτταρικό-τύπο στόχευσης και περιοχές τελεστή τοξίνης Shiga που προέρχονται από Α Υπομονάδες μελών της οικογένειας τοξινών Shiga για την πραγματοποίηση κυτταροτοξικότητας. Οι κυτταροτοξικές πρωτείνες έχουν χρήσεις για επιλεκτική θανάτωση συγκεκριμένων κυτταρικών τύπων και ως θεραπευτικές ουσίες για τη θεραπεία ποικίλων ασθενειών, συμπεριλαμβανομένων καρκίνων, ανοσολογικών διαταραχών, και μικροβιακών λοιμώξεων.
CY20201100456T 2013-03-12 2020-05-19 Κυτταροτοξικες πρωτεϊνες που περιλαμβανουν περιοχες δεσμευσης στοχευσης-κυtταρων και περιοχες α υπομοναδας τοξινης shiga για επιλεκτικη θανατωση συγκεκριμενων κυτταρικων τυπων CY1123138T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361777130P 2013-03-12 2013-03-12
PCT/US2014/023231 WO2014164693A2 (en) 2013-03-12 2014-03-11 Cytotoxic proteins comprising cell-targeting binding regions and shiga toxin a subunit regions for selective killing of specific cell types

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CY1123138T1 true CY1123138T1 (el) 2021-10-29

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US (4) US20160068577A1 (el)
EP (4) EP2970478B1 (el)
JP (6) JP6472784B2 (el)
KR (2) KR102110127B1 (el)
CN (2) CN111363047A (el)
AU (1) AU2014249107C1 (el)
CA (2) CA2902324A1 (el)
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ES2616728T3 (es) 2008-05-23 2017-06-14 Siwa Corporation Procedimientos y composiciones para facilitar la regeneración
CN111363047A (zh) * 2013-03-12 2020-07-03 分子模板公司 用于引起细胞内化的cd20结合免疫毒素及其使用方法
ES2749862T3 (es) 2014-01-27 2020-03-24 Molecular Templates Inc Polipéptidos efectores desinmunizados de subunidad A de toxina Shiga para aplicaciones en mamíferos
US20210138076A2 (en) * 2014-01-27 2021-05-13 Molecular Templates, Inc. Cell-targeting molecules comprising shiga toxin a subunit effectors and cd8+ t-cell epitopes
JP6814634B2 (ja) * 2014-02-05 2021-01-20 モレキュラー テンプレーツ, インク.Molecular Templates, Inc. リボ毒性の一時的な減少に基づき、細胞毒性組換えポリペプチドをスクリーニングし、選択し、同定する方法
US11142584B2 (en) 2014-03-11 2021-10-12 Molecular Templates, Inc. CD20-binding proteins comprising Shiga toxin A subunit effector regions for inducing cellular internalization and methods using same
EP3872090A1 (en) * 2014-03-11 2021-09-01 Molecular Templates, Inc. Proteins comprising amino-terminal proximal shiga toxin a subunit effector regions and cell-targeting immunoglobulin-type binding regions
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