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HK1215268A1 - 用於引起細胞內化的 結合免疫毒素及其使用方法 - Google Patents

用於引起細胞內化的 結合免疫毒素及其使用方法

Info

Publication number
HK1215268A1
HK1215268A1 HK16103313.6A HK16103313A HK1215268A1 HK 1215268 A1 HK1215268 A1 HK 1215268A1 HK 16103313 A HK16103313 A HK 16103313A HK 1215268 A1 HK1215268 A1 HK 1215268A1
Authority
HK
Hong Kong
Prior art keywords
methods
same
cellular internalization
inducing cellular
immunotoxins
Prior art date
Application number
HK16103313.6A
Other languages
English (en)
Inventor
Eric Poma
Erin Willert
Jason Kim
Jack Higgins
Sangeetha Rajagopalan
Original Assignee
Molecular Templates Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Templates Inc filed Critical Molecular Templates Inc
Publication of HK1215268A1 publication Critical patent/HK1215268A1/zh

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    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/25—Shigella (G)
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    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Diabetes (AREA)
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  • Tropical Medicine & Parasitology (AREA)
  • Cell Biology (AREA)
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HK16103313.6A 2013-03-12 2016-03-22 用於引起細胞內化的 結合免疫毒素及其使用方法 HK1215268A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361777130P 2013-03-12 2013-03-12
PCT/US2014/023198 WO2014164680A1 (en) 2013-03-12 2014-03-11 Cd20-binding immunotoxins for inducing cellular internalization and methods using same

Publications (1)

Publication Number Publication Date
HK1215268A1 true HK1215268A1 (zh) 2016-08-19

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HK16103313.6A HK1215268A1 (zh) 2013-03-12 2016-03-22 用於引起細胞內化的 結合免疫毒素及其使用方法

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Country Link
US (4) US20160068577A1 (zh)
EP (4) EP2970478B1 (zh)
JP (6) JP6472784B2 (zh)
KR (2) KR102110127B1 (zh)
CN (2) CN111363047A (zh)
AU (1) AU2014249107C1 (zh)
CA (2) CA2902324A1 (zh)
CY (1) CY1123138T1 (zh)
DK (1) DK2970487T3 (zh)
ES (2) ES2808726T3 (zh)
HK (1) HK1215268A1 (zh)
HR (1) HRP20200553T1 (zh)
HU (1) HUE049470T2 (zh)
IL (3) IL240433B (zh)
LT (1) LT2970487T (zh)
MX (1) MX378807B (zh)
PL (1) PL2970487T3 (zh)
PT (1) PT2970487T (zh)
RS (1) RS60280B1 (zh)
SI (1) SI2970487T1 (zh)
SM (1) SMT202000266T1 (zh)
WO (2) WO2014164680A1 (zh)

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ES2749862T3 (es) 2014-01-27 2020-03-24 Molecular Templates Inc Polipéptidos efectores desinmunizados de subunidad A de toxina Shiga para aplicaciones en mamíferos
US20210138076A2 (en) * 2014-01-27 2021-05-13 Molecular Templates, Inc. Cell-targeting molecules comprising shiga toxin a subunit effectors and cd8+ t-cell epitopes
JP6814634B2 (ja) * 2014-02-05 2021-01-20 モレキュラー テンプレーツ, インク.Molecular Templates, Inc. リボ毒性の一時的な減少に基づき、細胞毒性組換えポリペプチドをスクリーニングし、選択し、同定する方法
US11142584B2 (en) 2014-03-11 2021-10-12 Molecular Templates, Inc. CD20-binding proteins comprising Shiga toxin A subunit effector regions for inducing cellular internalization and methods using same
EP3872090A1 (en) * 2014-03-11 2021-09-01 Molecular Templates, Inc. Proteins comprising amino-terminal proximal shiga toxin a subunit effector regions and cell-targeting immunoglobulin-type binding regions
US20170002046A1 (en) 2014-03-11 2017-01-05 Molecular Templates, Inc. Proteins comprising binding regions, shiga toxin a subunit effector regions, and carboxy-terminal, endoplasmic reticulum localization signal motifs
US20150328263A1 (en) 2014-05-14 2015-11-19 University Of Maryland, Baltimore Cardiac stem cells for cardiac repair
EP3137488B1 (en) 2014-06-11 2019-01-02 Molecular Templates, Inc. Protease-cleavage resistant, shiga toxin a subunit effector polypeptides and cell-targeting molecules comprising the same
EP3194439B1 (en) 2014-09-19 2022-01-19 Siwa Corporation Anti-age antibodies for treating inflammation and auto-immune disorders
US10387178B2 (en) * 2014-10-29 2019-08-20 Red Hat Israel, Ltd. Idle based latency reduction for coalesced interrupts
US10358502B2 (en) 2014-12-18 2019-07-23 Siwa Corporation Product and method for treating sarcopenia
US9993535B2 (en) 2014-12-18 2018-06-12 Siwa Corporation Method and composition for treating sarcopenia
JP6444486B2 (ja) 2015-02-05 2018-12-26 モレキュラー テンプレーツ, インク.Molecular Templates, Inc. 志賀毒素ａサブユニットエフェクター領域を含む多価ｃｄ２０結合分子及びそれらの強化組成物
SI3303373T1 (sl) * 2015-05-30 2020-07-31 Molecular Templates, Inc. Deimunizirana ogrodja A podenot Shiga toksina in celice-ciljajoče molekule, ki jih obsegajo
MX2018001208A (es) * 2015-07-26 2018-03-26 Molecular Templates Inc Moleculas con direccion a las celulas que comprenden efectores de la subunidad a de la toxina shiga y epitopos de celulas-t cd8+.
EP3677598B1 (en) 2016-02-19 2022-04-06 Siwa Corporation Method and composition for treating cancer, killing metastatic cancer cells and preventing cancer metastasis using antibody to advanced glycation end products (age)
EP4276114A3 (en) * 2016-03-07 2024-02-21 Vib Vzw Cd20 binding single domain antibodies
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