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KR890701088A - 이식, 캡슐화된 세포에 의한 신경전달체의 생물체내 출생 방법과 기구 - Google Patents

이식, 캡슐화된 세포에 의한 신경전달체의 생물체내 출생 방법과 기구

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KR890701088A
KR890701088A KR1019890701324A KR890701324A KR890701088A KR 890701088 A KR890701088 A KR 890701088A KR 1019890701324 A KR1019890701324 A KR 1019890701324A KR 890701324 A KR890701324 A KR 890701324A KR 890701088 A KR890701088 A KR 890701088A
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neurotransmitter
cells
membrane
cell incubator
tissue
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KR0139223B1 (en
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애비셔 패트릭
알.윈 셀리
엠.갈리티 피에르
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원본미기재
브라운 유니버시티 리서치 파운데이션
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Abstract

내용 없음

Description

이식, 캡슐화된 세포에 의한 신경전달체의 생물체내 출생 방법과 기구
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제 1 도는 본 발명의 한 특징에 따라, 신경전달체를 출생시키기 위한 이식 가능한 세포 배양기를 예시한 개략도, 제 2 도는 본 발명의 다른 특징에 따라, 신경전달체를 출생시키기 위한 이식 가능한 세포 배양기를 예시한 개략도, 제 3 도는 본 발명의 또 다른 특징에 따라, 신경전달체를 출생시키기 위한 이식, 회복과 재관리 가능한 세포의 배양기를 예시한 개략도.

Claims (24)

  1. 신경전달체를 확산시키는 반면에 외주변에 존재하는 바이러스, 항체와 유해물을 차단하는 반투과성 막내에서 최소한 하나의 신경전달체 - 분비 세포를 캡슐화하는 단계 : 이 캡슐화된 세포를 환자의 표적 부분에 이식하는 단계로 이루어짐을 특징으로 하는 환자의 표적 부분에 신경전달체를 출생시키는 방법.
  2. 제 1 항에 있어서, 상기 캡슐화 단계에, 약 50,000 돌턴 이하의 분자량을 갖는 용질을 확산시키는 반투과성 막내에 상기 신경전달체 - 분비 세포를 더 배치함을 특징으로 하는 방법.
  3. 제 1 항에 있어서, 아크릴 공중합체, 폴리비닐리덴 플루오라이드, 폴리우레탄 이소시아네이트, 폴리알기네이트, 초산 셀루로오즈, 폴리술폰, 폴리비닐 알코올, 폴리 아크릴 니트릴과 이들의 유도체와 혼합물에서 선택한 물질로 구성된 상기 반투과성 막 내에 신경전달체 - 분비 세포를 상기 캡슐화단계에 더 배치함을 특징으로 하는 방법.
  4. 제 1 항에 있어서, 환자로부터 기구를 제거할 수 있는 회복성, 비흡수성과 생물학적 양립성 도가선에 상기 반투과성 막을 부착하여 상기 이식단계를 역으로 함을 특징으로 하는 단계.
  5. 제 4 항에 있어서, 세포를 추출할 수 있도록 이동할 수 있게 부착된 캡 요소를 갖는 첫째 단부와 둘째 단부를 갖는 관형으로 된 회복형의 막 내에 신경전달체 - 분비 세포를 상기 캡슐화 단계에 더 배치함을 특징으로 하는 방법.
  6. 제 1 항에 있어서, 상기 캡슐화 단계에서, 신경전달체가 도파민이고, 신경전달체 - 분비 세포를 부신수질 조직, 복부 중뇌 배아 조직과 신경체 조직에서 선택한 신경전달체 - 분비 세포내에서 상기 막을 더 배치함을 특징으로 하는 방법
  7. 제 1 항에 있어서, 캡슐화 단계에서, 전구물질, 아날로그, 아고니스트, 이의 유도체와 신경전달체 활성을 갖는 신경전달체의 단편중 하나를 분비하는 세포를 상기 막내에 더 배치함을 특징으로 하는 방법
  8. 제 7 항에 있어서, 신경전달체가 도파민이고, 전구물질이 L - 도파임을 특징으로 하는 방법.
  9. 제 7 항에 있어서, 신경전달체가 도파민이고, 아날로그가 브로모 크립틴임을 특징으로 하는 방법.
  10. 제 1 항에 있어서, 상기 캡슐화 단계에서, 세포가 동종 이식 조직인, 신경전달체 - 분비 세포를 상기 막내에 더 배치함을 특징으로 하는 방법
  11. 제 1 항에 있어서, 캡슐화 단계에서, 세포가 이종 이식 조직인, 신경전달체 - 분비 세포를 상기 막내에 더 배치함을 특징으로 하는 방법
  12. 제 1 항에 있어서, 상기 이식 단계에서, 표적 부분이 뇌인 환자의 표적 부분에 캡슐화된 신경전달체 - 분비 세포를 더 이식시킴을 특징으로 하는 방법.
  13. 신경전달체를 확산시키는 반면에 외주변에 존재하는 바이러스, 항체와 유해물을 차단하는 반투과성막: 막내에서 최소한 하나의 신경전달체 - 분비 세포로 이루어짐을 특징으로 하는, 환자에게 신경전달체를 구조적으로 출생시키기 위하여 환자내에 이식하는 세포배양기.
  14. 제13항에 있어서, 반투과성 막이 약 50,000 돌턴 이하의 분자량을 갖는 용질을 투과할 수 있음을 특징으로 하는 세포 배양기.
  15. 제13항에 있어서, 반투과성 막이 아크릴 공중합체, 폴리비닐리덴 플루오라이드, 폴리우레탄 이소시아네이트, 폴리 알기네이트, 초산 셀루로오즈, 폴리술폰, 폴리비닐 알코올, 폴리아크릴니트릴과 이들의 유도체 및 혼합물에서 선택한 물질로 이루어짐을 특징으로 하는 세포 배양기.
  16. 제13항에 있어서, 신경전달체 - 생성 세포가 동종 이식 조직으로 더 이루어짐을 특징으로 하는 세포 배양기.
  17. 제13항에 있어서, 신경전달체 - 생성 세포가 이종 이식 조직으로 더 이루어짐을 특징으로 하는 세포 배양기.
  18. 제13항에 있어서, 상기 신경전달체가 도파민이고, 상기 신경전달체 - 분비 세포를 부신 수질 조직, 복부 중뇌 배아 조직과 신경체 조직에서 선택함을 특징으로 하는 세포 배양기.
  19. 제13항에 있어서, 신경전달체를 아고니스트, 전구물질, 아날로그, 이의 유도체와 신경전달체 활성을 갖는 신경전달체의 단편에서 선택함을 특징으로 하는 세포 배양기.
  20. 제19항에 있어서, 상기 신경전달체 전구물질이 L - 도파임을 특징으로 하는 세포 배양기.
  21. 제19항에 있어서, 상기 신경전달체 아날로그가 브로모 크립틴임을 특징으로 하는 세포 배양기.
  22. 제13항에 있어서, 환자로부터 상기 배양기를 제거할 수 있도록, 상기 반투과성 막에 부착된 회복성, 비흡수성과 생물학적 양립성도가선으로 이루어짐을 특징으로 하는 세포 배양기.
  23. 제13항에 있어서, 반투과성 막이 역으로 부착되는 캡 요소를 갖는 최소한 하나의 단부를 갖는, 관형임을 특징으로 하는 세포 배양기.
  24. 제22항에 있어서, 신경전달체 - 분비 세포가 이동형의 상기 반투과성 막내에 배치되고, 이 막이, 상기 세포를 추출할 수 있도록, 이에 역으로 부착된 캡 요소를 갖는 하나의 단부를 갖는 관형임을 특징으로 하는 세포 배양기.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR89701324A 1987-11-17 1989-07-14 -i(in vivo)delivery of neurotransmitters by implanted, encapsulated cells Expired - Fee Related KR0139223B1 (en)

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US07/121,626 US4892538A (en) 1987-11-17 1987-11-17 In vivo delivery of neurotransmitters by implanted, encapsulated cells
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Families Citing this family (416)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048729A (en) 1987-05-01 2000-04-11 Transkaryotic Therapies, Inc. In vivo protein production and delivery system for gene therapy
US5283187A (en) * 1987-11-17 1994-02-01 Brown University Research Foundation Cell culture-containing tubular capsule produced by co-extrusion
US5773286A (en) * 1987-11-17 1998-06-30 Cytotherapeutics, Inc. Inner supported biocompatible cell capsules
US5418154A (en) * 1987-11-17 1995-05-23 Brown University Research Foundation Method of preparing elongated seamless capsules containing biological material
US5871472A (en) * 1987-11-17 1999-02-16 Brown University Research Foundation Planting devices for the focal release of neuroinhibitory compounds
US5182111A (en) * 1987-11-17 1993-01-26 Boston University Research Foundation In vivo delivery of active factors by co-cultured cell implants
US5106627A (en) * 1987-11-17 1992-04-21 Brown University Research Foundation Neurological therapy devices
US5158881A (en) * 1987-11-17 1992-10-27 Brown University Research Foundation Method and system for encapsulating cells in a tubular extrudate in separate cell compartments
US5786216A (en) * 1987-11-17 1998-07-28 Cytotherapeutics, Inc. Inner-supported, biocompatible cell capsules
US5487739A (en) 1987-11-17 1996-01-30 Brown University Research Foundation Implantable therapy systems and methods
ATE121954T1 (de) * 1988-08-24 1995-05-15 Marvin J Slepian Endoluminale dichtung mit bisdegradierbaren polymeren.
US5011472A (en) * 1988-09-06 1991-04-30 Brown University Research Foundation Implantable delivery system for biological factors
CA2062746C (en) * 1989-06-21 1999-02-02 Patrick Aebischer Neurological therapy system
WO1991000119A1 (en) * 1989-06-30 1991-01-10 Baxter International Inc. Implantable device
US5100392A (en) * 1989-12-08 1992-03-31 Biosynthesis, Inc. Implantable device for administration of drugs or other liquid solutions
US5843892A (en) * 1989-12-18 1998-12-01 California Institute Of Technology Stimulation of nerve growth and/or vitality
US5269785A (en) * 1990-06-28 1993-12-14 Bonutti Peter M Apparatus and method for tissue removal
US5618531A (en) 1990-10-19 1997-04-08 New York University Method for increasing the viability of cells which are administered to the brain or spinal cord
CA2094280C (en) * 1990-10-19 2003-07-29 Bruce D. Cherksey A method for transplanting cells into the brain and therapeutic uses therefor
US5713888A (en) * 1990-10-31 1998-02-03 Baxter International, Inc. Tissue implant systems
US5545223A (en) * 1990-10-31 1996-08-13 Baxter International, Inc. Ported tissue implant systems and methods of using same
JP3508023B2 (ja) * 1990-10-31 2004-03-22 バクスター、インターナショナル、インコーポレイテッド 密接血管化埋め込み材料
US5314471A (en) * 1991-07-24 1994-05-24 Baxter International Inc. Tissue inplant systems and methods for sustaining viable high cell densities within a host
US5344454A (en) * 1991-07-24 1994-09-06 Baxter International Inc. Closed porous chambers for implanting tissue in a host
US5222982A (en) * 1991-02-11 1993-06-29 Ommaya Ayub K Spinal fluid driven artificial organ
CA2103705C (en) * 1991-02-11 1996-01-30 Ayub K. Ommaya Spinal fluid driven artificial organ
EP0585368B1 (en) * 1991-04-25 1997-08-06 Brown University Research Foundation Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products
US5800829A (en) * 1991-04-25 1998-09-01 Brown University Research Foundation Methods for coextruding immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core
AU664848B2 (en) * 1991-05-21 1995-12-07 Brown University Research Foundation Apparatus for forming hollow fibers and said fibers
US5800390A (en) * 1991-05-24 1998-09-01 Sumitomo Pharmaceuticals Company, Limited Equipment for intracerebral administration of preparations
JPH06502120A (ja) * 1991-06-28 1994-03-10 ブラウン　ユニバーシティ　リサーチ　ファウンデイション カプセル押し出しシステム
US5232712A (en) * 1991-06-28 1993-08-03 Brown University Research Foundation Extrusion apparatus and systems
US6773458B1 (en) * 1991-07-24 2004-08-10 Baxter International Inc. Angiogenic tissue implant systems and methods
US5453278A (en) * 1991-07-24 1995-09-26 Baxter International Inc. Laminated barriers for tissue implants
US6503277B2 (en) 1991-08-12 2003-01-07 Peter M. Bonutti Method of transplanting human body tissue
EP0610254B1 (en) * 1991-09-20 2004-09-01 Amgen Inc. Glial derived neurotrophic factor
US20040175795A1 (en) * 1991-09-20 2004-09-09 Amgen Inc. Glial derived neurotrophic factor
JP3252361B2 (ja) * 1991-10-02 2002-02-04 ミルトン・エイチ・リプスキー インビボにおける癌の治療のアッセイ
US5792900A (en) * 1991-10-21 1998-08-11 The Trustees Of The University Of Pennsylvania Compositions and methods for producing and using homogenous neuronal cell transplants
US6692737B1 (en) 1991-11-05 2004-02-17 Transkaryotic Therapies, Inc. In vivo protein production and delivery system for gene therapy
US6054288A (en) * 1991-11-05 2000-04-25 Transkaryotic Therapies, Inc. In vivo protein production and delivery system for gene therapy
US6270989B1 (en) 1991-11-05 2001-08-07 Transkaryotic Therapies, Inc. Protein production and delivery
US5733761A (en) * 1991-11-05 1998-03-31 Transkaryotic Therapies, Inc. Protein production and protein delivery
PT101031B (pt) 1991-11-05 2002-07-31 Transkaryotic Therapies Inc Processo para o fornecimento de proteinas por terapia genetica
US6063630A (en) * 1991-11-05 2000-05-16 Transkaryotic Therapies, Inc. Targeted introduction of DNA into primary or secondary cells and their use for gene therapy
WO1993022360A1 (en) * 1992-04-24 1993-11-11 The Polymer Technology Group, Inc. Copolymers and non-porous, semi-permeable membrane thereof and its use for permeating molecules of predetermined molecular weight range
JPH07509694A (ja) * 1992-05-14 1995-10-26 ベイラー・カレッジ・オブ・メディシン 突然変異したステロイドホルモン受容体，その使用方法および遺伝子治療のための分子スイッチ
DE69330640T2 (de) * 1992-05-29 2002-07-04 Vivorx, Inc. Mikroverkapselung von zellen
US6531124B1 (en) 1992-07-10 2003-03-11 Transkaryotic Therapies, Inc. In vivo production and delivery of insulinotropin for gene therapy
US6670178B1 (en) 1992-07-10 2003-12-30 Transkaryotic Therapies, Inc. In Vivo production and delivery of insulinotropin for gene therapy
US5871985A (en) * 1992-09-28 1999-02-16 Brown University Research Foundation Particulate non cross-linked chitosan core matrices for encapsulated cells
CA2144059A1 (en) * 1992-09-28 1994-04-14 Patrick Aebischer Chitosan matrices for encapsulated cells
US5383873A (en) * 1992-12-09 1995-01-24 Regents Of The University Of Minnesota Smooth muscle chemical pacemaker
US5753491A (en) * 1993-04-13 1998-05-19 Us Health Use of neuro-derived fetal cell lines for transplantation therapy
AU690548B2 (en) * 1993-04-13 1998-04-30 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Use of neuro-derived fetal cell lines for transplantation therapy
DE69423522T2 (de) * 1993-04-27 2000-09-21 Cytotherapeutics, Inc. Membran aus einem acrylnitrilpolymer
US5698413A (en) * 1993-05-05 1997-12-16 The United States Of America As Represented By The Department Of Health And Human Services Method of evaluating chemotherapeutic agents in vivo
CA2166116A1 (en) * 1993-06-23 1995-01-12 John F. Mills Method and apparatus for sealing implantable, membrane encapsulation devices
DE69433970T2 (de) * 1993-08-10 2005-08-11 W.L. Gore & Associates, Inc., Newark Zelleinkapselungsvorrichtung
ES2178654T3 (es) * 1993-08-12 2003-01-01 Neurotech Sa Capsulas biocompatibles inmonoaisladoras que contienen celulas geneticamente alteradas para el suministro de moleculas biologicamente activas.
US5908623A (en) 1993-08-12 1999-06-01 Cytotherapeutics, Inc. Compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules
EP0716614A4 (en) * 1993-09-03 1998-02-04 Us Health TREATMENT OF HUMAN TUMORS BY GENETIC TRANSFORMATION OF HUMAN TUMORS
CA2148354A1 (en) * 1993-09-24 1995-03-30 Laura A. Martinson Methods for enhancing vascularization of implant devices
CA2176216A1 (en) * 1993-11-09 1995-05-18 Virginia M.-Y. Lee Compositions and methods for producing and using homogeneous neuronal cell transplants
US5550050A (en) * 1994-04-15 1996-08-27 Cytotherapeutics, Inc. Method for implanting encapsulated cells in a host
US6156305A (en) * 1994-07-08 2000-12-05 Baxter International Inc. Implanted tumor cells for the prevention and treatment of cancer
JPH10503105A (ja) * 1994-07-22 1998-03-24 ユニバーシティ オブ ワシントン 定位固定移植方法
US20030157074A1 (en) * 1994-11-16 2003-08-21 Mitrani Eduardo N. Vitro micro-organs, and uses related thereto
US20030152909A1 (en) * 1994-11-16 2003-08-14 Mitrani Eduardo N. In vitro micro-organs, and uses related thereto
JPH10513471A (ja) 1995-02-10 1998-12-22 メドトロニック、インコーポレイテッド 鎮痛薬投与のための方法と装置
WO1996032076A1 (en) * 1995-04-11 1996-10-17 Baxter Internatonal Inc. Tissue implant systems
US7069634B1 (en) 1995-04-28 2006-07-04 Medtronic, Inc. Method for manufacturing a catheter
AU5545596A (en) * 1995-04-28 1996-11-18 Medtronic, Inc. Intraparenchymal infusion catheter system
US6132463A (en) 1995-05-19 2000-10-17 Etex Corporation Cell seeding of ceramic compositions
US6060640A (en) * 1995-05-19 2000-05-09 Baxter International Inc. Multiple-layer, formed-in-place immunoisolation membrane structures for implantation of cells in host tissue
US5704910A (en) 1995-06-05 1998-01-06 Nephros Therapeutics, Inc. Implantable device and use therefor
US5681740A (en) * 1995-06-05 1997-10-28 Cytotherapeutics, Inc. Apparatus and method for storage and transporation of bioartificial organs
US5837234A (en) * 1995-06-07 1998-11-17 Cytotherapeutics, Inc. Bioartificial organ containing cells encapsulated in a permselective polyether suflfone membrane
AU6854696A (en) * 1995-09-22 1997-04-09 Gore Hybrid Technologies, Inc. Improved cell encapsulation device
US6184200B1 (en) 1995-09-28 2001-02-06 Amgen Inc. Truncated glial cell line-derived neurotrophic factor
US5731284A (en) * 1995-09-28 1998-03-24 Amgen Inc. Method for treating Alzheimer's disease using glial line-derived neurotrophic factor (GDNF) protein product
US5855613A (en) 1995-10-13 1999-01-05 Islet Sheet Medical, Inc. Retrievable bioartificial implants having dimensions allowing rapid diffusion of oxygen and rapid biological response to physiological change
ATE297702T1 (de) * 1995-10-26 2005-07-15 Paul P Latta Induktion von immunologischer toleranz
US5641750A (en) * 1995-11-29 1997-06-24 Amgen Inc. Methods for treating photoreceptors using glial cell line-derived neurotrophic factor (GDNF) protein product
US5641749A (en) * 1995-11-29 1997-06-24 Amgen Inc. Method for treating retinal ganglion cell injury using glial cell line-derived neurothrophic factor (GDNF) protein product
US6110707A (en) * 1996-01-19 2000-08-29 Board Of Regents, The University Of Texas System Recombinant expression of proteins from secretory cell lines
US6087129A (en) 1996-01-19 2000-07-11 Betagene, Inc. Recombinant expression of proteins from secretory cell lines
US5741778A (en) * 1996-03-19 1998-04-21 Amgen Inc. Method for treating Huntington's disease using glial cell line-derived neurotrophic factor (GDNF) protein product
US7138251B1 (en) * 1996-04-22 2006-11-21 Amgen Inc. Polynucleotides encoding a neurotrophic factor receptor
US6455277B1 (en) * 1996-04-22 2002-09-24 Amgen Inc. Polynucleotides encoding human glial cell line-derived neurotrophic factor receptor polypeptides
US6027721A (en) * 1996-05-20 2000-02-22 Cytotherapeutics, Inc. Device and method for encapsulated gene therapy
EP0938556B1 (en) * 1996-07-12 2005-03-09 Genentech, Inc. Gamma-heregulin
IL127892A0 (en) * 1996-07-12 1999-10-28 Genentech Inc Gamma-heregulin
US6054142A (en) 1996-08-01 2000-04-25 Cyto Therapeutics, Inc. Biocompatible devices with foam scaffolds
US6200589B1 (en) 1996-09-13 2001-03-13 The University Of Akron Biological implants of semipermeable amphiphilic membranes
AUPO251096A0 (en) 1996-09-23 1996-10-17 Cardiac Crc Nominees Pty Limited Polysiloxane-containing polyurethane elastomeric compositions
US8728536B2 (en) * 1996-10-16 2014-05-20 Etex Corporation Chemotherapeutic composition using nanocrystalline calcium phosphate paste
US6156728A (en) * 1996-11-01 2000-12-05 Genentech, Inc. Treatment of inner ear hair cells
US6593290B1 (en) 1996-11-01 2003-07-15 Genentech, Inc. Treatment of inner ear hair cells
WO1998024477A1 (en) 1996-12-06 1998-06-11 Amgen Inc. Combination therapy using an il-1 inhibitor for treating il-1 mediated diseases
AUPO431596A0 (en) 1996-12-20 1997-01-23 Scientec Research Pty Ltd Apparatus and method for coating a material
HK1045171A1 (zh) 1997-01-16 2002-11-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem 进行一种液体的生物学上改良的装置及方法
US6547787B1 (en) 1997-03-13 2003-04-15 Biocardia, Inc. Drug delivery catheters that attach to tissue and methods for their use
US6416510B1 (en) 1997-03-13 2002-07-09 Biocardia, Inc. Drug delivery catheters that attach to tissue and methods for their use
WO1999047677A2 (en) 1998-03-17 1999-09-23 Genentech, Inc. Polypeptides homologous to vegf and bmp1
US6128537A (en) * 1997-05-01 2000-10-03 Medtronic, Inc Techniques for treating anxiety by brain stimulation and drug infusion
EP0923640A1 (en) * 1997-05-07 1999-06-23 Neuralstem Biopharmaceuticals Embryonic and adult cns stem cells
US6272370B1 (en) 1998-08-07 2001-08-07 The Regents Of University Of Minnesota MR-visible medical device for neurological interventions using nonlinear magnetic stereotaxis and a method imaging
US6026316A (en) * 1997-05-15 2000-02-15 Regents Of The University Of Minnesota Method and apparatus for use with MR imaging
US6061587A (en) * 1997-05-15 2000-05-09 Regents Of The University Of Minnesota Method and apparatus for use with MR imaging
US7048716B1 (en) 1997-05-15 2006-05-23 Stanford University MR-compatible devices
AU7977198A (en) 1997-06-17 1999-01-04 University Technology Corporation Neural transplantation for treating neurological disease
US6121415A (en) 1997-07-09 2000-09-19 Genentech, Inc. ErbB4 receptor-specific neuregolin related ligands and uses therefor
ZA986077B (en) 1997-07-09 2000-01-10 Genentech Inc ErbB4 receptor-specific neuregulin related ligands and uses therefor.
US6994856B1 (en) * 1997-07-24 2006-02-07 Genentech, Inc. ErbB4 receptor-specific neuregulin related ligands and uses therefor
DE69838584T2 (de) 1997-08-04 2008-06-26 Cell Genesys, Inc., Foster City Enhancer des menschlichen glandulären kallikreingens, vektoren die ihn enthalten und methoden für seine verwendung
US6030358A (en) * 1997-08-08 2000-02-29 Odland; Rick Matthew Microcatheter and method for site specific therapy
US6042909A (en) * 1997-09-03 2000-03-28 Circe Biomedical, Inc. Encapsulation device
GB2329840C (en) * 1997-10-03 2007-10-05 Johnson & Johnson Medical Biopolymer sponge tubes
US7687057B2 (en) 1998-01-09 2010-03-30 Yissum Research Development Company Of The Hebrew University Of Jerusalem In vitro micro-organs, and uses related thereto
US7157083B2 (en) * 1998-04-17 2007-01-02 Surrogate Pharmaceutical Pathways, Llc Compositions and methods for treating retroviral infections
US6463317B1 (en) 1998-05-19 2002-10-08 Regents Of The University Of Minnesota Device and method for the endovascular treatment of aneurysms
US5973119A (en) 1998-06-05 1999-10-26 Amgen Inc. Cyclin E genes and proteins
US6787356B1 (en) 1998-07-24 2004-09-07 The United States Of America As Represented By The Department Of Health And Human Services Cell expansion system for use in neural transplantation
US6344541B1 (en) 1998-09-25 2002-02-05 Amgen Inc. DKR polypeptides
US6291516B1 (en) 1999-01-13 2001-09-18 Curis, Inc. Regulators of the hedgehog pathway, compositions and uses related thereto
US6303749B1 (en) 1999-01-29 2001-10-16 Amgen Inc. Agouti and agouti-related peptide analogs
US7708993B2 (en) * 1999-02-03 2010-05-04 Amgen Inc. Polypeptides involved in immune response
US8624010B1 (en) 1999-02-03 2014-01-07 Steven K. Yoshinaga Nucleic acids encoding B7RP1
US7435796B1 (en) 1999-02-03 2008-10-14 Amgen Inc. Antibodies which bind B7RP1
EP2332978B1 (en) 1999-02-03 2014-04-02 Amgen, Inc Novel polypeptides involved in immune response
JP2003518914A (ja) 1999-02-10 2003-06-17 キュリス インコーポレイテッド グルコース代謝障害を治療する方法および試薬
US7745216B2 (en) * 1999-02-10 2010-06-29 Curis, Inc. Methods and reagents for treating glucose metabolic disorders
AU3770800A (en) 1999-03-26 2000-10-16 Amgen, Inc. Beta secretase genes and polypeptides
US20070071734A1 (en) * 1999-04-06 2007-03-29 Weng Tao ARPE-19 as platform cell line for encapsulated cell-based delivery
US6361771B1 (en) 1999-04-06 2002-03-26 Neurotech S.A. ARPE-19 as a platform cell line for encapsulated cell-based delivery
US6109269A (en) * 1999-04-30 2000-08-29 Medtronic, Inc. Method of treating addiction by brain infusion
US6176242B1 (en) 1999-04-30 2001-01-23 Medtronic Inc Method of treating manic depression by brain infusion
EP1374889A1 (en) * 1999-06-25 2004-01-02 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of inducing angiogenesis by micro-organs
PL204629B1 (pl) 1999-06-25 2010-01-29 Genentech Inc Zastosowanie przeciwciała do wytwarzania leku do leczenia raka sutka, zastosowanie przeciwciała do leczenia raka jajnika, zastosowanie przeciwciała do wytwarzania leku do leczenia raka płuc i zastosowanie przeciwciała do leczenia raka okrężnicy, raka odbytnicy i raka jelita grubego i odbytu
US7459540B1 (en) * 1999-09-07 2008-12-02 Amgen Inc. Fibroblast growth factor-like polypeptides
US7408047B1 (en) * 1999-09-07 2008-08-05 Amgen Inc. Fibroblast growth factor-like polypeptides
US20030103978A1 (en) 2000-02-23 2003-06-05 Amgen Inc. Selective binding agents of osteoprotegerin binding protein
US20050239061A1 (en) * 2000-03-01 2005-10-27 Marshall William S Identification and use of effectors and allosteric molecules for the alteration of gene expression
TWI322154B (en) 2000-03-16 2010-03-21 Amgen Inc Il-17 receptor like molecules and uses thereof
US7514239B2 (en) 2000-03-28 2009-04-07 Amgen Inc. Nucleic acid molecules encoding beta-like glycoprotein hormone polypeptides and heterodimers thereof
US20050070578A1 (en) * 2000-03-30 2005-03-31 Baxter Anthony David Small organic molecule regulators of cell proliferation
US6683108B1 (en) * 2000-03-30 2004-01-27 Curis, Inc. Agonists of hedgehog signaling pathways and uses related thereto
US7115653B2 (en) * 2000-03-30 2006-10-03 Curis, Inc. Small organic molecule regulators of cell proliferation
US8852937B2 (en) * 2000-03-30 2014-10-07 Curis, Inc. Small organic molecule regulators of cell proliferation
US6613798B1 (en) 2000-03-30 2003-09-02 Curis, Inc. Small organic molecule regulators of cell proliferation
US6478776B1 (en) 2000-04-05 2002-11-12 Biocardia, Inc. Implant delivery catheter system and methods for its use
DK2857516T3 (en) 2000-04-11 2017-08-07 Genentech Inc Multivalent antibodies and uses thereof
JP2004512262A (ja) 2000-06-20 2004-04-22 アイデック　ファーマスーティカルズ　コーポレイション 非放射性抗ｃｄ２０抗体／放射標識抗ｃｄ２２抗体の組合せ
EP2042597B1 (en) 2000-06-23 2014-05-07 Genentech, Inc. Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
EP2168980A1 (en) 2000-06-23 2010-03-31 Genentech, Inc. Compositions and methods for the diagnosis and treatment of disorders involving angiogensis
US20090209831A1 (en) * 2000-06-28 2009-08-20 Nexgen Medical Systems, Incorporated Imaging methods for visualizing implanted living cells
MXPA02012718A (es) * 2000-06-28 2003-10-06 Amgen Inc Moleculas semejantes a b7 y sus usos.
US7964713B2 (en) 2000-06-28 2011-06-21 Amgen Inc. Nucleic acid molecules encoding thymic stromal lympopoietin receptor proteins and a process for producing the encoded polypeptides thereof
EP1978090A1 (en) 2000-08-09 2008-10-08 ES Cell International Pte Ltd. Pancreatic progenitor cells
US6908732B2 (en) 2000-10-13 2005-06-21 President & Fellows Of Harvard College Compounds and methods for regulating cell differentiation
US6871098B2 (en) * 2000-10-30 2005-03-22 Medtronic, Inc. Method for treating obsessive-compulsive disorder with electrical stimulation of the brain internal capsule
ES2536653T3 (es) 2000-11-28 2015-05-27 Amgen Inc. Polipéptidos implicados en la respuesta inmunitaria
MXPA03005388A (es) * 2000-12-14 2003-09-25 Amylin Pharmaceuticals Inc Peptido yy y agonistas de peptido yy para el tratamiento de desordenes metabolicos.
CZ298160B6 (cs) * 2001-01-18 2007-07-11 Prístroj pro vyvolání imunitní odezvy pri lécbe rakoviny
US20020159996A1 (en) 2001-01-31 2002-10-31 Kandasamy Hariharan Use of CD23 antagonists for the treatment of neoplastic disorders
EP3246396B1 (en) * 2001-02-14 2020-01-29 Celularity, Inc. Renovation and repopulation of decellularized tissues and cadaveric organs by stem cells
KR100788092B1 (ko) 2001-06-20 2007-12-21 제넨테크, 인크. 종양의 진단 및 치료를 위한 방법 및 이를 위한 조성물
EP1414517A4 (en) * 2001-06-26 2008-02-06 Photomed Technologies Inc MULTIPLE WAVELENGTH ILLUMINATOR
CN103232539B (zh) 2001-06-26 2015-06-03 安姆根弗里蒙特公司 抗opgl抗体
WO2003006669A2 (en) * 2001-07-09 2003-01-23 Yissum Research Development Company Of The Hebrew University Of Jerusalem Efficient methods for assessing and validating candidate protein-based therapeutic molecules encoded by nucleic acid sequences of interest
EP1639972B1 (en) 2001-08-01 2013-09-11 Anecova SA Intrauterine device
EP2382982A3 (en) 2001-08-24 2012-02-22 Neuren Pharmaceuticals Limited Neural regeneration peptide and methods for their use in treatment of brain damage
US20040235068A1 (en) * 2001-09-05 2004-11-25 Levinson Arthur D. Methods for the identification of polypeptide antigens associated with disorders involving aberrant cell proliferation and compositions useful for the treatment of such disorders
EP2143438B1 (en) 2001-09-18 2011-07-13 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumors
US8088568B2 (en) 2001-11-05 2012-01-03 Medgentics, Inc. Dermal micro-organs, methods and apparatuses for producing and using the same
US7468242B2 (en) * 2001-11-05 2008-12-23 Medgenics, Inc. Dermal micro organs, methods and apparatuses for producing and using the same
US8501396B2 (en) 2001-11-05 2013-08-06 Medgenics Medical Israel Ltd. Dermal micro-organs, methods and apparatuses for producing and using the same
US6758828B2 (en) 2001-12-10 2004-07-06 Regents Of The University Of Minnesota Catheter for cell delivery in tissue
EP2067472A1 (en) 2002-01-02 2009-06-10 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
WO2003072738A2 (en) * 2002-02-22 2003-09-04 Board Of Trustees Of The University Of Illinois Beta chain-associated regulator of apoptosis
US7662924B2 (en) * 2002-02-22 2010-02-16 The Board Of Trustees Of The University Of Illinois Beta chain-associated regulator of apoptosis
JP4761710B2 (ja) * 2002-04-05 2011-08-31 アムジェン インコーポレイテッド 選択的ｏｐｇｌ経路インヒビターとしてのヒト抗ｏｐｇｌ中和抗体
AU2003230874A1 (en) 2002-04-16 2003-11-03 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
US7655674B2 (en) 2002-04-22 2010-02-02 The Johns Hopkins University Modulators of hedgehog signaling pathways, compositions and uses related thereto
EP2305710A3 (en) 2002-06-03 2013-05-29 Genentech, Inc. Synthetic antibody phage libraries
EP1531676B1 (en) 2002-06-05 2015-07-22 Genentech, Inc. Compositions and methods for liver growth and liver protection
WO2003103725A1 (en) * 2002-06-07 2003-12-18 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
WO2003105763A2 (en) * 2002-06-14 2003-12-24 Amylin Pharmaceuticals, Inc. Prevention and/or treatment of inflammatory bowel disease using pyy or agonists thereof
EP1534345A4 (en) * 2002-07-12 2012-03-21 Yissum Res Dev Co METHOD AND DEVICE FOR INDUCING BIOLOGICAL PROCESSES WITH MICROORGANISMS
ES2392525T3 (es) 2002-07-15 2012-12-11 F. Hoffmann-La Roche Ag Tratamiento del cáncer con el anticuerpo dirigido contra ErbB2 rhuMAb 2C4
US20040176291A1 (en) * 2002-09-24 2004-09-09 Elly Nedivi Methods and compositions for soluble CPG15
AU2003291002A1 (en) 2002-11-15 2004-06-15 Chiron Corporation Methods for preventing and treating cancer metastasis and bone loss associated with cancer metastasis
WO2004096124A2 (en) 2003-04-01 2004-11-11 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
RU2358762C9 (ru) 2003-04-09 2016-10-10 Джинентех, Инк. Лечение аутоиммунных заболеваний у пациента с неадекватным ответом на ингибитор tnf-альфа
WO2004091435A2 (en) * 2003-04-11 2004-10-28 Etex Corporation Osteoinductive bone material
US7241283B2 (en) * 2003-04-25 2007-07-10 Ad-Tech Medical Instrument Corp. Method for intracranial catheter treatment of brain tissue
JP5128813B2 (ja) 2003-05-01 2013-01-23 メドジニックス・インコーポレイテッド 真皮小器官及びそれを作成及び使用するための方法及び器具
AU2004239301B2 (en) 2003-05-09 2010-08-19 Diadexus, Inc. OVR110 antibody compositions and methods of use
AU2004265226A1 (en) * 2003-05-16 2005-02-24 Receptor Biologix, Inc. Intron fusion proteins, and methods of identifying and using same
WO2005000896A2 (en) * 2003-05-30 2005-01-06 Genentech, Inc. Polypeptides that bind an anti-tissue factor antibody and uses thereof
US7601518B2 (en) 2003-06-10 2009-10-13 Nsgene A/S Secretion of neublastin
CA2432810A1 (en) 2003-06-19 2004-12-19 Andres M. Lozano Method of treating depression, mood disorders and anxiety disorders by brian infusion
US8501473B2 (en) 2003-07-16 2013-08-06 Evotec International Gmbh Use of pleitrophin for preventing and treating pancreatic diseases and/or obesity and/or metabolic syndrome
RU2370775C2 (ru) 2003-07-29 2009-10-20 Дженентек, Инк. Анализ нейтрализующих антител и его применение
JP4738337B2 (ja) 2003-09-12 2011-08-03 テルシカ インコーポレーティッド インスリン様成長因子−１（ｉｇｆ−１）欠損症の治療法
WO2005032476A2 (en) * 2003-09-30 2005-04-14 Massachusetts Institute Of Technology Methods and compositions for cpg15-2
MXPA06004329A (es) 2003-10-20 2006-06-05 Nsgene As Terapia genica in vivo de enfermedad de parkinson.
DK2161283T3 (da) 2003-11-17 2014-09-01 Genentech Inc SAMMENSÆTNINGER OMFATTENDE ANTISTOFFER MOD CD79b, SOM ER KONJUGERET TIL ET VÆKSTINHIBERENDE MIDDEL ELLER ET CYTOTOKSISK MIDDEL, OG FREMGANGSMÅDER TIL BEHANDLING AF TUMOR AF HÆMATOPOIETISK OPRINDELSE
RU2401277C2 (ru) 2004-01-07 2010-10-10 Чирон Корпорейшн Не мышиное анти-m-csf-антитело (варианты), его получение и использование
WO2005068498A2 (en) * 2004-01-19 2005-07-28 Nsgene A/S Human therapeutic cells secreting nerve growth factor
EP1789440A4 (en) 2004-02-11 2008-03-12 Amylin Pharmaceuticals Inc REASONS FOR THE FAMILY OF PANCREATIC POLYPEPTIDES AND POLYPEPTIDES CONTAINING THEM
ATE430763T1 (de) 2004-03-30 2009-05-15 Nsgene As Therapeutische verwendung des wachstumsfaktors nsg33
KR101218454B1 (ko) * 2004-04-15 2013-01-04 에텍스 코포레이션 세팅 지연 칼슘 포스페이트 페이스트
US20150017671A1 (en) 2004-04-16 2015-01-15 Yaping Shou Methods for detecting lp-pla2 activity and inhibition of lp-pla2 activity
WO2005115453A2 (en) * 2004-04-16 2005-12-08 Genentech, Inc. Treatment of polychondritis and mononeuritis multiplex with anti-cd20 antibodies
EP1750800A1 (en) * 2004-04-30 2007-02-14 Advanced Neuromodulation Systems, Inc. Method of treating mood disorders and/or anxiety disorders by brain stimulation
JP2008506366A (ja) * 2004-05-14 2008-03-06 レセプター バイオロジックス インコーポレイテッド 細胞表面受容体アイソフォームならびにその同定および使用方法
EP1753455A2 (en) 2004-06-04 2007-02-21 Genentech, Inc. Method for treating multiple sclerosis
US8410246B2 (en) 2004-06-17 2013-04-02 Thrasos, Inc. TDF-related compounds and analogs thereof
WO2006013462A2 (en) * 2004-07-30 2006-02-09 Nsgene A/S Growth factors nsg28, nsg30, and nsg32
US20070072294A1 (en) * 2004-09-30 2007-03-29 Doronin Sergey V Use of human stem cells and/or factors they produce to promote adult mammalian cardiac repair through cardiomyocyte cell division
JP2008515434A (ja) * 2004-10-08 2008-05-15 ジョージア テック リサーチ コーポレイション 静電ポテンシャルを用いたヒドロゲル中の細胞のマイクロカプセル化
JP2008515992A (ja) 2004-10-13 2008-05-15 ピーティーシー セラピューティクス，インコーポレーテッド 体細胞変異に起因する疾患の阻止／治療用医薬を製造するための規定化合物の使用
US7998930B2 (en) 2004-11-04 2011-08-16 Hanall Biopharma Co., Ltd. Modified growth hormones
WO2006074075A2 (en) * 2004-12-30 2006-07-13 Primegen Biotech, Llc Adipose-derived stem cells for tissue regeneration and wound healing
EP2230517A1 (en) 2005-01-07 2010-09-22 Diadexus, Inc. OVR110 antibody compositions and methods of use
US7713542B2 (en) * 2005-01-14 2010-05-11 Ada Foundation Three dimensional cell protector/pore architecture formation for bone and tissue constructs
UA94899C2 (ru) 2005-01-21 2011-06-25 Дженентек, Инк. Фиксированное дозирование антител к her
AU2006208226A1 (en) * 2005-01-24 2006-08-03 Amgen Inc. Humanized anti-amyloid antibody
EP1850874B1 (en) 2005-02-23 2013-10-16 Genentech, Inc. Extending time to disease progression or survival in ovarian cancer patients using pertuzumab
WO2006094072A2 (en) * 2005-03-01 2006-09-08 Functional Neuroscience Inc. Method of treating cognitive disorders using neuromodulation
CA2599959A1 (en) * 2005-03-01 2006-09-08 Functional Neuroscience Inc. Method of treating depression, mood disorders and anxiety disorders using neuromodulation
US20060204505A1 (en) * 2005-03-08 2006-09-14 Sliwkowski Mark X Methods for identifying tumors responsive to treatment with HER dimerization inhibitors (HDIs)
EP1869076A2 (en) 2005-03-10 2007-12-26 Genentech, Inc. Methods and compositions for modulating vascular integrity
CN103361302A (zh) 2005-03-31 2013-10-23 斯丹姆涅恩有限公司 从高度纯化来自羊膜的细胞群获得的细胞裂解产物的组合物
MX2007012155A (es) * 2005-04-01 2008-04-04 Nsgene As Linea celular precursora neural inmortalizada humana.
AU2006235695B2 (en) 2005-04-09 2011-10-13 Fusion Antibodies Limited Cathepsin S antibody
US20080207594A1 (en) 2005-05-04 2008-08-28 Davelogen Aktiengesellschaft Use of Gsk-3 Inhibitors for Preventing and Treating Pancreatic Autoimmune Disorders
US20070087406A1 (en) * 2005-05-04 2007-04-19 Pei Jin Isoforms of receptor for advanced glycation end products (RAGE) and methods of identifying and using same
US20060251619A1 (en) * 2005-05-04 2006-11-09 Gilles Borrelly Modified interferon-gamma polypeptides and methods for using modified interferon-gamma polypeptides
US20090170769A1 (en) * 2005-05-13 2009-07-02 Pei Jin Cell surface receptor isoforms and methods of identifying and using the same
NZ563313A (en) * 2005-05-17 2010-01-29 Nsgene As An implantable therapy system for treating a living being with an active factor
ES2335232T3 (es) 2005-06-21 2010-03-23 Xoma Technology Ltd. Anticuerpos y fragmentos de los mismos que se unen a la il-1 beta.
WO2007016285A2 (en) * 2005-07-28 2007-02-08 Novartis Ag M-csf specific monoclonal antibody and uses thereof
JP5657862B2 (ja) * 2005-07-28 2015-01-21 ノバルティス アーゲー Ｍ−ｃｓｆに対する抗体の使用
EP2428218A1 (en) 2005-10-21 2012-03-14 Catalyst Biosciences, Inc. Modified proteases that inhibit complement activation
US8986781B2 (en) * 2005-10-27 2015-03-24 Corning Incorporated Immobilized multi-layer artificial membrane for permeability measurements (PAMPA)
CA2627543A1 (en) * 2005-10-28 2007-05-03 Ns Gene A/S Implantable biocompatible immttnoisolatory vehicle for delivery of gdnf
BRPI0618488A2 (pt) * 2005-11-10 2011-08-30 Receptor Biologix Inc proteìnas de fusão de ìntron de fator de crescimento de hepatócito
US8147860B2 (en) 2005-12-06 2012-04-03 Etex Corporation Porous calcium phosphate bone material
DK1969003T3 (da) 2005-12-14 2010-12-13 Hermo Pharma Ltd Anvendelser af et neurotrofisk faktor-protein
WO2007078922A2 (en) 2005-12-30 2007-07-12 Neurotech Usa Inc. Micronized device for the delivery of biologically active molecules and methods of use thereof
US20090081296A1 (en) * 2006-02-02 2009-03-26 Humes H David Extracorporeal cell-based therapeutic device and delivery system
EP1989144A4 (en) 2006-02-02 2014-01-29 Innovative Bio Therapies EXTRACORPOREAL THERAPEUTIC DEVICE AND DELIVERY SYSTEM BASED ON CELLS
WO2007095113A2 (en) * 2006-02-10 2007-08-23 Massachusetts Institute Of Technology Cpg15 and cpg15-2 compounds and inhibitors as insulin receptor and insulin-like growth factor receptor agonists and antagonists
GB0604187D0 (en) * 2006-03-02 2006-04-12 Fusion Antibodies Ltd Peptide and uses thereof
AU2007227224A1 (en) 2006-03-23 2007-09-27 Novartis Ag Anti-tumor cell antigen antibody therapeutics
US20080003202A1 (en) * 2006-03-28 2008-01-03 Thierry Guyon Modified interferon-beta (IFN-beta) polypeptides
AU2007243946B2 (en) 2006-04-05 2012-11-29 Curis, Inc. Method for using BOC/CDO to modulate hedgehog signaling
MY157366A (en) * 2006-04-10 2016-05-31 Fusion Antibodies Ltd Therapies and compositions comprising cathepsin s antibodies
GB0620255D0 (en) * 2006-10-12 2006-11-22 Fusion Antibodies Ltd Antibody and uses thereof
WO2007131133A2 (en) 2006-05-04 2007-11-15 Genentech, Inc. Methods and compositions relating to zpa polypeptides
US20100030102A1 (en) * 2006-05-15 2010-02-04 David Poston Active Delivery and Flow Redirections: Novel Devices and Method of Delivery of Materials to Patients
US7998128B2 (en) 2006-05-15 2011-08-16 Therataxis, LLC. Active delivery and flow redirection: novel devices and method of delivery of materials to patients
US8383388B2 (en) 2006-06-19 2013-02-26 Catalyst Biosciences, Inc. Modified coagulation factor IX polypeptides and use thereof for treatment
KR20140072201A (ko) 2006-07-05 2014-06-12 카탈리스트 바이오사이언시즈, 인코포레이티드 프로테아제 스크리닝 방법 및 이에 의해 확인된 프로테아제
AU2007285855B2 (en) 2006-08-18 2013-03-07 Novartis Ag PRLR-specific antibody and uses thereof
US8454948B2 (en) 2006-09-14 2013-06-04 Medgenics Medical Israel Ltd. Long lasting drug formulations
US9155749B2 (en) 2006-09-14 2015-10-13 Medgenics Medical Israel Ltd. Long lasting drug formulations
CA2683109A1 (en) * 2006-10-11 2008-04-17 Fusion Antibodies Limited Combination therapy
US20090214474A1 (en) * 2006-11-01 2009-08-27 Barbara Brooke Jennings Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
CA2670696A1 (en) 2006-11-27 2008-06-05 Diadexus, Inc. Ovr110 antibody compositions and methods of use
KR101248252B1 (ko) 2006-11-28 2013-03-27 한올바이오파마주식회사 변형된 에리스로포이에틴 폴리펩티드와 이의 치료용 용도
WO2008070780A1 (en) 2006-12-07 2008-06-12 Novartis Ag Antagonist antibodies against ephb3
US8221741B2 (en) 2007-01-17 2012-07-17 Marshall Vivienne S Methods for modulating inflammatory and/or immune responses
PE20090722A1 (es) * 2007-02-02 2009-07-13 Amgen Inc Hepcidina, antagonistas de la hepcidina y metodos de uso
EP2132573B1 (en) 2007-03-02 2014-04-23 Genentech, Inc. Predicting response to a her dimerisation inhbitor based on low her3 expression
CA2683443A1 (en) 2007-04-13 2008-10-23 Catalyst Biosciences, Inc. Modified factor vii polypeptides and uses thereof
WO2008137281A1 (en) * 2007-05-03 2008-11-13 Fox Chase Cancer Center Compositions and methods for altering pancreas or liver function
US8329467B2 (en) * 2007-05-03 2012-12-11 Fox Chase Cancer Center Compositions and methods for altering pancreas or liver function
US9265577B2 (en) 2007-05-18 2016-02-23 The Johns Hopkins University Methods and systems for providing planning and dispensation of research and/or treatment for brain disease
WO2009012256A1 (en) 2007-07-16 2009-01-22 Genentech, Inc. Humanized anti-cd79b antibodies and immunoconjugates and methods of use
DK2176296T3 (da) 2007-07-16 2012-05-21 Genentech Inc Anti-CD79B-antistoffer og immunkonjugater og anvendelsesfremgangsmåder.
FI20070808A0 (fi) 2007-10-25 2007-10-25 Mart Saarma GDNF:n silmukointivariantit ja niiden käytöt
US8538537B2 (en) * 2007-12-07 2013-09-17 Advanced Neuromodulations Systems, Inc. Systems and methods for providing targeted neural stimulation therapy to address neurological disorders, including neuropyschiatric and neuropyschological disorders
AU2008343855B2 (en) 2007-12-21 2013-08-15 Amgen Inc. Anti-amyloid antibodies and uses thereof
DK2247620T3 (en) 2008-01-31 2016-08-22 Genentech Inc ANTI-CD79b ANTIBODIES AND IMMUNOCONJUGATES AND METHODS OF USE
US20090196854A1 (en) * 2008-02-04 2009-08-06 Kytos Biosystems S.A. Methods and compositions for use of crl 5803 cells for expression of biotherapeutics and encapsulated cell-based delivery
TWI538916B (zh) 2008-04-11 2016-06-21 介控生化科技公司 經修飾的因子vii多肽和其用途
GB0807018D0 (en) * 2008-04-17 2008-05-21 Fusion Antibodies Ltd Antibodies and treatment
FI20080326A0 (fi) 2008-04-30 2008-04-30 Licentia Oy Neurotroofinen tekijä MANF ja sen käytöt
JOP20190083A1 (ar) 2008-06-04 2017-06-16 Amgen Inc بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها
WO2009152084A2 (en) 2008-06-11 2009-12-17 Cell4Vet Llc Adipose tissue-derived stem cells for veterinary use
EP2291515A2 (en) * 2008-06-18 2011-03-09 Innovative Biotherapies, Inc. Methods for propagation of renal precursor cells
US8039437B2 (en) * 2008-06-30 2011-10-18 The Trustees Of The University Of Pennsylvania Fn14/TRAIL fusion proteins
JP2011526916A (ja) 2008-06-30 2011-10-20 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 全身性紅斑性狼瘡を同定および処置するための診断標的および治療標的としてのリソソームホスホリパーゼａ２（ｌｐｌａ２）活性
ES2332169B1 (es) 2008-07-24 2010-10-25 Universidad Del Pais Vasco Empleo de microparticulas que comprenden celulas modificadas geneticamente en el tratamiento de enfermedades neurodegenerativas.
AR073295A1 (es) 2008-09-16 2010-10-28 Genentech Inc Metodos para tratar la esclerosis multiple progresiva. articulo de fabricacion.
US9279013B2 (en) 2008-10-10 2016-03-08 Amgen Inc. FGF-21 mutants comprising polyethylene glycol and uses thereof
WO2010075249A2 (en) 2008-12-22 2010-07-01 Genentech, Inc. A method for treating rheumatoid arthritis with b-cell antagonists
AU2010206374B2 (en) 2009-01-23 2013-01-17 Gloriana Therapeutics Sarl Improved cell lines and their use in encapsulated cell biodelivery
EP2389191A2 (en) 2009-01-23 2011-11-30 NsGene A/S Expression of neuropeptides in mammalian cells
GB0902916D0 (en) 2009-02-20 2009-04-08 Fusion Antibodies Ltd Antibody therapy
CA2755198A1 (en) 2009-03-13 2010-09-16 Mark L. Tykocinski Ox40/trail fusion proteins
WO2010108154A2 (en) 2009-03-20 2010-09-23 Amgen Inc. Selective and potent peptide inhibitors of kv1.3
CN102471380B (zh) 2009-04-01 2015-01-14 霍夫曼-拉罗奇有限公司 抗FcRH5抗体和免疫偶联物及使用方法
CA2759244A1 (en) * 2009-04-23 2010-10-28 Neurotech Usa, Inc. Cell lines that produce prostaglandin f2 alpha (pgf2a) and uses thereof
CA2760674A1 (en) 2009-05-05 2010-11-11 Amgen Inc. Fgf21 mutants and uses thereof
JP5823954B2 (ja) 2009-05-05 2015-11-25 アムジエン・インコーポレーテツド Ｆｇｆ２１変異体及びその使用
WO2010148142A1 (en) * 2009-06-17 2010-12-23 Amgen Inc. Chimeric fgf19 polypeptides and uses thereof
US20110117083A1 (en) 2009-08-14 2011-05-19 Genentech, Inc. Biological markers for monitoring patient response to vegf antagonists
ES2599076T3 (es) 2009-09-02 2017-01-31 Genentech, Inc. Smoothened mutante y métodos de utilización del mismo
JP2013504595A (ja) 2009-09-11 2013-02-07 ジェネンテック， インコーポレイテッド 抗癌剤に対する応答の可能性が増加した患者を同定するための方法
EP2486128A4 (en) * 2009-10-08 2013-10-09 Neurotech Usa Inc USE OF THE PEDF IN AN ENCAPSULATED CELL DELIVERY SYSTEM
WO2011050194A1 (en) 2009-10-22 2011-04-28 Genentech, Inc. Methods and compositions for modulating hepsin activation of macrophage-stimulating protein
WO2011063277A1 (en) 2009-11-20 2011-05-26 Amgen Inc. Anti-orai1 antigen binding proteins and uses thereof
CN102741294A (zh) 2009-11-30 2012-10-17 霍夫曼-拉罗奇有限公司 治疗和诊断表达slc34a2(tat211=seqid2)的肿瘤的抗体
EP2679234A3 (en) * 2009-12-02 2014-04-23 Amgen Inc. Binding proteins that bind to human FGFR1C, human beta-klotho and both human FGFR1C and human beta-klotho
UA109888C2 (uk) 2009-12-07 2015-10-26 ІЗОЛЬОВАНЕ АНТИТІЛО АБО ЙОГО ФРАГМЕНТ, ЩО ЗВ'ЯЗУЄТЬСЯ З β-КЛОТО, РЕЦЕПТОРАМИ FGF І ЇХНІМИ КОМПЛЕКСАМИ
US8765432B2 (en) 2009-12-18 2014-07-01 Oligasis, Llc Targeted drug phosphorylcholine polymer conjugates
EP2516465B1 (en) 2009-12-23 2016-05-18 F.Hoffmann-La Roche Ag Anti-bv8 antibodies and uses thereof
WO2011106297A2 (en) 2010-02-23 2011-09-01 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
US9517264B2 (en) 2010-04-15 2016-12-13 Amgen Inc. Human FGF receptor and β-Klotho binding proteins
SMT201800691T1 (it) 2010-04-23 2019-01-11 Cold Spring Harbor Laboratory Shrna progettati strutturalmente innovativi
EP2566566B1 (en) 2010-05-03 2017-09-06 The Texas A&M University System Adult stem cells/progenitor cells and stem cell proteins for treatment of eye injuries and diseases
AU2011248354A1 (en) 2010-05-03 2012-11-08 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
WO2011146568A1 (en) 2010-05-19 2011-11-24 Genentech, Inc. Predicting response to a her inhibitor
WO2011159758A2 (en) 2010-06-15 2011-12-22 Medgenics Medical Israel Ltd. Long lasting drug formulations
CN103180737A (zh) 2010-07-19 2013-06-26 霍夫曼-拉罗奇有限公司 鉴定响应抗癌疗法的可能性升高的患者的方法
WO2012010549A1 (en) 2010-07-19 2012-01-26 F. Hoffmann-La Roche Ag Method to identify a patient with an increased likelihood of responding to an anti-cancer therapy
EP2619226B1 (en) 2010-09-22 2018-09-12 Amgen Inc. Carrier immunoglobulins and uses thereof
WO2012042480A1 (en) 2010-09-28 2012-04-05 Kahr Medical Ltd. Compositions and methods for treatment of hematological malignancies
EP2446898A1 (en) 2010-09-30 2012-05-02 Laboratorios Del. Dr. Esteve, S.A. Use of growth hormone to enhance the immune response in immunosuppressed patients
KR101886029B1 (ko) 2010-10-01 2018-08-07 호바 세라퓨틱스 에이피에스 무해자극통증, 통각과민증, 자발통증 및 헛통증의 치료를 위한 메테오린의 용도
DK2625197T3 (en) 2010-10-05 2016-10-03 Genentech Inc Smoothened MUTANT AND METHODS OF USING THE SAME
TWI557135B (zh) 2010-11-03 2016-11-11 介控生化科技公司 經修飾之第九因子多胜肽及其用途
ES2613302T3 (es) 2010-12-02 2017-05-23 Neurotech Usa, Inc. Líneas celulares que segregan estructuras de anticuerpos anti-angiogénicas y receptores solubles y usos de los mismos
US20140004209A1 (en) 2010-12-22 2014-01-02 Genentech, Inc. Autophagy inducer and inhibitor combination therapy for the treatment of neoplasms
KR101242656B1 (ko) * 2011-03-04 2013-03-20 포항공과대학교 산학협력단 인공 췌도 구조물 및 이의 제조 방법
EP2699593B2 (en) 2011-04-20 2020-11-04 University of Washington Through Its Center for Commercialization Beta-2 microglobulin-deficient cells
WO2013034157A1 (en) 2011-09-05 2013-03-14 Nsgene A/S Treatment of allodynia, hyperalgsia, spontaneous pain, and phantom pain
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use
AU2013207778B2 (en) 2012-01-13 2017-10-12 Genentech, Inc. Biological markers for identifying patients for treatment with VEGF antagonists
EP2634307B1 (en) 2012-03-02 2016-05-11 Valmet Technologies, Inc. Method for modernizing a supercalender and a modernized supercalender
JP2015514710A (ja) 2012-03-27 2015-05-21 ジェネンテック， インコーポレイテッド Ｈｅｒ３阻害剤に関する診断及び治療
MX2014011582A (es) 2012-03-30 2014-11-21 Genentech Inc Metodos y composiciones de diagnostico para el tratamiento de cancer.
CA3085032A1 (en) 2012-04-17 2013-10-24 University Of Washington Through Its Center For Commercialization Hla class ii deficient cells, hla class i deficient cells capable of expressing hla class ii proteins, and uses thereof
WO2013181424A1 (en) 2012-05-30 2013-12-05 Neurotech Usa, Inc. Cryopreserved implantable cell culture devices and uses thereof
NZ703148A (en) 2012-07-25 2016-08-26 Catalyst Biosciences Inc Modified factor x polypeptides and uses thereof
US9458246B2 (en) 2013-03-13 2016-10-04 Amgen Inc. Proteins specific for BAFF and B7RP1
PH12022550138A1 (en) 2013-03-13 2023-03-06 Amgen Inc Proteins specific for baff and b7rp1 and uses thereof
US20140283157A1 (en) 2013-03-15 2014-09-18 Diadexus, Inc. Lipoprotein-associated phospholipase a2 antibody compositions and methods of use
JP6325649B2 (ja) * 2013-04-24 2018-05-16 ネステク ソシエテ アノニム カプセル化デバイス
US9907496B1 (en) 2013-06-25 2018-03-06 National Technology & Engineering Solutions Of Sandia, Llc Optoelectronic system and apparatus for connection to biological systems
US10456470B2 (en) 2013-08-30 2019-10-29 Genentech, Inc. Diagnostic methods and compositions for treatment of glioblastoma
US10617755B2 (en) 2013-08-30 2020-04-14 Genentech, Inc. Combination therapy for the treatment of glioblastoma
WO2015035342A2 (en) 2013-09-08 2015-03-12 Oligasis Llc Factor viii zwitterionic polymer conjugates
US9925219B2 (en) 2013-09-11 2018-03-27 Neurotech Usa, Inc. Encapsulated cell therapy cartridge
WO2015116902A1 (en) 2014-01-31 2015-08-06 Genentech, Inc. G-protein coupled receptors in hedgehog signaling
CA2937539A1 (en) 2014-02-04 2015-08-13 Genentech, Inc. Mutant smoothened and methods of using the same
KR20160146747A (ko) 2014-03-31 2016-12-21 제넨테크, 인크. 항혈관신생제 및 ox40 결합 효능제를 포함하는 조합 요법
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
WO2016011052A1 (en) 2014-07-14 2016-01-21 Genentech, Inc. Diagnostic methods and compositions for treatment of glioblastoma
US9775978B2 (en) 2014-07-25 2017-10-03 Warsaw Orthopedic, Inc. Drug delivery device and methods having a retaining member
US10080877B2 (en) 2014-07-25 2018-09-25 Warsaw Orthopedic, Inc. Drug delivery device and methods having a drug cartridge
US10463716B2 (en) 2014-10-13 2019-11-05 University Of Maryland, Baltimore Methods for treating cardiovascular dysfunction and improving fluid homeostasis with Elabela peptide hormone
JP6849590B2 (ja) 2014-10-17 2021-03-24 コディアック サイエンシーズ インコーポレイテッドＫｏｄｉａｋ Ｓｃｉｅｎｃｅｓ Ｉｎｃ． ブチリルコリンエステラーゼ両性イオン性ポリマーコンジュゲート
SG11201704707PA (en) 2014-12-23 2017-07-28 Genentech Inc Compositions and methods for treating and diagnosing chemotherapy-resistant cancers
EP3699290A1 (en) 2014-12-24 2020-08-26 F. Hoffmann-La Roche AG Therapeutic, diagnostic, and prognostic methods for cancer
CN107208138A (zh) 2014-12-30 2017-09-26 豪夫迈·罗氏有限公司 用于癌症预后和治疗的方法和组合物
EP3253784B1 (en) 2015-02-04 2020-05-06 Genentech, Inc. Mutant smoothened and methods of using the same
EP3662923A1 (en) 2015-05-27 2020-06-10 Neurotech USA, Inc. Use of encapsulated cell therapy for treatment of ophthalmic disorders
US20170000885A1 (en) 2015-06-08 2017-01-05 Genentech, Inc. Methods of treating cancer using anti-ox40 antibodies and pd-1 axis binding antagonists
DK3313879T3 (da) 2015-06-24 2022-03-14 Hoffmann La Roche Anti-transferrinreceptor-antistoffer med tilpasset affinitet
EP3356406A1 (en) 2015-10-02 2018-08-08 H. Hoffnabb-La Roche Ag Bispecific anti-human cd20/human transferrin receptor antibodies and methods of use
AR106189A1 (es) 2015-10-02 2017-12-20 Hoffmann La Roche ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO
LT3359572T (lt) 2015-10-06 2025-02-10 F. Hoffmann-La Roche Ag Išsėtinės sklerozės gydymo būdas
US10076650B2 (en) 2015-11-23 2018-09-18 Warsaw Orthopedic, Inc. Enhanced stylet for drug depot injector
EP3397276A4 (en) 2015-12-30 2019-12-18 Kodiak Sciences Inc. ANTIBODIES AND CONJUGATES THEREOF
WO2017136558A1 (en) 2016-02-04 2017-08-10 Curis, Inc. Mutant smoothened and methods of using the same
EP3458608B1 (en) 2016-05-17 2025-07-23 F. Hoffmann-La Roche AG Stromal gene signatures for diagnosis and use in immunotherapy
US10183058B2 (en) 2016-06-17 2019-01-22 Nymox Corporation Method of preventing or reducing the progression of prostate cancer
US10549081B2 (en) 2016-06-23 2020-02-04 Warsaw Orthopedic, Inc. Drug delivery device and methods having a retaining member
JP7054523B2 (ja) * 2016-06-28 2022-04-14 国立研究開発法人農業・食品産業技術総合研究機構 細胞封入用デバイス及びその使用
US10172910B2 (en) 2016-07-28 2019-01-08 Nymox Corporation Method of preventing or reducing the incidence of acute urinary retention
US10532081B2 (en) 2016-09-07 2020-01-14 Nymox Corporation Method of ameliorating or preventing the worsening or the progression of symptoms of BPH
US10434261B2 (en) 2016-11-08 2019-10-08 Warsaw Orthopedic, Inc. Drug pellet delivery system and method
WO2018152496A1 (en) 2017-02-17 2018-08-23 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Compositions and methods for the diagnosis and treatment of zika virus infection
AU2018250695A1 (en) 2017-04-14 2019-11-07 Kodiak Sciences Inc. Complement factor D antagonist antibodies and conjugates thereof
EP4230649A3 (en) 2017-04-25 2023-10-25 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services Antibodies and methods for the diagnosis and treatment of epstein barr virus infection
SG10202110500TA (en) 2017-06-22 2021-11-29 Catalyst Biosciences Inc Modified membrane type serine protease 1 (mtsp-1) polypeptides and methods of use
EP3655430A1 (en) 2017-07-19 2020-05-27 The U.S.A. as represented by the Secretary, Department of Health and Human Services Antibodies and methods for the diagnosis and treatment of hepatitis b virus infection
CN111491617B (zh) * 2017-09-29 2024-12-31 沃泰克斯药物股份有限公司 细胞容纳装置
KR20200140817A (ko) 2018-03-02 2020-12-16 코디악 사이언시스 인코포레이티드 Il-6 항체 그리고 이의 융합 작제물 및 접합체
US12084489B2 (en) 2018-05-02 2024-09-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Antibodies and methods for the diagnosis, prevention, and treatment of Epstein Barr virus infection
CN112771177A (zh) 2018-05-21 2021-05-07 纳米线科技公司 分子基因标签及其使用方法
JP7778301B2 (ja) 2018-06-06 2025-12-02 国立大学法人大阪大学 Ｒｅｇｎａｓｅ－１が関与する疾患の治療および／または予防方法
DE102018006061A1 (de) * 2018-08-01 2020-02-06 Universität Duisburg-Essen Implantat
CN111116745B (zh) 2018-11-01 2022-10-14 上海新理念生物医药科技有限公司 抗CD79b抗体、其药物偶联物及其应用
MX2021007843A (es) 2018-12-28 2021-08-11 Vertex Pharma Polipeptidos de activador de plasminogeno, tipo urocinasa, modificados y metodos de uso.
US11613744B2 (en) 2018-12-28 2023-03-28 Vertex Pharmaceuticals Incorporated Modified urokinase-type plasminogen activator polypeptides and methods of use
EP3947441A1 (en) 2019-03-27 2022-02-09 UMC Utrecht Holding B.V. Engineered iga antibodies and methods of use
EP3833381B1 (en) 2019-08-15 2022-08-03 Catalyst Biosciences, Inc. Modified factor vii polypeptides for subcutaneous administration
CN114786731A (zh) 2019-10-10 2022-07-22 科达制药股份有限公司 治疗眼部病症的方法
HUE071069T2 (hu) 2019-10-28 2025-07-28 Medimmune Ltd Tímusz sztrómális limfopoietint (TSLP) kötõ antitestek szárazpor készítményei és eljárások ezek alkalmazására
AU2020375055B2 (en) * 2019-11-01 2026-01-22 Neurotech Usa, Inc. System, apparatuses, devices, and methods for packaging an analyte diffusive implantable device
WO2022011081A1 (en) 2020-07-09 2022-01-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Cell lines that produce human retinoschisin proteins and uses thereof
CN115591025B (zh) * 2022-11-09 2024-01-02 深圳先进技术研究院 神经调控器件、制备方法及其应用
CN120344665A (zh) 2022-12-27 2025-07-18 中外制药株式会社 具有受控缔合的多肽
CN120898000A (zh) 2023-01-13 2025-11-04 拉维洛克治疗有限责任公司 新的多核苷酸、细胞和方法
GB202303531D0 (en) 2023-03-10 2023-04-26 Fusion Antibodies Plc Antibodies and uses thereof
WO2025049818A1 (en) 2023-08-29 2025-03-06 Enosi Therapeutics Corporation Tnfr1 antagonists lacking agonist activity and uses thereof
US20250109209A1 (en) 2023-10-03 2025-04-03 Absci Corporation Tl1a associated antibody compositions and methods of use
WO2025122885A1 (en) 2023-12-08 2025-06-12 Absci Corporation Anti-her2 associated antibody compositions designed by artificial intelligence and methods of use

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3093831A (en) * 1959-10-22 1963-06-18 Jordan Gerhard Paul Wilhelm Artificial gland
US4241187A (en) * 1979-03-27 1980-12-23 United States Of America Method and apparatus for cell and tissue culture
US4352883A (en) * 1979-03-28 1982-10-05 Damon Corporation Encapsulation of biological material
US4391909A (en) * 1979-03-28 1983-07-05 Damon Corporation Microcapsules containing viable tissue cells
US4353888A (en) * 1980-12-23 1982-10-12 Sefton Michael V Encapsulation of live animal cells
US4378016A (en) * 1981-07-15 1983-03-29 Biotek, Inc. Artificial endocrine gland containing hormone-producing cells
US4402694A (en) * 1981-07-16 1983-09-06 Biotek, Inc. Body cavity access device containing a hormone source
AU3542684A (en) * 1983-11-15 1985-05-23 Johnson & Johnson Corporation Glycemia regulating implant
US4686098A (en) * 1984-05-14 1987-08-11 Merck & Co., Inc. Encapsulated mouse cells transformed with avian retrovirus-bovine growth hormone DNA, and a method of administering BGH in vivo
EP0213908A3 (en) * 1985-08-26 1989-03-22 Hana Biologics, Inc. Transplantable artificial tissue and process
DE3545237A1 (de) * 1985-12-20 1987-06-25 Juergen Dr Med Schrezenmeir Vorrichtung fuer die aufnahme und zum einbringen von geweben in den menschlichen koerper sowie hierfuer verwendbares instrument

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