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KR890016029A - 박카틴 ⅲ 및 10-데아세틸박카틴 ⅲ의 유도체를 제조하는 방법 - Google Patents

박카틴 ⅲ 및 10-데아세틸박카틴 ⅲ의 유도체를 제조하는 방법 Download PDF

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Publication number
KR890016029A
KR890016029A KR1019890004540A KR890004540A KR890016029A KR 890016029 A KR890016029 A KR 890016029A KR 1019890004540 A KR1019890004540 A KR 1019890004540A KR 890004540 A KR890004540 A KR 890004540A KR 890016029 A KR890016029 A KR 890016029A
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South Korea
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hydroxy
iii
protecting group
trichloroethoxycarbonyl
activator
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KR1019890004540A
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KR970009729B1 (ko
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꼴랭 미셀
게나르 다니엘
게리뜨-봔젤렝 프랑스와즈
뽀띠에 삐에르
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로오느-푸우랜크 상뜨
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

내용 없음

Description

박카틴 Ⅲ 및 10-데아세틸박카틴 Ⅲ의 유도체를 제조하는 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (11)

  1. 하기 일반식(Ⅲ)의 산을 하기 일반식(Ⅳ)의 탁산 유도체와 축합시킨 다음, 이들 식중의 보호기 R1, R3및 적당한 경우 R2를 수소로 치환시키는, 하기 일반식(Ⅰ)의 박카딘 Ⅲ 또는 10-데아세틸 박카딘 Ⅲ의 유도체를 제조하는 방법 :
    상기식들에서, R은 수소 또는 아세틸을 나타내고, R1은 히드록시-보호기이며, R2는 아세틸기 또는 히드록시-보호기이고, R3는 히드록시-보호기이다.
  2. 제 1 항에 있어서, R1이 1-에톡시에틸인, 벤질옥시메팅, (β-트리메틸시릴에톡시)메틸, 테트라 히드로피라닐 및 2,2,2-트리클로로에톡시카르보닐을 포함하는 군에서 선택되는 방법.
  3. 제 2 항에 있어서, R1이 1-에톡시에틸인 방법.
  4. 제 1 항에 있어서, 같거나 다를 수 있는 히드록시-보호기 R2및 R3가 2,2,2-트리클로로에톡시카르보닐 또는 알킬 부분이 C1-C3를 포함하는 트리알킬실릴기로부터 선택되는 방법.
  5. 제 4 항에 있어서, 히드록시-보호기가 2,2,2-트리클로로에톡시카르보닐인 방법.
  6. 제 1 항에 있어서, 축합 반응이 축합제와 활성화제 존재하에서 수행되는 방법.
  7. 제 6 항에 있어서, 축합제가 카르보디이미드와 반응성카르보네이트로에서 선택되고 활성화제가 디알킬아미노피리딘으로 선택된 방법.
  8. 제 7 항에 있어서, 축합제가 디시클로헥실카르보디이미드와 디-2-피리딜 카르보네이트로에서 선택되고, 활성화제가 4-디메틸아미노 피리딘으로 선택된 방법.
  9. 제 1 항에 있어서, 축합 반응이 벤젠, 톨루엔, 크실렌, 에틸벤젠, 이소프로필벤젠 및 클로로벤젠에서 선택된 방향성 용매 내에서 수행되는 방법.
  10. 제 1 항에 있어서, 축합 반응이 60~90℃의 온도에서 수행되는 방법.
  11. 제 1 항에 있어서, 하기 중간체를 아세트산 존재내에서 아연으로, 또는 C1-C3지방족 알콜내에 용해된 무기 또는 유기산으로 처리하는 것을 포함하는, 하기 일반식 중간체 생성물상의 보호기 R1-C3및 적당한 경우, R2를 수소로 치환시키는 방법:
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890004540A 1988-04-06 1989-04-06 박카틴 ⅲ 및 10-데아세틸박카틴 ⅲ의 유도체를 제조하는 방법. KR970009729B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8804513 1988-04-06
FR8804513A FR2629819B1 (fr) 1988-04-06 1988-04-06 Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii

Publications (2)

Publication Number Publication Date
KR890016029A true KR890016029A (ko) 1989-11-28
KR970009729B1 KR970009729B1 (ko) 1997-06-17

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KR1019890004540A KR970009729B1 (ko) 1988-04-06 1989-04-06 박카틴 ⅲ 및 10-데아세틸박카틴 ⅲ의 유도체를 제조하는 방법.

Country Status (13)

Country Link
US (1) US4924012A (ko)
EP (1) EP0336841B1 (ko)
JP (1) JPH0686441B2 (ko)
KR (1) KR970009729B1 (ko)
AT (1) ATE89823T1 (ko)
AU (1) AU618333B2 (ko)
CA (1) CA1308417C (ko)
DE (1) DE68906705T2 (ko)
ES (1) ES2055119T3 (ko)
FR (1) FR2629819B1 (ko)
GR (1) GR3007982T3 (ko)
IL (1) IL89831A (ko)
ZA (1) ZA892474B (ko)

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US4924012A (en) 1990-05-08
EP0336841B1 (fr) 1993-05-26
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JPH01305077A (ja) 1989-12-08
FR2629819B1 (fr) 1990-11-16
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IL89831A (en) 1992-12-01
EP0336841A1 (fr) 1989-10-11
KR970009729B1 (ko) 1997-06-17
ATE89823T1 (de) 1993-06-15
IL89831A0 (en) 1989-12-15
AU618333B2 (en) 1991-12-19
ZA892474B (en) 1989-12-27
DE68906705D1 (de) 1993-07-01
GR3007982T3 (ko) 1993-08-31
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FR2629819A1 (fr) 1989-10-13
AU3242689A (en) 1989-10-12

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