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KR920012105A - 파트리신 유도체 - Google Patents

파트리신 유도체 Download PDF

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Publication number
KR920012105A
KR920012105A KR1019910021700A KR910021700A KR920012105A KR 920012105 A KR920012105 A KR 920012105A KR 1019910021700 A KR1019910021700 A KR 1019910021700A KR 910021700 A KR910021700 A KR 910021700A KR 920012105 A KR920012105 A KR 920012105A
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KR
South Korea
Prior art keywords
compound
acid
patrizine
patricin
amide
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KR1019910021700A
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English (en)
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KR100205933B1 (ko
Inventor
브루제세 티베리오
시그노리니 마씨모
오토니 프란코
Original Assignee
알폰소 지암브로코노
스파 소이에타′ 프로도티 안티비오티시 에스. 피. 에이.
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Publication of KR920012105A publication Critical patent/KR920012105A/ko
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Publication of KR100205933B1 publication Critical patent/KR100205933B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용 없음

Description

파트리신 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (15)

  1. 다음 구조식(I)의 파트리신 및 이것의 성분인 파트리신 A 및 B의 유도체.
    식중, R은 수소원자(파트리신 B) 또는 메틸 그룹(파트리신 A), R1은 아미노아실 라디칼인 -CO(CH2)mNR3R4, m은 1, 2 또는 3, R3및 R4는 동일하거나 상이한바 수소원자 또는 C1-3알킬 그룹이거나 또는 이것에 결합된 질소 원자와 함께 O, S 및 N으로부터 선택된 부가적인 이종원자를 임의로 함유하는 5원(five-membered)또는 6원 복소환식 고리를 형성, R2는 하이드록시, C1-6알콕시, NR3R4아미노 또는 -NH-(CH2)mNR2R4아미노알킬 아미노 그룹(m, R3및 R4는 상기 정의된 바와 같음)이거나 또는 치환된 -NH-(CH2)m-R5알킬아미노 그룹(m은 상기 정의된 바와 같고 R5는 임의로 N-메틸-또는 N-에틸로 치환된 5원 또는 6원의 질소 복소환식 고리), X는 제약학적으로 허용가능한 유기산이나 무기산의 음이온, 및 n은 0, 1 또는 2.
  2. 제1항에 있어서, 상기 복소환식인 NR3R4의 부가적인 이종원자가 2-하이드록시에틸로 치환된 질소원자인 화합물.
  3. 제1항에 있어서, R1이 다음 그룹들중의 하나의 화합물.
  4. 제1항에 있어서, R2가 다음 그룹들중의 하나인 화합물.
  5. 제1항에 있어서, X가 아스파라긴산, 글루타민산, 글리콜산, 글루쿠론산, 글루콘산, 아스코르빈산의 음이온인 화합물.
  6. 제1항에 있어서, N-디메틸아미노아세틸-파트리신 A 디메틸아미노-에틸아미드인 화합물.
  7. 제1항에 있어서, N-디메틸아미노아세틸-파트리신 A 디메틸아미노-에틸아미드 디아스파테이트인 화합물.
  8. 제1항에 있어서, N-(4-메틸-1-피페라지노아세틸)파트리신 A 2-디메틸아미노에틸 아미드인 화합물.
  9. 제1항에 있어서, N-(4-하이드록시에틸-1-피페라지노아세틸)파트리신 A 2-디메틸아미노에틸 아미드인 화합물.
  10. 제1항에 있어서, N-디메틸아미노아세틸-파트리신 A 2-피리딜에틸 아미드인 화합물.
  11. 제1항에 있어서, N-피페리디노프로피오닐-파트리신 A 2-피리딜에틸 아미드인 화합물.
  12. 파트리신 또는 파트리신 A나 B유도체를 미코사민 아미노 그룹에서 R1-OH산과 축합시키는 것으로 특징되는, 제1항 화합물의 제조방법.
  13. 제12항에 있어서, 상기 축합 반응이 디페닐포스로아지데이트의 존재하에서 행해지는 방법.
  14. 제12항에 있어서, 상기 축합 반응이 디페닐포스포아지데이트 및 트리에틸아민이 존재하에서 행해지는 방법.
  15. 제약학적으로 적당한 부형제 및 보조물질과 함께 치료하는데 효과적인 양의 제1항의 구조식(I) 화합물을 함유하며, 진균과 원생동물에 의한 감염, 콰콜레스테린혈증, 과지방혈증, 양성 전립선 비대 및 비루스 감염에 대한 활성을 갖는 제약학적 제제.
    ※ 참고사항: 최초출원 내용에 의하여 공개하는 것임.
KR1019910021700A 1990-12-03 1991-11-29 파트리신 유도체 KR100205933B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT02226890A IT1243404B (it) 1990-12-03 1990-12-03 Derivati della partricina
IT22268A/90 1990-12-03

Publications (2)

Publication Number Publication Date
KR920012105A true KR920012105A (ko) 1992-07-25
KR100205933B1 KR100205933B1 (ko) 1999-07-01

Family

ID=11193919

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910021700A KR100205933B1 (ko) 1990-12-03 1991-11-29 파트리신 유도체

Country Status (8)

Country Link
US (1) US5298495A (ko)
EP (1) EP0489308B1 (ko)
JP (1) JP3113880B2 (ko)
KR (1) KR100205933B1 (ko)
AT (1) ATE170529T1 (ko)
DE (1) DE69130107T2 (ko)
ES (1) ES2119750T3 (ko)
IT (1) IT1243404B (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102444918B1 (ko) 2022-07-21 2022-09-22 주식회사 삼우에코 에어나이프의 전후진 장치

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1283149B1 (it) * 1996-07-12 1998-04-07 Prodotti Antibiotici Spa Complessi di n'-dimetilaminoacetilpartricina a dimetilaminoetilamide, o suoi sali, e colesterol 3-solfato
EP0829486A2 (de) * 1996-08-19 1998-03-18 Hoechst Aktiengesellschaft Neue Polyenantibiotika, 3874 H1 bis H6, Verfahren zu ihrer Herstellung und Verwendung
IT1294740B1 (it) * 1997-09-16 1999-04-12 Prospa Bv Derivati della partricina per il trattamento profilattico e/o curativo delle contaminazioni fungine di colture cellulari e di tessuti
US6121244A (en) * 1997-09-19 2000-09-19 Prospa B.V. Antitumoral method by administration of partricin derivatives
IT1295042B1 (it) * 1997-09-19 1999-04-27 Prospa Bv Uso di derivati della partricina nelle terapie antitumorali
IT1301807B1 (it) * 1998-06-25 2000-07-07 Tiberio Bruzzese Formulazioni farmaceutiche iniettabili di derivati della partricina.
CA2394833A1 (en) 2000-01-14 2001-07-19 Binh T. Dang Derivatives of polyene macrolides and preparation and use thereof
US6664241B2 (en) * 2000-05-31 2003-12-16 Micrologix Biotech Inc. Water-soluble amide derivatives of polyene macrolides and preparation and uses thereof
ITMI20032280A1 (it) * 2003-11-24 2005-05-25 Tiberio Bruzzese Formulazioni farmaceutiche contenenti derivati della partricina e loro uso orale per il trattamento di infezioni fungine e protozoarie localizzate
MX365184B (es) * 2010-12-21 2019-05-21 Centro De Investig Y De Estudios Avanzados Del I P N Nuevos compuestos analogos de la anfotericina y composiciones farmaceuticas que los contienen.
US20240317791A1 (en) * 2021-07-12 2024-09-26 Bioseutica B.V. A process for the production of amcipatricin diascorbate and the use of the same for the treatment of invasive fungal infections resistant to traditional antifungal agents

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1406774A (en) * 1973-02-15 1975-09-17 Prodotti Antibiotici Spa Esters of patricin and of partricin derivatives
PL122086B1 (en) * 1979-04-09 1982-06-30 Politechnika Gdanska Process for preparing amides of antibiotics from the group of polyene macrolides and their derivativesvykh makrolidov i ikh proizvodnykh
FR2654339B1 (fr) * 1989-11-14 1994-10-28 Mayoly Spindler Laboratoires Nouveaux derives solubles et non toxiques des macrolides polyeniques basiques, leur preparation et leurs applications.
IT1237772B (it) * 1989-11-16 1993-06-17 Tiberio Bruzzese Derivati di macrolidi polienici.
EP0431874A1 (en) * 1989-12-08 1991-06-12 Beecham Group p.l.c. Novel compounds
EP0431870A1 (en) * 1989-12-08 1991-06-12 Beecham Group p.l.c. Amphotericin B derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102444918B1 (ko) 2022-07-21 2022-09-22 주식회사 삼우에코 에어나이프의 전후진 장치

Also Published As

Publication number Publication date
DE69130107T2 (de) 1999-01-21
IT1243404B (it) 1994-06-10
EP0489308A1 (en) 1992-06-10
JPH04300892A (ja) 1992-10-23
IT9022268A1 (it) 1992-06-04
KR100205933B1 (ko) 1999-07-01
JP3113880B2 (ja) 2000-12-04
IT9022268A0 (it) 1990-12-03
ATE170529T1 (de) 1998-09-15
US5298495A (en) 1994-03-29
DE69130107D1 (de) 1998-10-08
EP0489308B1 (en) 1998-09-02
ES2119750T3 (es) 1998-10-16

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