JP6483489B2 - Cosmetics - Google Patents
Cosmetics Download PDFInfo
- Publication number
- JP6483489B2 JP6483489B2 JP2015054551A JP2015054551A JP6483489B2 JP 6483489 B2 JP6483489 B2 JP 6483489B2 JP 2015054551 A JP2015054551 A JP 2015054551A JP 2015054551 A JP2015054551 A JP 2015054551A JP 6483489 B2 JP6483489 B2 JP 6483489B2
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- acid
- oil
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- Prior art date
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- 239000002537 cosmetic Substances 0.000 title claims description 31
- 240000007594 Oryza sativa Species 0.000 claims description 39
- 235000007164 Oryza sativa Nutrition 0.000 claims description 39
- 235000009566 rice Nutrition 0.000 claims description 39
- 239000000284 extract Substances 0.000 claims description 33
- 238000000855 fermentation Methods 0.000 claims description 31
- 230000004151 fermentation Effects 0.000 claims description 31
- 238000002156 mixing Methods 0.000 claims description 27
- 239000000419 plant extract Substances 0.000 claims description 16
- 239000000171 lavandula angustifolia l. flower oil Substances 0.000 claims description 13
- 235000013399 edible fruits Nutrition 0.000 claims description 4
- 240000004307 Citrus medica Species 0.000 claims description 2
- 235000008708 Morus alba Nutrition 0.000 claims description 2
- 240000000249 Morus alba Species 0.000 claims description 2
- 241001647091 Saxifraga granulata Species 0.000 claims description 2
- -1 ethyl ascorbate Chemical compound 0.000 description 38
- 230000003020 moisturizing effect Effects 0.000 description 27
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- 238000003860 storage Methods 0.000 description 13
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 3
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 3
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- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 3
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- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 2
- HFDVRLIODXPAHB-UHFFFAOYSA-N 1-tetradecene Chemical compound CCCCCCCCCCCCC=C HFDVRLIODXPAHB-UHFFFAOYSA-N 0.000 description 2
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- ULQISTXYYBZJSJ-UHFFFAOYSA-N 12-hydroxyoctadecanoic acid Chemical compound CCCCCCC(O)CCCCCCCCCCC(O)=O ULQISTXYYBZJSJ-UHFFFAOYSA-N 0.000 description 2
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- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 2
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- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- QPQANCNBWQXGTQ-UHFFFAOYSA-N trihydroxy(trimethylsilylperoxy)silane Chemical compound C[Si](C)(C)OO[Si](O)(O)O QPQANCNBWQXGTQ-UHFFFAOYSA-N 0.000 description 1
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 description 1
- COXJMKGEQAWXNP-UHFFFAOYSA-N tris(14-methylpentadecyl) 2-hydroxypropane-1,2,3-tricarboxylate Chemical compound CC(C)CCCCCCCCCCCCCOC(=O)CC(O)(C(=O)OCCCCCCCCCCCCCC(C)C)CC(=O)OCCCCCCCCCCCCCC(C)C COXJMKGEQAWXNP-UHFFFAOYSA-N 0.000 description 1
- SOBHUZYZLFQYFK-UHFFFAOYSA-K trisodium;hydroxy-[[phosphonatomethyl(phosphonomethyl)amino]methyl]phosphinate Chemical compound [Na+].[Na+].[Na+].OP(O)(=O)CN(CP(O)([O-])=O)CP([O-])([O-])=O SOBHUZYZLFQYFK-UHFFFAOYSA-K 0.000 description 1
- 229960004441 tyrosine Drugs 0.000 description 1
- 229940035936 ubiquinone Drugs 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 1
- 235000001892 vitamin D2 Nutrition 0.000 description 1
- 239000011653 vitamin D2 Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 239000010497 wheat germ oil Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- 239000004711 α-olefin Substances 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
- 229930007845 β-thujaplicin Natural products 0.000 description 1
- GZIFEOYASATJEH-VHFRWLAGSA-N δ-tocopherol Chemical compound OC1=CC(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 GZIFEOYASATJEH-VHFRWLAGSA-N 0.000 description 1
Landscapes
- Cosmetics (AREA)
Description
本発明は、化粧料に関するものである。 The present invention relates to a cosmetic.
従来より、米発酵液は、美容や健康に良いといわれている。
近年、米発酵液は、アトピー性皮膚炎に効果があることが大学病院や国立小児病院等の研究で明らかになっている。このような米発酵液の特性を利用した入浴剤や化粧品の開発が行われている(特許文献1参照)。
Traditionally, rice fermentation broth is said to be good for beauty and health.
In recent years, it has been clarified in studies by university hospitals and national children's hospitals that rice fermentation broth is effective for atopic dermatitis. Development of bathing agents and cosmetics utilizing the characteristics of such rice fermentation broth has been carried out (see Patent Document 1).
しかしながら、米発酵液を入浴剤や化粧品に配合した場合、肌の保温効果は発揮されるが、肌の保湿効果という点では十分とは言えなかった。これに対して、米発酵液単独で十分な保湿効果を発揮する量、特に10質量%を超えた米発酵液を配合すると、経時的に他の含有成分が析出したり、着色が認められたりという問題点があった(特許文献2参照)。 However, when the rice fermentation broth is blended with a bath agent or cosmetic, the heat-retaining effect of the skin is exhibited, but it is not sufficient in terms of the moisturizing effect of the skin. On the other hand, when the amount of the rice fermentation broth alone exerts a sufficient moisturizing effect, particularly when the rice fermentation broth exceeding 10% by mass is blended, other components may be deposited over time or coloring may be observed. (See Patent Document 2).
このため、高い保湿効果を有するとともに、使用感および安定性に優れた米発酵液配合の化粧料が望まれていた。 For this reason, a cosmetic containing a rice fermented liquid that has a high moisturizing effect and is excellent in usability and stability has been desired.
本発明の目的は、肌の保湿効果を有するとともに、使用感および保存安定性に優れた化粧料を提供することにある。 An object of the present invention is to provide a cosmetic having a skin moisturizing effect and excellent in feeling of use and storage stability.
このような目的は、下記(1)〜(4)の本発明により達成される。
(1) 米発酵液と、
ラベンダー油と、
ユキノシタエキス、ボタンエキス、ソウハクヒエキス、クジンエキス、トウキエキス、ユズ果実エキスからなる群から選択される少なくとも1種の植物エキスと、を含み、
前記米発酵液の配合量が10〜80質量%であり、
前記植物エキスの総配合量が0.005〜2.5質量%であることを特徴とする化粧料。
Such an object is achieved by the present inventions (1) to ( 4 ) below.
(1) rice fermentation broth,
With lavender oil,
Saxifrage extract, button extract, mulberry bark extract, Kujin'ekisu, seen including Toukiekisu, at least one plant extract is selected from the group consisting of citron fruit extract, a,
The blending amount of the rice fermentation broth is 10-80% by mass,
Cosmetics, wherein the total amount of the plant extract is 0.005 to 2.5% by mass .
(2) 前記ラベンダー油の配合量は、0.005〜5質量%である上記(1)に記載の化粧料。 ( 2 ) Cosmetics as described in said (1) whose compounding quantity of the said lavender oil is 0.005-5 mass%.
(3) 前記米発酵液の配合量をA[質量%]、前記植物エキスの総配合量をB[質量%]としたとき、6.25×10 −5 ≦B/A≦0.25の関係を満足する上記(1)または(2)に記載の化粧料。 ( 3 ) When the blending amount of the rice fermentation liquid is A [mass%] and the total blending amount of the plant extract is B [mass%], 6.25 × 10 −5 ≦ B / A ≦ 0.25 The cosmetic according to (1) or (2) , which satisfies the relationship.
(4) 前記米発酵液の配合量をA[質量%]、前記ラベンダー油の総配合量をC[質量%]としたとき、6.25×10 −5 ≦C/A≦0.5の関係を満足する上記(1)ないし(3)のいずれかに記載の化粧料。 ( 4 ) When the blending amount of the rice fermentation broth is A [mass%] and the total blending amount of the lavender oil is C [mass%], 6.25 × 10 −5 ≦ C / A ≦ 0.5 The cosmetic according to any one of (1) to ( 3 ), which satisfies the relationship.
本発明によれば、肌の保湿効果を有するとともに、使用感および保存安定性に優れた化粧料を提供することができる。 ADVANTAGE OF THE INVENTION According to this invention, while having the moisturizing effect of skin, the cosmetics excellent in a usability | use_condition and storage stability can be provided.
以下、本発明の化粧料の好適な実施形態について詳細に説明する。
なお、本明細書中における化粧料は、いかなる形態のものであってもよく、例えば、液状、ゲル(ジェル)状、乳液状、クリーム状等であってもよい。
Hereinafter, preferred embodiments of the cosmetic of the present invention will be described in detail.
In addition, the cosmetics in this specification may be in any form, and may be, for example, liquid, gel (gel), emulsion, cream or the like.
本発明の化粧料は、米発酵液と、ラベンダー油と、ユキノシタエキス、ボタンエキス、ソウハクヒエキス、クジンエキス、トウキエキス、ユズ果実エキスからなる群から選択される少なくとも1種の植物エキスと、を含んでいる。 The cosmetic of the present invention comprises a rice fermentation broth, lavender oil, and at least one plant extract selected from the group consisting of Yukinoshita extract, button extract, Sorakuhi extract, Kujin extract, Toki extract, Yuzu fruit extract. It is out.
以下、各成分について詳細に説明する。
[米発酵液]
米発酵液は、米または米ぬかを、酵素分解または麹による糖化、酒母あるいは酵母による発酵を行うことにより得られるものである。
米発酵液は、肌の保温効果や保湿効果を発揮する成分である。
Hereinafter, each component will be described in detail.
[Rice fermentation broth]
The rice fermentation broth is obtained by subjecting rice or rice bran to enzymatic decomposition or saccharification with koji, or fermentation with a liquor or yeast.
Rice fermentation liquor is a component that exerts a skin warming and moisturizing effect.
ところで、従来の米発酵液を配合した化粧料では、肌の保温効果は発揮されるが、肌の保湿効果という点では十分とは言えなかった。これに対して、米発酵液単独で十分な保湿効果を発揮する量の米発酵液を配合すると、経時的に他の含有成分が析出したり、着色が認められたりという問題点があった。 By the way, although the cosmetics which mix | blended the conventional rice fermented liquid show the heat retention effect of the skin, it could not be said that it was sufficient in terms of the moisture retention effect of the skin. On the other hand, when the rice fermented liquid of an amount that exhibits a sufficient moisturizing effect with the rice fermented liquid alone is blended, there is a problem that other components are deposited over time or coloring is observed.
これに対して、本発明では、米発酵液とともに、ラベンダー油と後述するような所定の植物エキスとを配合することで、高い保湿効果を有するとともに、使用感および保存安定性に優れた化粧料を提供することができる。 On the other hand, in the present invention, by blending lavender oil and a predetermined plant extract as will be described later together with the rice fermented liquid, it has a high moisturizing effect and is excellent in usability and storage stability. Can be provided.
米発酵液の配合量は、0.1〜95質量%であるのが好ましく、10〜80質量%であるのがより好ましい。これにより、使用感および保存安定性をより優れたものとすることができる。また、肌の保湿効果を効果的に発揮させることができる。 The blending amount of the rice fermentation broth is preferably 0.1 to 95% by mass, and more preferably 10 to 80% by mass. Thereby, usability and storage stability can be further improved. Moreover, the moisturizing effect of skin can be exhibited effectively.
[ラベンダー油]
本発明の化粧料は、ラベンダー油を含んでいる。
[Lavender oil]
The cosmetic of the present invention contains lavender oil.
ラベンダー油を含むことにより、米発酵液の添加量を多くしても、使用感および保存安定性をより優れたものとすることができる。また、米発酵液の高い保湿効果をより効果的に発揮させることができる。 By including lavender oil, even if the addition amount of the rice fermentation liquor is increased, the usability and storage stability can be further improved. Moreover, the high moisturizing effect of rice fermentation liquid can be exhibited more effectively.
ラベンダー油の配合量は、0.005〜5質量%であるのが好ましく、0.01〜2.5質量%であるのがより好ましい。これにより、使用感および保存安定性をさらに優れたものとすることができる。また、肌の保湿効果をさらに効果的に発揮させることができる。 The blending amount of lavender oil is preferably 0.005 to 5% by mass, and more preferably 0.01 to 2.5% by mass. Thereby, usability and storage stability can be further improved. In addition, the skin moisturizing effect can be more effectively exhibited.
米発酵液の配合量をA[質量%]、ラベンダー油の総配合量をC[質量%]としたとき、5.3×10−5≦C/A≦50の関係を満足するのが好ましく、1.3×10−4≦C/A≦0.25の関係を満足するのがより好ましい。このような関係を満足することにより、使用感および保存安定性をさらに優れたものとすることができる。また、米発酵液の高い保湿効果をさらに向上させることができる。 It is preferable to satisfy the relationship of 5.3 × 10 −5 ≦ C / A ≦ 50 when the blending amount of the rice fermentation broth is A [mass%] and the total blending amount of lavender oil is C [mass%]. 1.3 × 10 −4 ≦ C / A ≦ 0.25 is more preferable. By satisfying such a relationship, the feeling of use and the storage stability can be further improved. Moreover, the high moisturizing effect of the rice fermentation broth can be further improved.
[植物エキス]
本発明の化粧料は、ユキノシタエキス、ボタンエキス、ソウハクヒエキス、クジンエキス、トウキエキス、ユズ果実エキスからなる群から選択される少なくとも1種の植物エキスを含んでいる。このような植物エキスを含むことにより、米発酵液の添加量を多くしても、使用感および保存安定性をより優れたものとすることができる。
[Plant extract]
The cosmetic of the present invention contains at least one plant extract selected from the group consisting of a Yukinoshita extract, a button extract, a Sakuhakuhi extract, a Kujin extract, a Toki extract, and a Yuzu fruit extract. By including such a plant extract, even if the addition amount of the rice fermentation liquor is increased, the usability and storage stability can be further improved.
植物エキスの総配合量は、0.005〜5質量%であるのが好ましく、0.01〜2.5質量%であるのがより好ましい。これにより、使用感および保存安定性をより優れたものとすることができる。また、高い肌保湿効果をより効率よく発揮させることができる。 The total amount of the plant extract is preferably 0.005 to 5% by mass, and more preferably 0.01 to 2.5% by mass. Thereby, usability and storage stability can be further improved. Moreover, the high skin moisturizing effect can be exhibited more efficiently.
米発酵液の配合量をA[質量%]、前記植物エキスの総配合量をB[質量%]としたとき、5.3×10−5≦B/A≦50の関係を満足するのが好ましく、1.3×10−4≦B/A≦0.25の関係を満足するのがより好ましい。このような関係を満足することにより、高い肌保湿効果をさらに効率よく発揮させることができる。また、使用感および保存安定性をさらに優れたものとすることができる。 When the blending amount of the rice fermentation broth is A [mass%] and the total blending amount of the plant extract is B [mass%], the relationship of 5.3 × 10 −5 ≦ B / A ≦ 50 is satisfied. Preferably, it is more preferable to satisfy the relationship of 1.3 × 10 −4 ≦ B / A ≦ 0.25. By satisfying such a relationship, a high skin moisturizing effect can be exhibited more efficiently. In addition, the usability and storage stability can be further improved.
[アスコルビン酸またはその誘導体]
本発明の化粧料は、アスコルビン酸またはその誘導体を含んでいてもよい。アスコルビン酸またはその誘導体を含むことにより、米発酵液の添加量を多くしても、使用感および保存安定性をより優れたものとすることができる。
[Ascorbic acid or its derivatives]
The cosmetic of the present invention may contain ascorbic acid or a derivative thereof. By including ascorbic acid or a derivative thereof, even when the amount of rice fermentation broth added is increased, the usability and storage stability can be further improved.
アスコルビン酸の誘導体としては、例えば、アスコルビン酸エチル、アスコルビン酸グルコシド、テトライソパルミチン酸アスコビル、テトライソパルミチン酸アスコルビル、アスコルビン酸−2リン酸−6パルミチン酸(APPS)等を挙げることができる。 Examples of the derivatives of ascorbic acid include ethyl ascorbate, ascorbic acid glucoside, ascorbyl tetraisopalmitate, ascorbyl tetraisopalmitate, ascorbic acid-2-phosphate-6 palmitic acid (APPS), and the like.
アスコルビン酸またはその誘導体の配合量は、0.005〜5質量%であるのが好ましく、0.01〜2.5質量%であるのがより好ましい。これにより、米発酵液を配合することによる効果をより効率よく高めることができる。 The blending amount of ascorbic acid or a derivative thereof is preferably 0.005 to 5% by mass, and more preferably 0.01 to 2.5% by mass. Thereby, the effect by mix | blending rice fermentation liquor can be improved more efficiently.
米発酵液の配合量をA[質量%]、前記アスコルビン酸またはその誘導体の配合量をD[質量%]としたとき、5.3×10−5≦D/A≦50の関係を満足するのが好ましく、1.3×10−4≦D/A≦0.25の関係を満足するのがより好ましい。このような関係を満足することにより、高い肌保湿効果をさらに効率よく発揮させることができる。 When the blending amount of the rice fermentation broth is A [mass%] and the blending amount of the ascorbic acid or derivative thereof is D [mass%], the relationship of 5.3 × 10 −5 ≦ D / A ≦ 50 is satisfied. It is preferable that the relationship of 1.3 × 10 −4 ≦ D / A ≦ 0.25 is satisfied. By satisfying such a relationship, a high skin moisturizing effect can be exhibited more efficiently.
[尿素]
本発明の化粧料は、尿素を含んでいてもよい。尿素を含むことで、米発酵液との相乗効果により、保湿効果をさらに高いものとすることができる。
[urea]
The cosmetic of the present invention may contain urea. By containing urea, the moisturizing effect can be further enhanced by a synergistic effect with the rice fermentation broth.
尿素の配合量は、0.005〜5質量%であるのが好ましく、0.01〜2.5質量%であるのがより好ましい。これにより、高い肌保湿効果をより効率よく発揮させることができる。 The blending amount of urea is preferably 0.005 to 5% by mass, and more preferably 0.01 to 2.5% by mass. Thereby, a high skin moisturizing effect can be exhibited more efficiently.
米発酵液の配合量をA[質量%]、前記尿素の配合量をE[質量%]としたとき、5.3×10−5≦E/A≦50の関係を満足するのが好ましく、1.3×10−4≦E/A≦0.25の関係を満足するのがより好ましい。このような関係を満足することにより、高い肌保湿効果をさらに効率よく発揮させることができる。 When the blending amount of the rice fermentation broth is A [mass%] and the blending amount of the urea is E [mass%], it is preferable to satisfy the relationship of 5.3 × 10 −5 ≦ E / A ≦ 50, It is more preferable to satisfy the relationship of 1.3 × 10 −4 ≦ E / A ≦ 0.25. By satisfying such a relationship, a high skin moisturizing effect can be exhibited more efficiently.
[その他の成分]
また、本発明の化粧料には、上記成分の他、目的および剤形に応じて通常用いられる基剤成分並びに薬効成分を配合することができる。
[Other ingredients]
In addition to the above components, the cosmetics of the present invention may contain base components and medicinal components that are usually used according to the purpose and dosage form.
そのような基剤成分並びに薬効成分の例として、ヒアルロン酸、ヒアルロン酸塩、鉱物・合成油、動植物油、ロウ類、脂肪酸、アルコール、エステル油、シリコン油、界面活性剤、湿潤剤、高分子化合物、動植物抽出物、アミノ酸類、溶剤、ビタミン類、消炎剤、防腐剤、紫外線吸収剤、金属イオン封鎖剤、酸化防止剤、pH調整剤、色素・顔料、香料などが挙げられ、本発明の効果を損なわない範囲で配合することができる。 Examples of such base ingredients and medicinal ingredients include hyaluronic acid, hyaluronic acid salts, mineral and synthetic oils, animal and vegetable oils, waxes, fatty acids, alcohols, ester oils, silicone oils, surfactants, wetting agents, polymers Compounds, animal and plant extracts, amino acids, solvents, vitamins, anti-inflammatory agents, preservatives, UV absorbers, sequestering agents, antioxidants, pH adjusters, dyes / pigments, fragrances, etc. It can mix | blend in the range which does not impair an effect.
以下にそれらの具体例を挙げる。
(鉱物・合成油)
鉱物・合成油としては、例えば、流動パラフィン、流動イソパラフィン、ワセリン、パラフィン、セレシン、マイクロスタリンワックス、α−オレフィンオリゴマー、ポリエチレン、ポリブテン、合成スクワラン等が挙げられ、これらのうち、1種または2種以上を組み合わせて用いることができる。
Specific examples thereof are given below.
(Mineral / Synthetic oil)
Examples of the mineral / synthetic oil include liquid paraffin, liquid isoparaffin, petrolatum, paraffin, ceresin, microstalin wax, α-olefin oligomer, polyethylene, polybutene, and synthetic squalane. A combination of the above can be used.
(動植物油)
動植物油としては、例えば、スクワラン、オリブ油、ツバキ油、コムギ胚芽油、ホホバ油、アボガド油、カロット油、シア脂、液状シア脂、パーム油、パーム核油、硬化油、馬油、ラノリン類、卵黄油、チョウジ油、ローズヒップ油、ハッカ油、スペアミント油、ローズマリー油、マカデミアナッツ油、杏仁油、サフラワー油、ヒマワリ油、メドゥホーム油、アーモンド油、エゴマ油、ゴマ油、ボラージ油、カカオ脂、コメヌカ油、コメ胚芽油、ウイキョウ油、オレンジ油、カミツレ油、キューカンバー油、ククイナッツ油、大豆油、トウモロコシ油、ナタネ油、パーシック油、ヒマシ油、綿実油、落花生油、タートル油、ミンク油、アルガニアスピサ核油、クランベアビシニカ種子油、アルモンド油、パーシック油、桃仁油、グレープシード油、エミュー油、ミンク油、アサ種子油、アマニ油、サザンカ油、モクロウ、ヤシ油、月見草油、ピスタシオ種子油、マンゴーバター等が挙げられ、これらのうち、1種または2種以上を組み合わせて用いることができる。
(Animal and vegetable oil)
As animal and vegetable oils, for example, squalane, olive oil, camellia oil, wheat germ oil, jojoba oil, avocado oil, carrot oil, shea fat, liquid shea fat, palm oil, palm kernel oil, hydrogenated oil, horse oil, lanolins , Egg yolk oil, clove oil, rosehip oil, peppermint oil, spearmint oil, rosemary oil, macadamia nut oil, apricot oil, safflower oil, sunflower oil, medhome oil, almond oil, sesame oil, sesame oil, borage oil, cacao Fat, rice bran oil, rice germ oil, fennel oil, orange oil, chamomile oil, cucumber oil, kukui nut oil, soybean oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, Argania spisa kernel oil, cranbear vicnica seed oil, almond oil, persic oil, peach seed oil, grapeseey Oil, emu oil, mink oil, Asa seed oil, flaxseed oil, sasanqua oil, owl, palm oil, evening primrose oil, pistachio seed oil, mango butter, etc. Among these, one or a combination of two or more Can be used.
(ロウ類)
ロウ類としては、例えば、ホホバ油、ミツロウ、カルナウバロウ、コメヌカロウ、鯨ロウ、ラノリン、液状ラノリン、還元ラノリン、硬質ラノリン、キャンデリラロウ、モンタンロウ、セラック、オレンジラフィー油等が挙げられ、これらのうち、1種または2種以上を組み合わせて用いることができる。
(Wax)
Examples of the waxes include jojoba oil, beeswax, carnauba wax, rice bran wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac, orange luffy oil, etc. One kind or a combination of two or more kinds can be used.
(脂肪酸)
脂肪酸としては、例えば、ラウリン酸、ミリスチン酸、パルミチン酸、ステアリン酸、オレイン酸、イソステアリン酸、ベヘニン酸、リノール酸、リノレン酸、ドコサヘキサエン酸、エイコサペンタエン酸、12−ヒドロキシステアリン酸、ウンデシレン酸、ラノリン脂肪酸等の天然脂肪酸、イソノナン酸、カプロン酸、2−エチルブタン酸、イソペンタン酸、2−メチルペンタン酸、イソペンタン酸等の合成脂肪酸等が挙げられ、これらのうち、1種または2種以上を組み合わせて用いることができる。
(fatty acid)
Examples of fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, isostearic acid, behenic acid, linoleic acid, linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, lanolin Examples include natural fatty acids such as fatty acids, synthetic fatty acids such as isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, and isopentanoic acid. Among these, one kind or a combination of two or more kinds is included. Can be used.
(アルコール)
エタノール、イソプロパノール、ブチルアルコール、ベンジルアルコール、ラウリルアルコール、ミリスチルアルコール、セタノール、セトステアリルアルコール、ステアリルアルコール、イソステアリルアルコール、オレイルアルコール、ヘキシルデカノール、ベヘニルアルコール、オクチルドデカノール、ラノリンアルコール、コレステロール、フィトステロール、2−ヘキシルデカノール、2−オクチルドデカノール、バチルアルコール等が挙げられ、これらのうち、1種または2種以上を組み合わせて用いることができる。
(alcohol)
Ethanol, isopropanol, butyl alcohol, benzyl alcohol, lauryl alcohol, myristyl alcohol, cetanol, cetostearyl alcohol, stearyl alcohol, isostearyl alcohol, oleyl alcohol, hexyl decanol, behenyl alcohol, octyldodecanol, lanolin alcohol, cholesterol, phytosterol, 2-hexyl decanol , 2-octyldodecanol, batyl alcohol, and the like. Among these, one kind or two or more kinds can be used in combination.
(エステル油)
エステル油としては、例えば、トリカプリル酸グリセリル、トリ2−エチルヘキサン酸グリセリル、イソノナン酸イソノニル、ジオクタン酸エチレングリコール、トリ(カプリル・カプリン酸)グリセリル、ミリスチン酸イソプロピル、ミリスチン酸ブチル、パルミチン酸イソプロピル、ステアリン酸エチル、ステアリン酸ブチル、オレイン酸エチル、リノール酸エチル、リノール酸イソプロピル、カプリル酸セチル、ミリスチン酸デシル、ラウリン酸ヘキシル、ミリスチン酸ミリスチル、ミリスチン酸セチル、パルミチン酸セチル、ステアリン酸ステアリル、オレイン酸オレイル、オレイン酸デシル、リシノール酸セチル、ラウリン酸イソステアリル、ミリスチン酸イソトリデシル、ミリスチン酸イソセチル、ミリスチン酸イソステアリル、ミリスチン酸2−オクチルドデシル、パルミチン酸オクチル、パルミチン酸イソセチル、ステアリン酸オクチル、ステアリン酸イソセチル、オレイン酸イソデシル、オレイン酸2−オクチルドデシル、リシノール酸2−オクチルドデシル、イソステアリン酸エチル、イソステアリン酸イソプロピル、オクタン酸セチル、オクタン酸セトステアリル、オクタン酸ステアリル、イソステアリン酸ヘキシル、ジオレイン酸エチレングリコール、ジカプリン酸プロピレングリコール、ジ(カプリル・カプリン酸)プロピレングリコール、ジオレイン酸プロピレングリコール、ジカプリン酸ネオペンチルグリコール、ジ2−エチルヘキサン酸ネオペンチルグリコール、トリウンデシル酸グリセリル、トリイソパルミチン酸グリセリル、トリイソステアリン酸グリセリル、トリ2−エチルヘキサン酸トリメチロールプロパン、トリイソステアリン酸トリメチロールプロパン、テトラ2−エチルヘキサン酸ペンタエリスリトール、テトラミリスチン酸ペンタエリスリトール、テトライソステアリン酸ペンタエリスリトール、ネオペンタン酸2−オクチルドデシル、オクタン酸イソセチル、オクタン酸イソステアリル、イソペアルゴン酸オクチル、ネオデカン酸2−ヘキシルデシル、ネオデカン酸2−オクチルドデシル、イソパルミチン酸オクチル、イソステアリン酸イソセチル、イソステアリン酸イソステアリル、イソステアリン酸2−オクチルドデシル、乳酸ラウリル、乳酸ミリスチル、乳酸セチル、乳酸2−オクチルドデシル、クエン酸トリエチル、クエン酸アセチルトリエチル、クエン酸アセチルトリブチル、クエン酸トリ2−エチルヘキシル、クエン酸トリイソセチル、クエン酸トリ2−オクチルドデシル、リンゴ酸ジイソステアリル、ヒドロキシステアリン酸2−エチルヘキシル、コハク酸ジオクチル、アジピン酸ジイソプロピル、アジピン酸ジイソブチル、アジピン酸ジオクチル、セバシン酸ジエチル、セバシン酸ジイソプロピル、セバシン酸ジオクチル、セバシン酸ジブチルオクチル、ステアリン酸コレステリル、イソステアリン酸コレステリル、ヒドロキシステアリン酸コレステリル、オレイン酸コレステリル、オレイン酸ジヒドロコレステリル、イソステアリン酸フィトステリル、オレイン酸フィトステリル、ジメチルオクタン酸ヘキシルデシル、フタル酸ジエチル、フタル酸ジブチル、炭酸ジアルキル等が挙げられ、これらのうち、1種または2種以上を組み合わせて用いることができる。
(Ester oil)
Examples of ester oils include glyceryl tricaprylate, glyceryl tri-2-ethylhexanoate, isononyl isononanoate, ethylene glycol dioctanoate, glyceryl tri (caprylate / caprate), isopropyl myristate, butyl myristate, isopropyl palmitate, stearin Ethyl acetate, butyl stearate, ethyl oleate, ethyl linoleate, isopropyl linoleate, cetyl caprylate, decyl myristate, hexyl laurate, myristyl myristate, cetyl myristate, cetyl palmitate, stearyl stearate, oleyl oleate , Decyl oleate, cetyl ricinoleate, isostearyl laurate, isotridecyl myristate, isocetyl myristate, isostearyl myristate 2-octyldodecyl myristate, octyl palmitate, isocetyl palmitate, octyl stearate, isocetyl stearate, isodecyl oleate, 2-octyl dodecyl oleate, 2-octyl dodecyl ricinoleate, ethyl isostearate, isopropyl isostearate, octane Cetyl acid, cetostearyl octoate, stearyl octoate, hexyl isostearate, ethylene glycol dioleate, propylene glycol dicaprate, propylene glycol di (capryl / caprate), propylene glycol dioleate, neopentyl glycol dicaprate, di-2- Neopentyl glycol ethylhexanoate, glyceryl triundecylate, glyceryl triisopalmitate, triisostearate Glyceryl acid, tri-2-ethylhexanoic acid trimethylolpropane, triisostearic acid trimethylolpropane, tetra-2-ethylhexanoic acid pentaerythritol, tetramyristic acid pentaerythritol, tetraisostearic acid pentaerythritol, neopentanoic acid 2-octyldodecyl, octane Isocetyl acid, isostearyl octoate, octyl isopeargonate, 2-hexyldecyl neodecanoate, 2-octyldodecyl neodecanoate, octyl isopalmitate, isocetyl isostearate, isostearyl isostearate, 2-octyldodecyl isostearate, lauryl lactate, Myristyl lactate, cetyl lactate, 2-octyldodecyl lactate, triethyl citrate, acetyl triethyl citrate, citric acid Cetyltributyl, tri-2-ethylhexyl citrate, triisocetyl citrate, tri-2-octyldodecyl citrate, diisostearyl malate, 2-ethylhexyl hydroxystearate, dioctyl succinate, diisopropyl adipate, diisobutyl adipate, dioctyl adipate , Diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, dibutyl octyl sebacate, cholesteryl stearate, cholesteryl isostearate, cholesteryl hydroxystearate, cholesteryl oleate, dihydrocholesteryl oleate, phytosteryl isostearate, phytosteryl oleate, dimethyloctane Examples include hexyl decyl acid, diethyl phthalate, dibutyl phthalate, and dialkyl carbonate. Among these may be used alone or in combination.
(シリコン油)
シリコン油としては、例えば、メチルポリシロキサン、メチルフェニルポリシロキサン、シリコン樹脂、メチルハイドロジェンポリシロキサン、メチルシクロポリシロキサン、オクタメチルシクロテトラシロキサン、デカメチルシクロペンタシロキサン、ドデカメチルシクロヘキサシロキサン、環状シリコン樹脂、オクタメチルトリシロキサン、テトラデカメチルヘキサシロキサン、高重合メチルポリシロキサン、トリメチルシロキシケイ酸、ポリ(オキシエチレン・オキシプロピレン)メチルポリシロキサン共重合体、ポリ(オキシエチレン・オキシプロピレン)・ブチレン・メチルポリシロキサン共重合体、ポリオキシエチレン・メチルポリシロキ酸共重合体、ポリオキシプロピレン・メチルポリシロキサン共重合体、ジメチルシロキサン・メチルセチルオキシシロキサン共重合体、ジメチルシロキサン・メチルステアロキシシロキサン共重合体等が挙げられ、これらのうち、1種または2種以上を組み合わせて用いることができる。
(Silicone oil)
Examples of silicone oil include methylpolysiloxane, methylphenylpolysiloxane, silicone resin, methylhydrogenpolysiloxane, methylcyclopolysiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, and cyclic silicon. Resin, octamethyltrisiloxane, tetradecamethylhexasiloxane, highly polymerized methylpolysiloxane, trimethylsiloxysilicic acid, poly (oxyethylene / oxypropylene) methylpolysiloxane copolymer, poly (oxyethylene / oxypropylene) / butylene / Methyl polysiloxane copolymer, polyoxyethylene / methyl polysiloxy acid copolymer, polyoxypropylene / methyl polysiloxane copolymer, dimethylsiloxa - methyl cetyl oxy siloxane copolymer, dimethyl siloxane-methyl stearoxysiloxane copolymer, and the like, among these, can be used alone or in combination.
(界面活性剤)
界面活性剤としては、例えば、ラウリル硫酸塩、アルキル硫酸塩、ポリオキシエチレンアルキル硫酸塩、テトラデセンスルホン酸塩、ポリオキシエチレンアルキルスルホコハク酸塩、ラウロイルサルコシン塩、アルキルメチル−β−アラニン塩、ポリオキシエチレンアルキルエーテルリン酸塩、脂肪酸石けん、N−アシルグルタミン酸塩、ラウリン酸ジエタノールアミド、ヤシ油脂肪酸ジエタノールアミド、アルキルジメチルアミンオキシド、アルキルメチルタウリン塩、アルキルアミノプロキオン酸塩、ポリオキシエチレンアルキルエーテルカルボン酸塩、アルキルリン酸塩、アルキルグルコシド、ポリエーテル変性シリコン、塩化アルキルトリメチルアンモニウム、臭化アルキルトリメチルアンモニウム、アミドアミン、塩化ジアルキルジメチルアンモニウムジメチル酢酸ベタイン、アルキルアミドプロピルベタイン、アルキルカルボキシメチルヒドロキシエチルイミダゾリニウムベタイン、レシチン(大豆又は卵黄)およびその誘導体、プロピレングリコール脂肪酸エステル、グリセリン脂肪酸エステル、ポリオキシエチレングリセリン脂肪酸エステル、ポリオキシエチレンソルビット脂肪酸エステル、ポリオキシエチレン硬化ヒマシ油、ポリエチレングリコール脂肪酸エステル、ポリオキシエチレンアルキルエーテル、ポリオキシエチレンポリオキシプロピレンアルキルエーテル、ポリオキシエチレンアルキルノニルフェニルエーテル、ポリオキシエチレンアルキルエーテルリン酸・リン酸塩、ショ糖脂肪酸エステル等が挙げられ、これらのうち、1種または2種以上を組み合わせて用いることができる。
(Surfactant)
Examples of the surfactant include lauryl sulfate, alkyl sulfate, polyoxyethylene alkyl sulfate, tetradecene sulfonate, polyoxyethylene alkyl sulfosuccinate, lauroyl sarcosine salt, alkylmethyl-β-alanine salt, poly Oxyethylene alkyl ether phosphate, fatty acid soap, N-acyl glutamate, lauric acid diethanolamide, coconut oil fatty acid diethanolamide, alkyl dimethylamine oxide, alkyl methyl taurate, alkyl amino procionate, polyoxyethylene alkyl ether carboxyl Acid salt, alkyl phosphate, alkyl glucoside, polyether-modified silicon, alkyltrimethylammonium chloride, alkyltrimethylammonium bromide, amidoamine, dialkyl chloride Methyl ammonium dimethyl acetate betaine, alkylamidopropyl betaine, alkyl carboxymethyl hydroxyethyl imidazolinium betaine, lecithin (soybean or egg yolk) and its derivatives, propylene glycol fatty acid ester, glycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene Sorbit fatty acid ester, polyoxyethylene hydrogenated castor oil, polyethylene glycol fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene alkyl nonylphenyl ether, polyoxyethylene alkyl ether phosphate and phosphate , Sucrose fatty acid esters, etc., and one or more of these are combined They can be used together.
(湿潤剤)
湿潤剤としては、上記多価アルコールの他、例えば、酸化エチレン、エチレングリコールモノエチルエーテル、エチレングリコールモノブチルエーテル、ジエチレングリコールモノエチルエーテル、酸化プロピレン等が挙げられ、これらのうち、1種または2種以上を組み合わせて用いることができる。
(Wetting agent)
Examples of the wetting agent include, in addition to the above polyhydric alcohol, ethylene oxide, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monoethyl ether, propylene oxide, and the like. Among these, one or more of them are used. Can be used in combination.
(高分子化合物)
高分子化合物としては、例えば、アルギン酸ナトリウム、カラギーナン、寒天、ファーセレラン、グァーガム、クインスシード、コンニャクマンナン、タマリンドガム、タラガム、デキストリン、デンプン、ローカストビーンガム、アラビアガム、ガッティガム、カラヤガム、トラガカントガム、アラビノガラクタン、ペクチン、マルメロ、小麦タンパク質、大豆タンパク質、アルブミン、カゼイン、ゼラチン、キトサン、ヒアルロン酸、カードラン、キサンタンガム、ジェランガム、シクロデキストリン、デキストラン、プルラン、結晶セルロース、メチルセルロース、エチルセルロース、ヒドロキシエチルセルロース、ヒドロキシプロピルセルロース、ヒドロキシプロピルメチルセルロース、カルボキシメチルセルロース、カチオン化セルロース、カチオン化グァーガム、ヒドロキシプロピル化グァーガム、カルボキシビニルポリマー、ポリアクリル酸アミド、ポリアクリル酸ナトリウム、ポリエチレンイミン、高重合ポリエチレングリコール、ポリビニルアルコール、ポリビニルピロリドン等が挙げられ、これらのうち、1種または2種以上を組み合わせて用いることができる。
(Polymer compound)
Examples of the polymer compound include sodium alginate, carrageenan, agar, far celerin, guar gum, quince seed, konjac mannan, tamarind gum, tara gum, dextrin, starch, locust bean gum, gum arabic, gati gum, caraya gum, tragacanth gum, arabinogalactan , Pectin, quince, wheat protein, soy protein, albumin, casein, gelatin, chitosan, hyaluronic acid, curdlan, xanthan gum, gellan gum, cyclodextrin, dextran, pullulan, crystalline cellulose, methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, Hydroxypropyl methylcellulose, carboxymethylcellulose, cationized cell Rose, cationized guar gum, hydroxypropylated guar gum, carboxyvinyl polymer, polyacrylic acid amide, sodium polyacrylate, polyethyleneimine, highly polymerized polyethylene glycol, polyvinyl alcohol, polyvinylpyrrolidone, etc. Two or more kinds can be used in combination.
(動植物抽出物)
動植物抽出物としては、例えば、プラセンタエキス、加水分解ケラチン、加水分解シルク、酵母エキス、アロエエキス、コンフリーエキス、シャクヤクエキス、シソエキス、セージエキス、センブリエキス、ハマメリス水、ヒキオコシエキス、ホップエキス、マロニエエキス、モモ葉エキス、ユキノシタエキス、メリッサエキス、ヨモギエキス、ローズマリーエキス、コメヌカ発酵エキス等が挙げられ、これらのうち、1種または2種以上を組み合わせて用いることができる。
(Animal and plant extracts)
Animal and plant extracts include, for example, placenta extract, hydrolyzed keratin, hydrolyzed silk, yeast extract, aloe extract, comfrey extract, peony extract, perilla extract, sage extract, assembly extract, hamamelis water, hyacinth extract, hop extract, maronier An extract, a peach leaf extract, a Yukinoshita extract, a Melissa extract, a mugwort extract, a rosemary extract, a rice bran extract, and the like can be used. Among these, one kind or two or more kinds can be used in combination.
(アミノ酸類)
アミノ酸類としては、例えば、L−アラニン、L−アルギニン、L−アスパラギン酸、L−グルタミン、L−アスパラギン、L−システイン、L−セリン、L−チロシン、L−プロリン、ピロリドンカルボン酸塩、グリシン、バリン、ロイシン、イソロイシン、トレオニン、メチオニン、フェニルアラニン、トリプトファン、リシン、シスチン、ヒドロキシプロリン、ヒドロキシリジン、オルニチン、ヒスチジン、γ−アミノ酪酸、ε−アミノカプロン酸等が挙げられ、これらのうち、1種または2種以上を組み合わせて用いることができる。
(Amino acids)
As amino acids, for example, L-alanine, L-arginine, L-aspartic acid, L-glutamine, L-asparagine, L-cysteine, L-serine, L-tyrosine, L-proline, pyrrolidone carboxylate, glycine , Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, cystine, hydroxyproline, hydroxylysine, ornithine, histidine, γ-aminobutyric acid, ε-aminocaproic acid, etc. Two or more kinds can be used in combination.
(溶剤)
溶剤としては、例えば、精製水、常水、エタノール、イソプロパノール、ベンジルアルコール等が挙げられ、これらのうち、1種または2種以上を組み合わせて用いることができる。
(solvent)
Examples of the solvent include purified water, normal water, ethanol, isopropanol, benzyl alcohol, and the like. Among these, one kind or a combination of two or more kinds can be used.
(ビタミン類)
ビタミン類としては、例えば、レチノール、レチノイン酸、ビタミンA油、酢酸レチノール、パルミチン酸レチノール、β−カロチン、リコピン、アスタキサンチン、ルテイン、クリプトキサンチン、塩酸ピリドキシン、ジカプリル酸ピリドキシン、ビオチン、ニコチン酸、ニコチン酸アミド、ニコチン酸ベンジル、リボフラビン、葉酸、パントテン酸カルシウム、D−パントテニルアルコール、エルゴカルシフェロール、dl−α−トコフェロール、dl−α−酢酸トコフェロール、天然ビタミンE、ユビキノン、カルニチン、α−リポ酸、ビタミンP(ヘスペリジン、メチルヘスペリジン、ルチン)等が挙げられ、これらのうち、1種または2種以上を組み合わせて用いることができる。
(Vitamins)
Examples of vitamins include retinol, retinoic acid, vitamin A oil, retinol acetate, retinol palmitate, β-carotene, lycopene, astaxanthin, lutein, cryptoxanthine, pyridoxine hydrochloride, pyridoxine dicaprylate, biotin, nicotinic acid, nicotinic acid Amide, benzyl nicotinate, riboflavin, folic acid, calcium pantothenate, D-pantothenyl alcohol, ergocalciferol, dl-α-tocopherol, dl-α-tocopherol acetate, natural vitamin E, ubiquinone, carnitine, α-lipoic acid, Vitamin P (hesperidin, methyl hesperidin, rutin) and the like can be mentioned, and one or more of these can be used in combination.
(消炎剤)
消炎剤としては、例えば、グリチルリチン酸、グリチルリチン酸ジカリウム、グリチルリチン酸モノアンモニウム、グリチルレチン酸、グリチルレチン酸ステアリル、グアイアズレン、グアイアズレンスルホン酸ナトリウム、アラントイン、ε−アミノカプロン酸等が挙げられ、これらのうち、1種または2種以上を組み合わせて用いることができる。
(Anti-inflammatory agent)
Examples of the anti-inflammatory agent include glycyrrhizic acid, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, glycyrrhetinic acid, stearyl glycyrrhetinate, guaiazulene, sodium guaiazulenesulfonate, allantoin, and ε-aminocaproic acid. Alternatively, two or more kinds can be used in combination.
(防腐剤)
防腐剤としては、例えば、メチルパラベン、エチルパラベン、プロピルパラベン、ブチルパラベン、イソブチルパラベン、フェノキシエタノール、ビサボロール、ヒノキチオール、安息香酸、安息香酸ナトリウム、サリチル酸、サリチル酸ナトリウム、ソルビン酸、ソルビン酸カリウム、ウンデシレン酸、ピオニン、l−メントール、d−カンフル、イソプロピルメチルフェノール、塩化ベンゼトニウム、塩酸アルキルジアミノエチルグリシン等が挙げられ、これらのうち、1種または2種以上を組み合わせて用いることができる。
(Preservative)
Examples of the preservatives include methyl paraben, ethyl paraben, propyl paraben, butyl paraben, isobutyl paraben, phenoxyethanol, bisabolol, hinokitiol, benzoic acid, sodium benzoate, salicylic acid, sodium salicylate, sorbic acid, potassium sorbate, undecylenic acid, and pionein. , L-menthol, d-camphor, isopropylmethylphenol, benzethonium chloride, alkyldiaminoethylglycine hydrochloride, and the like. Among these, one kind or two or more kinds can be used in combination.
(紫外線防止剤)
紫外線防止剤としては、例えば、パラアミノ安息香酸、パラアミノ安息香酸エチル、パラアミノ安息香酸グリセリル、パラジメチルアミノ安息香酸2−エチルヘキシル、オキシベンゾン、ジヒドロキシベンゾフェノン、ジヒドロキシジメトキシベンゾフェノン、ジヒドロキシジメトキシベンゾフェノンスルホン酸ナトリウム、ヒドロキシメトキシベンゾフェノンスルホン酸ナトリウム、サリチル酸オクチル、4−tert−ブチル−4’−メトキシ−ジベンゾイルメタン、フェルラ酸、酸化チタン、微粒子酸化チタン、酸化亜鉛、微粒子酸化亜鉛等が挙げられ、これらのうち、1種または2種以上を組み合わせて用いることができる。
(UV protection agent)
Examples of UV inhibitors include paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, 2-ethylhexyl paradimethylaminobenzoate, oxybenzone, dihydroxybenzophenone, dihydroxydimethoxybenzophenone, sodium dihydroxydimethoxybenzophenone sulfonate, hydroxymethoxybenzophenone Examples thereof include sodium sulfonate, octyl salicylate, 4-tert-butyl-4′-methoxy-dibenzoylmethane, ferulic acid, titanium oxide, fine particle titanium oxide, zinc oxide, and fine particle zinc oxide. Two or more kinds can be used in combination.
(金属イオン封鎖剤)
金属イオン封鎖剤としては、例えば、エデト酸、エデト酸塩、エチレンジアミンヒドロキシエチル三酢酸三ナトリウム、ジエチレントリアミン五酢酸、ジエチレントリアミン五酢酸五ナトリウム、エチレンジアミンテトラキス(2−ヒドロキシイソプロピル)ジオレイン酸塩、ヒドロキシエタンジスルホン酸、ヒドロキシエタンジスルホン酸四ナトリウム、フィチン酸等が挙げられ、これらのうち、1種または2種以上を組み合わせて用いることができる。
(Metal sequestering agent)
Examples of the sequestering agent include edetic acid, edetate, trisodium ethylenediaminehydroxyethyl triacetate, diethylenetriaminepentaacetic acid, pentasodium diethylenetriaminepentaacetate, ethylenediaminetetrakis (2-hydroxyisopropyl) dioleate, hydroxyethanedisulfonic acid , Hydroxyethanedisulfonic acid tetrasodium, phytic acid, and the like. Among these, one kind or two or more kinds can be used in combination.
(酸化防止剤)
酸化防止剤としては、例えば、ジブチルヒドロキシトルエン、ブチルヒドロキシアニソール、エリソルビン酸、没食子酸プロピル、d−δ−トコフェロール等が挙げられ、これらのうち、1種または2種以上を組み合わせて用いることができる。
(Antioxidant)
Examples of the antioxidant include dibutylhydroxytoluene, butylhydroxyanisole, erythorbic acid, propyl gallate, d-δ-tocopherol, etc. Among these, one or a combination of two or more can be used. .
(pH調整剤)
pH調整剤としては、例えば、クエン酸、グリコール酸、リンゴ酸、酒石酸、乳酸、コハク酸、リン酸およびその塩等が挙げられ、これらのうち、1種または2種以上を組み合わせて用いることができる。
(PH adjuster)
Examples of the pH adjuster include citric acid, glycolic acid, malic acid, tartaric acid, lactic acid, succinic acid, phosphoric acid and salts thereof. Among these, one or a combination of two or more may be used. it can.
以上説明した本発明の化粧料のpHは、3.0〜9.0であるのが好ましく、4.0〜7.0であるのがより好ましい。これにより、皮膚への浸透性をより高いものとすることができる。その結果、より高い保湿効果を発揮させることができる。
以上、本発明の化粧料について説明したが、本発明はこれに限定されない。
The pH of the cosmetic of the present invention described above is preferably 3.0 to 9.0, and more preferably 4.0 to 7.0. Thereby, the permeability to skin can be made higher. As a result, a higher moisturizing effect can be exhibited.
As mentioned above, although the cosmetics of this invention were demonstrated, this invention is not limited to this.
次に、本発明の具体的実施例について説明する。
<化粧料の製造>
(実施例1)
表1に示す成分を表1に示す配合量にて混合し、液状の化粧料(化粧水)を製造した。
Next, specific examples of the present invention will be described.
<Manufacture of cosmetics>
Example 1
The components shown in Table 1 were mixed in the amounts shown in Table 1 to produce a liquid cosmetic (lotion).
(実施例2〜4、比較例1〜5)
表1に示す成分および配合量を用いた以外は、前記実施例1と同様にして化粧水を製造した。
実施例1〜4および比較例1〜5の配合成分および配合量を表1に示した。
(Examples 2 to 4 and Comparative Examples 1 to 5 )
A lotion was produced in the same manner as in Example 1 except that the components and amounts shown in Table 1 were used.
The blending components and blending amounts of Examples 1 to 4 and Comparative Examples 1 to 5 are shown in Table 1.
<評価>
[保湿効果の評価]
25〜50才の男女10名をパネルとし、保湿効果に対する使用試験を行った。上記化粧料を毎日、朝と夜の2回、1ヶ月にわたって適量を上腕内側部に塗布し、保湿効果を観察した。さらに、その結果を平均して下記基準により評価した。
<Evaluation>
[Evaluation of moisturizing effect]
Ten males and females aged 25 to 50 years were used as panels, and a use test for the moisturizing effect was conducted. An appropriate amount of the above cosmetic was applied to the inner side of the upper arm twice daily in the morning and evening for one month, and the moisturizing effect was observed. Furthermore, the results were averaged and evaluated according to the following criteria.
(観察)
3点:保湿効果が感じられる
2点:保湿効果がやや感じられる
1点:保湿効果がほとんど感じられない
0点:保湿効果が全く感じられない
(Observation)
3 points: Moisturizing effect is felt 2 points: Moisturizing effect is felt slightly 1 point: Moisturizing effect is hardly felt 0 point: Moisturizing effect is not felt at all
(評価)
A:平均点2.5点以上
B:平均点2.0点以上2.5点未満
C:平均点1.0点以上2.0点未満
D:平均点1.0点未満
(Evaluation)
A: Average point 2.5 points or more B: Average point 2.0 points or more and less than 2.5 points C: Average point 1.0 points or more and less than 2.0 points D: Average point less than 1.0 points
[保存安定性の評価]
上記化粧料を50℃の恒温槽に1ヶ月間保存し、変色の有無、pHの変化および匂いの変化について下記の基準に従い評価した。
[Evaluation of storage stability]
The cosmetic was stored in a thermostatic bath at 50 ° C. for 1 month, and the presence or absence of discoloration, change in pH, and change in odor were evaluated according to the following criteria.
(1)変色の有無
A:なし
B:ほとんどなし
C:わずかにあり
D:明らかにあり
(1) Presence or absence of discoloration A: None B: Almost none C: Slightly D: Obviously
(2)pHの変化
A:pHの変化が0.2未満
B:pHの変化が0.2以上0.5未満
C:pHの変化が0.5以上1.0未満
D:pHの変化が1.0以上
(2) Change in pH A: Change in pH is less than 0.2 B: Change in pH is 0.2 or more and less than 0.5 C: Change in pH is 0.5 or more and less than 1.0 D: Change in pH 1.0 or more
(3)匂いの変化
A:なし
B:ほとんどなし
C:わずかにあり
D:明らかにあり
これらの結果を、表2に示した。
(3) Odor change A: None B: Almost none C: Slightly D: Obviously These results are shown in Table 2.
表2から明らかなように、本発明の化粧料は、肌の保湿効果に優れたものであった。また、使用感、保存安定性にも優れていた。これに対して、比較例では、十分な結果が得られなかった。 As is clear from Table 2, the cosmetic of the present invention was excellent in the skin moisturizing effect. Moreover, it was excellent in usability and storage stability. On the other hand, in the comparative example, sufficient results were not obtained.
Claims (4)
ラベンダー油と、
ユキノシタエキス、ボタンエキス、ソウハクヒエキス、クジンエキス、トウキエキス、ユズ果実エキスからなる群から選択される少なくとも1種の植物エキスと、を含み、
前記米発酵液の配合量が10〜80質量%であり、
前記植物エキスの総配合量が0.005〜2.5質量%であることを特徴とする化粧料。 Rice fermentation broth,
With lavender oil,
Saxifrage extract, button extract, mulberry bark extract, Kujin'ekisu, seen including Toukiekisu, at least one plant extract is selected from the group consisting of citron fruit extract, a,
The blending amount of the rice fermentation broth is 10-80% by mass,
Cosmetics, wherein the total amount of the plant extract is 0.005 to 2.5% by mass .
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