JP2005187466A - Skin care preparation for external use containing salt of higher fatty acid ester of ascorbic acid-2-phosphoric acid ester, method for stabilizing the salt of ester, and stabilizing agent - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a skin care preparation for external use, having improved stability of a salt of a higher fatty acid ester of ascorbic acid-2-phosphoric acid ester expressed by formula (1) (R is a higher fatty acid residue) among ascorbic acid derivatives. <P>SOLUTION: The skin care preparation for external use contains the specific salt of the higher fatty acid ester of ascorbic acid-2-phosphoric acid ester (A), a water-soluble synthetic polymer compound (B), and water (C). It is preferable that the water-soluble synthetic polymer compound (B) comprises a polymer which has a carbon chain formed by cleavage of a plurality of ethylenic unsaturated carbon-carbon bonds as its main chain. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention provides the following formula (1)

（式（１）中、Ｒは、高級脂肪酸残基を表わす。）で表されるアスコルビン酸−２−リン酸エステルの高級脂肪酸エステルの塩を含有し、安定性、溶解性に優れた皮膚外用剤、該エステル塩の安定化方法および安定化剤に関する。

(In the formula (1), R represents a higher fatty acid residue), containing a salt of a higher fatty acid ester of ascorbic acid-2-phosphate represented by the formula (1), and having excellent stability and solubility. The present invention relates to an agent, a method for stabilizing the ester salt and a stabilizer.

  Ascorbic acid and various derivatives thereof are known as compounds exhibiting effects such as whitening action, antioxidant action, and collagen synthesis promoting action, and are incorporated in pharmaceuticals, cosmetics, feeds and the like.

  In particular, among ascorbic acid derivatives, a compound in which the hydroxyl group at the 2-position of ascorbic acid is converted to a phosphate ester and the hydroxyl group at the 6-position is converted to a higher fatty acid ester (hereinafter also referred to as a higher fatty acid ester of ascorbic acid-2-phosphate). .) And its salts are difficult to oxidize, stable and amphiphilic, so have high affinity to living bodies, and can be rapidly transferred to living tissues such as skin, and can be applied to pharmaceuticals, cosmetics, feeds, etc. Expected.

  However, when this higher fatty acid ester of ascorbic acid-2-phosphate ester and / or a salt thereof is formulated as an external preparation for skin, their stability and solubility are impaired, and the decomposition, coloring, and / or Or there was a problem that precipitation occurred.

  Conventionally, a method of using an alkylated water-soluble polymer has been known for the purpose of preventing viscosity reduction and separation of an external composition containing an ascorbic acid derivative (such as ascorbic acid glucoside) (see Patent Document 1). However, Patent Document 1 does not describe any effect of increasing the stability of the higher fatty acid ester of ascorbic acid-2-phosphate ester represented by the above formula (1) and the salt itself.

  In addition, in the preparation for external use on the skin containing a salt of a higher fatty acid ester of ascorbic acid-2-phosphate, the present inventors adjusted the pH to 7 to 9 to prepare the ester salt agent. An external preparation for skin and cosmetics that have improved the stability and solubility have been already proposed (see Patent Document 2). However, depending on the dosage form of the external preparation for skin, the stability of the higher fatty acid ester salt of ascorbic acid-2-phosphate present in the agent may be insufficient, and the stability over time may be effective. There is a need for an improved method.

As a result of intensive studies in view of the above circumstances, the present inventors have found that a salt of a higher fatty acid ester of ascorbic acid-2-phosphate represented by the above formula (1), a water-soluble synthetic polymer compound, water, According to the skin external preparation containing, the stability and solubility of the higher fatty acid ester salt of ascorbic acid-2-phosphate in the agent is improved, the ester salt is uniformly dissolved in the agent, decomposed, The inventors have found that coloring and / or precipitation can be suppressed, and have completed the present invention.
JP 2003-12498 A JP 2003-176217 A

  The present invention relates to an ascorbic acid derivative represented by the following formula (1):

（式（１）中、Ｒは、高級脂肪酸残基を表わす。）で示されるアスコルビン酸−２−リン酸エステルの高級脂肪酸エステルの塩の安定性を高めた皮膚外用剤を提供することを課題としている。

(In formula (1), R represents a higher fatty acid residue.) An object of the present invention is to provide a skin external preparation having improved stability of a salt of a higher fatty acid ester of ascorbic acid-2-phosphate represented by It is said.

  Another object of the present invention is to provide a method for stabilizing a salt of a higher fatty acid ester of the ascorbic acid-2-phosphate ester and a stabilizer for the ester salt.

That is, the present invention relates to the following matters.
[1] The following formula (1)

（式（１）中、Ｒは、高級脂肪酸残基を表わす。）で示されるアスコルビン酸−２−リン酸エステルの高級脂肪酸エステルの塩（Ａ）と、水溶性合成高分子化合物（Ｂ）と、水（Ｃ）とを含有することを特徴とする皮膚外用剤。

(In formula (1), R represents a higher fatty acid residue) Ascorbic acid-2-phosphate salt of higher fatty acid ester (A), water-soluble synthetic polymer compound (B), A skin external preparation characterized by containing water (C).

  [2] In the above [1], the water-soluble synthetic polymer compound (B) is a polymer having as a main chain a carbon chain formed by cleaving a plurality of ethylenically unsaturated carbon-carbon bonds. The skin external preparation as described.

[3] The external preparation for skin according to [2], wherein the water-soluble synthetic polymer compound (B) is a carboxyvinyl polymer and / or sodium polyacrylate.
[4] The external preparation for skin according to any one of [1] to [3], wherein R in the formula (1) is a fatty acid residue having 8 to 22 carbon atoms.

  [5] The skin according to [4], wherein R in the formula (1) is a residue of lauric acid, myristic acid, palmitic acid, stearic acid, 2-hexyldecanoic acid or isostearic acid Topical agent.

[6] The external preparation for skin according to [5], wherein R in the general formula (1) is a residue of palmitic acid.
[7] The external preparation for skin according to [5], wherein R in the general formula (1) is a residue of 2-hexyldecanoic acid.

  [8] Any of [1] to [7] above, wherein the salt (A) of the higher fatty acid ester of ascorbic acid-2-phosphate is Na salt, K salt, Mg salt or Zn salt A skin external preparation according to the above.

  [9] Any of [1] to [8] above, wherein the salt (A) of a higher fatty acid ester of ascorbic acid-2-phosphate is contained in an amount of 0.01 to 20% by mass. A skin external preparation according to the above.

[10] The skin external preparation according to any one of [1] to [9], wherein the water-soluble synthetic polymer compound (B) is contained in an amount of 0.001 to 3% by mass. .
[11] The skin external preparation as described in any one of [1] to [10], wherein water (C) is contained in an amount of 20 to 99.5% by mass.

[12] The external preparation for skin according to any one of [1] to [11], which is a cosmetic.
[13] The following formula (1)

（式（１）中、Ｒは高級脂肪酸残基を表わす。）で示されるアスコルビン酸−２−リン酸エステルの高級脂肪酸エステルの塩（Ａ）を安定化する方法であって、
少なくとも水溶性合成高分子化合物（Ｂ）と水（Ｃ）とを含む組成物と、
前記アスコルビン酸−２−リン酸エステルの高級脂肪酸エステルの塩（Ａ）とを接触させることを特徴とする安定化方法。

(In the formula (1), R represents a higher fatty acid residue), which is a method for stabilizing a salt (A) of a higher fatty acid ester of ascorbic acid-2-phosphate ester,
A composition comprising at least a water-soluble synthetic polymer compound (B) and water (C);
A stabilizing method comprising contacting the salt (A) of a higher fatty acid ester of the ascorbic acid-2-phosphate ester.

[14] A water-soluble synthetic polymer compound (B), wherein the following formula (1)

（式（１）中、Ｒは、高級脂肪酸残基を表わす。）で示されるアスコルビン酸−２−リン酸エステルの高級脂肪酸エステルの塩（Ａ）の安定化剤。

(In formula (1), R represents a higher fatty acid residue) A stabilizer of a salt (A) of a higher fatty acid ester of ascorbic acid-2-phosphate represented by formula (1).

  [15] The stabilizer according to [14], further comprising water (C).

  According to the skin external preparation of the present invention, it is possible to prevent decomposition and reduction of a salt of a higher fatty acid ester of ascorbic acid-2-phosphate ester represented by the above formula (1) in the preparation, and coloring the skin external preparation And / or generation | occurrence | production of precipitation (turbidity) can be suppressed. Therefore, the external preparation for skin of the present invention can be usefully used for all applications of external preparations for skin including cosmetics.

  In addition, according to the stabilization method or stabilizer of the present invention, decomposition and reduction of the higher fatty acid ester salt of ascorbic acid-2-phosphate can be effectively suppressed.

Hereinafter, the present invention will be specifically described.
<External preparation for skin>
The external preparation for skin of the present invention contains a salt (A) of a higher fatty acid ester of ascorbic acid-2-phosphate, a water-soluble synthetic polymer compound (B), and water (C).

First, each of these components will be described, and then the skin external preparation of the present invention will be described.
(A) Salt of higher fatty acid ester of ascorbic acid-2-phosphate
The skin external preparation of the present invention contains a salt (A) of a higher fatty acid ester of ascorbic acid-2-phosphate.

The higher fatty acid ester of ascorbic acid-2-phosphate is a compound represented by the above formula (1), in which ascorbic acid-2-phosphate and a higher fatty acid form an ester, more specifically Specifically, the hydroxyl group at the 6-position of the ascorbic acid-2-phosphate ester and the higher fatty acid residue form an ester bond. The higher fatty acid corresponds to the higher fatty acid residue defined as R in the above formula (1), and is not particularly limited, but a fatty acid having 8 to 22 carbon atoms is preferable. Examples include lauric acid, myristic acid, palmitic acid, stearic acid, 2-hexyldecanoic acid, and isostearic acid. Among these, palmitic acid and 2-hexyldecanoic acid are preferable. Therefore, R in the above formula (1) is preferably a fatty acid residue corresponding to these fatty acids.

  The salt of higher fatty acid ester of ascorbic acid-2-phosphate used in the present invention is a compound in which a phosphate group of the higher fatty acid ester of ascorbic acid-2-phosphate and a base form a salt. It is.

  Preferred examples of the salt of the higher fatty acid ester of ascorbic acid-2-phosphate include Na salt, K salt, Mg salt, Zn salt and the like. Among these, Na salt is more preferable.

  Specifically, as salts of higher fatty acid esters of ascorbic acid-2-phosphate, for example, ascorbic acid-2-phosphate-6-laurate sodium, ascorbic acid-2-phosphate-6-myristin Acid sodium, sodium ascorbyl-2-phosphate-6-palmitate, sodium ascorbyl-2-phosphate-6-stearate, sodium ascorbyl-2-phosphate-6-isostearate, ascorbic acid-2- Examples include sodium 6- (2-hexyldecanoate) phosphate.

These compounds may be used individually by 1 type, and 2 or more types may be mixed and used for them.
In the skin external preparation of the present invention, the higher fatty acid ester salt of ascorbic acid-2-phosphate is 0.01 to 20% by mass, more preferably 0.05 to 12% by mass in the total amount of the skin external preparation. It is used so that it may be contained with the quantity.

  In such an amount, when a salt of a higher fatty acid ester of ascorbic acid-2-phosphate is contained in the external preparation for skin, the transition to the skin is quick and the efficacy effect required for the external preparation for skin is demonstrated. This is preferable because it is possible.

(B) Water-soluble synthetic polymer compound
The external preparation for skin of the present invention contains a water-soluble synthetic polymer compound.
The water-soluble synthetic polymer compound that can be used in the external preparation for skin of the present invention is a water-soluble polymeric compound that can be obtained by synthesis, and is usually any compound that can be blended in an external preparation for skin. Although the average weight molecular weight in terms of polystyrene measured by GPC (gel permeation chromatography) is usually in the range of 1,000 to 20,000,000, preferably 5,000 to 5,000,000. Is desirable.

Specific examples of such water-soluble synthetic polymer compounds include sodium polyacrylate, polyacrylate amide, carboxyvinyl polymer (hereinafter also referred to as carbomer), polyethyleneimine, highly polymerized polyethylene glycol, and polyvinyl alcohol. , Polyvinyl pyrrolidone, polyvinyl ether, polyacrylamide, acrylic acid polymer, methacrylic acid polymer, maleic acid polymer, vinyl pyridine polymer, ethylene / acrylic acid copolymer, vinyl pyrrolidone polymer, vinyl alcohol / vinyl pyrrolidone copolymer Polymer, nitrogen-substituted acrylamide polymer, amino-modified silicone, cationized polymer, dimethylacrylammonium polymer, acrylic acid-based anion polymer, methacrylic acid-based anion polymer, modified silico Emissions, acrylic acid / alkyl methacrylate (C ₁₀ ~ ₃₀₎
Examples thereof include a copolymer and a polyoxyethylene / polyoxypropylene copolymer.

Among these, a polymer having, as a main chain, a carbon chain obtained by cleaving a plurality of ethylenically unsaturated carbon-carbon bonds, that is, a carbon chain obtained by polymerizing a compound having an unsaturated carbon-carbon double bond. Is preferred. As described above, when a polymer having a continuous carbon chain as a main chain is used as the water-soluble synthetic polymer compound, the main chain of the polymer is in a solvent containing water because the main chain is fat-soluble. It takes a structure that goes inside, and the interaction between this fat-soluble part and the higher fatty acid residue part of the salt (A) of the higher fatty acid ester of ascorbic acid-2-phosphate makes the environment near the ester salt (A). Is considered to be special, and hydrolysis of the ester salt (A) is considered to be suppressed.

  Preferred examples of the polymer having such a carbon chain as a main chain include polyacrylic acid, sodium polyacrylate, polymethacrylic acid, polyvinyl alcohol, and carboxyvinyl polymer. Furthermore, copolymers of these polymers, copolymers of these polymers with other monomers, and those modified with other monomers, as long as water solubility is not impaired I do not care.

  Among these, carboxyvinyl polymer and / or sodium polyacrylate are more preferable, and it is more preferable to use carboxyvinyl polymer and sodium polyacrylate together.

  Thus, the skin external preparation of the present invention contains the water-soluble synthetic polymer compound (B) and the salt (A) of a higher fatty acid ester of ascorbic acid-2-phosphate. The ester salt (A) in the can be stabilized.

  The above-mentioned water-soluble synthetic polymer compound, particularly a polymer having a carbon chain as the main chain, can also be used as a stabilizer for the salt (A) of the higher fatty acid ester of ascorbic acid-2-phosphate. it can.

  In the external preparation for skin of the present invention, the water-soluble synthetic polymer compound may be used in an amount suitable for suppressing the coloring and / or precipitation of the obtained external preparation for skin, and is preferably used in the total amount of the external preparation for skin. Is used in an amount of 0.001 to 3% by mass, more preferably 0.1 to 3% by mass.

(C) Water
The skin external preparation of the present invention contains water. Although the water used for this invention is not specifically limited, What gave purification operations, such as purified water, ion-exchange water, distilled water, is preferable.

  Water may be used in an amount capable of dissolving the above-described components (A) and (B). Specifically, the total amount of the external preparation for skin of the present invention is preferably 20 to 99.5% by mass, more preferably Is used so as to be contained in an amount of 30 to 90% by mass.

(D) Other ingredients
Moreover, the component generally used for a skin external preparation can be suitably mix | blended with the skin external preparation of this invention in the range which does not impair the effect of this invention.

As such a component, for example,
Ozokerite, α-olefin oligomer, light isoparaffin, light liquid isoparaffin, squalene, squalane, synthetic squalane, vegetable squalane, ceresin, paraffin, polyethylene powder, polybutene, microcrystalline wax, liquid isoparaffin, liquid paraffin, mineral oil, petroleum jelly, etc. Hydrocarbons;

Jojoba oil, carnauba wax, candelilla wax, rice bran wax, shellac, lanolin, mink sebum wax, whale wax, sugar cane wax, sperm whale oil, beeswax, montan wax and other natural waxes, avocado oil, almond oil, olive oil, extra virgin olive oil, Sesame oil, rice bran oil, rice oil, rice germ oil, corn oil, safflower oil, soybean oil, corn oil, rapeseed oil, persic oil, palm kernel oil, palm oil, castor oil, sunflower oil, high oleic sunflower oil, Grape seed oil, cottonseed oil, palm oil, hydrogenated palm oil, beef tallow, hardened oil, horse oil, mink oil, egg yolk oil, egg yolk fat oil, rosehip oil, cucumber nut oil, evening primrose oil, wheat germ oil, peanut oil, camellia oil Oil, sasanqua oil, cacao butter, molasses, beef bone fat, beef leg oil, pork fat, horse fat, sheep fat, sheabata , Macadamia nut oil, natural fats and oils of meadowfoam oil, and the like;

Fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, γ-linolenic acid, isostearic acid, 12-hydroxystearic acid, undecylenic acid, coconut oil fatty acid;
Higher monoalcohols such as isostearyl alcohol, octyldodecanol, hexyldecanol, cholesterol, phytosterol, lauryl alcohol, myristyl alcohol, cetanol, stearyl alcohol, oleyl alcohol, behenyl alcohol, cetostearyl alcohol;

Alkyl glyceryl ethers such as batyl alcohol, chimyl alcohol, ceralkyl alcohol, isostearyl glyceryl ether;
Isopropyl myristate, butyl myristate, isopropyl palmitate, ethyl stearate, butyl stearate, ethyl oleate, ethyl linoleate, isopropyl linoleate, cetyl caprylate, hexyl laurate, isooctyl myristate, decyl myristate, myristic acid Myristyl, cetyl myristate, octadecyl myristate, cetyl palmitate, stearyl stearate, decyl oleate, oleyl oleate, cetyl ricinoleate, isostearyl laurate, isotridecyl myristate, isocetyl myristate, isostearyl myristate, myristic acid Octyldodecyl, 2-ethylhexyl palmitate, isocetyl palmitate, isostearyl palmitate, 2-ethyl stearate Hexyl, isocetyl stearate, isodecyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, ethyl isostearate, isopropyl isostearate, cetyl 2-ethylhexanoate, cetostearyl 2-ethylhexanoate, stearyl 2-ethylhexanoate, Hexyl isostearate,

Ethylene glycol dioctanoate, ethylene glycol dioleate, propylene glycol dicaprylate, di (capryl / capric) propylene glycol, propylene glycol dicaprate, propylene glycol dioleate, neopentyl glycol dicaprate, neopentyl glycol dioctanoate, glyceryl tricaprylate , Glyceryl tri-2-ethylhexanoate, tri (caprylic / capric acid) glyceryl, tri (caprylic acid / capric acid / stearic acid) glyceryl, glyceryl triundecylate, glyceryl triisopalmitate, glyceryl triisostearate, tri-2-ethyl triisostearate Trimethylolpropane hexanoate, trimethylolpropane triisostearate, pentaerythrityl tetra-2-ethylhexanoate, Pentaerythrityl lamyristate, pentaerythrityl tetraisostearate, diglyceryl tetraisostearate, octyldodecyl neopentanoate, isocetyl octoate, isostearyl octoate, 2-ethylhexyl isoperargonate, hexyldecyl dimethyloctanoate, dimethyloctane Octyldodecyl acid, 2-ethylhexyl isopalmitate, isocetyl isostearate, isostearyl isostearate, octyldodecyl isostearate, lauryl lactate, myristyl lactate, cetyl lactate, octyldodecyl lactate, triethyl citrate, acetyltriethyl citrate, acetyl citrate Tributyl, trioctyl citrate, triisocetyl citrate, trioctyldodecyl citrate, diisostearyl malate Hydroxystearic acid 2-ethylhexyl, succinate di-2-ethylhexyl, diisopropyl adipate,

Diisobutyl adipate, dioctyl adipate, diheptyl undecyl adipate, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, cholesteryl stearate, cholesteryl isostearate, cholesteryl hydroxystearate, cholesteryl oleate, dihydrocholesteryl oleate, isostearine Phytosteryl acid, phytosteryl oleate, isocetyl 12-stearoylhydroxystearate, stearyl 12-stearoylhydroxystearate, isostearyl 12-stearoylhydroxystearate, polyoxyethylene acetate (3) polyoxypropylene (1) cetyl ether, polyacetate Oxyethylene (3) Polyoxypropylene (1) Isocetyl ether, isononane Isononyl, octyl isononanoate, tridecyl isononanoate, esters such as isotridecyl isononanoate;

  Methylpolysiloxane, methylphenylpolysiloxane, methylhydrogenpolysiloxane, methylcyclopolysiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, octamethyltrisiloxane, decamethyltetrasiloxane, tetradeca Methyl hexasiloxane, highly polymerized methyl polysiloxane, dimethyl siloxane methyl (polyoxyethylene) siloxane methyl (polyoxypropylene) siloxane copolymer, dimethyl siloxane methyl (polyoxyethylene) siloxane copolymer, dimethyl siloxane methyl (Polyoxypropylene) siloxane copolymer, dimethylsiloxane / methylcetyloxysiloxane copolymer, dimethylsiloxane / Silicone oils such as chill stearoxy copolymer;

Ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, polypropylene glycol, 1,3-butylene glycol, glycerin, diglycerin, polyglycerin, 3-methyl-1,3-butanediol, 1, Polyhydric alcohols such as 3-butanediol, 1,2-pentanediol, 1,2-hexanediol;
Sugars such as mannitol, sorbitol, xylitol, maltitol, erythritol, pentaerythritol, glucose, sucrose, fructose, lactose, maltose, xylose, trehalose;

  Sodium alginate, carrageenan, agar, fur celerin, guar gum, quince seed, konjac mannan, tamarind gum, tara gum, dextrin, starch, locust bean gum, gum arabic, gati gum, karaya gum, tragacanth gum, arabinogalactan, pectin, quince, chitosan, card Orchid, xanthan gum, gellan gum, cyclodextrin, dextran, pullulan, microcrystalline cellulose, methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose, carboxystarch, cationized cellulose, starch phosphate ester, cationized guar gum , Carboxymethyl hydroxyp Pills guar gum, hydroxypropylated guar gum, albumin, casein, naturally occurring polymer compounds such as gelatin;

Lower monoalcohols such as ethanol, isopropyl alcohol, 1-butanol, 2-butanol, benzyl alcohol;
Palm oil fatty acid potassium, coconut oil fatty acid sodium, coconut oil fatty acid triethanolamine, potassium laurate, sodium laurate, triethanolamine laurate, potassium myristate, sodium myristate, isopropanolamine myristate, potassium palmitate, palmitic acid Sodium, isopropanolamine palmitate, potassium stearate, sodium stearate, triethanolamine stearate, potassium oleate, sodium oleate, castor oil fatty acid sodium, zinc undecylenate, zinc laurate, zinc myristate, magnesium myristate, Zinc palmitate, zinc stearate, calcium stearate, magnesium stearate, aluminum stearate, myristi Calcium, magnesium myristate, dimyristate, aluminum isostearate,

Polyoxyethylene lauryl ether acetic acid, sodium polyoxyethylene lauryl ether acetate, polyoxyethylene tridecyl ether acetic acid, sodium polyoxyethylene tridecyl ether acetate, sodium stearoyl lactate, sodium isostearoyl lactate, sodium lauroyl sarcosine, coconut oil fatty acid sarcosine, Palm oil fatty acid sarcosine sodium, coconut oil fatty acid sarcosine triethanolamine, lauroyl sarcosine, lauroyl sarcosine potassium, lauroyl sarcosine triethanolamine, oleoyl sarcosine, myristoyl sarcosine sodium, sodium stearoyl glutamate, coconut oil fatty acid acyl glutamic acid, coconut oil fatty acid acyl glutamic acid Potassium, palm oil fatty acid acyl glutamic acid Thorium, palm oil fatty acid acyl glutamate triethanolamine, lauroyl acyl glutamate, lauroyl acyl glutamate potassium, lauroyl acyl glutamate, lauroyl acyl glutamate triethanolamine, myristoyl acyl glutamate, myristoyl acyl glutamate, myristoyl acyl glutamate, stearoyl acyl glutamate, Potassium stearoyl acyl glutamate, disodium stearoyl acyl glutamate, hardened beef tallow fatty acid acyl sodium glutamate, coconut oil fatty acid / hardened beef tallow fatty acid sodium acyl glutamate,

Coconut oil fatty acid sodium methylalanine, Lauroylmethylalanine, Lauroylmethylalanine sodium, Lauroylmethylalanine triethanolamine, Myristoylmethylalanine sodium, Lauroylmethyltaurine sodium, Coconut oil fatty acid methyltaurine potassium, Coconut oil fatty acid methyltaurine sodium, Coconut oil fatty acid Methyl taurine magnesium, myristoyl methyl taurine sodium, palmitoyl methyl taurine sodium, stearoyl methyl taurine sodium, oleoyl methyl taurine sodium, sodium alkane sulfonate, sodium tetradecene sulfonate, dioctyl sodium sulfosuccinate, disodium lauryl sulfosuccinate, palm oil fatty acid Sodium ethyl ester sulfonate Sodium lauryl sulfate, triethanolamine lauryl sulfate, sodium cetyl sulfate, alkyl (11,13,15) triethanolamine sulfate, alkyl (12,13) sodium sulfate, alkyl (12,13) triethanolamine sulfate, alkyl (12 , 14, 16) ammonium sulfate, alkyl (12-13) diethanolamine sulfate,

Alkyl (12-14) sulfate triethanolamine, alkyl (12-15) sulfate triethanolamine, coconut oil alkyl magnesium sulfate / triethanolamine, ammonium lauryl sulfate, potassium lauryl sulfate, magnesium lauryl sulfate, monoethanolamine lauryl sulfate, lauryl Diethanolamine sulfate, sodium myristyl sulfate, sodium stearyl sulfate, sodium oleyl sulfate, oleyl sulfate triethanolamine, polyoxyethylene lauryl ether sodium sulfate, polyoxyethylene lauryl ether sulfate triethanolamine, polyoxyethylene (1) alkyl (11,13) 15) Sodium ether sulfate, polyoxyethylene (1) alkyl (11, 13, 15) ether triethanolamine sulfate, Polyoxyethylene (3) alkyl (11-15) ether sodium sulfate, polyoxyethylene (2) alkyl (12,13) ether sodium sulfate,

Polyoxyethylene (3) alkyl (12-14) ether sulfate sodium, polyoxyethylene (3) alkyl (12-15) ether sulfate sodium, polyoxyethylene (2) sodium lauryl ether sulfate, polyoxyethylene (3) myristyl Sodium ether sulfate, higher fatty acid alkanolamide sulfate sodium ester, lauryl phosphate, sodium lauryl phosphate, potassium cetyl phosphate, diethanolamine cetyl phosphate, polyoxyethylene oleyl ether phosphate, polyoxyethylene lauryl ether phosphate, polyoxyethylene lauryl ether Sodium phosphate, polyoxyethylene cetyl ether phosphate, polyoxyethylene cetyl ether sodium phosphate, polyoxyethylene stearyl ether Acid, polyoxyethylene oleyl ether phosphate, polyoxyethylene oleyl ether sodium phosphate, polyoxyethylene alkylphenyl ether phosphate, polyoxyethylene alkylphenyl ether sodium phosphate, polyoxyethylene alkylphenyl ether triethanolamine, Polyoxyethylene octyl ether phosphoric acid, polyoxyethylene (10) alkyl (12,13) ether phosphoric acid, polyoxyethylene alkyl (12-15) ether phosphoric acid, polyoxyethylene alkyl (12-16) ether phosphoric acid, Anionic surfactants such as polyoxyethylene lauryl ether phosphate triethanolamine, polyoxyethylene oleyl ether phosphate diethanolamine;

Dioctylamine, dimethylstearylamine, trilaurylamine, diethylaminoethylamide stearate, lauryltrimethylammonium chloride, cetyltrimethylammonium chloride, cetyltrimethylammonium bromide, cetyltrimethylammonium saccharin, stearyltrimethylammonium chloride, alkyl chloride (20-22) Trimethylammonium, lauryltrimethylammonium bromide, alkyl (16,18) trimethylammonium chloride, stearyltrimethylammonium bromide, stearyltrimethylammonium saccharin, alkyl (28) trimethylammonium chloride, di (polyoxyethylene) oleylmethylammonium chloride (2EO) ), Dipolyoxyethylene stearylmethylammonium chloride Polyoxyethylene chloride (1) polyoxypropylene (
25) Diethylmethylammonium chloride, tri (polyoxyethylene) stearylammonium chloride (5EO), distearyldimethylammonium chloride, dialkyl (12-15) dimethylammonium chloride, dialkyl (12-18) dimethylammonium chloride,

Dialkyl (14-18) dimethyl ammonium chloride, dicocoyl dimethyl ammonium chloride, dicetyl dimethyl ammonium chloride, isostearyl lauryl dimethyl ammonium chloride, benzalkonium chloride, myristyl dimethyl benzyl ammonium chloride, lauryl dimethyl (ethyl benzyl) ammonium chloride, chloride Cationic surfactants such as stearyldimethylbenzylammonium, laurylpyridinium chloride, cetylpyridinium chloride, lauroylcolaminoformylmethylpyridinium chloride, stearoylcoraminoformylmethylpyridinium chloride, alkylisoquinolium bromide, methylbenzethonium chloride, benzethonium chloride;

2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, alkyldiaminoethylglycine hydrochloride, sodium lauryldiaminoethylglycine, sodium undecylhydroxyethylimidazolium betaine, undecyl-N-carboxymethylimidazolium betaine Coconut oil fatty acid acyl-N-carboxyethyl-N-hydroxyethylethylenediamine disodium, coconut oil fatty acid acyl-N-carboxyethoxyethyl-N-carboxyethylethylenediamine disodium, coconut oil fatty acid acyl-N-carboxymethoxyethyl-N -Carboxymethylethylenediamine disodium, sodium laurylaminopropionate, sodium laurylaminodipropionate, laurylaminopropyl Triethanolamine pionate, palm oil fatty acid acyl-N-carboxyethyl-N-hydroxyethylethylenediamine sodium, lauryldimethylaminoacetic acid betaine, coconut oil alkyldimethylaminoacetic acid betaine, stearyldimethylaminoacetic acid betaine, stearyldimethylbetaine sodium, coconut oil Amphoteric surfactants such as fatty acid amidopropyl betaine, palm oil fatty acid amidopropyl betaine, lauric acid amidopropyl acetic acid betaine, ricinoleic acid amidopropyl betaine, stearyl dihydroxyethyl betaine, lauryl hydroxysulfo betaine;

  Polyoxyethylene (10) alkyl (12,13) ether, polyoxyethylene lauryl ether, polyoxyethylene cetyl ether, polyoxyethylene stearyl ether, polyoxyethylene oleyl ether, polyoxyethylene (3, 7, 12) alkyl ( 12-14) ether, polyoxyethylene tridecyl ether, polyoxyethylene myristyl ether, polyoxyethylene-sec-alkyl (14) ether, polyoxyethylene isocetyl ether, polyoxyethylene cetostearyl ether, polyoxyethylene (2 , 10, 20) Isostearyl ether, polyoxyethylene oleyl cetyl ether, polyoxyethylene (20) aralkyl ether, polyoxyethylene octyldodecyl ether Polyoxyethylene behenyl ether, polyoxyethylene octyl phenyl ether, polyoxyethylene nonyl phenyl ether, polyoxyethylene dinonyl phenyl ether, polyoxyethylene (1) polyoxypropylene (1,2,4,8) cetyl ether, poly Oxyethylene (5) polyoxypropylene (1,2,4,8) cetyl ether, polyoxyethylene (10) polyoxypropylene (1,2,4,8) cetyl ether, polyoxyethylene (20) polyoxypropylene (1,2,4,8) cetyl ether, polyoxyethylene polyoxypropylene lauryl ether, polyoxyethylene (3) polyoxypropylene (34) stearyl ether, polyoxyethylene (4) polyoxypropylene (30) Allyl ether, polyoxyethylene (34) polyoxypropylene (23) stearyl ether,

Polyoxyethylene polyoxypropylene cetyl ether, polyoxyethylene polyoxypropylene decyl tetradecyl ether, polyethylene glycol monolaurate, ethylene glycol monostearate, polyethylene glycol monostearate, polyethylene glycol monooleate, ethylene glycol fatty acid ester, self-emulsifying Ethylene glycol monostearate, diethylene glycol laurate, polyethylene glycol myristate, polyethylene glycol palmitate, diethylene glycol stearate, self-emulsifying polyethylene glycol monostearate (2), polyethylene glycol isostearate, ethylene glycol dioctanoate, diethylene glycol dilaurate ,

Polyethylene glycol dilaurate, polyethylene glycol dipalmitate (150), ethylene glycol distearate, diethylene glycol distearate, polyethylene glycol distearate, ethylene glycol dioleate, polyethylene glycol dioleate, polyethylene glycol diricinoleate, polyoxyethylene monolaurate ( 20) sorbitan, polyoxyethylene monopalmitate (20) sorbitan, polyoxyethylene monostearate (6) sorbitan, polyoxyethylene monostearate (20) sorbitan, polyoxyethylene tristearate (20) sorbitan, monoolein Acid polyoxyethylene (6) sorbitan, monooleic acid polyoxyethylene (20) sorbitan Polyoxyethylene trioleate (20) sorbitan, polyoxyethylene (20) coconut fatty acid sorbitan, polyoxyethylene monolaurate (10-80) sorbitan, polyoxyethylene sorbitan tristearate, polyoxyethylene isostearate (20) Sorbitan, polyoxyethylene tristearate (150) sorbitan,

Polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, polyoxyethylene (10) hydrogenated castor oil, polyoxyethylene (20) hydrogenated castor oil, polyoxyethylene (40) hydrogenated castor oil, polyoxyethylene (50) hydrogenated Castor oil, polyoxyethylene (60) hydrogenated castor oil, lipophilic glyceryl monostearate, lipophilic glyceryl monooleate, glyceryl monostearate, palm oil fatty acid glyceryl, glyceryl laurate, glyceryl myristate, Glyceryl isostearate, glyceryl ricinoleate, glyceryl monohydroxystearate, glyceryl oleate, glyceryl linoleate, glyceryl erucate, glyceryl behenate, wheat germ oil fatty acid glyceride, safflower oil fatty acid glyceryl Hydrogenated soybean fatty acid glyceryl, saturated fatty acid glyceride, cottonseed oil fatty acid glyceryl, monoisostearate monomyristate glyceryl, mono-bovine fatty acid glyceride, monolanolin fatty acid glyceryl, sesquioleate glyceryl distearate, glyceryl diisostearate, glyceryl diarachiate, monolaurin Sorbitan acid, sorbitan monopalmitate, sorbitan monostearate, sorbitan monoisostearate, sorbitan monooleate, sorbitan sesquistearate, sorbitan sesquioleate, sorbitan tristearate, sorbitan trioleate, coconut fatty acid sorbitan, isostearic acid Sorbitan,

Sorbitan sesquiisostearate, sorbitan distearate, diglyceryl isopalmitate, poly (4-10) glyceryl monolaurate, poly (10) glyceryl monomyristate, poly (2-10) glyceryl monostearate, poly (isoisostearate poly ( 2-10) glyceryl, poly (2-10) glyceryl monooleate, diglyceryl sesquioleate, poly (2-10) glyceryl diisostearate, poly (6-10) glyceryl distearate, diglyceryl triisostearate, tri Poly (10) glyceryl stearate, poly (10) glyceryl trioleate, poly (2) glyceryl tetraisostearate, decaglyceryl pentastearate, poly (6-10) glyceryl pentaoleate, Heptas Poly (10) glyceryl allate, decaglyceryl decastearate, poly (10) glyceryl dekaoleate, poly (6) glyceryl condensed ricinoleate, sucrose fatty acid ester, coconut oil fatty acid sucrose ester, alkyl glucoside, coconut oil alkyldimethyl Nonionic surfactants such as amine oxide, lauryl dimethylamine oxide, dihydroxyethyl lauryl dimethylamine oxide, stearyl dimethylamine oxide, oleyl dimethylamine oxide, polyoxyethylene coconut oil alkyl dimethylamine oxide;

  Saponin, lecithin, soybean phospholipid, hydrogenated soybean phospholipid, soybean lysophospholipid, hydrogenated soybean lysophospholipid, egg yolk lecithin, hydrogenated egg yolk lysophosphatidylcholine, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, sphingophospholipid, sphingomyelin, ganglioside Natural surfactants such as bile acid, cholic acid, deoxycholic acid, sodium cholate, sodium deoxycholate, spicrispolic acid, rhamnolipid, trehalose lipid, sophorolipid, mannosylerythritol lipid;

Paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, paraaminobenzoic acid derivatives such as 2-ethylhexyl paradimethylaminobenzoate, benzyl cinnamate, monoparamethoxycinnamic acid mono-2 -Glyceryl ethylhexanoate, methyl 2,4-diisopropylcinnamate, ethyl 2,4-diisopropylcinnamate, potassium paramethoxycinnamate, sodium paramethoxycinnamate, isopropyl paramethoxycinnamate, paramethoxycinnamate Cinnamic acid derivatives such as 2-ethylhexyl cinnamate, 2-ethoxyethyl paramethoxycinnamate, ethyl paraethoxycinnamate, urocanic acid derivatives such as urocanic acid, ethyl urocanate, 2,4-dihydroxybenzophenone, 2, 2 ', 4, 4 '-Tetrahydroxybenzophenone, 2-hydroxy-4-methoxy-5-sulfobenzophenone sodium, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone, 2,2'-dihydroxy- Benzophenone derivatives such as sodium 4,4′-dimethoxybenzophenone and sodium 2,2′-dihydroxy-4,4′-dimethoxy-5-sulfobenzophenone, ethylene glycol salicylate, 2-ethylhexyl salicylate, phenyl salicylate, benzyl salicylate, salicylic acid p -Salicylic acid derivatives such as tert-butylphenyl, homomenthyl salicylate, salicylic acid-3,3,5-trimethylcyclohexyl, 2- (2'-hydroxy-5'-methoxyphenyl) benzotriazole, UV absorbers such as 4-tert-butyl-4′-methoxybenzoylmethane;

  Kaolin, anhydrous silicic acid, magnesium aluminum silicate, sericite, talc, boron nitride, mica, montmorillonite, hemp cellulose powder, wheat starch, silk powder, corn starch, nitro dye, azo dye, nitroso dye, triphenyl Methane dyes, xanthene dyes, quinoline dyes, anthraquinone dyes, indigo dyes, pyrene dyes, phthalocyanine dyes, flavonoids, quinone, porphyrins, water-soluble anato, squid powder, caramel, guaiazulene, gardenia blue, gardenia yellow , Cochineal, shikonin, copper chlorophyllin sodium, paprika dye, safflower red, safflower yellow, lacqueric acid, riboflavin butyrate, and other natural dyes, carbon black, yellow iron oxide, black iron oxide, red rose, conger, group , Zinc oxide, chromium oxide, titanium oxide, black titanium oxide, zirconium oxide, chromium hydroxide, alumina, magnesium oxide, barium sulfate, aluminum hydroxide, calcium carbonate, lithium cobalt titanate, manganese violet, pearl pigment powder, etc. And coloring materials;

  Ashitaba extract, Acacia extract, Avocado extract, Achacha extract, Achachazul extract, Altea extract, Arnica extract, Oil-soluble Arnica extract, Almond extract, Aloe extract, Anthony extract, Ginkgo biloba extract, Nettle extract, Iris root extract, Fennel extract , Turmeric extract, Ages extract, Echinacea leaf extract, Ogon extract, Oat extract, Prunus extract, Barley extract, Okra extract, Hypericum extract, Oil-soluble Hypericum extract, Adriatic extract , Orange flower water, seaweed extract, oyster tannin, cuckoo extract, valerian extract, cattail extract, chamomile extract, oil-soluble chamomile extract, chamomile Water, oat extract, carrot extract, oil-soluble carrot extract, carrot oil, pearl millet extract, licorice extract, licorice extract powder, licorice flavonoids, cantalis tincture, raspberry extract, kiwi extract, quina extract, cucumber extract, kyonin extract, quince seed extract Gardenia extract, Kumazasa extract, Clara extract, Walnut shell extract, Grapefruit extract, Clematis extract, Brown sugar extract, Chlorella extract, Mulberry extract, Keihi extract, Gentian extract,

Gentian pepper extract, black tea extract, cornflower extract, burdock extract, oil-soluble burdock extract, wheat germ extract, hydrolyzed wheat powder, rice bran extract, rice bran ferment extract, comfrey extract, saicin extract, saffron extract, bonito extract, oil-soluble salvia extract , Hawthorn extract, salamander extract, shiitake extract, shiitake extract powder, ziama extract, shikon extract, oil-soluble shikon extract, perilla extract, linden extract, oil-soluble linden extract, citrus extract, peonies extract, juniper extract, ginger extract, oil-soluble ginger Extract, ginger tincture, ginger root extract, birch extract, oil-soluble birch extract, birch sap, honeysuckle extract, horsetail extract, oil-soluble horsetail extract, sorghini , Stevia extract, Atlantic kizuta extract, Hawthorn extract, Atlantic elder extract, Atlantic rat extract, Achillea millefolium extract, oil-soluble Achillea millefolium extract, mint extract, sage extract, oil-soluble sage extract, sage water, mallow extract, celery extract, Senkyu extract, Senkyu water, Assembly extract, Soybean extract, Taisou extract, Thyme extract, Tea extract, Tea dry extract, Tea seed extract, Clove extract, Chimpi extract, Camellia extract, Clover extract, Oil soluble Teuchigurumi extract, Duke extract, Terminaria extract, Pepper tincture, Toki extract, Oil-soluble Toki extract, Toki water, Toki-Senka extract, Oil-soluble Toki-Senka extract, Soymilk powder, Tonin extract, Spruce , Dokudami extract, tomato extract, tormentilla extract, natto extract, carrot extract, oil soluble carrot extract, garlic extract, wild rose extract, oil soluble wild rose extract, buckthorn extract, buckthorn root extract, buckthorn extract, parsley extract, leafhopper extract Concentrate, distilled mint water, hamamelis water,

Hamamelis extract, rose extract, parietalia extract, toad extract, loquat leaf extract, oil soluble loquat leaf extract, dandelion extract, butterfly extract, butcher bloom extract, butcher bloom extract powder, grape extract, grape leaf extract, grape water, hayflower Extract, loofah extract, loofah water, safflower extract, oil-soluble bodaige extract, bodaiju water, button extract, hop extract, oil-soluble hop extract, pine extract, maria thistle extract, malonie extract, oil-soluble maronie extract, muclozi extract, melissa extract, Merirot extract, peach leaf extract, oil-soluble peach leaf extract, coconut extract, cornflower extract, cornflower water, eucalyptus extract, yukinoshita extract, lily extract, yokuinin extract, oil-soluble yokuinine , Mugwort extract, mugwort water, lavender extract, lavender water, apple extract, litchi extract, lettuce extract, lemon extract, forsythia extract, rose water, rosemary extract, oil-soluble rosemary extract, roman chamomile extract, bitumen extract, etc. Plant extracts;

  Glycine, alanine, valine, leucine, isoleucine, serine, threonine, phenylalanine, tyrosine, tryptophan, cystine, cysteine, methionine, proline, hydroxyproline, aspartic acid, asparagine, glutamic acid, glutamine, arginine, histidine, lysine, γ-aminobutyric acid Amino acids and peptides such as DL-pyrrolidonecarboxylic acid, ε-aminocaproic acid, hydrolyzed elastin, water-soluble elastin, hydrolyzed collagen, water-soluble collagen, glutathione, wheat peptide, soybean peptide;

  Vitamin A such as retinol, retinal, retinoic acid, retinol acetate, retinol palmitate, etc., carotenoids such as α-carotene, β-carotene, γ-carotene, δ-carotene, lycopene, zeaxanthin, cryptoxanthine, echinone, astaxanthin, Vitamin B1 such as thiamine, vitamin B2 such as riboflavin, vitamin B6 such as pyridoxine, pyridoxal, pyridoxamine, vitamin B12 such as cyanocobalamin, folic acid, nicotinic acid, nicotinamide, pantothenic acid, biotins, L -Ascorbic acid, sodium L-ascorbate, L-ascorbyl stearate, L-ascorbyl palmitate, L-ascorbyl dipalmitate, L-ascorbyl tetraisopalmitate, L-ascorb Vitamin Cs such as disodium acid sulfate ester, L-ascorbyl magnesium, sodium L-ascorbyl phosphate, L-ascorbic acid-2-glucoside, vitamins D such as ergocalciferol, cholecalciferol, d-α- Vitamin E such as tocopherol, DL-α-tocopherol, dl-α-tocopherol acetate, dl-α-tocopherol succinate, β-tocopherol, γ-tocopherol, d-δ-tocopherol, ubiquinones, vitamin K, carnitine Vitamins such as ferulic acid, γ-oryzanol, α-lipoic acid, orotic acid and vitamin-like agents;

  Benzoic acid, sodium benzoate, undecylenic acid, salicylic acid, sorbic acid, potassium sorbate, dehydroacetic acid, sodium dehydroacetate, isobutyl parahydroxybenzoate, isopropyl parahydroxybenzoate, ethyl parahydroxybenzoate, butyl parahydroxybenzoate, Preservatives such as propyl parahydroxybenzoate, benzyl parahydroxybenzoate, methyl parahydroxybenzoate, methyl sodium parahydroxybenzoate, phenoxyethanol, photosensitizer 101, photosensitizer 201, photosensitizer 401, and the like;

Antioxidants such as butylhydroxyanisole, butylhydroxytoluene, propyl gallate, erythorbic acid, sodium erythorbate, parahydroxyanisole, octyl gallate;
Metal ion sequestering agents such as trisodium ethylenediaminehydroxyethyl triacetate, edetic acid, disodium edetate, trisodium edetate, tetrasodium edetate, sodium citrate, gluconic acid, phytic acid, sodium polyphosphate, sodium metaphosphate ;
Moisturizers such as hyaluronic acid, sodium hyaluronate, sodium chondroitin sulfate, sodium lactate, sodium pyrrolidonecarboxylate, betaine, lactic acid bacteria culture, yeast extract, ceramide;

Anti-inflammatory agents such as glycyrrhizic acid, trisodium glycyrrhizinate, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, β-glycyrrhetinic acid, glyceryl glycyrrhetinate, stearyl glycyrrhetinate, lysozyme chloride, hydrocortisone, allantoin;
PH adjusters such as sodium hydroxide, potassium hydroxide, triethanolamine;
Salts such as sodium chloride, potassium chloride, magnesium chloride, sodium sulfate;
Α-hydroxy acids such as citric acid, glycolic acid, tartaric acid, lactic acid;
Whitening agents such as arbutin, α-arbutin, placenta extract;

  Angelica oil, Ylang-Ylang oil, Elemi oil, Orange oil, Chamomile oil, Roman chamomile oil, Cardamom oil, Calamus oil, Galvanum oil, Camphor oil, Carrot seed oil, Clarage sage oil, Grapefruit oil, Clove oil, Keihi oil, Coriander oil , Cypress oil, Sandalwood oil, Cedarwood oil, Citronella oil, Cinnamon leaf oil, Jasmine absolute, Juniper berry oil, Ginger extract, Spearmint oil, Sage oil, Cedar oil, Geranium oil, Thyme oil, Tea tree oil, Nutmeg oil , Near uri oil, neroli oil, pine oil, basil oil, peppermint oil, patchouli oil, palmarosa oil, fennel oil, petitgren oil, black pepper oil, frankincense oil, vetiver oil, peppermint oil, bergamot oil Zoin oil, Boad Rose oil, Marjoram oil, Mandarin oil, Myrrh oil, Melissa oil, Eucalyptus oil, Yuzu oil, Lime oil, Lavensara oil, Lavandin oil, Lavender oil, Linden oil, Lemon oil, Lemongrass oil, Rose oil, Rose Essential oils such as wood oil, rosemary oil, lobe oil;

Terpenes such as limonene, pinene, terpinene, terpinolene, myrcene, longiferin, etc .;
A fragrance | flavor etc. are mentioned. These components can be used individually by 1 type or in combination of 2 or more types.

Production of topical skin preparation
The skin external preparation of this invention can be manufactured by mixing by a conventional method, using the component mentioned above so that it may become predetermined | prescribed content.

<Cosmetics>
Regarding the use of the external preparation for skin obtained as described above, the most common aspect is cosmetics. The form of the cosmetic is not limited.

The cosmetics include skin milk, skin cream, foundation cream, massage cream, cleansing cream, shaving cream, cleansing foam, lotion, lotion, pack, shampoo, rinse, hair restorer, hair nourishing agent, hair dye, hair conditioner, Toothpaste, mouthwash, permanent wave agent, ointment, bathing agent, body soap, etc. are included in a broad sense, and any type can be used as long as it comes into contact with the skin during use. Regardless of the gender and age of the user.

  Furthermore, existing cosmetic raw materials other than the components (A) to (D) described above can be added to the cosmetic at a general concentration. For example, commentary on the second edition of the Cosmetic Raw Material Standards (edited by the Japan Standards Association, 1984 (Pharmaceutical Daily)), non-standard ingredients for cosmetic raw materials (supervised by the Pharmaceutical Affairs Bureau, Ministry of Health and Welfare, 1993 (Pharmaceutical Daily)), cosmetic raw material standards Supplemental specifications for external ingredients (supervised by the Pharmaceutical Affairs Bureau, Ministry of Health and Welfare, 1993 (Pharmaceutical Daily)), permission standards by cosmetic type (supervised by the Pharmaceutical Affairs Bureau, Ministry of Health, Health and Welfare, 1993 (Pharmaceutical Daily)), formulation standards by cosmetics (Ministry of Health and Welfare) Of all the cosmetic raw materials described in the supervision of the Ministry of Internal Affairs and Communications, 1997 (Pharmaceutical Daily), and the Cosmetic Raw Material Dictionary (1991 (Nikko Chemicals)), etc., the above-mentioned components (A) to (D) Other than can be used.

The preferable content of these cosmetic raw materials is 0.01 to 90% by mass, more preferably 0.1 to 25% by mass, and still more preferably when added to the component (D). Is 0.3 to 10% by mass.
<Method for stabilizing salt (A) of higher fatty acid ester of ascorbic acid-2-phosphate ester and stabilizer>
As described above, the external preparation for skin of the present invention contains a salt (A) of a higher fatty acid ester of ascorbic acid-2-phosphate represented by the formula (1), and the salt (A) By improving the stability in the preparation, it is possible to prevent the decomposition of the salt (A) and the decrease in the abundance, and at the same time suppress the coloring and / or precipitation (turbidity) of the external preparation for skin.

  In other words, among the components described above, the composition containing at least the water-soluble synthetic polymer compound (B) and water (C) is contacted with the salt (A) of a higher fatty acid ester of ascorbic acid-2-phosphate. More specifically, the ester salt (A) can be stabilized by the presence of the ester salt (A) in the composition.

  Thus, in this invention, the salt (A) of the higher fatty acid ester of ascorbic acid-2-phosphate ester, the water-soluble synthetic polymer compound (B), and water (C) coexist in the external preparation for skin. By this, this ester salt (A) can be stabilized.

  Therefore, the water-soluble synthetic polymer compound (B), preferably a polymer having a carbon chain as the main chain, is used as a stabilizer for the salt (A) of the higher fatty acid ester of ascorbyl 2-phosphate. Can be used. Furthermore, the stabilizer preferably contains water (C).

[Example]
EXAMPLES Hereinafter, although this invention is demonstrated further more concretely based on an Example, this invention is not limited to these Examples. In addition, the compounding quantity in the following example shall represent the mass%.

First, conditions and criteria for measurement and evaluation performed in the following examples will be described.
<Measurement conditions and evaluation criteria>
1) Absorbance measurement conditions Each agent was diluted 10-fold with purified water, filtered through a filter having a pore size of 0.5 µm, and the absorbance of the filtrate was measured.

A spectrophotometer (manufactured by Hitachi, Ltd., U-2000) was used for the absorbance measurement, and was performed by a conventional method using a cell having an optical path length of 10 mm. The measurement wavelength was 400 nm.
2) Turbidity generation observation evaluation Visually evaluated according to the following evaluation criteria.

-: No turbidity is observed at all; ±: Slight turbidity is observed +: Turbidity is remarkable 3) High-performance liquid chromatography measurement conditions Column: Shodex (registered trademark of Showa Denko KK) C18P
4E
Column temperature: 40 ° C
Eluent: 0.1 M dipotassium hydrogen phosphate (pH 7.0) / tetrahydrofuran = 65/35
Flow rate: 0.7 ml / min Detection: UV 265 nm
In addition, the residual rate (%) of the salt (A) of the higher fatty acid ester of ascorbic acid-2-phosphate in the agent is determined by the concentration of the salt (A) in the agent immediately after preparation and the standing at 40 ° C. for 1 month. The salt (A) concentration in the later agent was measured by high performance liquid chromatography under the above measurement conditions and calculated according to the following formula.

Residual rate (%) = 100 × [concentration of salt (A) in agent after standing at 40 ° C. for 1 month (g / l) / concentration of salt (A) in agent immediately after preparation (g / l)]
[Examples 1 to 3]
In accordance with the formulations of Examples 1 to 3 in Table 1, the components 1 to 6 in Table 1 were uniformly mixed and dissolved, and then the component 7 in Table 1 was dissolved in the component 8 and added. Then, it fully stirred and deaerated and obtained the skin external preparation of Examples 1-3.

  The obtained external preparation for skin was allowed to stand at 40 ° C., and the occurrence of coloring and turbidity was examined over time according to the above measurement conditions and evaluation criteria. Coloring was measured using a spectrophotometer, and the occurrence of turbidity was evaluated visually.

  Moreover, after measuring content of the sodium ascorbic acid-2-phosphate-6-palmitate in an agent by the high performance liquid chromatography according to the said measurement conditions about the obtained skin external preparation, it left still at 40 degreeC. The content of sodium ascorbyl-2-phosphate-6-palmitate in the agent was measured over time by high performance liquid chromatography, and the residual rate was calculated according to the above formula.

Table 2 shows the coloration, turbidity, and the residual rate of sodium ascorbyl-2-phosphate-6-palmitate in the preparation after 1 month of standing at 40 ° C.
[Comparative Examples 1 and 2]
According to the prescriptions of Comparative Examples 1 and 2 in Table 1, the ingredients described in Table 1 were uniformly mixed and dissolved to obtain external preparations for skin of Comparative Examples 1 and 2.

  Except for using the obtained skin external preparation of Comparative Example 1 or Comparative Example 2, the same as in Examples 1 to 3, coloring of the agent, turbidity, ascorbic acid-2-phosphate-6-palmitin in the agent The content of sodium acid was measured or evaluated over time according to the above measurement conditions and evaluation criteria.

  The results after 1 month of standing at 40 ° C. are shown in Table 2.

表２から、実施例１〜３では比較例１および２に比べて、着色および濁りの発生が抑えられており、剤中のアスコルビン酸−２−リン酸−６−パルミチン酸ナトリウム量の減少も抑えられていることがわかる。

From Table 2, generation | occurrence | production of coloring and turbidity was suppressed compared with Comparative Examples 1 and 2 in Examples 1-3, and the reduction | decrease of the amount of sodium ascorbic acid-2-phosphate-6-palmitate in an agent is also possible. You can see that it is suppressed.

[Examples 4 to 6]
According to the formulation of Examples 4 to 6 in Table 3, the components 1 to 6 in Table 3 were uniformly mixed and dissolved, and then the component 7 in Table 3 was dissolved in the component 8 and added. Then, it fully stirred and deaerated and obtained the skin external preparation of Examples 4-6.

  Except for using the obtained skin external preparations of Examples 4 to 6, coloring of the agent, turbidity, ascorbic acid-2-phosphate-6- (2- The content of sodium hexyldecanoate) was measured or evaluated over time according to the above measurement conditions and evaluation criteria.

The results after 1 month of standing at 40 ° C. are shown in Table 4.
[Comparative Examples 3 and 4]
According to the prescriptions of Comparative Example 3 and Comparative Example 4 in Table 3, the components described in Table 3 were uniformly mixed and dissolved to obtain external preparations for skin of Comparative Examples 3 and 4.

  Except for using the obtained skin external preparation of Comparative Example 3 or Comparative Example 4, the coloring of the agent, turbidity, ascorbic acid-2-phosphate-6- ( The content of sodium 2-hexyldecanoate) was measured or evaluated over time according to the above measurement conditions and evaluation criteria.

  The results after 1 month of standing at 40 ° C. are shown in Table 4.

表４から、実施例４〜６では比較例３および４に比べて、着色および濁りの発生が抑えられており、剤中のアスコルビン酸−２−リン酸−６−（２−ヘキシルデカン酸）ナトリウム量の減少も抑えられていることがわかる。

From Table 4, in Examples 4-6, compared with Comparative Examples 3 and 4, the occurrence of coloring and turbidity was suppressed, and ascorbic acid-2-phosphate-6- (2-hexyldecanoic acid) sodium in the agent It can be seen that the decrease in the amount is also suppressed.

Claims (15)

Following formula (1)

(In formula (1), R represents a higher fatty acid residue) Ascorbic acid-2-phosphate salt of higher fatty acid ester (A), water-soluble synthetic polymer compound (B), A skin external preparation characterized by containing water (C).   The skin external application according to claim 1, wherein the water-soluble synthetic polymer compound (B) is a polymer having a carbon chain formed by cleaving a plurality of ethylenically unsaturated carbon-carbon bonds as a main chain. Agent.   The skin external preparation according to claim 2, wherein the water-soluble synthetic polymer compound (B) is a carboxyvinyl polymer and / or sodium polyacrylate.   R in said Formula (1) is a C8-C22 fatty acid residue, The skin external preparation in any one of Claims 1-3 characterized by the above-mentioned.   The external preparation for skin according to claim 4, wherein R in the formula (1) is a residue of lauric acid, myristic acid, palmitic acid, stearic acid, 2-hexyldecanoic acid or isostearic acid.   The external preparation for skin according to claim 5, wherein R in the general formula (1) is a residue of palmitic acid.   The external preparation for skin according to claim 5, wherein R in the general formula (1) is a residue of 2-hexyldecanoic acid.   The skin external application according to any one of claims 1 to 7, wherein the salt (A) of the higher fatty acid ester of ascorbic acid-2-phosphate is Na salt, K salt, Mg salt or Zn salt. Agent.   The skin external use according to any one of claims 1 to 8, wherein the salt (A) of a higher fatty acid ester of ascorbic acid-2-phosphate is contained in an amount of 0.01 to 20% by mass. Agent.   The skin external preparation according to any one of claims 1 to 9, wherein the water-soluble synthetic polymer compound (B) is contained in an amount of 0.001 to 3 mass%. The water (C) is contained in an amount of 20 to 99.5% by mass.
The skin external preparation in any one of 10.   It is a cosmetic, The skin external preparation in any one of Claims 1-11 characterized by the above-mentioned. Following formula (1)

(In the formula (1), R represents a higher fatty acid residue), which is a method for stabilizing a salt (A) of a higher fatty acid ester of ascorbic acid-2-phosphate ester,
A composition comprising at least a water-soluble synthetic polymer compound (B) and water (C);
A stabilizing method comprising contacting the salt (A) of a higher fatty acid ester of the ascorbic acid-2-phosphate ester. A water-soluble synthetic polymer compound (B), wherein the following formula (1)

(In formula (1), R represents a higher fatty acid residue) A stabilizer of a salt (A) of a higher fatty acid ester of ascorbic acid-2-phosphate represented by formula (1). The stabilizer according to claim 14, further comprising water (C).