JP2007099670A - External preparation for skin - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an external preparation for the skin, not only having a bioactivation activities such as lipid peroxide-inhibiting activities, collagen production-promoting activities, melanin synthesis-inhibiting activities in the skin, and activities for reducing black-color melanin synthesized in the skin to lighten the color, but also having excellent penetrability to the skin, and hardly causing discoloration or decrease of an ascorbic acid derivative in the environment with time by oxidative decomposition. <P>SOLUTION: The external preparation for the skin contains the ascorbic acid derivative of a compound represented by general formula (1) (wherein, R is a residue of a higher fatty acid selected from lauric acid, myristic acid, palmitic acid and stearic acid) or a salt thereof, and edetic acid and/or a salt thereof. The compound represented by general formula (1) is preferably ascorbic acid-2 phosphate-6-palmitate. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a skin external preparation containing an ascorbic acid derivative.

    In general, ascorbic acid has physiologically active actions such as lipid peroxide inhibitory action, collagen production promoting action, skin melanin synthesis inhibitory action, and the action of reducing and lightening black melanin synthesized in the skin. Therefore, ascorbic acid is blended in cosmetics, pharmaceuticals, and quasi drugs. Thus, when ascorbic acid is blended in cosmetics, pharmaceuticals, and quasi-drugs, improvement of aging symptoms such as “wrinkles”, “stains”, and “sobacas” can be expected.

  However, since ascorbic acid is a compound that exhibits direct reducing properties, it is extremely unstable and susceptible to oxidative degradation, so that its physiological activity may be easily lost.

  Therefore, an ascorbic acid glucoside derivative (see Patent Document 1) in which glucose is ether-bonded to the hydroxyl group at the 2-position of ascorbic acid showing reducibility is proposed, and ascorbic acid phosphate ester in which phosphoric acid is ester-bonded. Derivatives (see Patent Documents 2 and 3) have been proposed.

  These ascorbic acid derivatives have improved stability compared to ascorbic acid, but because of their high hydrophilicity, they have low permeability to the skin even when applied to the skin. There was a problem that a physiologically active action could not be obtained.

  Therefore, in order to improve the skin permeability of ascorbic acid, the 2nd position of ascorbic acid is converted to a phosphate ester, and the 6th position of ascorbic acid is converted to a higher fatty acid ester to introduce a hydrophobic group into ascorbic acid. Ascorbic acid derivatives with added properties (Patent Document 4) have been proposed. And the ascorbic acid derivative to which this amphiphilic property was imparted had an appropriate fat solubility, and thus was excellent in skin permeability and very useful.

However, the ascorbic acid derivative (for example, ascorbic acid-2-phosphate-6-palmitic acid and its salt) imparted with amphiphilic properties is a cosmetic or quasi-drug that requires long-term storage stability. When it is added to a skin external preparation such as pharmaceuticals, there is a problem that the ascorbic acid derivative is oxidatively decomposed over time in the environment and discolors or decreases.
Japanese Patent Laid-Open No. 03-139288 Japanese Patent Publication No.52-18191 Japanese Patent Laid-Open No. 02-279690 JP-A-10-298174

  The present invention aims to solve this problem.

  That is, the present invention has physiological activity such as lipid peroxide inhibitory action, collagen production promoting action, skin melanin synthesis inhibitory action, and the action of reducing and lightening black melanin synthesized in the skin. Another object of the present invention is to provide an external preparation for skin which is excellent in skin permeability and does not discolor or decrease due to oxidative degradation of ascorbic acid derivatives over time in the environment.

（式中、Ｒは、ラウリン酸、ミリスチン酸、パルミチン酸、および、ステアリン酸から選ばれる高級脂肪酸の残基である。）
で示される化合物またはその塩であるアスコルビン酸誘導体を含有する皮膚外用剤の処方について鋭意検討したところ、アスコルビン酸誘導体にエデト酸および／またはその塩を配合して皮膚外用剤とすると、アスコルビン酸誘導体が環境中で経時的に酸化分解されて変色したり、減少したりすることのない皮膚外用剤とすることができることを見出して、本発明を完成するに至った。 We have the following general formula

(In the formula, R is a residue of a higher fatty acid selected from lauric acid, myristic acid, palmitic acid, and stearic acid.)
As a result of intensive studies on the formulation of an external preparation for skin containing an ascorbic acid derivative, which is a compound represented by formula (1) or a salt thereof, an ascorbic acid derivative is obtained by adding edetic acid and / or a salt thereof to the ascorbic acid derivative. Has been found to be a topical skin preparation that does not undergo oxidative degradation over time in the environment and change color or decrease, leading to the completion of the present invention.

（式中、Ｒは、ラウリン酸、ミリスチン酸、パルミチン酸、および、ステアリン酸から選ばれる高級脂肪酸の残基である。）
で示される化合物またはその塩であるアスコルビン酸誘導体と、
（ロ）エデト酸および／またはその塩と、
を含有することを特徴とする皮膚外用剤である。 That is, in order to achieve the above object, the invention described in claim 1
(B) The following general formula

(In the formula, R is a residue of a higher fatty acid selected from lauric acid, myristic acid, palmitic acid, and stearic acid.)
An ascorbic acid derivative that is a compound represented by the formula:
(B) edetic acid and / or a salt thereof;
It is a skin external preparation characterized by containing this.

  The invention described in claim 2 is characterized in that, in the invention described in claim 1, the compound represented by the general formula (1) is ascorbic acid-2-phosphate-6-palmitic acid. To do.

  The invention described in claim 3 is the invention described in claim 1, wherein the salt of the compound represented by the general formula (1) is an alkali metal salt, an alkaline earth metal salt, an aluminum salt, an iron salt, It is a metal salt selected from a zinc salt and a bismuth salt, a basic amino acid salt, or an organic amine salt.

  The invention described in claim 4 is the invention described in any one of claims 1 to 3, wherein the ascorbic acid derivative is contained in a proportion of 0.01 to 20% by mass. It is what.

  The invention described in claim 5 is the invention described in any one of claims 1 to 4, wherein the edetic acid and / or salt thereof is contained in a proportion of 0.01 to 5 mass%. It is characterized by this.

  The invention described in claim 6 is characterized in that, in the invention described in any one of claims 1 to 5, the pH of the external preparation for skin is 6.5 to 9.5. is there.

  The invention described in claim 7 is the invention described in any one of claims 1 to 6, wherein the external preparation for skin contains fullerene.

  The invention described in claim 8 is characterized in that in the invention described in any one of claims 1 to 7, the external preparation for skin contains hydrolyzed collagen.

（式中、Ｒは、ラウリン酸、ミリスチン酸、パルミチン酸、および、ステアリン酸から選ばれる高級脂肪酸の残基である。）
で示される化合物またはその塩であるアスコルビン酸誘導体と、（ロ）エデト酸および／またはその塩と、を含有しているので、過酸化脂質抑制作用、コラーゲン産生促進作用、皮膚内のメラニン合成抑制作用、および、皮膚内で合成された黒色メラニンを還元して淡色化させる作用等の生理活性作用を有すると共に、皮膚浸透性に優れ、しかも、アスコルビン酸誘導体が環境中で経時的に酸化分解されて変色したり、減少したりすることのない皮膚外用剤を提供することができる。 According to the invention described in claims 1 to 3, (a) the following general formula

(In the formula, R is a residue of a higher fatty acid selected from lauric acid, myristic acid, palmitic acid, and stearic acid.)
Ascorbic acid derivative, which is a compound represented by the formula (1) or a salt thereof, and (b) edetic acid and / or a salt thereof, the lipid peroxide inhibitory action, the collagen production promoting action, and the melanin synthesis in the skin are inhibited. It has a physiologically active action such as the action and the action of reducing and lightening black melanin synthesized in the skin, and has excellent skin permeability, and the ascorbic acid derivative is oxidatively decomposed over time in the environment. Therefore, it is possible to provide an external preparation for skin that does not discolor or decrease.

  According to the invention described in claim 4, since the ascorbic acid derivative is contained at a ratio of 0.01 to 20% by mass, a skin external preparation that sufficiently exhibits the physiologically active action of the ascorbic acid derivative; can do.

  According to the invention described in claim 5, since the edetic acid and / or salt thereof is contained at a ratio of 0.01 to 5% by mass, excessive skin irritation caused by the edetic acid and / or salt thereof. Ascorbic acid derivatives can be made into an external preparation for skin that does not undergo oxidative decomposition over time in the environment and change color or decrease.

  According to the invention described in claim 6, since the pH of the external preparation for skin is 6.5 to 9.5, the ascorbic acid derivative is oxidized over time in the environment while avoiding excessive skin irritation due to alkali. It can be made into an external preparation for skin which is not decomposed and discolored or reduced.

  According to the invention described in claim 7, since the external preparation for skin contains fullerene, the external preparation for skin which can improve the skin beautifying effect and can remove active oxygen generated on the surface of the skin. can do.

  According to the invention described in claim 8, since the external preparation for skin contains hydrolyzed collagen, the hydrolyzed collagen penetrates to the dermis of the skin together with the ascorbic acid derivative, It can be set as the skin external preparation which can produce the component collagen and hyaluronic acid.

（式中、Ｒは、ラウリン酸、ミリスチン酸、パルミチン酸、および、ステアリン酸から選ばれる高級脂肪酸の残基である。）
で示される化合物またはその塩であるアスコルビン酸誘導体と、（ロ）エデト酸および／またはその塩と、を含有している。 The external preparation for skin of the present invention comprises (a) the following general formula

(In the formula, R is a residue of a higher fatty acid selected from lauric acid, myristic acid, palmitic acid, and stearic acid.)
Or an ascorbic acid derivative which is a salt thereof and (b) edetic acid and / or a salt thereof.

  The above-mentioned external preparation for skin means general uses of agents that can be applied externally to the skin such as cosmetics, quasi drugs, and pharmaceuticals. The cosmetics are, for example, lotions, emulsions, creams, gel cosmetics, cleansing creams, gel cleansings, packs, facial cleansers, shampoos, and rinses. Cosmetics may be used.

  The salt of the compound represented by the general formula (1) is preferably an alkali metal salt such as a sodium salt or a potassium salt, an alkaline earth metal salt such as a calcium salt or a magnesium salt, an aluminum salt, an iron salt, a zinc salt, and It is a metal salt selected from bismuth salts, or a basic amino acid salt such as arginine, or an organic amine salt such as triethanolamine salt, but other metals than these unless they are contrary to the object of the present invention. It may be a salt, a basic amino acid salt, or an organic amine salt.

  The edetate is preferably edetate, disodium edetate, trisodium edetate, and tetrasodium edetate, but other edetates may be used unless they are contrary to the object of the present invention. It doesn't matter.

  The compounds used in the external preparation for skin of the present invention, that is, the ascorbic acid derivative (b) and the “edetic acid and / or salt thereof” (b) are used singly. Moreover, you may use it, mixing 2 or more types.

（式中、Ｒは、ラウリン酸、ミリスチン酸、パルミチン酸、および、ステアリン酸から選ばれる高級脂肪酸の残基である。）
で示される化合物またはその塩であるアスコルビン酸誘導体と、（ロ）エデト酸および／またはその塩と、を含有していると、過酸化脂質抑制作用、コラーゲン産生促進作用、皮膚内のメラニン合成抑制作用、および、皮膚内で合成された黒色メラニンを還元して淡色化させる作用等の生理活性作用を有すると共に、皮膚浸透性に優れ、しかも、アスコルビン酸誘導体が環境中で経時的に酸化分解されて変色したり、減少したりすることのない皮膚外用剤を提供することができる。 Thus, (b) the following general formula

(In the formula, R is a residue of a higher fatty acid selected from lauric acid, myristic acid, palmitic acid, and stearic acid.)
And (b) edetic acid and / or a salt thereof, lipid peroxide inhibitory action, collagen production promoting action, skin melanin synthesis inhibition It has a physiologically active action such as the action and the action of reducing and lightening black melanin synthesized in the skin, and has excellent skin permeability, and the ascorbic acid derivative is oxidatively decomposed over time in the environment. Therefore, it is possible to provide an external preparation for skin that does not discolor or decrease.

In the present invention, the ascorbic acid derivative is preferably contained in a proportion of 0.01 to 20% by mass, more preferably 0.05 to 12% by mass. When the content of the ascorbic acid derivative is 0.01% by mass or less, the bioactive action of the ascorbic acid derivative cannot be sufficiently exerted, and the content of the ascorbic acid derivative exceeds 20% by mass. However, the bioactive activity of the ascorbic acid derivative is not improved. Therefore, when the said ascorbic acid derivative is contained in the ratio of 0.01-20 mass%, it can be set as the skin external preparation which fully exhibits the bioactivity effect | action of this ascorbic acid derivative.

  In the present invention, the edetic acid and / or salt thereof is preferably contained in a proportion of 0.01 to 5% by mass. When the content of the edetic acid and / or salt thereof is less than 0.01% by mass, the ascorbic acid derivative is oxidatively decomposed over time in the environment and discolored or decreased, and a sufficient stabilizing effect is obtained. In addition, when the content of the edetic acid and / or salt thereof exceeds 5% by mass, the stabilizing effect described above is not changed, but it is not suitable for a skin external preparation from the viewpoint of skin irritation. Therefore, when the edetic acid and / or salt thereof is contained at a ratio of 0.01 to 5% by mass, the ascorbic acid derivative is prevented in the environment while avoiding excessive skin irritation by the edetic acid and / or salt thereof. A stable external preparation for skin that does not undergo oxidative degradation over time and change color or decrease can be obtained.

  In the present invention, the pH of the external preparation for skin is preferably 6.5 to 9.5. If the pH of the external preparation for skin is lower than 6.5, the ascorbic acid derivative is oxidatively decomposed over time in the environment and discolored or decreased, and a sufficient stabilizing effect cannot be obtained. When the pH of the external preparation exceeds 9.5, excessive skin irritation due to alkali is generated. Therefore, when the pH of the external preparation for skin is 6.5 to 9.5, the ascorbic acid derivative is oxidatively decomposed over time in the environment, discoloring or decreasing while avoiding excessive skin irritation due to alkali. It can be set as the stable skin external preparation which does not do.

  In the present invention, the external preparation for skin preferably contains fullerene. Thus, when the said skin external preparation contains fullerene, while being able to improve the skin beautifying effect, it can be set as the skin external preparation which can remove the active oxygen which generate | occur | produces on the skin surface.

  In the present invention, the external preparation for skin preferably contains hydrolyzed collagen. As described above, when the external preparation for skin contains hydrolyzed collagen, it penetrates into the dermis of the skin together with the hydrolyzed collagen, where collagen and hyaluronic acid, which are constituents of the skin, can be produced. It can be used as a skin external preparation.

  In the external preparation for skin of the present invention, a compounding agent generally used for an external preparation for skin can be blended unless it is contrary to the object of the present invention. Examples of such a compounding agent include the following.

  Ozokerite, α-olefin oligomer, light isoparaffin, light liquid isoparaffin, squalene, squalane, synthetic squalane, vegetable squalane, ceresin, paraffin, polyethylene powder, polybutene, microcrystalline wax, liquid isoparaffin, liquid paraffin, mineral oil, petroleum jelly, etc. Hydrocarbons.

  Jojoba oil, carnauba wax, candelilla wax, rice bran wax, shellac, lanolin, mink sebum wax, whale wax, sugar cane wax, sperm whale oil, beeswax, montan wax and other natural waxes, avocado oil, almond oil, olive oil, extra virgin olive oil, Sesame oil, rice bran oil, rice oil, rice germ oil, corn oil, safflower oil, soybean oil, corn oil, rapeseed oil, persic oil, palm kernel oil, palm oil, castor oil, sunflower oil, high oleic sunflower oil, Grape seed oil, cottonseed oil, palm oil, hydrogenated palm oil, beef tallow, hardened oil, horse oil, mink oil, egg yolk oil, egg yolk fat oil, rosehip oil, cucumber nut oil, evening primrose oil, wheat germ oil, peanut oil, camellia oil Oil, sasanqua oil, cacao butter, molasses, beef bone fat, beef leg oil, pork fat, horse fat, sheep fat, sheabata , Macadamia nut oil, natural fats and oils of meadowfoam oil, and the like.

  Fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, γ-linolenic acid, isostearic acid, 12-hydroxystearic acid, undecylenic acid, and coconut oil fatty acid.

  Higher monoalcohols such as isostearyl alcohol, octyldodecanol, hexyldecanol, cholesterol, phytosterol, lauryl alcohol, myristyl alcohol, cetanol, stearyl alcohol, oleyl alcohol, behenyl alcohol, cetostearyl alcohol.

  Alkyl glyceryl ethers such as batyl alcohol, chimyl alcohol, ceralkyl alcohol, and isostearyl glyceryl ether.

  Isopropyl myristate, butyl myristate, isopropyl palmitate, ethyl stearate, butyl stearate, ethyl oleate, ethyl linoleate, isopropyl linoleate, cetyl caprylate, hexyl laurate, isooctyl myristate, decyl myristate, myristic acid Myristyl, cetyl myristate, octadecyl myristate, cetyl palmitate, stearyl stearate, decyl oleate, oleyl oleate, cetyl ricinoleate, isostearyl laurate, isotridecyl myristate, isocetyl myristate, isostearyl myristate, myristic acid Octyldodecyl, 2-ethylhexyl palmitate, isocetyl palmitate, isostearyl palmitate, 2-ethyl stearate Hexyl, isocetyl stearate, isodecyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, ethyl isostearate, isopropyl isostearate, cetyl 2-ethylhexanoate, cetostearyl 2-ethylhexanoate, stearyl 2-ethylhexanoate, Hexyl isostearate, ethylene glycol dioctanoate, ethylene glycol dioleate, propylene glycol dicaprylate, propylene glycol di (capryl / capric acid), propylene glycol dicaprate, propylene glycol dioleate, neopentyl glycol dicaprate, neopentyl glycol dioctanoate , Glyceryl tricaprylate, glyceryl tri-2-ethylhexanoate, tri (caprylic / capric acid) glyceryl , Tri (caprylic acid / capric acid / stearic acid) glyceryl, glyceryl triundecylate, glyceryl triisopalmitate, glyceryl triisostearate, tri-2-ethylhexanoic acid trimethylolpropane, triisostearic acid trimethylolpropane, tetra-2-ethyl Pentaerythrityl hexanoate, pentaerythrityl tetramyristate, pentaerythrityl tetraisostearate, diglyceryl tetraisostearate, octyldodecyl neopentanoate, isocetyl octoate, isostearyl octoate, 2-ethylhexyl isoperargonate, dimethyloctane Hexyldecyl acid, octyldodecyl dimethyloctanoate, 2-ethylhexyl isopalmitate, isocetyl isostearate, isoisostearate Stearyl, octyl dodecyl isostearate, lauryl lactate, myristyl lactate, cetyl lactate, octyl dodecyl lactate, triethyl citrate, acetyl triethyl citrate, acetyl tributyl citrate, trioctyl citrate, triisocetyl citrate, trioctyl dodecyl citrate, malic acid Diisostearyl, 2-ethylhexyl hydroxystearate, di-2-ethylhexyl succinate, diisopropyl adipate, diisobutyl adipate, dioctyl adipate, diheptyl undecyl adipate, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, stearin Cholesteryl acid, cholesteryl isostearate, cholesteryl hydroxystearate, cholesteryl oleate, dihydrocolate oleate Steryl, phytosteryl isostearate, phytosteryl oleate, isocetyl 12-stearoylhydroxystearate, stearyl 12-stearoylhydroxystearate, isostearyl 12-stearoylhydroxystearate, polyoxyethylene acetate (3) polyoxypropylene (1) cetyl ether , Esters such as polyoxyethylene acetate (3) polyoxypropylene (1) isocetyl ether, isononyl isononanoate, octyl isononanoate, tridecyl isononanoate, isotridecyl isononanoate.

  Methylpolysiloxane, methylphenylpolysiloxane, methylhydrogenpolysiloxane, methylcyclopolysiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, octamethyltrisiloxane, decamethyltetrasiloxane, tetradeca Methyl hexasiloxane, highly polymerized methyl polysiloxane, dimethyl siloxane methyl (polyoxyethylene) siloxane methyl (polyoxypropylene) siloxane copolymer, dimethyl siloxane methyl (polyoxyethylene) siloxane copolymer, dimethyl siloxane methyl (Polyoxypropylene) siloxane copolymer, dimethylsiloxane / methylcetyloxysiloxane copolymer, dimethylsiloxane / Silicone oils such as chill stearoxy copolymer.

  Ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, polypropylene glycol, 1,3-butylene glycol, glycerin, diglycerin, polyglycerin, 3-methyl-1,3-butanediol, 1, Polyhydric alcohols such as 3-butanediol, 1,2-pentanediol and 1,2-hexanediol;

  Sugars such as mannitol, sorbitol, xylitol, maltitol, erythritol, pentaerythritol, glucose, sucrose, fructose, lactose, maltose, xylose and trehalose.

Sodium polyacrylate, polyacrylate amide, carboxyvinyl polymer (hereinafter also referred to as “carbomer”), polyethyleneimine, highly polymerized polyethylene glycol, polyvinyl alcohol, polyvinylpyrrolidone, polyvinyl ether, polyacrylamide, acrylic acid polymer, methacrylic acid Acid polymer, maleic acid polymer, vinyl pyridine polymer, ethylene / acrylic acid copolymer, vinyl pyrrolidone polymer, vinyl alcohol / vinyl pyrrolidone copolymer, nitrogen-substituted acrylamide polymer, amino-modified silicone, cationized polymer, dimethyl acryl ammonium polymers, acrylic acid-based anionic polymers, methacrylic acid-based anionic polymers, modified silicones, acrylic acid / alkyl methacrylate (C ₁₀ ~ ₃₀₎ copolycondensation Body, polyoxyethylene / polyoxypropylene copolymers.

  Sodium alginate, carrageenan, agar, fur celerin, guar gum, quince seed, konjac mannan, tamarind gum, tara gum, dextrin, starch, locust bean gum, gum arabic, gati gum, karaya gum, tragacanth gum, arabinogalactan, pectin, quince, chitosan, card Orchid, xanthan gum, gellan gum, cyclodextrin, dextran, pullulan, microcrystalline cellulose, methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose, carboxystarch, cationized cellulose, starch phosphate ester, cationized guar gum , Carboxymethyl hydroxyp Pills guar gum, hydroxypropylated guar gum, albumin, casein, naturally occurring polymer compounds such as gelatin.

  Lower monoalcohols such as ethanol, isopropyl alcohol, 1-butanol, 2-butanol, and benzyl alcohol.

  Palm oil fatty acid potassium, coconut oil fatty acid sodium, coconut oil fatty acid triethanolamine, potassium laurate, sodium laurate, triethanolamine laurate, potassium myristate, sodium myristate, isopropanolamine myristate, potassium palmitate, palmitic acid Sodium, isopropanolamine palmitate, potassium stearate, sodium stearate, triethanolamine stearate, potassium oleate, sodium oleate, castor oil fatty acid sodium, zinc undecylenate, zinc laurate, zinc myristate, magnesium myristate, Zinc palmitate, zinc stearate, calcium stearate, magnesium stearate, aluminum stearate, myristi Calcium oxide, magnesium myristate, aluminum dimyristate, aluminum isostearate polyoxyethylene lauryl ether acetic acid, sodium polyoxyethylene lauryl ether acetate, polyoxyethylene tridecyl ether acetic acid, sodium polyoxyethylene tridecyl ether acetate, sodium stearoyl lactate , Sodium isostearoyl lactate, sodium lauroyl sarcosine, coconut oil fatty acid sarcosine, coconut oil fatty acid sarcosine sodium, coconut oil fatty acid sarcosine triethanolamine, lauroyl sarcosine, lauroyl sarcosine potassium, lauroyl sarcosine triethanolamine, oleoyl sarcosine, myristoyl sarcosine sodium, Sodium stearoyl glutamate, palm Fatty acid acyl glutamic acid, coconut oil fatty acid potassium potassium glutamate, coconut oil fatty acid acyl glutamic acid sodium, coconut oil fatty acid acyl glutamic acid triethanolamine, lauroyl acyl glutamic acid, lauroyl acyl glutamic acid potassium, lauroyl acyl glutamic acid sodium, lauroyl acyl glutamic acid triethanolamine, myristoyl acyl Glutamic acid, potassium myristoyl acyl glutamate, sodium myristoyl acyl glutamate, stearoyl acyl glutamate, potassium stearoyl acyl glutamate, disodium stearoyl acyl glutamate, sodium cured beef tallow fatty acid acyl glutamate, coconut oil fatty acid / cured tallow fatty acid sodium acyl glutamate, coconut oil fatty acid methyl Sodium lualanine, lauroylmethylalanine, sodium lauroylmethylalanine, lauroylmethylalanine triethanolamine, sodium myristoylmethylalanine, sodium lauroylmethyltaurine, coconut oil fatty acid methyltaurine potassium, coconut oil fatty acid methyltaurine sodium, coconut oil fatty acid methyltaurine magnesium , Myristoyl methyl taurine sodium, palmitoyl methyl taurine sodium, stearoyl methyl taurine sodium, oleoyl methyl taurine sodium, sodium alkane sulfonate, sodium tetradecene sulfonate, dioctyl sodium sulfosuccinate, disodium lauryl sulfosuccinate, palm oil fatty acid ethyl ester sulfone Sodium salt, sodium lauryl sulfate Lithium, lauryl sulfate triethanolamine, sodium cetyl sulfate, alkyl (11,13,15) sulfate triethanolamine, alkyl (12,13) sodium sulfate, alkyl (12,13) triethanolamine sulfate, alkyl (12,14) , 16) Ammonium sulfate, alkyl (12-13) diethanolamine sulfate, alkyl (12-14) triethanolamine sulfate, alkyl (12-15) triethanolamine sulfate, palm oil alkyl magnesium sulfate / triethanolamine, ammonium lauryl sulfate, lauryl Potassium sulfate, magnesium lauryl sulfate, monoethanolamine lauryl sulfate, diethanolamine lauryl sulfate, sodium myristyl sulfate, sodium stearyl sulfate, sodium oleyl sulfate, oleyl sulfate triethanol Amine, sodium polyoxyethylene lauryl ether sulfate, polyoxyethylene lauryl ether sulfate triethanolamine, polyoxyethylene (1) alkyl (11, 13, 15) ether sodium sulfate, polyoxyethylene (1) alkyl (11, 13, 15) ether sulfate triethanolamine, polyoxyethylene (3) alkyl (11-15) sodium ether sulfate, polyoxyethylene (2) alkyl (12,13) sodium ether sulfate, polyoxyethylene (3) alkyl (12- 14) Sodium ether sulfate, polyoxyethylene (3) alkyl (12-15) sodium ether sulfate, polyoxyethylene (2) sodium lauryl ether sulfate, polyoxyethylene (3) sodium myristyl ether sulfate , Sodium higher fatty acid alkanolamide sulfate, lauryl phosphate, sodium lauryl phosphate, potassium cetyl phosphate, diethanolamine cetyl phosphate, polyoxyethylene oleyl ether phosphate, polyoxyethylene lauryl ether phosphate, polyoxyethylene lauryl ether phosphate Sodium, polyoxyethylene cetyl ether phosphate, sodium polyoxyethylene cetyl ether phosphate, polyoxyethylene stearyl ether phosphate, polyoxyethylene oleyl ether phosphate, polyoxyethylene oleyl ether sodium phosphate, polyoxyethylene alkylphenyl ether Phosphoric acid, sodium polyoxyethylene alkylphenyl ether, polyoxyethylene alkylphenyl ether Telluric acid triethanolamine, polyoxyethylene octyl ether phosphoric acid, polyoxyethylene (10) alkyl (12,13) ether phosphoric acid, polyoxyethylene alkyl (12-15) ether phosphoric acid, polyoxyethylene alkyl (12- 16) Anionic surfactants such as ether phosphoric acid, polyoxyethylene lauryl ether triethanolamine, and polyoxyethylene oleyl ether phosphoric acid diethanolamine.

  Dioctylamine, dimethylstearylamine, trilaurylamine, diethylaminoethylamide stearate, lauryltrimethylammonium chloride, cetyltrimethylammonium chloride, cetyltrimethylammonium bromide, cetyltrimethylammonium saccharin, stearyltrimethylammonium chloride, alkyl chloride (20-22) Trimethylammonium, lauryltrimethylammonium bromide, alkyl (16,18) trimethylammonium chloride, stearyltrimethylammonium bromide, stearyltrimethylammonium saccharin, alkyl (28) trimethylammonium chloride, di (polyoxyethylene) oleylmethylammonium chloride (2EO) ), Dipolyoxyethylene stearylmethylammonium chloride Polyoxyethylene chloride (1) polyoxypropylene (25) diethylmethylammonium chloride, tri (polyoxyethylene) stearylammonium chloride (5EO), distearyldimethylammonium chloride, dialkyl (12-15) dimethylammonium chloride, dialkylchloride (12 -18) Dimethyl ammonium, dialkyl chloride (14-18) dimethyl ammonium, dicocoyl dimethyl ammonium chloride, dicetyl dimethyl ammonium chloride, isostearyl lauryl dimethyl ammonium chloride, benzalkonium chloride, myristyl dimethyl benzyl ammonium chloride, lauryl dimethyl chloride ( Ethylbenzyl) ammonium, stearyldimethylbenzylammonium chloride, laurylpyridinium chloride, cetylpyridinium chloride Lauroyl kola amino formyl methyl pyridinium chloride, stearoyl colaminoformyl methylpyridinium bromide alkyl isoquinolizinyloxy potassium, chloride methyl benzethonium, cationic surfactants such as benzethonium chloride.

  2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, alkyldiaminoethylglycine hydrochloride, sodium lauryldiaminoethylglycine, sodium undecylhydroxyethylimidazolium betaine, undecyl-N-carboxymethylimidazolium betaine Coconut oil fatty acid acyl-N-carboxyethyl-N-hydroxyethylethylenediamine disodium, coconut oil fatty acid acyl-N-carboxyethoxyethyl-N-carboxyethylethylenediamine disodium, coconut oil fatty acid acyl-N-carboxymethoxyethyl-N -Carboxymethylethylenediamine disodium, sodium laurylaminopropionate, sodium laurylaminodipropionate, laurylaminopropyl Triethanolamine pionate, palm oil fatty acid acyl-N-carboxyethyl-N-hydroxyethylethylenediamine sodium, lauryldimethylaminoacetic acid betaine, coconut oil alkyldimethylaminoacetic acid betaine, stearyldimethylaminoacetic acid betaine, stearyldimethylbetaine sodium, coconut oil Amphoteric surfactants such as fatty acid amidopropyl betaine, palm oil fatty acid amidopropyl betaine, lauric acid amidopropyl acetic acid betaine, ricinoleic acid amidopropyl betaine, stearyl dihydroxyethyl betaine, lauryl hydroxysulfo betaine.

  Polyoxyethylene (10) alkyl (12,13) ether, polyoxyethylene lauryl ether, polyoxyethylene cetyl ether, polyoxyethylene stearyl ether, polyoxyethylene oleyl ether, polyoxyethylene (3, 7, 12) alkyl ( 12-14) ether, polyoxyethylene tridecyl ether, polyoxyethylene myristyl ether, polyoxyethylene-sec-alkyl (14) ether, polyoxyethylene isocetyl ether, polyoxyethylene cetostearyl ether, polyoxyethylene (2 , 10, 20) Isostearyl ether, polyoxyethylene oleyl cetyl ether, polyoxyethylene (20) aralkyl ether, polyoxyethylene octyldodecyl ether Polyoxyethylene behenyl ether, polyoxyethylene octyl phenyl ether, polyoxyethylene nonyl phenyl ether, polyoxyethylene dinonyl phenyl ether, polyoxyethylene (1) polyoxypropylene (1,2,4,8) cetyl ether, poly Oxyethylene (5) polyoxypropylene (1,2,4,8) cetyl ether, polyoxyethylene (10) polyoxypropylene (1,2,4,8) cetyl ether, polyoxyethylene (20) polyoxypropylene (1,2,4,8) cetyl ether, polyoxyethylene polyoxypropylene lauryl ether, polyoxyethylene (3) polyoxypropylene (34) stearyl ether, polyoxyethylene (4) polyoxypropylene (30) Allyl ether, polyoxyethylene (34) polyoxypropylene (23) stearyl ether, polyoxyethylene polyoxypropylene cetyl ether, polyoxyethylene polyoxypropylene decyl tetradecyl ether, polyethylene glycol monolaurate, ethylene glycol monostearate, mono Polyethylene glycol stearate, polyethylene glycol monooleate, ethylene glycol fatty acid ester, self-emulsifying ethylene glycol monostearate, diethylene glycol laurate, polyethylene glycol myristate, polyethylene glycol palmitate, diethylene glycol stearate, polyethylene monostearate self-emulsifying Glycol (2), polyethylene isostearate Recall, ethylene glycol dioctanoate, diethylene glycol dilaurate, polyethylene glycol dilaurate, polyethylene glycol dipalmitate (150), ethylene glycol distearate, diethylene glycol distearate, polyethylene glycol distearate, ethylene glycol dioleate, polyethylene glycol dioleate, diglycol Polyethylene glycol ricinoleate, polyoxyethylene (20) sorbitan monolaurate, polyoxyethylene (20) sorbitan monopalmitate, polyoxyethylene (6) sorbitan monostearate, polyoxyethylene (20) sorbitan monostearate, tristearin Acid polyoxyethylene (20) sorbitan, monooleic acid polyoxy Tylene (6) sorbitan, polyoxyethylene monooleate (20) sorbitan, polyoxyethylene trioleate (20) sorbitan, polyoxyethylene (20) coconut oil fatty acid sorbitan, polyoxyethylene monolaurate (10-80) sorbitan , Polyoxyethylene sorbitan tristearate, polyoxyethylene (20) sorbitan isostearate, polyoxyethylene (150) sorbitan tristearate, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, polyoxyethylene (10) cured Castor oil, polyoxyethylene (20) hydrogenated castor oil, polyoxyethylene (40) hydrogenated castor oil, polyoxyethylene (50) hydrogenated castor oil, polyoxyethylene (60) hydrogenated castor oil, lipophilic monos Glyceryl allate, glyceryl monooleate, glyceryl monostearate, self-emulsifying glyceryl monostearate, glyceryl coconut fatty acid, glyceryl laurate, glyceryl myristate, glyceryl isostearate, glyceryl ricinoleate, glyceryl monohydroxystearate, glyceryl oleate , Glyceryl linoleate, glyceryl erucate, glyceryl behenate, wheat germ oil fatty acid glyceride, safflower oil fatty acid glyceryl, hydrogenated soybean fatty acid glyceryl, saturated fatty acid glyceride, cottonseed oil fatty acid glyceryl, monoisostearic acid monomyristate glyceryl, mono cow fatty acid Glycerides, monolanolin fatty acid glyceryl, glyceryl sesquioleate, glyceryl distearate, glyceryl diisostearate, diarachin Glyceryl acid, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan monoisostearate, sorbitan monooleate, sorbitan sesquistearate, sorbitan sesquioleate, sorbitan tristearate, sorbitan trioleate, coconut fatty acid Sorbitan, sorbitan isostearate, sorbitan sesquiisostearate, sorbitan distearate, diglyceryl isopalmitate, poly (4-10) glyceryl monolaurate, poly (10) glyceryl monomyristate, poly (2-10) glyceryl monostearate , Poly (2-10) glyceryl monoisostearate, poly (2-10) glyceryl monooleate, diglyceryl sesquioleate, diisostearate Poly (2-10) glyceryl acid, poly (6-10) glyceryl distearate, diglyceryl triisostearate, poly (10) glyceryl tristearate, poly (10) glyceryl trioleate, poly (2) tetraisostearate ) Glyceryl, decaglyceryl pentastearate, poly (6-10) glyceryl pentaoleate, poly (10) glyceryl heptearate, decaglyceryl decastearate, poly (10) glyceryl dekaoleate, poly (6) condensed ricinoleate Glyceryl, sucrose fatty acid ester, coconut oil fatty acid sucrose ester, alkyl glucoside, coconut oil alkyl dimethylamine oxide, lauryl dimethylamine oxide, dihydroxyethyl lauryl dimethylamine oxide, stearyl dimethyl ester Le amine oxide, oleyl dimethyl amine oxide, and nonionic surfactants such as polyoxyethylene coconut oil alkyldimethylamine oxide.

  Saponin, lecithin, soybean phospholipid, hydrogenated soybean phospholipid, soybean lysophospholipid, hydrogenated soybean lysophospholipid, egg yolk lecithin, hydrogenated egg yolk lysophosphatidylcholine, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, sphingophospholipid, sphingomyelin, ganglioside Natural surfactants such as bile acid, cholic acid, deoxycholic acid, sodium cholate, sodium deoxycholate, spicrispolic acid, rhamnolipid, trehalose lipid, sophorolipid, mannosylerythritol lipid.

  Paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, paraaminobenzoic acid derivatives such as 2-ethylhexyl paradimethylaminobenzoate, benzyl cinnamate, monoparamethoxycinnamic acid mono-2 -Glyceryl ethylhexanoate, methyl 2,4-diisopropylcinnamate, ethyl 2,4-diisopropylcinnamate, potassium paramethoxycinnamate, sodium paramethoxycinnamate, isopropyl paramethoxycinnamate, paramethoxycinnamate Cinnamic acid derivatives such as 2-ethylhexyl cinnamate, 2-ethoxyethyl paramethoxycinnamate, ethyl paraethoxycinnamate, urocanic acid derivatives such as urocanic acid, ethyl urocanate, 2,4-dihydroxybenzophenone, 2, 2 ', 4, '-Tetrahydroxybenzophenone, 2-hydroxy-4-methoxy-5-sulfobenzophenone sodium, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone, 2,2'-dihydroxy- Benzophenone derivatives such as sodium 4,4′-dimethoxybenzophenone and sodium 2,2′-dihydroxy-4,4′-dimethoxy-5-sulfobenzophenone, ethylene glycol salicylate, 2-ethylhexyl salicylate, phenyl salicylate, benzyl salicylate, salicylic acid p -Salicylic acid derivatives such as tert-butylphenyl, homomenthyl salicylate, salicylic acid-3,3,5-trimethylcyclohexyl, 2- (2'-hydroxy-5'-methoxyphenyl) benzoto Azole, 4-tert-butyl-4'-methoxybenzoyl ultraviolet absorbers such as methane.

  Kaolin, anhydrous silicic acid, magnesium aluminum silicate, sericite, talc, boron nitride, mica, montmorillonite, hemp cellulose powder, wheat starch, silk powder, corn starch, nitro dye, azo dye, nitroso dye, triphenyl Methane dyes, xanthene dyes, quinoline dyes, anthraquinone dyes, indigo dyes, pyrene dyes, phthalocyanine dyes, flavonoids, quinone, porphyrin, water-soluble anato, squid powder, caramel, guaiazulene, gardenia blue, gardenia yellow , Cochineal, shikonin, copper chlorophyllin sodium, paprika dye, safflower red, safflower yellow, lacqueric acid, riboflavin butyrate, and other natural dyes, carbon black, yellow iron oxide, black iron oxide, red rose, conger, group , Zinc oxide, chromium oxide, titanium oxide, black titanium oxide, zirconium oxide, chromium hydroxide, alumina, magnesium oxide, barium sulfate, aluminum hydroxide, calcium carbonate, lithium cobalt titanate, manganese violet, pearl pigment powder, etc. And color materials.

  Ashitaba extract, Acacia catechu extract, Avocado extract, Achacha extract, Achachazul extract, Altea extract, Arnica extract, Oil-soluble Arnica extract, Almond extract, Aloe extract, Anchovy extract, Ginkgo biloba extract, Nettle extract, Iris root extract, Fennel extract , Turmeric extract, Ages extract, Echinacea leaf extract, Ogon extract, Oat extract, Prunus extract, Barley extract, Okra extract, Hypericum extract, Oil-soluble Hypericum extract, Adriatic extract, Oil-soluble extract , Orange flower water, seaweed extract, oyster tannin, cuckoo extract, valerian extract, cattail extract, chamomile extract, oil-soluble chamomile extract, chamomile Water, oat extract, carrot extract, oil-soluble carrot extract, carrot oil, pearl millet extract, licorice extract, licorice extract powder, licorice flavonoids, cantalis tincture, raspberry extract, kiwi extract, quina extract, cucumber extract, kyonin extract, quince seed extract , Gardenia extract, Kumazasa extract, Clara extract, walnut shell extract, grapefruit extract, clematis extract, brown sugar extract, chlorella extract, mulberry extract, cinnamon extract, gentian extract, gentian pepper extract, black tea extract, citrus extract, burdock extract, oil-soluble burdock Extract, wheat germ extract, hydrolyzed wheat powder, rice bran extract, rice bran fermented extract, comfrey extract, saicin extract, saffron extract, savonso Kiss, Oil-soluble Salvia extract, Hawthorn extract, Salamander extract, Shiitake extract, Shiitake extract powder, Ginger extract, Shikon extract, Oil-soluble shikon extract, Perilla extract, Linden extract, Oil-soluble Linden extract, Shimotake extract, Peonies extract, Jujudama extract, Pepper extract Extract, Oil-soluble Pepper extract, Pepper tincture, Ginger root extract, Birch extract, Oil-soluble birch extract, Birch sap, Honeysuckle extract, Japanese horsetail extract, Oil-soluble Japanese horse chestnut extract, Scorginin, Stevia extract, Atlantic kizuta extract, Hawthorn extract , Elderberry extract, juniper extract, yarrow extract, oil-soluble yarrow extract, mint extract, sage extract, oil-soluble Di extract, sage water, mallow extract, celery extract, nematode extract, nematode water, assembly extract, soybean extract, tiso extract, thyme extract, tea extract, tea dry extract, tea seed extract, clove extract, chimpi extract, camellia extract, camellia extract, oil Soluble Teuchigurumi extract, Duke extract, Terminaria extract, Capsicum tincture, Toki extract, Oil-soluble Toki extract, Toki water, Toki-senka extract, Oil-soluble Toki-senka extract, Soy milk powder, Tonin extract, Spruce extract, Dokudami extract, Tomato extract, Toll Mentilla extract, natto extract, carrot extract, oil-soluble carrot extract, garlic extract, wild rose extract, oil-soluble wild rose extract, bakuga extract, bakuga root extract, bacmond extract, parsley extract Concentrated leaf juice, distilled mint water, hamamelis water, hamamelis extract, rose extract, parietalia extract, toad extract, loquat leaf extract, oil-soluble loquat leaf extract, dandelion extract, butterfly extract, butcher bloom extract, butcher bloom extract powder , Grape extract, grape leaf extract, grape water, hay flower extract, loofah extract, loofah water, safflower extract, oil soluble bodai extract, bodaiju water, button extract, hop extract, oil soluble hop extract, pine extract, maria thistle extract, maronier Extract, Oil-soluble Maronnier extract, Mukuroji extract, Melissa extract, Merirot extract, Peach leaf extract, Oil-soluble Peach leaf extract, Palm extract, Cornflower extract, Cornflower water, Eucalyptus extract, Yukinoshita Eki , Lily extract, Yokuinin extract, oil soluble Yokuinin extract, mugwort extract, mugwort water, lavender extract, lavender water, apple extract, litchi extract, lettuce extract, lemon extract, lotus extract, rose water, rosemary extract, oil soluble rosemary extract , Plant extracts such as Roman chamomile extract and bituminous extract.

  Glycine, alanine, valine, leucine, isoleucine, serine, threonine, phenylalanine, tyrosine, tryptophan, cystine, cysteine, methionine, proline, hydroxyproline, aspartic acid, asparagine, glutamic acid, glutamine, arginine, histidine, lysine, γ-aminobutyric acid Amino acids such as DL-pyrrolidonecarboxylic acid, ε-aminocaproic acid, hydrolyzed elastin, water-soluble elastin, hydrolyzed collagen, water-soluble collagen, glutathione, wheat peptide, soybean peptide, and peptides.

  Vitamin A such as retinol, retinal, retinoic acid, retinol acetate, retinol palmitate, etc., carotenoids such as α-carotene, β-carotene, γ-carotene, δ-carotene, lycopene, zeaxanthin, cryptoxanthine, echinone, astaxanthin, Vitamin B1 such as thiamine, vitamin B2 such as riboflavin, vitamin B6 such as pyridoxine, pyridoxal, pyridoxamine, vitamin B12 such as cyanocobalamin, folic acid, nicotinic acid, nicotinamide, pantothenic acid, biotins, L -Ascorbic acid, sodium L-ascorbate, L-ascorbyl stearate, L-ascorbyl palmitate, L-ascorbyl dipalmitate, L-ascorbyl tetraisopalmitate, L-ascorb Vitamin Cs such as disodium acid sulfate ester, L-ascorbyl magnesium, sodium L-ascorbyl phosphate, L-ascorbic acid-2-glucoside, vitamins D such as ergocalciferol, cholecalciferol, d-α- Vitamin E such as tocopherol, DL-α-tocopherol, dl-α-tocopherol acetate, dl-α-tocopherol succinate, β-tocopherol, γ-tocopherol, d-δ-tocopherol, ubiquinones, vitamin K, carnitine Vitamins such as ferulic acid, γ-oryzanol, α-lipoic acid, orotic acid and vitamin-like agents.

  Benzoic acid, sodium benzoate, undecylenic acid, salicylic acid, sorbic acid, potassium sorbate, dehydroacetic acid, sodium dehydroacetate, isobutyl parahydroxybenzoate, isopropyl parahydroxybenzoate, ethyl parahydroxybenzoate, butyl parahydroxybenzoate, Preservatives such as propyl parahydroxybenzoate, benzyl parahydroxybenzoate, methyl parahydroxybenzoate, methyl sodium parahydroxybenzoate, phenoxyethanol, photosensitive element 101, photosensitive element 201, photosensitive element 401, and the like.

  Antioxidants such as butylhydroxyanisole, butylhydroxytoluene, propyl gallate, erythorbic acid, sodium erythorbate, parahydroxyanisole, octyl gallate.

  Moisturizers such as hyaluronic acid, sodium hyaluronate, sodium chondroitin sulfate, sodium lactate, sodium pyrrolidonecarboxylate, betaine, lactic acid bacteria culture solution, yeast extract, ceramide and the like.

  Anti-inflammatory agents such as glycyrrhizic acid, trisodium glycyrrhizinate, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, β-glycyrrhetinic acid, glyceryl glycyrrhetinate, stearyl glycyrrhetinate, lysozyme chloride, hydrocortisone, allantoin.

  PH adjusting agents such as sodium hydroxide, potassium hydroxide and triethanolamine.

  Salts such as sodium chloride, potassium chloride, magnesium chloride, sodium sulfate.

  Metal ion sequestering agents such as trisodium ethylenediaminehydroxyethyl triacetate, sodium citrate, gluconic acid, phytic acid, sodium polyphosphate, sodium metaphosphate.

  Α-hydroxy acids such as citric acid, glycolic acid, tartaric acid and lactic acid.

  Whitening agents such as arbutin, α-arbutin and placenta extract.

  Angelica oil, Ylang-Ylang oil, Elemi oil, Orange oil, Chamomile oil, Roman chamomile oil, Cardamom oil, Calamus oil, Galvanum oil, Camphor oil, Carrot seed oil, Clarage sage oil, Grapefruit oil, Clove oil, Keihi oil, Coriander oil , Cypress oil, Sandalwood oil, Cedarwood oil, Citronella oil, Cinnamon leaf oil, Jasmine absolute, Juniper berry oil, Ginger extract, Spearmint oil, Sage oil, Cedar oil, Geranium oil, Thyme oil, Tea tree oil, Nutmeg oil , Near uri oil, neroli oil, pine oil, basil oil, peppermint oil, patchouli oil, palmarosa oil, fennel oil, petitgren oil, black pepper oil, frankincense oil, vetiver oil, peppermint oil, bergamot oil Zoin oil, Boad Rose oil, Marjoram oil, Mandarin oil, Myrrh oil, Melissa oil, Eucalyptus oil, Yuzu oil, Lime oil, Lavensara oil, Lavandin oil, Lavender oil, Linden oil, Lemon oil, Lemongrass oil, Rose oil, Rose Essential oils such as wood oil, rosemary oil, and lobe oil.

  Terpenes and perfumes such as limonene, pinene, terpinene, terpinolene, myrcene, and longifylene.

  These compounding agents can be used individually by 1 type, and can also be used in combination of 2 or more type.

  Examples of the present invention will be described below, but the present invention is not limited to these examples.

Example 1
2% by mass of polyoxyethylene hydrogenated castor oil (60EO) was added to 10% by mass of glycerin, and these were heated and dissolved at 80 ° C., and then cooled to 50 ° C. to obtain a mixed solution. Then, 1% by mass of trisodium ascorbyl-2-phosphate-6-palmitate and 0.01% by mass of tetrasodium edetate are dispersed and dissolved in this mixed solution, and purified water is added thereto to add 100% by mass. As a result, a lotion having a pH of 7.2 was obtained.

(Example 2)
2% by mass of polyoxyethylene hydrogenated castor oil (60EO) was added to 10% by mass of glycerin, and these were heated and dissolved at 80 ° C., and then cooled to 50 ° C. to obtain a mixed solution. Then, 1% by mass of trisodium ascorbic acid-2-phosphate-6-palmitate and 0.5% by mass of tetrasodium edetate are dispersed and dissolved in this mixed solution, and purified water is added thereto to add 100% by mass. As a result, a lotion having a pH of 7.2 was obtained.

(Example 3)
2% by mass of polyoxyethylene hydrogenated castor oil (60EO) was added to 10% by mass of glycerin, and these were heated and dissolved at 80 ° C., and then cooled to 50 ° C. to obtain a mixed solution. Then, 1% by mass of trisodium ascorbyl-2-phosphate-6-palmitate and 0.1% by mass of tetrasodium edetate are dispersed and dissolved in this mixed solution, and these are sufficiently stirred and mixed to obtain ascorbic acid. A mixed solution was obtained. Next, 1% by mass of a 1% hydrolyzed collagen aqueous solution and 1% by mass of a 300 ppm fullerene dispersion are added to this ascorbic acid mixed solution and stirred well. .5 lotion was obtained.

Example 4
2% by mass of polyoxyethylene hydrogenated castor oil (60EO) was added to 10% by mass of glycerin, and these were heated and dissolved at 80 ° C., and then cooled to 50 ° C. to obtain a mixed solution. Then, 1% by mass of trisodium ascorbyl-2-phosphate-6-palmitate and 0.1% by mass of tetrasodium edetate are dispersed and dissolved in this mixed solution, and these are sufficiently stirred and mixed to obtain ascorbic acid. A mixed solution was obtained. Next, 1% by mass of 1% hydrolyzed collagen aqueous solution, 1% by mass of 300 ppm fullerene dispersion and 0.1% by mass of citric acid are added to this ascorbic acid mixed solution and stirred well, and then purified water is added thereto. In addition, a lotion having a pH of 8.0 was obtained by adjusting the content to 100% by mass.

(Example 5)
10% by mass of isopropyl alcohol, 0.2% by mass of olefin oligomer, and 0.5% by mass of polyoxyethylene hydrogenated castor oil (60EO) were mixed at 80 ° C., and then cooled to room temperature to obtain a mixed solution. And after adding purified water (the quantity which makes the whole 100 mass%) to this mixed solution, 0.5 mass% of ascorbic acid-2-phosphate-6-palmitate trisodium is added to 8.0 mass% of ethyl alcohol. Was added, and these were sufficiently stirred and mixed to obtain an ascorbic acid mixed solution. Next, edetate tetrasodium 0.3% by mass, 1% hydrolyzed collagen aqueous solution 1.0% by mass, 300 ppm fullerene dispersion 1.0% by mass, citric acid 0.2% by mass, parabens were added to this ascorbic acid mixed solution. (Appropriate amount) and sodium hydroxide (amount adjusted to pH 7.5) were added and stirred well to obtain a lotion having a pH of 7.5.

(Example 6)
A mixed solution was prepared by mixing 5.0% by mass of squalane and 10% by mass of behenyl alcohol at 80 ° C. Then, to this mixed solution, polyglycerin fatty acid ester 2.0% by mass, carboxyvinyl polymer 0.1% by mass, edetate tetrasodium 0.5% by mass, paraben (appropriate amount), and purified water (100 mass in total) %) At 80 ° C. and 5000 r.d. p. The mixture was mixed for 5 minutes with a m homomixer and then cooled. Next, a solution in which 1.0% by mass of trisodium ascorbate-2-phosphate-6-palmitate is dispersed and dissolved in 10.0% by mass of 1,3-butylene glycol at room temperature, and a 1% hydrolyzed collagen aqueous solution 1.0 mass%, 300 ppm fullerene dispersion 0.5 mass%, and sodium hydroxide (amount to be adjusted to pH 7.5) were added and stirred thoroughly to obtain a pH 7.5 emulsion.

(Example 7)
Cetyl 2-ethylhexanoate 10.0% by mass, squalane 5.0% by mass, macadamia nut oil 5.0% by mass, self-emulsifying glyceryl monostearate 2.0% by mass, and monostearate polyethylene glycol (60EO) 1.0% by mass was mixed and heated to 80 ° C. to obtain a mixed solution. Then, glycerin 10.0% by mass, edetate tetrasodium 0.3% by mass, paraben (appropriate amount) and purified water (amount to make the whole 100% by mass) are added to this mixed solution, and these are added at 80 ° C. At 5000 r. p. The mixture was mixed for 5 minutes with a m homomixer and then cooled. Next, a solution obtained by dispersing and dissolving 0.5% by mass of trisodium ascorbyl-2-phosphate-6-palmitate in 5.0% by mass of 1,3-butylene glycol at room temperature, and a 1% hydrolyzed collagen aqueous solution 1.0% by mass, 1.0% by mass of a 300 ppm fullerene dispersion, and sodium hydroxide (amount adjusted to pH 7.5) were added and stirred sufficiently to obtain a pH 7.5 cream.

(Example 8)
1,3 butyl alcohol 10% by weight, glycerin 5.0% by weight, carboxyvinyl polymer 0.1% by weight, sodium L-ascorbate phosphate 3.0% by weight, edetate tetrasodium 0.5% by weight, and Purified water (amount to make the whole 100% by mass) was mixed to prepare a mixed solution. Then, 2.0% by mass of trisodium ascorbyl-2-phosphate-6-palmitate was added to this mixed solution, and then 1.0% by mass of 1% hydrolyzed collagen aqueous solution and 300 ppm fullerene dispersion 1. 0% by mass and sodium hydroxide (amount adjusted to pH 7.5) were added and stirred well to obtain a whitening cosmetic liquid having a pH of 7.5.

(Comparative Example 1)
2% by mass of polyoxyethylene hydrogenated castor oil (60EO) was added to 10% by mass of glycerin, and these were heated and dissolved at 80 ° C., and then cooled to 50 ° C. to obtain a mixed solution. Then, 1% by mass of trisodium ascorbyl-2-phosphate-6-palmitate was dispersed and dissolved in this mixed solution, and these were sufficiently stirred and mixed to obtain an ascorbic acid mixed solution. Next, after adding 1% hydrolyzed collagen aqueous solution 1% by mass and 300ppm fullerene dispersion 1% by mass to this ascorbic acid mixed solution and stirring well, add purified water to this to make 100% by mass. To obtain a lotion having a pH of 7.3.

(Comparative Example 2)
2% by mass of polyoxyethylene hydrogenated castor oil (60EO) was added to 10% by mass of glycerin, and these were heated and dissolved at 80 ° C., and then cooled to 50 ° C. to obtain a mixed solution. Then, 1% by mass of trisodium ascorbyl-2-phosphate-6-palmitate was dispersed and dissolved in this mixed solution, and these were sufficiently stirred and mixed to obtain an ascorbic acid mixed solution. Next, 0.1% by mass of citric acid was added to this ascorbic acid mixed solution and stirred well, and then purified water was added thereto to make 100% by mass to obtain a lotion having a pH of 5.5.

As described above, the appearance color change after 1 month storage of the lotions obtained in Examples 1 to 4 and Comparative Examples 1 and 2 was visually evaluated. The change in the appearance color was carried out by five specialist panels as follows: ○: No change Δ: Slightly yellowing ×: Clearly yellowing. The evaluation results are shown in the following Table 1.

  As is clear from Table 1, in cosmetics containing ascorbic acid-2-phosphate-6-palmitate, by using edetate in combination, ascorbic acid-2-phosphate-6-palmitate It is clear that yellowing can be prevented.

  And the lotion obtained in Example 5, the emulsion obtained in Example 6, the cream obtained in Example 7, and the whitening serum obtained in Example 8 were also evaluated. The ascorbic acid derivative was not discolored over time, and the ascorbic acid derivative was stable without decreasing.

Claims (8)

(B) The following general formula

(In the formula, R is a residue of a higher fatty acid selected from lauric acid, myristic acid, palmitic acid, and stearic acid.)
An ascorbic acid derivative that is a compound represented by the formula:
(B) edetic acid and / or a salt thereof;
An external preparation for skin, comprising:   The skin external preparation according to claim 1, wherein the compound represented by the general formula (1) is ascorbic acid-2-phosphate-6-palmitic acid.   The salt of the compound represented by the general formula (1) is a metal salt selected from alkali metal, alkaline earth metal, aluminum, iron, zinc and bismuth, a basic amino acid salt, or an organic amine salt. The external preparation for skin according to claim 1, wherein the preparation is externally applied.   The said ascorbic acid derivative is contained in the ratio of 0.01-20 mass%, The skin external preparation of any one of Claims 1-3 characterized by the above-mentioned.   The external preparation for skin according to any one of claims 1 to 4, wherein the edetic acid and / or salt thereof is contained in a proportion of 0.01 to 5% by mass.   The skin external preparation according to any one of claims 1 to 5, wherein the skin external preparation has a pH of 6.5 to 9.5.   The skin external preparation according to any one of claims 1 to 6, wherein the skin external preparation contains fullerene.   The skin external preparation according to any one of claims 1 to 7, wherein the skin external preparation contains hydrolyzed collagen.