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IN2014DN10161A - - Google Patents

Info

Publication number
IN2014DN10161A
IN2014DN10161A IN10161DEN2014A IN2014DN10161A IN 2014DN10161 A IN2014DN10161 A IN 2014DN10161A IN 10161DEN2014 A IN10161DEN2014 A IN 10161DEN2014A IN 2014DN10161 A IN2014DN10161 A IN 2014DN10161A
Authority
IN
India
Prior art keywords
base portion
microneedle array
microneedles
forming
bioactive
Prior art date
Application number
Other languages
English (en)
Inventor
Louis D Falo Jr
Geza Erdos
O Burak Ozdoganlar
Original Assignee
Univ Pittsburgh
Univ Carnegie Mellon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pittsburgh, Univ Carnegie Mellon filed Critical Univ Pittsburgh
Publication of IN2014DN10161A publication Critical patent/IN2014DN10161A/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C67/00—Shaping techniques not covered by groups B29C39/00 - B29C65/00, B29C70/00 or B29C73/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/042—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
    • B23C—MILLING
    • B23C3/00—Milling particular work; Special milling operations; Machines therefor
    • B23C3/16—Working surfaces curved in two directions
    • B23C3/20—Working surfaces curved in two directions for shaping dies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00526—Methods of manufacturing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
    • A61L2300/802—Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061—Methods for using microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/753—Medical equipment; Accessories therefor
    • B29L2031/7544—Injection needles, syringes

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Medical Informatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
IN10161DEN2014 2012-05-01 2013-05-01 IN2014DN10161A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261641209P 2012-05-01 2012-05-01
PCT/US2013/039084 WO2013166162A1 (fr) 2012-05-01 2013-05-01 Réseaux de micro-aiguilles à extrémité chargée pour l'insertion transdermique

Publications (1)

Publication Number Publication Date
IN2014DN10161A true IN2014DN10161A (fr) 2015-08-21

Family

ID=49514855

Family Applications (1)

Application Number Title Priority Date Filing Date
IN10161DEN2014 IN2014DN10161A (fr) 2012-05-01 2013-05-01

Country Status (11)

Country Link
US (3) US9944019B2 (fr)
EP (2) EP2841147A4 (fr)
JP (7) JP2015515886A (fr)
CN (2) CN104703651A (fr)
AU (5) AU2013256348B2 (fr)
BR (1) BR112014027242A2 (fr)
CA (2) CA2871770C (fr)
HK (1) HK1209658A1 (fr)
IN (1) IN2014DN10161A (fr)
MX (1) MX370579B (fr)
WO (1) WO2013166162A1 (fr)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8834423B2 (en) 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
IN2014DN10161A (fr) 2012-05-01 2015-08-21 Univ Pittsburgh
JP2015157072A (ja) * 2014-01-27 2015-09-03 コスメディ製薬株式会社 ３ｄプリンターによるマイクロニードルの製造
CN113908424B (zh) * 2014-04-24 2025-01-14 佐治亚科技研究公司 微针和其制造方法
IL252096B (en) * 2014-11-06 2022-07-01 Univ Pittsburgh Commonwealth Sys Higher Education Microneedle arrays for cancer therapy applications
WO2016149673A1 (fr) 2015-03-18 2016-09-22 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Composés bioactifs conjugués à des substrats de réseaux de micro-aiguilles
US10894151B2 (en) 2015-04-23 2021-01-19 Carnegie Mellon University Biosensor tattoos and uses therefor for biomarker monitoring
US10737082B2 (en) * 2015-07-24 2020-08-11 Sorrento Therapeutics, Inc. Methods for lymphatic delivery of active agents
US11684763B2 (en) 2015-10-16 2023-06-27 University of Pittsburgh—of the Commonwealth System of Higher Education Multi-component bio-active drug delivery and controlled release to the skin by microneedle array devices
KR101811513B1 (ko) * 2015-11-25 2017-12-20 주식회사 파이안에스테틱스 마이크로 스피큘과 이의 제조용 몰드 및 이의 제조방법
US11744889B2 (en) 2016-01-05 2023-09-05 University of Pittsburgh—of the Commonwealth System of Higher Education Skin microenvironment targeted delivery for promoting immune and other responses
US20170209553A1 (en) * 2016-01-22 2017-07-27 Transderm, Inc. Delivery of botulinum with microneedle arrays
EP3434314B1 (fr) * 2016-03-25 2022-11-09 Toppan Printing Co., Ltd. Dispositif d'administration transdermique
KR101719319B1 (ko) * 2016-04-05 2017-03-23 주식회사 엘지생활건강 효율적인 피부 천공을 위한 마이크로니들 구조
US20200230846A1 (en) * 2016-04-12 2020-07-23 Juvic Inc. Rotating assembly and apparatus for manufacturing microstructure comprising same
KR101692266B1 (ko) * 2016-08-01 2017-01-03 부산대학교 산학협력단 마이크로니들 패치 및 이의 제조 방법
JP6700144B2 (ja) * 2016-09-06 2020-05-27 富士フイルム株式会社 マイクロニードルアレイ撮像方法及びマイクロニードルアレイ検査方法
US10913776B2 (en) 2016-09-30 2021-02-09 University of Pittsburgh—of the Commonwealth System of Higher Education Zika virus vaccines
CN107913459A (zh) * 2016-10-10 2018-04-17 苏州纳通生物纳米技术有限公司 一种液体定量输送装置
CN107913460B (zh) * 2016-10-10 2021-06-22 苏州纳通生物纳米技术有限公司 一种液体定量输送系统
EP3582752A1 (fr) * 2017-02-17 2019-12-25 Allergan, Inc. Réseau de micro-aiguilles avec principe actif
CN106727273A (zh) * 2017-03-02 2017-05-31 李成国 可溶性微针的制造方法
US11701506B2 (en) * 2017-05-10 2023-07-18 Chee Yen Lim Pyramidal microneedles with enhanced drug loading capacity and method for manufacturing
US11541015B2 (en) 2017-05-17 2023-01-03 Massachusetts Institute Of Technology Self-righting systems, methods, and related components
CN110785157B (zh) 2017-05-17 2022-11-04 麻省理工学院 自扶正系统及相关组件和方法
US20210128897A1 (en) * 2017-08-17 2021-05-06 New York University Bone growth stimulator and methods of use
JP6624333B2 (ja) * 2017-09-29 2019-12-25 凸版印刷株式会社 細胞移植用ユニット
WO2019094349A1 (fr) * 2017-11-07 2019-05-16 NanoCav, LLC Dispositifs de type réseaux de micro-aiguilles, leurs procédés de fabrication et utilisation
WO2019222570A1 (fr) 2018-05-17 2019-11-21 Massachusetts Institute Of Technology Système pour stimulation électrique
WO2020069564A1 (fr) 2018-10-02 2020-04-09 WearOptimo Pty Ltd Système pour déterminer un niveau de fluide dans un sujet biologique
US12258586B2 (en) * 2018-10-29 2025-03-25 University Of South Carolina Culture system and media for skin explants providing enhanced viability and enabling molecular studies
US12214150B2 (en) 2019-05-16 2025-02-04 University of Pittsburgh—of the Commonwealth System of Higher Education Microneedle arrays with undercut features for cutaneous and non-cutaneous drug delivery
EP3772329A1 (fr) * 2019-08-08 2021-02-10 PKvitality Systeme de surveillance corporelle comprenant une microaiguille
CN110368576A (zh) * 2019-08-23 2019-10-25 苏州纳生微电子有限公司 定量液体供给装置
US11213482B1 (en) 2020-03-05 2022-01-04 University of Pittsburgh—Of the Commonwealth System of Higher Educat SARS-CoV-2 subunit vaccine and microneedle array delivery system
US11202753B1 (en) 2020-03-06 2021-12-21 Aquavit Pharmaceuticals, Inc. Systems and methods for generating immune responses in subjects using microchannel delivery devices
AU2021265743A1 (en) 2020-04-28 2022-11-03 Ticona Llc Microneedle assembly
US20220008007A1 (en) * 2020-07-13 2022-01-13 Icreate Technology (Zhuhai) Co., Ltd. Microneedle array and sensor including the same
CN112569465B (zh) * 2020-12-29 2022-07-19 华东理工大学 一种微针贴片的制备方法
TW202300514A (zh) * 2021-05-21 2023-01-01 高端疫苗生物製劑股份有限公司 抗新型冠狀病毒之微針疫苗
GB2607115B (en) * 2021-06-25 2023-10-04 Cipherx Tech Ltd Method of producing a microneedle array
WO2024196881A2 (fr) * 2023-03-17 2024-09-26 Corrective Development, Llc Procédé de micro-aiguilles

Family Cites Families (153)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5246783A (en) 1991-08-15 1993-09-21 Exxon Chemical Patents Inc. Electrical devices comprising polymeric insulating or semiconducting members
US6290991B1 (en) 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
US7422574B2 (en) 1995-05-19 2008-09-09 Applied Tissue Technologies, Llc Microseeding device for gene delivery by microneedle injection
US5658515A (en) 1995-09-25 1997-08-19 Lee; Abraham P. Polymer micromold and fabrication process
WO1998000194A2 (fr) * 1996-06-28 1998-01-08 Sontra Medical, L.P. Amelioration du transport transdermique par ultrason
DK1314400T3 (da) * 1996-12-31 2007-10-15 Altea Therapeutics Corp Mikroporering af væv til levering af bioaktive midler
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US6496629B2 (en) 1999-05-28 2002-12-17 Tycom (Us) Inc. Undersea telecommunications cable
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6379324B1 (en) 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6312612B1 (en) 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6331266B1 (en) 1999-09-29 2001-12-18 Becton Dickinson And Company Process of making a molded device
US6511463B1 (en) 1999-11-18 2003-01-28 Jds Uniphase Corporation Methods of fabricating microneedle arrays using sacrificial molds
IL134997A0 (en) 2000-03-09 2001-05-20 Yehoshua Yeshurun Health care system based on micro device
US6595947B1 (en) 2000-05-22 2003-07-22 Becton, Dickinson And Company Topical delivery of vaccines
US6607513B1 (en) 2000-06-08 2003-08-19 Becton, Dickinson And Company Device for withdrawing or administering a substance and method of manufacturing a device
US6623707B1 (en) 2000-06-19 2003-09-23 Corning Incorporated Monolithic catalyst dehydrogenation reactor
US20050008683A1 (en) * 2000-06-29 2005-01-13 Becton Dickinson And Company Method for delivering interferons to the intradermal compartment
US6656147B1 (en) 2000-07-17 2003-12-02 Becton, Dickinson And Company Method and delivery device for the transdermal administration of a substance
US6533949B1 (en) 2000-08-28 2003-03-18 Nanopass Ltd. Microneedle structure and production method therefor
KR20030068136A (ko) 2000-10-13 2003-08-19 알자 코포레이션 미세 돌기부로 피부를 천공하기 위한 장치 및 방법
US6821281B2 (en) 2000-10-16 2004-11-23 The Procter & Gamble Company Microstructures for treating and conditioning skin
WO2002064193A2 (fr) * 2000-12-14 2002-08-22 Georgia Tech Research Corporation Appareils a microaiguilles et fabrication
US6767211B2 (en) 2001-03-13 2004-07-27 Carolyn W. Hall Method and apparatus for behaviorally reinforced training with guided practice
US6663820B2 (en) 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
US20020193729A1 (en) * 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
JP2004531578A (ja) 2001-06-29 2004-10-14 ベクトン・ディキンソン・アンド・カンパニー ワクチンおよび遺伝子治療剤のマイクロカニューレによる皮内送達
US6881203B2 (en) 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
WO2003024507A2 (fr) 2001-09-19 2003-03-27 Biovalve Technologies, Inc. Microaiguilles, jeux de microaiguilles, et systemes et procedes associes
US7429258B2 (en) 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
US6908453B2 (en) 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
US6714707B2 (en) 2002-01-24 2004-03-30 Alcatel Optical cable housing an optical unit surrounded by a plurality of gel layers
AU2003209645A1 (en) 2002-03-04 2003-09-16 Nano Pass Technologies Ltd. Devices and methods for transporting fluid across a biological barrier
US6945952B2 (en) 2002-06-25 2005-09-20 Theraject, Inc. Solid solution perforator for drug delivery and other applications
US6899838B2 (en) 2002-07-12 2005-05-31 Becton, Dickinson And Company Method of forming a mold and molding a micro-device
AU2003275311A1 (en) * 2002-09-16 2004-04-30 Sung-Yun Kwon Solid micro-perforators and methods of use
EP1590034B1 (fr) 2002-10-07 2014-05-14 Biovalve Technologies, Inc. Emplatre a serie de micro-aiguilles
IL152271A (en) 2002-10-13 2006-04-10 Meir Hefetz Structures of micro needles and manufacturing methods
US7578954B2 (en) 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
US8796436B2 (en) 2003-04-17 2014-08-05 Alnylam Pharmaceuticals, Inc. Modified iRNA agents
JP2005035945A (ja) 2003-07-16 2005-02-10 Cardio Corp 組織再生複合療法
MXPA06001414A (es) * 2003-08-04 2006-08-25 Johnson & Johnson Metodo y dispositivo para incrementar el flujo de agente transdermico.
US8353861B2 (en) * 2003-09-18 2013-01-15 Texmac, Inc. Applicator for applying functional substances into human skin
EP1677688A4 (fr) 2003-10-28 2008-06-04 Alza Corp Procede et appareil de reduction de l'incidence du tabagisme
WO2005044364A1 (fr) 2003-11-10 2005-05-19 Agency For Science, Technology And Research Micro-aiguilles et fabrication de micro-aiguilles
CA2546443A1 (fr) * 2003-11-18 2005-06-02 Nanopass Technologies Ltd. Systeme de penetration ameliore et procede permettant de faire coulisser des micro-aiguilles
WO2005060621A2 (fr) 2003-11-21 2005-07-07 The Regents Of The University Of California Procede et dispositif permettant de perforer une surface afin d'extraire, d'analyser et/ou d'administrer une substance, au moyen de micro-aiguilles
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
US8551391B2 (en) 2004-02-17 2013-10-08 Avery Dennison Corporation Method of making microneedles
US8671544B2 (en) 2004-03-12 2014-03-18 Agency For Science, Technology And Research Methods and moulds for use in fabricating side-ported microneedles
US7591806B2 (en) 2004-05-18 2009-09-22 Bai Xu High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
US7315758B2 (en) 2004-06-03 2008-01-01 Lynntech, Inc. Transdermal delivery of therapeutic agent
US7560036B2 (en) 2004-08-05 2009-07-14 Apogee Technology, Inc. System and method for drug delivery and microfluidic applications using microneedles
EP1786580B1 (fr) 2004-08-16 2010-12-01 Functional Microstructures Limited Procede de production d'une micro-aiguille ou d'un micro-implant
US7316665B2 (en) 2004-08-25 2008-01-08 Becton, Dickinson And Company Method and device for the delivery of a substance including a covering
US7132054B1 (en) 2004-09-08 2006-11-07 Sandia Corporation Method to fabricate hollow microneedle arrays
US7846488B2 (en) 2004-11-18 2010-12-07 3M Innovative Properties Company Masking method for coating a microneedle array
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
AU2005306372B2 (en) 2004-11-18 2011-01-06 Kindeva Drug Delivery L.P. Method of contact coating a microneedle array
EP1833547A1 (fr) 2004-11-18 2007-09-19 3M Innovative Properties Company Applicateur de jeux de micro-aiguilles a profil bas
CN101072668B (zh) 2004-12-07 2011-08-31 3M创新有限公司 模制微型针的方法
CA2595894C (fr) * 2005-01-31 2013-09-10 Kanji Takada Preparation absorbable par voie percutanee, feuille support de preparation absorbable par voie percutanee et materiel support de preparation absorbable par voie percutanee
US20080213461A1 (en) * 2005-06-17 2008-09-04 Georgia Tech Research Corporation Coated Microstructures and Methods of Manufacture Thereof
US8376984B2 (en) 2005-07-14 2013-02-19 Terry L. James Apparatus, system, and method to deliver optimal elements in order to enhance the aesthetic appearance of the skin
WO2007041355A2 (fr) 2005-09-30 2007-04-12 Intuity Medical, Inc. Agents catalytiques pour extraire un échantillon de liquide biologique
US8784860B2 (en) 2005-10-27 2014-07-22 Cordis Corporation Local administration of a combination of rapamycin and cilostazol for the treatment of vascular disease
US8554317B2 (en) 2005-11-30 2013-10-08 3M Innovative Properties Company Microneedle arrays and methods of use thereof
US7658728B2 (en) 2006-01-10 2010-02-09 Yuzhakov Vadim V Microneedle array, patch, and applicator for transdermal drug delivery
US8419708B2 (en) 2006-02-10 2013-04-16 Hisamitsu Pharmaceuticals Co., Inc. Transdermal drug administration apparatus having microneedles
US7699819B2 (en) 2006-02-21 2010-04-20 The Hong Kong University Of Science And Technology Molecular sieve and zeolite microneedles and preparation thereof
EP2007423A2 (fr) * 2006-04-05 2008-12-31 Pfizer Products Incorporated Polythérapie à base d'un anticorps anti-ctla4
WO2007127976A2 (fr) * 2006-05-01 2007-11-08 Georgia Tech Research Corporation Procédé de moulage basé sur des particules
WO2007131050A2 (fr) * 2006-05-02 2007-11-15 Georgia Tech Research Corporation Méthode d'administration de médicament dans les tissus oculaires par micro-aiguille
TW200744534A (en) 2006-06-09 2007-12-16 Univ Nat Chiao Tung Microprobe array structure and manufacturing method thereof
DE102006028781A1 (de) 2006-06-23 2007-12-27 Robert Bosch Gmbh Verfahren zur Herstellung von porösen Mikronadeln und ihre Verwendung
US8250729B2 (en) 2006-07-12 2012-08-28 University Of Utah Research Foundation 3D fabrication of needle tip geometry and knife blade
KR100781702B1 (ko) 2006-07-21 2007-12-03 연세대학교 산학협력단 중공형 마이크로니들 및 이의 제조방법
EP2062611A4 (fr) 2006-08-18 2010-01-06 Toppan Printing Co Ltd Micro-aiguille et timbre à micro-aiguilles
WO2008020631A1 (fr) 2006-08-18 2008-02-21 Toppan Printing Co., Ltd. Procédé de production de plaque originale, procédé de production de timbre à micro-aiguilles, timbre à micro-aiguilles et appareils d'exposition
DE102006040642A1 (de) 2006-08-30 2008-03-13 Robert Bosch Gmbh Mikronadeln zur Platzierung in der Haut zwecks transdermaler Applikation von Pharmazeutika
US8785400B2 (en) 2006-11-22 2014-07-22 Curedm Group Holdings, Llc Methods and compositions relating to islet cell neogenesis
US7785301B2 (en) 2006-11-28 2010-08-31 Vadim V Yuzhakov Tissue conforming microneedle array and patch for transdermal drug delivery or biological fluid collection
JP2008142183A (ja) 2006-12-07 2008-06-26 Fujifilm Corp マイクロニードルシート及びその製造方法
TW200829215A (en) 2007-01-03 2008-07-16 Univ Nat Chiao Tung Micro probe array and manufacturing method of the trans-print mold thereof
US8821446B2 (en) 2007-01-22 2014-09-02 Corium International, Inc. Applicators for microneedles
US8560059B2 (en) 2007-03-09 2013-10-15 Covidien Lp System and methods for optical sensing and drug delivery using microneedles
ES2820335T3 (es) * 2007-04-16 2021-04-20 Corium Inc Matrices de microagujas coladas con disolvente que contienen agente activo
JP5298011B2 (ja) 2007-05-15 2013-09-25 久光製薬株式会社 マイクロニードルのコーティング方法
JP2008284318A (ja) 2007-05-15 2008-11-27 Kosumedei Seiyaku Kk 生体由来物質からなる投薬用微細針
JP2010530327A (ja) 2007-06-20 2010-09-09 スリーエム イノベイティブ プロパティズ カンパニー ウェブ上への超音波射出成形
JP5547964B2 (ja) 2007-06-29 2014-07-16 株式会社ステリック再生医科学研究所 生理活性物質を定着および発現させる方法
US20090017210A1 (en) * 2007-07-09 2009-01-15 Andrianov Alexander K Methods and systems for coating a microneedle with a dosage of a biologically active compound
US20090016935A1 (en) * 2007-07-09 2009-01-15 Andrianov Alexander K Coating formulations including polyphosphazene polyelectrolytes and biologically active agents and asperities coated with such formulations
MX2010001054A (es) 2007-07-26 2010-04-21 Sanofi Pasteur Ltd Composiciones adyuvantes antigenicas y metodos.
US8366677B2 (en) 2007-08-06 2013-02-05 Transderm, Inc. Microneedle arrays formed from polymer films
US20090076345A1 (en) 2007-09-14 2009-03-19 Corventis, Inc. Adherent Device with Multiple Physiological Sensors
WO2009036329A1 (fr) 2007-09-14 2009-03-19 Corventis, Inc. Moniteur multicapteurs pour patient conçu pour détecter une décompensation cardiaque imminente
EP2205076A4 (fr) * 2007-09-24 2010-12-29 Tragara Pharmaceuticals Inc Polythérapie pour le traitement de cancer au moyen d'inhibiteurs de la cox-2 et d'inhibiteurs doubles de l'egfr ýerbb1¨et de l'her-2 ýerbb2¨
ES2612061T3 (es) 2007-09-28 2017-05-11 The Queen's University Of Belfast Dispositivo y método de suministro
GB0719577D0 (en) * 2007-10-08 2007-11-14 Kirby Andrew J Microimplant devices and methods of making and use thereof
AU2008327083B2 (en) 2007-11-21 2014-01-16 Bioserentach Co., Ltd. Preparation for application to body surface and preparation holding sheet for application to body surface
EP2231228A4 (fr) * 2007-12-17 2015-08-12 New World Pharmaceuticals Llc Administration intradermique intégrée, système de diagnostic et de communication
GB0725018D0 (en) * 2007-12-21 2008-01-30 Univ Cardiff Monitoring system for microneedle delivery
WO2009105564A2 (fr) * 2008-02-19 2009-08-27 Xvasive, Inc. Thérapies d'acupuncture et d'acupressure
EP2100850A1 (fr) 2008-03-11 2009-09-16 Stichting Voor De Technische Wetenschappen Ensemble de micro-aiguille et procédé de fabrication de micro-aiguilles
NL2001718C2 (nl) * 2008-06-24 2009-12-28 Needle Holding B V U Micronaald, micronaaldarray en fabricagewerkwijze daarvoor.
US8795259B2 (en) 2008-08-01 2014-08-05 Wisconsin Alumni Research Foundation Drug delivery platform incorporating hydrogel pumping mechanism with guided fluid flow
EP2320991B1 (fr) 2008-08-21 2020-05-20 Kibur Medical, Inc. Dispositif pour l'évaluation d'un médicament et traitement local
CN101347652B (zh) 2008-09-09 2011-01-12 南京大学 一种空心微针阵列注射器的制备方法
JP5063544B2 (ja) * 2008-09-22 2012-10-31 富士フイルム株式会社 経皮吸収シート及びその製造方法
US8793075B2 (en) 2008-10-31 2014-07-29 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8613937B2 (en) 2008-10-31 2013-12-24 The Invention Science Fund I, Llc Compositions and methods for biological remodeling with frozen particle compositions
US8788211B2 (en) 2008-10-31 2014-07-22 The Invention Science Fund I, Llc Method and system for comparing tissue ablation or abrasion data to data related to administration of a frozen particle composition
US8798933B2 (en) 2008-10-31 2014-08-05 The Invention Science Fund I, Llc Frozen compositions and methods for piercing a substrate
CN102325563A (zh) * 2008-12-22 2012-01-18 昆士兰大学 贴剂制备
WO2010095456A1 (fr) 2009-02-23 2010-08-26 株式会社メドレックス Applicateur pour réseau de micro-aiguilles
WO2010099548A2 (fr) 2009-02-27 2010-09-02 Virginia Tech Intellectual Properties, Inc. Réseau de fibres pour imagerie et thérapeutique optiques
KR101142730B1 (ko) * 2009-03-16 2012-05-04 가천의과학대학교 산학협력단 상자성-이노시톨 포스페이트 복합체를 이용한 자기공명영상용 조영제
JP2010233673A (ja) * 2009-03-30 2010-10-21 Fujifilm Corp 経皮吸収シート及びその製造方法
US9517023B2 (en) * 2009-06-01 2016-12-13 Profusa, Inc. Method and system for directing a localized biological response to an implant
EP2441437B1 (fr) 2009-06-10 2018-08-08 Hisamitsu Pharmaceutical Co., Inc. Dispositif de micro-aiguilles
KR101213223B1 (ko) 2009-07-07 2013-01-09 한국전자통신연구원 할로우를 가지는 미세 바늘 및 미세 바늘 구조체의 제조 방법
JP5620911B2 (ja) 2009-07-23 2014-11-05 久光製薬株式会社 マイクロニードルアレイ
WO2011050283A2 (fr) 2009-10-22 2011-04-28 Corventis, Inc. Détection et surveillance à distance de l'incompétence chronotrope fonctionnelle
US8834423B2 (en) * 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
US8439896B2 (en) 2009-11-13 2013-05-14 The Invention Science Fund I, Llc Device, system, and method for targeted delivery of anti-inflammatory medicaments to a mammalian subject
US8784368B2 (en) 2009-11-13 2014-07-22 The Invention Science Fund I, Llc Device, system, and method for targeted delivery of anti-inflammatory medicaments to a mammalian subject
US8321012B2 (en) 2009-12-22 2012-11-27 The Invention Science Fund I, Llc Device, method, and system for neural modulation as vaccine adjuvant in a vertebrate subject
EP2338557A1 (fr) * 2009-12-23 2011-06-29 Debiotech S.A. Micro-aiguille soluble
USD638534S1 (en) 2010-01-08 2011-05-24 Ratio, Inc. Drug delivery device
US8328757B2 (en) 2010-01-08 2012-12-11 Wisconsin Alumni Research Foundation Bladder arrangement for microneedle-based drug delivery device
USD619245S1 (en) 2010-01-08 2010-07-06 Ratio, Inc. Drug delivery device
JP2011224332A (ja) 2010-03-29 2011-11-10 Fujifilm Corp 経皮吸収シート及びその製造方法
US8545741B2 (en) 2010-04-01 2013-10-01 Nurim Wellness Co. Ltd. Method of manufacturing microstructure
WO2012006677A1 (fr) * 2010-07-14 2012-01-19 The University Of Queensland Appareil d'application de timbre transdermique
WO2012031164A2 (fr) 2010-09-02 2012-03-08 California Institute Of Technology Administration de médicaments par réseaux de nanotubes de carbone
JP5770055B2 (ja) 2010-09-29 2015-08-26 富士フイルム株式会社 針状アレイ経皮吸収シートの製造方法
CA2815285C (fr) * 2010-10-19 2019-12-31 Trustees Of Tufts College Micro-aiguilles a base de fibroine de soie et procedes pour les fabriquer
JP2014500867A (ja) 2010-11-09 2014-01-16 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 皮膚浸透性および細胞侵入性（ｓｐａｃｅ）ペプチドとその使用法
US8795230B2 (en) 2010-11-30 2014-08-05 Becton, Dickinson And Company Adjustable height needle infusion device
US8795234B2 (en) 2010-11-30 2014-08-05 Becton, Dickinson And Company Integrated spring-activated ballistic insertion for drug infusion device
US8784383B2 (en) 2010-11-30 2014-07-22 Becton, Dickinson And Company Insulin pump dermal infusion set having partially integrated mechanized cannula insertion with disposable activation portion
EP2678342B1 (fr) 2011-02-25 2015-01-07 Takeda Pharmaceutical Company Limited Oxazinoptéridines et oxazonoptéridinones n-substituées
US8696637B2 (en) 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles
EP2683359B1 (fr) * 2011-03-07 2015-04-22 3M Innovative Properties Company Dispositifs et procédés de micro-aiguille
GB201107642D0 (en) * 2011-05-09 2011-06-22 Univ Cork Method
US8636696B2 (en) 2011-06-10 2014-01-28 Kimberly-Clark Worldwide, Inc. Transdermal device containing microneedles
CA2795995C (fr) * 2011-06-28 2020-03-24 Bioserentach Co. Ltd. Dispositif microaiguille pour le traitement de la peau
CN103301092B (zh) * 2012-03-06 2014-12-03 中国科学院理化技术研究所 聚合物微针阵列芯片及其制备方法和应用
IN2014DN10161A (fr) 2012-05-01 2015-08-21 Univ Pittsburgh
US9526884B2 (en) 2012-11-16 2016-12-27 City University Of Hong Kong Mechanically robust fast-dissolving microneedles for transdermal drug and vaccine delivery

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CN112933391A (zh) 2021-06-11
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JP6712963B2 (ja) 2020-06-24
AU2022291555B2 (en) 2025-01-09
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AU2022291555A1 (en) 2023-02-23
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US9944019B2 (en) 2018-04-17
AU2017225155A1 (en) 2017-10-05
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EP2841147A1 (fr) 2015-03-04
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AU2013256348B2 (en) 2017-06-15
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US20150126923A1 (en) 2015-05-07
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