IL154995A0 - Polypeptide bombesin antagonists, their preparation and pharmaceutical preparations containing them - Google Patents
Polypeptide bombesin antagonists, their preparation and pharmaceutical preparations containing themInfo
- Publication number
- IL154995A0 IL154995A0 IL15499503A IL15499503A IL154995A0 IL 154995 A0 IL154995 A0 IL 154995A0 IL 15499503 A IL15499503 A IL 15499503A IL 15499503 A IL15499503 A IL 15499503A IL 154995 A0 IL154995 A0 IL 154995A0
- Authority
- IL
- Israel
- Prior art keywords
- phenyl
- alkyl
- hydrogen
- moiety
- 10alkyl
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 239000002790 bombesin antagonist Substances 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 8
- 239000001257 hydrogen Substances 0.000 abstract 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 6
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 5
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 4
- -1 naphthyl-C1-10-alkyl Chemical group 0.000 abstract 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
- 125000003277 amino group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000001041 indolyl group Chemical group 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- C07K7/086—Bombesin; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL15499503A IL154995A0 (en) | 1993-03-15 | 2003-03-19 | Polypeptide bombesin antagonists, their preparation and pharmaceutical preparations containing them |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/031,325 US5369094A (en) | 1990-11-29 | 1993-03-15 | Polypeptide bombesin antagonists |
| IL10885194A IL108851A (en) | 1993-03-15 | 1994-03-03 | Polypeptide bombesin antagonists, their preparation and pharmaceutical preparations containing them |
| IL15499503A IL154995A0 (en) | 1993-03-15 | 2003-03-19 | Polypeptide bombesin antagonists, their preparation and pharmaceutical preparations containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL154995A0 true IL154995A0 (en) | 2003-10-31 |
Family
ID=21858823
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10885194A IL108851A (en) | 1993-03-15 | 1994-03-03 | Polypeptide bombesin antagonists, their preparation and pharmaceutical preparations containing them |
| IL15499503A IL154995A0 (en) | 1993-03-15 | 2003-03-19 | Polypeptide bombesin antagonists, their preparation and pharmaceutical preparations containing them |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10885194A IL108851A (en) | 1993-03-15 | 1994-03-03 | Polypeptide bombesin antagonists, their preparation and pharmaceutical preparations containing them |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US5369094A (xx) |
| EP (1) | EP0646127B1 (xx) |
| JP (1) | JP3838656B2 (xx) |
| KR (1) | KR100306506B1 (xx) |
| AT (1) | ATE167874T1 (xx) |
| AU (1) | AU666270B2 (xx) |
| BR (1) | BR9404341A (xx) |
| CA (1) | CA2135787C (xx) |
| CZ (1) | CZ286750B6 (xx) |
| DE (1) | DE69411342T2 (xx) |
| DK (1) | DK0646127T3 (xx) |
| EE (1) | EE03180B1 (xx) |
| ES (1) | ES2120615T3 (xx) |
| FI (1) | FI945378A0 (xx) |
| HR (1) | HRP940164B1 (xx) |
| HU (1) | HU218288B (xx) |
| IL (2) | IL108851A (xx) |
| NO (1) | NO313418B1 (xx) |
| NZ (2) | NZ299913A (xx) |
| PL (1) | PL180372B1 (xx) |
| RU (1) | RU2114118C1 (xx) |
| SI (1) | SI9420001B (xx) |
| SK (1) | SK282267B6 (xx) |
| TW (1) | TW325478B (xx) |
| UA (1) | UA34456C2 (xx) |
| WO (1) | WO1994021674A1 (xx) |
| ZA (1) | ZA941767B (xx) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5877277A (en) | 1987-09-24 | 1999-03-02 | Biomeasure, Inc. | Octapeptide bombesin analogs |
| US5723578A (en) * | 1987-09-24 | 1998-03-03 | The Administrators Of Tulane Educational Fund | Peptide analogs of bombesin |
| US5650395A (en) * | 1995-03-13 | 1997-07-22 | Hurel; Steven | Treatment of pulmonary hypertension |
| US6989371B1 (en) | 1996-08-16 | 2006-01-24 | Dabur Research Foundation | Bombesin analogs for treatment of cancer |
| DE69840647D1 (de) * | 1997-04-22 | 2009-04-23 | Curator Of The University Of M | Konjugate aus peptiden, die liganden von gastrinrezeptoren sind |
| IL155814A0 (en) * | 2000-11-17 | 2003-12-23 | Warner Lambert Co | Treatment of sexual dysfunction using bombesin antagonist |
| US20060239923A1 (en) * | 2003-01-13 | 2006-10-26 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
| US8420050B2 (en) * | 2003-01-13 | 2013-04-16 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
| US7611692B2 (en) * | 2003-01-13 | 2009-11-03 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
| US7922998B2 (en) * | 2003-01-13 | 2011-04-12 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
| US7850947B2 (en) | 2003-01-13 | 2010-12-14 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
| EP1583564B1 (en) * | 2003-01-13 | 2009-07-01 | Bracco Imaging S.p.A | Improved linkers for radiopharmaceutical compounds |
| US7226577B2 (en) * | 2003-01-13 | 2007-06-05 | Bracco Imaging, S. P. A. | Gastrin releasing peptide compounds |
| MXPA05011233A (es) | 2003-04-22 | 2005-12-14 | Conseils De Rech S Et D Aplica | Vectores peptidicos. |
| US7795385B2 (en) * | 2004-12-17 | 2010-09-14 | Bexar Global, Inc. | Use of bombesin/gastrin-releasing peptide antagonists for the treatment of inflammatory conditions, acute lung injury and bipolar disorder |
| FR2918566B1 (fr) * | 2007-07-11 | 2009-10-09 | Pierre Fabre Medicament Sa | Composition pharmaceutique stable d'un sel hydrosoluble de vinflunine. |
| EP2100900A1 (en) * | 2008-03-07 | 2009-09-16 | Universitätsspital Basel | Bombesin analog peptide antagonist conjugates |
| EP2198878A1 (en) * | 2008-12-18 | 2010-06-23 | University Of Miami | Polypeptide bombesin antagonists |
| WO2011043954A1 (en) | 2009-10-07 | 2011-04-14 | Merck Sharp & Dohme Corp. | Novel trpa1 antagonists |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989002897A1 (en) * | 1987-09-24 | 1989-04-06 | The Administrators Of The Tulane Educational Fund | Therapeutic peptides |
| US5084555A (en) * | 1989-08-21 | 1992-01-28 | The Administrators Of The Tulane Educational Fund | An octapeptide bombesin analog |
| US5162497A (en) * | 1987-09-24 | 1992-11-10 | The Administrators Of The Tulane Educational Fund | Bradykinin analogs with non-peptide bond |
| AU618029B2 (en) * | 1987-11-02 | 1991-12-12 | Imperial Chemical Industries Plc | Polypeptide compounds |
| GB8813356D0 (en) * | 1988-06-06 | 1988-07-13 | Ici Plc | Polypeptide compounds |
| GR1000608B (el) * | 1988-07-21 | 1992-08-31 | Erba Carlo Spa | Μεθοδος για την παρασκευη ανταγωνιστων bombesin. |
| JP2919889B2 (ja) * | 1988-10-14 | 1999-07-19 | アドミニストレイターズ オブ ザ テューレイン エデュケイショナル ファンド | 治療用ペプチド |
| US5217955A (en) * | 1989-09-15 | 1993-06-08 | Biomeasure, Inc. | Treatment of cancer with peptide analog of bombesin, grp, litorin or neuromedin |
| US5244883A (en) * | 1990-11-29 | 1993-09-14 | The Administrators Of The Tulane Educational Fund | Nonapeptide bombesin antagonists |
-
1993
- 1993-03-15 US US08/031,325 patent/US5369094A/en not_active Expired - Lifetime
-
1994
- 1994-02-23 TW TW083101048A patent/TW325478B/zh not_active IP Right Cessation
- 1994-03-03 IL IL10885194A patent/IL108851A/xx not_active IP Right Cessation
- 1994-03-07 EP EP94912199A patent/EP0646127B1/en not_active Expired - Lifetime
- 1994-03-07 BR BR9404341-8A patent/BR9404341A/pt not_active Application Discontinuation
- 1994-03-07 ES ES94912199T patent/ES2120615T3/es not_active Expired - Lifetime
- 1994-03-07 SK SK1364-94A patent/SK282267B6/sk unknown
- 1994-03-07 NZ NZ299913A patent/NZ299913A/en not_active IP Right Cessation
- 1994-03-07 CZ CZ19942807A patent/CZ286750B6/cs not_active IP Right Cessation
- 1994-03-07 KR KR1019940704104A patent/KR100306506B1/ko not_active IP Right Cessation
- 1994-03-07 SI SI9420001A patent/SI9420001B/sl not_active IP Right Cessation
- 1994-03-07 AT AT94912199T patent/ATE167874T1/de not_active IP Right Cessation
- 1994-03-07 NZ NZ263668A patent/NZ263668A/en unknown
- 1994-03-07 WO PCT/US1994/002511 patent/WO1994021674A1/en active IP Right Grant
- 1994-03-07 CA CA002135787A patent/CA2135787C/en not_active Expired - Fee Related
- 1994-03-07 HU HU9403244A patent/HU218288B/hu not_active IP Right Cessation
- 1994-03-07 RU RU94046091A patent/RU2114118C1/ru not_active IP Right Cessation
- 1994-03-07 PL PL94306209A patent/PL180372B1/pl not_active IP Right Cessation
- 1994-03-07 DK DK94912199T patent/DK0646127T3/da active
- 1994-03-07 UA UA94119008A patent/UA34456C2/uk unknown
- 1994-03-07 AU AU64446/94A patent/AU666270B2/en not_active Ceased
- 1994-03-07 JP JP52109194A patent/JP3838656B2/ja not_active Expired - Fee Related
- 1994-03-07 DE DE69411342T patent/DE69411342T2/de not_active Expired - Fee Related
- 1994-03-10 HR HR08/031,325A patent/HRP940164B1/xx not_active IP Right Cessation
- 1994-03-14 ZA ZA941767A patent/ZA941767B/xx unknown
- 1994-11-10 NO NO19944293A patent/NO313418B1/no unknown
- 1994-11-15 FI FI945378A patent/FI945378A0/fi unknown
- 1994-11-23 EE EE9400166A patent/EE03180B1/xx not_active IP Right Cessation
-
2003
- 2003-03-19 IL IL15499503A patent/IL154995A0/xx unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL154995A0 (en) | Polypeptide bombesin antagonists, their preparation and pharmaceutical preparations containing them | |
| CA2097192A1 (en) | Bombesin antagonists | |
| HUP0003592A2 (hu) | LH-RH peptid analógok, alkalmazásuk, és ezeket tartalmazó gyógyászati készítmények | |
| NO952744L (no) | Cytokinbegrensende midler | |
| TW343198B (en) | Cyclopeptides useful as adhesion inhibitors, process for the preparation thereof, and pharmaceutical composition containing them | |
| GB1403642A (en) | Nonapeptide amide derivatives | |
| SE8007763L (sv) | Sett att framstella en polypeptid | |
| FI892208A0 (fi) | Foerfarande och mellanprodukt foer framstaellning av aggregationshaemmande peptider. | |
| GB1533077A (en) | 4-substituted enkephalin derivatives | |
| GB1526367A (en) | Polypeptide | |
| GR3017297T3 (en) | Novel substrate peptides. | |
| DE3476666D1 (en) | Novel peptide, process for the preparation thereof and pharmaceutical composition containing said peptide | |
| GB1363801A (en) | Peptides and their preparation | |
| GB1357121A (en) | Peptide enzyme inhibitors | |
| GB1273873A (en) | Corticotropically highly active octadecapeptides | |
| ES248724A1 (es) | Procedimiento para la obtenciën de nuevosdecapeptures ciclicos | |
| ES416516A1 (es) | Un procedimiento para la preparacion de nonapeptidos. | |
| GB1269898A (en) | Amino acid derivatives | |
| GB1298318A (en) | Corticotropin peptides | |
| TW340849B (en) | Novel cyclopeptides and pharmaceutical compositions as integrin inhibitors comprizing the same | |
| GB1224658A (en) | Cyclic decapeptides | |
| TH17064B (th) | ตัวปฏิปักษ์ต่อโปลีเปปไทด์บอมเบซิน | |
| TH35998A (th) | Lh-rh เป็ปไทด์ อะนาล็อก ประโยชน์ของสิ่งเหล่านั้นและองค์ประกอบทางเภสัชกรรมซึ่งประกอบด้วยสิ่งเหล่านั้น | |
| GB1532148A (en) | 1-substituted enkepholin derivatives |