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IL110568A0 - A process for the preparation of optically active (2s) - or (2r) - endo-bicyclo [2.2.1] heptan-2-ol - Google Patents

A process for the preparation of optically active (2s) - or (2r) - endo-bicyclo [2.2.1] heptan-2-ol

Info

Publication number
IL110568A0
IL110568A0 IL11056894A IL11056894A IL110568A0 IL 110568 A0 IL110568 A0 IL 110568A0 IL 11056894 A IL11056894 A IL 11056894A IL 11056894 A IL11056894 A IL 11056894A IL 110568 A0 IL110568 A0 IL 110568A0
Authority
IL
Israel
Prior art keywords
endo
heptan
bicyclo
preparation
optically active
Prior art date
Application number
IL11056894A
Other languages
English (en)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IL110568A0 publication Critical patent/IL110568A0/xx

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/10Oxygen or sulfur atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/01Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/37Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by etherified hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00Compounds having —CHO groups
    • C07C47/52Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/02Preparation of oxygen-containing organic compounds containing a hydroxy group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
IL11056894A 1989-11-13 1994-08-04 A process for the preparation of optically active (2s) - or (2r) - endo-bicyclo [2.2.1] heptan-2-ol IL110568A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1989/005228 WO1991007501A1 (en) 1989-11-13 1989-11-13 Enzymatic resolution of endo-bicyclo[2.2.1]heptan-2-ol and derived pharmaceutical agents

Publications (1)

Publication Number Publication Date
IL110568A0 true IL110568A0 (en) 1994-11-11

Family

ID=22215375

Family Applications (5)

Application Number Title Priority Date Filing Date
IL11056890A IL110568A (en) 1989-11-13 1990-11-06 Process for the preparation of S2 (- or) R2 (- endo-bicyclo] 2.2.1 [Heptan-2-ol optically active
IL9626190A IL96261A (en) 1989-11-13 1990-11-06 S)] - 3) -25 (- Exo-bicyclo] 2.2.1 (- Hept-2-Iloxy [-4-methoxyphenyl (- 3,4,5,6-tetrahydropyrimidine-H) 12) -On and R )] -3) -25 (- exo-bicyclo] .2.1 [heft-
IL110564A IL110564A (en) 1989-11-13 1990-11-06 Derivatives of optical activity of 3-] 3) exo-bicyclo [2.2.1] heptyloxy-4-methoxyphenil [pentanedinitrile) or glutaramide (
IL11056494A IL110564A0 (en) 1989-11-13 1994-08-04 Intermediates eo endo-bicyclo [2.2.1] heptan-2-ol
IL11056894A IL110568A0 (en) 1989-11-13 1994-08-04 A process for the preparation of optically active (2s) - or (2r) - endo-bicyclo [2.2.1] heptan-2-ol

Family Applications Before (4)

Application Number Title Priority Date Filing Date
IL11056890A IL110568A (en) 1989-11-13 1990-11-06 Process for the preparation of S2 (- or) R2 (- endo-bicyclo] 2.2.1 [Heptan-2-ol optically active
IL9626190A IL96261A (en) 1989-11-13 1990-11-06 S)] - 3) -25 (- Exo-bicyclo] 2.2.1 (- Hept-2-Iloxy [-4-methoxyphenyl (- 3,4,5,6-tetrahydropyrimidine-H) 12) -On and R )] -3) -25 (- exo-bicyclo] .2.1 [heft-
IL110564A IL110564A (en) 1989-11-13 1990-11-06 Derivatives of optical activity of 3-] 3) exo-bicyclo [2.2.1] heptyloxy-4-methoxyphenil [pentanedinitrile) or glutaramide (
IL11056494A IL110564A0 (en) 1989-11-13 1994-08-04 Intermediates eo endo-bicyclo [2.2.1] heptan-2-ol

Country Status (27)

Country Link
EP (2) EP0801135A1 (xx)
JP (1) JPH06104661B2 (xx)
KR (1) KR930004654B1 (xx)
CN (1) CN1040423C (xx)
AT (1) ATE158577T1 (xx)
AU (3) AU633157B2 (xx)
CA (1) CA2029705C (xx)
CZ (2) CZ280006B6 (xx)
DE (1) DE69031487T2 (xx)
DK (1) DK0428302T3 (xx)
EG (1) EG19860A (xx)
ES (1) ES2107420T3 (xx)
FI (1) FI105106B (xx)
GR (1) GR3025196T3 (xx)
HU (2) HU215441B (xx)
IE (2) IE904059A1 (xx)
IL (5) IL110568A (xx)
MY (1) MY104517A (xx)
NO (1) NO304838B1 (xx)
NZ (1) NZ236037A (xx)
PH (1) PH30255A (xx)
PL (4) PL165132B1 (xx)
PT (1) PT95855B (xx)
RU (1) RU2104306C1 (xx)
WO (1) WO1991007501A1 (xx)
YU (1) YU48413B (xx)
ZA (1) ZA909044B (xx)

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HU215441B (hu) * 1989-11-13 1999-04-28 Pfizer Inc. Eljárás az endo-biciklo [2.2.1]-heptan-2-ol előállítására és az ebből kapott hatóanyagok enzimatikus úton történő elválasztására
US5124455A (en) * 1990-08-08 1992-06-23 American Home Products Corporation Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents
IE71647B1 (en) 1991-01-28 1997-02-26 Rhone Poulenc Rorer Ltd Benzamide derivatives
WO1993011256A1 (fr) * 1991-12-06 1993-06-10 Shionogi Seiyaku Kabushiki Kaisha Procede de production d'un norborneol presentant une activite optique
PL309257A1 (en) * 1992-12-02 1995-10-02 Pfizer Pirocatechin doethers as selective inhibitors of ped iv
US5814651A (en) * 1992-12-02 1998-09-29 Pfizer Inc. Catechol diethers as selective PDEIV inhibitors
JP3431204B2 (ja) * 1993-04-22 2003-07-28 塩野義製薬株式会社 ノルボルナン型エステル・ヒドロラーゼ
CN1041436C (zh) * 1993-05-07 1998-12-30 佛山市制药一厂 一种稳定冯了性风湿跌打药酒的方法
US5482944A (en) * 1993-07-13 1996-01-09 Pfizer Inc. Pyrimidones and imidazolinones for treatment of shock
JPH1142095A (ja) * 1997-07-25 1999-02-16 Chisso Corp 新規なオキソジシクロペンタジエンの製造方法
KR100479019B1 (ko) * 1998-05-22 2005-08-29 씨제이 주식회사 캐테콜히드라존유도체,이의제조방법및그를함유한약제학적조성물
HU229439B1 (hu) 1999-08-21 2013-12-30 Takeda Gmbh Roflumilast és salmeterol szinergetikus kombinációja
EP1405844A4 (en) 2001-06-29 2006-09-20 Nikken Chemicals Co Ltd CYCLOALKENONDERIVAT
ES2194588B1 (es) * 2001-07-13 2004-10-16 Astur Pharma S.A. Precursores opticamente puros de paroxetina.
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
AU2004226353A1 (en) 2003-04-01 2004-10-14 Laboratoires Serono Sa Inhibitors of phosphodiesterases in infertility
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US7879802B2 (en) 2007-06-04 2011-02-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US20100120694A1 (en) 2008-06-04 2010-05-13 Synergy Pharmaceuticals, Inc. Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
MX357121B (es) 2011-03-01 2018-06-27 Synergy Pharmaceuticals Inc Star Proceso de preparacion de agonistas c de guanilato ciclasa.
US9545446B2 (en) 2013-02-25 2017-01-17 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
CA2905438A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
EP3004138B1 (en) 2013-06-05 2024-03-13 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase c, method of making and using same
JP6694385B2 (ja) 2013-08-09 2020-05-13 アーデリクス,インコーポレーテッド リン酸塩輸送阻害のための化合物及び方法
US20200368223A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Methods for inhibiting phosphate transport

Family Cites Families (4)

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Publication number Priority date Publication date Assignee Title
US4261995A (en) * 1979-08-31 1981-04-14 Syntex (U.S.A.) Inc. 4-Phenyl-and 5-phenyl-1,4,5,6-tetrahydropyrimidine derivatives
US4732853A (en) * 1984-11-21 1988-03-22 President And Fellows Of Harvard College Method of making chiral epoxy alcohols
WO1987006576A1 (en) * 1986-04-29 1987-11-05 Pfizer Inc. Calcium independent camp phosphodiesterase inhibitor antidepressant
HU215441B (hu) * 1989-11-13 1999-04-28 Pfizer Inc. Eljárás az endo-biciklo [2.2.1]-heptan-2-ol előállítására és az ebből kapott hatóanyagok enzimatikus úton történő elválasztására

Also Published As

Publication number Publication date
CA2029705C (en) 1998-11-24
FI922142A (fi) 1992-05-12
HU9802988D0 (en) 1999-11-29
HU215441B (hu) 1999-04-28
WO1991007501A1 (en) 1991-05-30
AU633157B2 (en) 1993-01-21
YU48413B (sh) 1998-07-10
IL110564A0 (en) 1994-11-11
KR910009622A (ko) 1991-06-28
ATE158577T1 (de) 1997-10-15
PT95855B (pt) 1998-01-30
CZ124092A3 (en) 1995-04-12
EG19860A (en) 1996-03-31
PL165132B1 (pl) 1994-11-30
EP0428302B1 (en) 1997-09-24
NO304838B1 (no) 1999-02-22
EP0801135A1 (en) 1997-10-15
PL164202B1 (pl) 1994-06-30
AU6653590A (en) 1991-05-16
NO921876L (no) 1992-07-10
RU2104306C1 (ru) 1998-02-10
PL164176B1 (pl) 1994-06-30
CN1040423C (zh) 1998-10-28
YU214290A (sh) 1992-12-21
ZA909044B (en) 1992-06-24
DE69031487T2 (de) 1998-02-05
CZ560990A3 (en) 1995-04-12
FI922142A0 (fi) 1992-05-12
AU645449B2 (en) 1994-01-13
PT95855A (pt) 1991-09-13
IE904059A1 (en) 1991-05-22
IE980174A1 (en) 2000-02-23
JPH06104661B2 (ja) 1994-12-21
CA2029705A1 (en) 1991-05-14
MY104517A (en) 1994-04-30
GR3025196T3 (en) 1998-02-27
IL110568A (en) 1995-10-31
HUT64604A (en) 1994-01-28
CZ280011B6 (cs) 1995-09-13
NO921876D0 (no) 1992-05-12
KR930004654B1 (ko) 1993-06-02
AU3197993A (en) 1993-04-22
AU3292093A (en) 1993-04-22
PL292069A1 (en) 1992-04-21
IL96261A (en) 1996-12-05
HU220962B1 (hu) 2002-07-29
IL110564A (en) 1998-03-10
PL287727A1 (en) 1992-02-24
PL164457B1 (pl) 1994-07-29
EP0428302A2 (en) 1991-05-22
PH30255A (en) 1997-02-05
JPH03173871A (ja) 1991-07-29
DK0428302T3 (da) 1997-10-13
IL96261A0 (en) 1991-08-16
CN1051905A (zh) 1991-06-05
NZ236037A (en) 1992-08-26
FI105106B (fi) 2000-06-15
ES2107420T3 (es) 1997-12-01
DE69031487D1 (de) 1997-10-30
EP0428302A3 (en) 1992-05-13
PL292070A1 (en) 1992-04-21
CZ280006B6 (cs) 1995-09-13

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