[go: up one dir, main page]

IL109397A0 - Quinoxalinedione derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same - Google Patents

Quinoxalinedione derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same

Info

Publication number
IL109397A0
IL109397A0 IL10939794A IL10939794A IL109397A0 IL 109397 A0 IL109397 A0 IL 109397A0 IL 10939794 A IL10939794 A IL 10939794A IL 10939794 A IL10939794 A IL 10939794A IL 109397 A0 IL109397 A0 IL 109397A0
Authority
IL
Israel
Prior art keywords
substd
opt
halo
phenyl
processes
Prior art date
Application number
IL10939794A
Other languages
English (en)
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4314591A external-priority patent/DE4314591A1/de
Priority claimed from DE19934344486 external-priority patent/DE4344486A1/de
Application filed by Schering Ag filed Critical Schering Ag
Publication of IL109397A0 publication Critical patent/IL109397A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40Benzopyrazines
    • C07D241/44Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509Six-membered rings
    • C07F9/650952Six-membered rings having the nitrogen atoms in the positions 1 and 4
    • C07F9/650994Six-membered rings having the nitrogen atoms in the positions 1 and 4 condensed with carbocyclic rings or carbocyclic ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL10939794A 1993-04-28 1994-04-22 Quinoxalinedione derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same IL109397A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4314591A DE4314591A1 (de) 1993-04-28 1993-04-28 Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
DE19934344486 DE4344486A1 (de) 1993-12-21 1993-12-21 Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln

Publications (1)

Publication Number Publication Date
IL109397A0 true IL109397A0 (en) 1994-07-31

Family

ID=25925529

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10939794A IL109397A0 (en) 1993-04-28 1994-04-22 Quinoxalinedione derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same

Country Status (23)

Country Link
US (2) US5750525A (xx)
EP (2) EP0696288B1 (xx)
JP (1) JP3530190B2 (xx)
KR (1) KR100293880B1 (xx)
CN (1) CN1053190C (xx)
AT (1) ATE196474T1 (xx)
AU (1) AU690550B2 (xx)
CA (1) CA2161425A1 (xx)
CZ (1) CZ290295B6 (xx)
DE (1) DE59409534D1 (xx)
DK (1) DK0696288T3 (xx)
ES (1) ES2150989T3 (xx)
FI (1) FI955140A0 (xx)
GR (1) GR3035053T3 (xx)
HU (1) HUT73676A (xx)
IL (1) IL109397A0 (xx)
NO (2) NO308902B1 (xx)
NZ (1) NZ265599A (xx)
PL (1) PL180332B1 (xx)
PT (1) PT696288E (xx)
RU (1) RU2140420C1 (xx)
SK (1) SK282851B6 (xx)
WO (1) WO1994025469A1 (xx)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6057304A (en) * 1992-10-26 2000-05-02 Schering Aktiengesellschaft Quinoxaline-phosphonic acid derivatives
ATE404201T1 (de) * 1992-06-22 2008-08-15 Univ California Glycinrezeptorantagonisten und ihre verwendung
HU217837B (hu) * 1994-05-18 2000-04-28 EGIS Gyógyszergyár Rt. Savamidok, ezeket tartalmazó gyógyászati készítmények és eljárás a hatóanyagok előállítására
GB9419318D0 (en) * 1994-09-24 1994-11-09 Pfizer Ltd Therapeutic agents
CN1067387C (zh) * 1994-09-27 2001-06-20 山之内制药株式会社 1,2,3,4-四氢喹喔啉二酮衍生物
DE4439492A1 (de) * 1994-10-25 1996-05-02 Schering Ag Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
DE4439493A1 (de) * 1994-10-25 1996-05-02 Schering Ag Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
DE19519979A1 (de) * 1995-05-24 1996-11-28 Schering Ag Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
JPH11508902A (ja) * 1995-07-10 1999-08-03 ノバルティス・アクチエンゲゼルシャフト 新規キノキサリン−およびキノキサリンアルカン−ホスホン酸
DE19545251A1 (de) * 1995-11-24 1997-05-28 Schering Ag Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
TW448171B (en) * 1996-06-06 2001-08-01 Yamanouchi Pharma Co Ltd Imidazole-substituted quinoxalinedione derivatives
ATE361909T1 (de) * 1996-10-23 2007-06-15 Warner Lambert Co Substituierte gamma-aminobuttersäurederivate als arzneimittel
NZ334891A (en) * 1996-10-24 2001-04-27 Novartis Ag Substituted aminoalkane phosphonic acids for treating block excitatory amino acid receptors related diseases
DE19728326A1 (de) * 1997-06-27 1999-01-07 Schering Ag Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
DE19737446A1 (de) * 1997-08-22 1999-02-25 Schering Ag Verfahren zur Herstellung von Phosphonsäurederivaten
HUP0002853A3 (en) * 1997-09-01 2001-12-28 Kyorin Seiyaku Kk 6,7-asymmetrically disubstituted quinoxalinecarboxylic acid derivatives, and pharmaceutical compositions containing them
US6015800A (en) * 1997-09-03 2000-01-18 Warner-Lambert Company Substituted quinoxaline-2-ones as glutamate receptor antagonists
WO2000001376A2 (en) * 1998-07-02 2000-01-13 Eisai Co., Ltd Pharmaceutical compositions and their uses for treatment of demyelinating disorders
CA2362385C (en) 1999-02-15 2009-08-11 Eisai Co., Ltd. Heterodiazinon compound
FR2791982B1 (fr) * 1999-04-06 2002-12-27 Inst Nat Sante Rech Med Inhibiteurs de lta4 hydrolase et leurs applications therapeutiques.
CA2412172C (en) 2000-06-12 2012-07-24 Eisai Co., Ltd. 1,2-dihydropyridine compounds, manufacturing method thereof and use thereof
GB0129260D0 (en) 2001-12-06 2002-01-23 Eisai London Res Lab Ltd Pharmaceutical compositions and their uses
MY148809A (en) 2004-07-06 2013-05-31 Eisai R&D Man Co Ltd Crystals of 1,2-dihydropyridine compound and their production process
CN100490835C (zh) * 2004-12-14 2009-05-27 朱木林 一种治疗骨折的药物
EP2338492A1 (en) 2009-12-24 2011-06-29 Universidad del Pais Vasco Methods and compositions for the treatment of alzheimer
KR20210107644A (ko) 2018-12-14 2021-09-01 에자이 알앤드디 매니지먼트 가부시키가이샤 1,2-디하이드로피리딘 화합물의 수성 기반 약학적 제형
CN112142797B (zh) * 2020-09-11 2023-07-14 江西师范大学 含磷的喹喔啉类化合物及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO179551C (no) * 1987-11-10 1996-10-30 Novo Nordisk As Analogifremgangsmåte for fremstilling av terapeutisk virksomme kinoxalinforbindelser
IL90315A0 (en) * 1988-06-01 1989-12-15 Ferrosan As Imidazoquinoxaline compounds,their preparation and pharmaceutical compositions containing them
DK69790D0 (da) * 1990-03-16 1990-03-16 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling af anvendelse
JP2550456B2 (ja) * 1990-11-06 1996-11-06 山之内製薬株式会社 縮合ピラジン誘導体
PT101004B (pt) * 1991-10-26 1999-10-29 Schering Ag Derivados da quinoxalina, processo para a sua preparacao e composicoes farmaceuticas que os contem
ATE404201T1 (de) * 1992-06-22 2008-08-15 Univ California Glycinrezeptorantagonisten und ihre verwendung

Also Published As

Publication number Publication date
CN1153517A (zh) 1997-07-02
FI955140L (fi) 1995-10-27
GR3035053T3 (en) 2001-03-30
NO308902B1 (no) 2000-11-13
CA2161425A1 (en) 1994-11-10
JPH08508037A (ja) 1996-08-27
US5750525A (en) 1998-05-12
PL317075A1 (en) 1997-03-03
AU6675594A (en) 1994-11-21
EP1002796A3 (de) 2001-09-12
SK282851B6 (sk) 2002-12-03
EP0696288A1 (de) 1996-02-14
CZ282895A3 (en) 1996-02-14
PL180332B1 (pl) 2001-01-31
CN1053190C (zh) 2000-06-07
AU690550B2 (en) 1998-04-30
ES2150989T3 (es) 2000-12-16
NZ265599A (en) 1997-10-24
CZ290295B6 (cs) 2002-07-17
NO311428B1 (no) 2001-11-26
KR100293880B1 (ko) 2001-09-17
PT696288E (pt) 2001-01-31
NO954315L (no) 1995-12-28
NO20001604D0 (no) 2000-03-28
DE59409534D1 (de) 2000-10-26
RU2140420C1 (ru) 1999-10-27
EP1002796A2 (de) 2000-05-24
FI955140A0 (fi) 1995-10-27
US5955461A (en) 1999-09-21
NO954315D0 (no) 1995-10-27
WO1994025469A1 (de) 1994-11-10
ATE196474T1 (de) 2000-10-15
EP0696288B1 (de) 2000-09-20
HU9503078D0 (en) 1995-12-28
JP3530190B2 (ja) 2004-05-24
DK0696288T3 (da) 2000-11-13
SK131895A3 (en) 1996-07-03
HUT73676A (en) 1996-09-30
NO20001604L (no) 1995-12-28

Similar Documents

Publication Publication Date Title
IL109397A0 (en) Quinoxalinedione derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
MY108800A (en) 5-aryl isoxazole derivatives, compositions containing them, process for their preparation and their use as herbicides
SE8200815L (sv) Kemisk forening till anvendning som mellanprodukt vid framstellning av vissa triazolforeningar
ATE137228T1 (de) Aminocarbonsäure und derivate
NZ242243A (en) 2-substituted adenine triphosphate derivatives and pharmaceutical compositions
IL88784A (en) Substituted 6-phenyldihydro-3-(2h)- pyridazinones, a process for their preparation and pharmaceutical preparations containing these compounds
NZ225408A (en) Acetohydroxamic acid derivatives and compositions thereof
HU913062D0 (en) Method for producing benzol, pyridyl and pyridine derivatives and pharmaceutical preparatives containing such compounds
HU9300202D0 (en) Benzo-pyrane derivatives, pharmaceutical preparatives containing them as active substance as well as method for producing them
GB997037A (en) New hydrantoin derivatives
ES8301196A1 (es) Procedimiento de preparacion de un nuevo derivado de acido cinamoil-cinamico
IL88518A0 (en) Purine derivatives,their preparation and pharmaceutical compositions containing them
AU585895B2 (en) New process for the preparation of derivatives of 4H-1,2,4- triazole, new triazoles so obtained, their use as medicaments and the pharmaceutical compositions containing them
IL116386A (en) Preparation of pharmaceutical compositions containing 1,2-bridged 1,4-dihydropyridines for the control of cns disorders and sickle cell anemia certain such novel compounds and their preparation
IL119054A0 (en) Substituted 4H-pyrans their preparation and pharmaceutical compositions containing them
DE3877454D1 (de) Guanidincarbonsaeureester, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel.
HUP9802950A1 (hu) Hidroximsavszármazékok alkalmazása vírusellenes hatású gyógyászati készítmények előállítására