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DK0696288T3 - Hidtil ukendte quinoxalindionderivater deres fremstilling og anvendelse i lægemidler - Google Patents

Hidtil ukendte quinoxalindionderivater deres fremstilling og anvendelse i lægemidler

Info

Publication number
DK0696288T3
DK0696288T3 DK94914313T DK94914313T DK0696288T3 DK 0696288 T3 DK0696288 T3 DK 0696288T3 DK 94914313 T DK94914313 T DK 94914313T DK 94914313 T DK94914313 T DK 94914313T DK 0696288 T3 DK0696288 T3 DK 0696288T3
Authority
DK
Denmark
Prior art keywords
substd
opt
halo
phenyl
poxy
Prior art date
Application number
DK94914313T
Other languages
English (en)
Inventor
Andreas Huth
Lechoslaw Turski
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4314591A external-priority patent/DE4314591A1/de
Priority claimed from DE19934344486 external-priority patent/DE4344486A1/de
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of DK0696288T3 publication Critical patent/DK0696288T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40Benzopyrazines
    • C07D241/44Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509Six-membered rings
    • C07F9/650952Six-membered rings having the nitrogen atoms in the positions 1 and 4
    • C07F9/650994Six-membered rings having the nitrogen atoms in the positions 1 and 4 condensed with carbocyclic rings or carbocyclic ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK94914313T 1993-04-28 1994-04-28 Hidtil ukendte quinoxalindionderivater deres fremstilling og anvendelse i lægemidler DK0696288T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4314591A DE4314591A1 (de) 1993-04-28 1993-04-28 Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
DE19934344486 DE4344486A1 (de) 1993-12-21 1993-12-21 Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
PCT/DE1994/000493 WO1994025469A1 (de) 1993-04-28 1994-04-28 Neue chinoxalindionderivative, deren herstellung und verwendung in arzneimitteln

Publications (1)

Publication Number Publication Date
DK0696288T3 true DK0696288T3 (da) 2000-11-13

Family

ID=25925529

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94914313T DK0696288T3 (da) 1993-04-28 1994-04-28 Hidtil ukendte quinoxalindionderivater deres fremstilling og anvendelse i lægemidler

Country Status (23)

Country Link
US (2) US5750525A (da)
EP (2) EP1002796A3 (da)
JP (1) JP3530190B2 (da)
KR (1) KR100293880B1 (da)
CN (1) CN1053190C (da)
AT (1) ATE196474T1 (da)
AU (1) AU690550B2 (da)
CA (1) CA2161425A1 (da)
CZ (1) CZ290295B6 (da)
DE (1) DE59409534D1 (da)
DK (1) DK0696288T3 (da)
ES (1) ES2150989T3 (da)
FI (1) FI955140L (da)
GR (1) GR3035053T3 (da)
HU (1) HUT73676A (da)
IL (1) IL109397A0 (da)
NO (2) NO308902B1 (da)
NZ (1) NZ265599A (da)
PL (1) PL180332B1 (da)
PT (1) PT696288E (da)
RU (1) RU2140420C1 (da)
SK (1) SK282851B6 (da)
WO (1) WO1994025469A1 (da)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6057304A (en) * 1992-10-26 2000-05-02 Schering Aktiengesellschaft Quinoxaline-phosphonic acid derivatives
PT647137E (pt) * 1992-06-22 2008-11-24 Univ California Antagonistas dos receptores da glicina e a sua utilização
HU217837B (hu) * 1994-05-18 2000-04-28 EGIS Gyógyszergyár Rt. Savamidok, ezeket tartalmazó gyógyászati készítmények és eljárás a hatóanyagok előállítására
GB9419318D0 (en) * 1994-09-24 1994-11-09 Pfizer Ltd Therapeutic agents
DE69524246T2 (de) * 1994-09-27 2002-06-27 Yamanouchi Pharmaceutical Co., Ltd. 1,2,3,4-Tetrahydroquinoxalindion Derivate und ihre Verwendung als Glutamat Rezeptor Antagonisten
DE4439492A1 (de) * 1994-10-25 1996-05-02 Schering Ag Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
DE4439493A1 (de) * 1994-10-25 1996-05-02 Schering Ag Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
DE19519979A1 (de) * 1995-05-24 1996-11-28 Schering Ag Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
KR19990028839A (ko) * 1995-07-10 1999-04-15 한스 루돌프 하우스, 헨리테 브룬너, 베아트리체 귄터 신규 퀴녹살린- 및 퀴녹살리닐알칸-포스폰산
DE19545251A1 (de) * 1995-11-24 1997-05-28 Schering Ag Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
TW448171B (en) * 1996-06-06 2001-08-01 Yamanouchi Pharma Co Ltd Imidazole-substituted quinoxalinedione derivatives
CA2263663C (en) * 1996-10-23 2006-05-30 Justin Stephen Bryans Substituted gamma aminobutyric acids as pharmaceutical agents
TR199900897T2 (xx) * 1996-10-24 1999-07-21 Novartis Ag Ornat�lm�� aminoalkanfosfonik asitler.
DE19728326A1 (de) * 1997-06-27 1999-01-07 Schering Ag Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
DE19737446A1 (de) * 1997-08-22 1999-02-25 Schering Ag Verfahren zur Herstellung von Phosphonsäurederivaten
CA2302161A1 (en) * 1997-09-01 1999-03-11 Kyorin Pharmaceutical Co., Ltd. 6,7-asymmetrically disubstituted quinoxalinecarboxylic acid derivatives, addition salts thereof, and processes for the preparation of both
US6015800A (en) * 1997-09-03 2000-01-18 Warner-Lambert Company Substituted quinoxaline-2-ones as glutamate receptor antagonists
WO2000001376A2 (en) * 1998-07-02 2000-01-13 Eisai Co., Ltd Pharmaceutical compositions and their uses for treatment of demyelinating disorders
WO2000047567A1 (fr) 1999-02-15 2000-08-17 Eisai Co., Ltd. Derives d'heterodiazinone
FR2791982B1 (fr) * 1999-04-06 2002-12-27 Inst Nat Sante Rech Med Inhibiteurs de lta4 hydrolase et leurs applications therapeutiques.
NZ522773A (en) 2000-06-12 2005-06-24 Eisai Co Ltd 1,2-dihydropyridine compounds, manufacturing method thereof and use thereof
GB0129260D0 (en) 2001-12-06 2002-01-23 Eisai London Res Lab Ltd Pharmaceutical compositions and their uses
MY148809A (en) 2004-07-06 2013-05-31 Eisai R&D Man Co Ltd Crystals of 1,2-dihydropyridine compound and their production process
CN100490835C (zh) * 2004-12-14 2009-05-27 朱木林 一种治疗骨折的药物
EP2338492A1 (en) 2009-12-24 2011-06-29 Universidad del Pais Vasco Methods and compositions for the treatment of alzheimer
WO2020124090A1 (en) 2018-12-14 2020-06-18 Eisai R&D Management Co., Ltd. Aqueous based pharmaceutical formulations of 1,2-dihydropyridine compounds
CN112142797B (zh) * 2020-09-11 2023-07-14 江西师范大学 含磷的喹喔啉类化合物及其制备方法和应用
US11939302B2 (en) * 2020-10-21 2024-03-26 The Governors Of The University Of Alberta Compounds for the treatment of Alzheimer's disease

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO179551C (no) * 1987-11-10 1996-10-30 Novo Nordisk As Analogifremgangsmåte for fremstilling av terapeutisk virksomme kinoxalinforbindelser
IL90315A0 (en) * 1988-06-01 1989-12-15 Ferrosan As Imidazoquinoxaline compounds,their preparation and pharmaceutical compositions containing them
DK69790D0 (da) * 1990-03-16 1990-03-16 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling af anvendelse
RU2095352C1 (ru) * 1990-11-06 1997-11-10 Яманоути Фармасьютикал Ко., Лтд. Производное сконденсированного пиразина
PT101004B (pt) * 1991-10-26 1999-10-29 Schering Ag Derivados da quinoxalina, processo para a sua preparacao e composicoes farmaceuticas que os contem
PT647137E (pt) * 1992-06-22 2008-11-24 Univ California Antagonistas dos receptores da glicina e a sua utilização

Also Published As

Publication number Publication date
EP1002796A3 (de) 2001-09-12
CZ282895A3 (en) 1996-02-14
HUT73676A (en) 1996-09-30
AU690550B2 (en) 1998-04-30
AU6675594A (en) 1994-11-21
HU9503078D0 (en) 1995-12-28
NO954315L (no) 1995-12-28
SK131895A3 (en) 1996-07-03
CZ290295B6 (cs) 2002-07-17
CN1153517A (zh) 1997-07-02
EP1002796A2 (de) 2000-05-24
NO311428B1 (no) 2001-11-26
US5955461A (en) 1999-09-21
WO1994025469A1 (de) 1994-11-10
NO20001604L (no) 1995-12-28
JPH08508037A (ja) 1996-08-27
IL109397A0 (en) 1994-07-31
NZ265599A (en) 1997-10-24
ES2150989T3 (es) 2000-12-16
EP0696288A1 (de) 1996-02-14
NO954315D0 (no) 1995-10-27
KR100293880B1 (ko) 2001-09-17
US5750525A (en) 1998-05-12
PT696288E (pt) 2001-01-31
FI955140A0 (fi) 1995-10-27
RU2140420C1 (ru) 1999-10-27
ATE196474T1 (de) 2000-10-15
PL180332B1 (pl) 2001-01-31
DE59409534D1 (de) 2000-10-26
EP0696288B1 (de) 2000-09-20
FI955140A7 (fi) 1995-10-27
JP3530190B2 (ja) 2004-05-24
CN1053190C (zh) 2000-06-07
GR3035053T3 (en) 2001-03-30
NO20001604D0 (no) 2000-03-28
FI955140L (fi) 1995-10-27
NO308902B1 (no) 2000-11-13
SK282851B6 (sk) 2002-12-03
PL317075A1 (en) 1997-03-03
CA2161425A1 (en) 1994-11-10

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