[go: up one dir, main page]

IL107166A - Complex combinatorial chemical libraries encoded with tags - Google Patents

Complex combinatorial chemical libraries encoded with tags

Info

Publication number
IL107166A
IL107166A IL10716693A IL10716693A IL107166A IL 107166 A IL107166 A IL 107166A IL 10716693 A IL10716693 A IL 10716693A IL 10716693 A IL10716693 A IL 10716693A IL 107166 A IL107166 A IL 107166A
Authority
IL
Israel
Prior art keywords
define
tags
choice
particle
stage
Prior art date
Application number
IL10716693A
Other languages
English (en)
Other versions
IL107166A0 (en
Original Assignee
Univ Columbia
Cold Spring Harbor Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Columbia, Cold Spring Harbor Lab filed Critical Univ Columbia
Publication of IL107166A0 publication Critical patent/IL107166A0/xx
Priority to IL13694800A priority Critical patent/IL136948A0/xx
Publication of IL107166A publication Critical patent/IL107166A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • G01N33/532Production of labelled immunochemicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/181,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047Simultaneous synthesis of different peptide species; Peptide libraries
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/0054Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572Chemical means
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11Compounds covalently bound to a solid support
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Public Health (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
IL10716693A 1992-10-01 1993-10-01 Complex combinatorial chemical libraries encoded with tags IL107166A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL13694800A IL136948A0 (en) 1992-10-01 2000-06-22 A method of recording a reaction history of a solid support

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95537192A 1992-10-01 1992-10-01
US1394893A 1993-02-04 1993-02-04

Publications (2)

Publication Number Publication Date
IL107166A0 IL107166A0 (en) 1994-01-25
IL107166A true IL107166A (en) 2000-10-31

Family

ID=26685452

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10716693A IL107166A (en) 1992-10-01 1993-10-01 Complex combinatorial chemical libraries encoded with tags

Country Status (14)

Country Link
EP (1) EP0665897B1 (no)
JP (1) JPH08506175A (no)
KR (1) KR100310939B1 (no)
AT (1) ATE244769T1 (no)
AU (1) AU686579B2 (no)
CA (1) CA2143848C (no)
DE (1) DE69333087T2 (no)
DK (1) DK0665897T3 (no)
ES (1) ES2204910T3 (no)
HU (1) HUT72495A (no)
IL (1) IL107166A (no)
NO (1) NO951230D0 (no)
PT (1) PT665897E (no)
WO (1) WO1994008051A1 (no)

Families Citing this family (205)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5608046A (en) * 1990-07-27 1997-03-04 Isis Pharmaceuticals, Inc. Conjugated 4'-desmethyl nucleoside analog compounds
US5688941A (en) * 1990-07-27 1997-11-18 Isis Pharmaceuticals, Inc. Methods of making conjugated 4' desmethyl nucleoside analog compounds
US5998603A (en) 1994-09-29 1999-12-07 Isis Pharmaceuticals, Inc. 4'-desmethyl nucleoside analogs, and oligomers thereof
US5646123A (en) * 1991-06-10 1997-07-08 Alberta Research Council Time dependent administration of oligosaccharide glycosides related to blood group determinants having a type I or type II core structure in reducing inflammation in a sensitized mammal arising form exposure to an antigen
US5639603A (en) * 1991-09-18 1997-06-17 Affymax Technologies N.V. Synthesizing and screening molecular diversity
US5770358A (en) * 1991-09-18 1998-06-23 Affymax Technologies N.V. Tagged synthetic oligomer libraries
AU5827294A (en) * 1992-12-11 1994-07-04 Chiron Corporation Synthesis of encoded polymers
US5840485A (en) * 1993-05-27 1998-11-24 Selectide Corporation Topologically segregated, encoded solid phase libraries
ATE366741T1 (de) * 1993-05-27 2007-08-15 Aventis Pharma Inc Topologisch getrennte, kodierende festphasen- bibliotheken
US5837689A (en) * 1993-06-16 1998-11-17 Glycomed Incorporated Sialyl lewis-x mimetics containing naphthyl backbones
US5789385A (en) * 1993-06-16 1998-08-04 Glycomed Incorporated Sialyl Lewisx mimetics containing phenyl backbones
IL106106A0 (en) * 1993-06-22 1993-10-20 Interpharm Lab Ltd Library of polymeric molecules and its preparation
US6087186A (en) * 1993-07-16 2000-07-11 Irori Methods and apparatus for synthesizing labeled combinatorial chemistry libraries
US6165778A (en) * 1993-11-02 2000-12-26 Affymax Technologies N.V. Reaction vessel agitation apparatus
US5503805A (en) * 1993-11-02 1996-04-02 Affymax Technologies N.V. Apparatus and method for parallel coupling reactions
US7034110B2 (en) 1994-01-05 2006-04-25 Arqule, Inc. Method of identifying chemical compounds having selected properties for a particular application
US6828427B1 (en) 1994-01-11 2004-12-07 Isis Pharmaceuticals, Inc. Oligomeric aminodiol-containing compounds, libraries thereof, and process of preparing the same
US6184389B1 (en) 1994-01-11 2001-02-06 Isis Pharmaceuticals, Inc. Combinatorial libraries having aminodiol monomer subunits
JPH09510442A (ja) * 1994-03-11 1997-10-21 ファーマコペイア,インコーポレイテッド スルホンアミド誘導体及びそれらの使用
US5856083A (en) * 1994-05-06 1999-01-05 Pharmacopeia, Inc. Lawn assay for compounds that affect enzyme activity or bind to target molecules
US6790965B1 (en) 1994-05-06 2004-09-14 Pharmacopeia Drug Discovery, Inc. Combinatorial dihydrobenzopyran library
EP0758313A4 (en) * 1994-05-06 1999-09-15 Pharmacopeia Inc COMBINATORIAL LIBRARY OF DIHYDROBENZOPYRANES
DK0774116T3 (da) * 1994-07-22 2000-05-08 Zeneca Ltd Fremgangsmåde til screening af biblioteker af forbindelser
US5939268A (en) * 1994-07-26 1999-08-17 The Scripps Research Institute Combinatorial libraries of molecules and methods for producing same
US5604097A (en) * 1994-10-13 1997-02-18 Spectragen, Inc. Methods for sorting polynucleotides using oligonucleotide tags
US5846719A (en) 1994-10-13 1998-12-08 Lynx Therapeutics, Inc. Oligonucleotide tags for sorting and identification
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US5695934A (en) * 1994-10-13 1997-12-09 Lynx Therapeutics, Inc. Massively parallel sequencing of sorted polynucleotides
US6207826B1 (en) 1995-03-27 2001-03-27 Isis Pharmaceuticals, Inc. Macrocyclic compounds having nitrogen-containing linkages
CA2210349A1 (en) * 1995-01-20 1996-07-25 Molecumetics, Ltd Conformationally constrained reverse-turn library and methods relating thereto
US5712171A (en) 1995-01-20 1998-01-27 Arqule, Inc. Method of generating a plurality of chemical compounds in a spatially arranged array
GB9502225D0 (en) * 1995-02-04 1995-03-22 Zeneca Ltd Method
JPH10508036A (ja) 1995-03-27 1998-08-04 アイシス・ファーマシューティカルス・インコーポレーテッド 窒素含有大環状化合物
WO1996030392A1 (en) * 1995-03-28 1996-10-03 Novartis Ag Process for the production of combinatorial compound libraries
US5801175A (en) 1995-04-07 1998-09-01 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5925562A (en) * 1995-04-25 1999-07-20 Irori Remotely programmable matrices with memories
US6100026A (en) * 1995-04-25 2000-08-08 Irori Matrices with memories and uses thereof
US5961923A (en) * 1995-04-25 1999-10-05 Irori Matrices with memories and uses thereof
US6284459B1 (en) 1995-04-25 2001-09-04 Discovery Partners International Solid support matrices with memories and combinatorial libraries therefrom
WO1996033972A1 (en) * 1995-04-28 1996-10-31 Glaxo Group Limited Methods for synthesizing diverse collections of pyridines, pyrimidines, 1,4-dihydro derivatives thereof, and piperidine derivatives
WO1996040732A1 (en) * 1995-06-07 1996-12-19 Zymogenetics, Inc. Combinatorial non-peptide libraries
EP0839152B1 (en) * 1995-06-21 2002-03-13 Martek Biosciences Corporation Combinatorial libraries of labeled biochemical compounds and methods for producing same
JPH11508563A (ja) * 1995-06-29 1999-07-27 ファーマコペイア,インコーポレイテッド 1,4−ベンゾジアゼピン−2,5−ジオン組合わせライブラリー
GB9515070D0 (en) * 1995-07-22 1995-09-20 Zeneca Ltd Label
GB9517661D0 (en) * 1995-08-30 1995-11-01 Smithkline Beecham Plc Novel compounds
US5886186A (en) * 1995-10-25 1999-03-23 Versicor, Inc. Synthesis of substituted N-heteroaromatic compounds and methods of use thereof
US5605616A (en) * 1995-11-06 1997-02-25 Versicor, Inc. Reversible charge-based sequestration on solid support
US5846839A (en) * 1995-12-22 1998-12-08 Glaxo Group Limited Methods for hard-tagging an encoded synthetic library
US6027890A (en) * 1996-01-23 2000-02-22 Rapigene, Inc. Methods and compositions for enhancing sensitivity in the analysis of biological-based assays
CN1202260C (zh) * 1996-01-23 2005-05-18 佳根基因组学公司 利用大小分离技术分析核酸分子的方法和组合物
US6613508B1 (en) 1996-01-23 2003-09-02 Qiagen Genomics, Inc. Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques
US6312893B1 (en) 1996-01-23 2001-11-06 Qiagen Genomics, Inc. Methods and compositions for determining the sequence of nucleic acid molecules
US5766963A (en) * 1996-01-26 1998-06-16 Pharmacopeia, Inc. Combination hydroxypropylamine library
US5880972A (en) * 1996-02-26 1999-03-09 Pharmacopeia, Inc. Method and apparatus for generating and representing combinatorial chemistry libraries
US5649576A (en) * 1996-02-26 1997-07-22 Pharmacopeia, Inc. Partitioning device
GB9604858D0 (en) * 1996-03-07 1996-05-08 Imperial College A composite
GB2326152B (en) * 1996-03-07 2000-06-28 Imperial College A composite for combinatorial organic synthesis
US6777217B1 (en) 1996-03-26 2004-08-17 President And Fellows Of Harvard College Histone deacetylases, and uses related thereto
US5792431A (en) * 1996-05-30 1998-08-11 Smithkline Beecham Corporation Multi-reactor synthesizer and method for combinatorial chemistry
US6077954A (en) 1996-08-01 2000-06-20 Isis Pharmaceuticals, Inc. Substituted heterocyclic compounds
US6355490B1 (en) 1996-09-13 2002-03-12 Jill Edie Hochlowski Attached tags for use in combinatorial chemistry synthesis
US5798035A (en) * 1996-10-03 1998-08-25 Pharmacopeia, Inc. High throughput solid phase chemical synthesis utilizing thin cylindrical reaction vessels useable for biological assay
US5780241A (en) 1996-11-05 1998-07-14 Isis Pharmaceuticals, Inc. Complex chemical libraries
JP2001508050A (ja) * 1996-12-18 2001-06-19 イーライ・リリー・アンド・カンパニー ヒドロフロキノリンライブラリーを作製するためのコンビネーション法
US5908960A (en) * 1997-05-07 1999-06-01 Smithkline Beecham Corporation Compounds
US6004823A (en) * 1997-05-07 1999-12-21 Smithkline Beecham Corporation Compounds
US6037340A (en) * 1997-05-28 2000-03-14 Cadus Pharmaceutical Corporation Synthesis and use of thiophene- and pyrrole-based heteroaromatic compounds
US6376670B1 (en) 1997-06-19 2002-04-23 Sepracor Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
KR20010014030A (ko) 1997-06-19 2001-02-26 더글라스이.리디치 퀴놀린-인돌 항균제, 이들의 용도 및 조성물
US6103905A (en) * 1997-06-19 2000-08-15 Sepracor, Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
US6207679B1 (en) 1997-06-19 2001-03-27 Sepracor, Inc. Antimicrobial agents uses and compositions related thereto
US6750344B1 (en) 1997-09-05 2004-06-15 Isis Pharmaceuticals, Inc. Amine compounds and combinatorial libraries comprising same
US6168913B1 (en) 1997-10-14 2001-01-02 Abbott Laboratories Coding combinatorial libraries with fluorine tags
AUPP032897A0 (en) * 1997-11-12 1997-12-04 University Of Queensland, The Oligomer libraries
TWI239847B (en) 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
US7964192B1 (en) 1997-12-02 2011-06-21 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidgenic disease
WO1999028290A1 (en) 1997-12-03 1999-06-10 Massachusetts Institute Of Technology Synthesis of oligoarylamines, and uses and reagents related thereto
GB9814259D0 (en) * 1998-07-02 1998-09-02 Univ Hertfordshire Improvements to the fabrication and method of use of coded particles in the field of combinatorial chemistry
US6642062B2 (en) * 1998-09-03 2003-11-04 Trellis Bioinformatics, Inc. Multihued labels
US6291516B1 (en) 1999-01-13 2001-09-18 Curis, Inc. Regulators of the hedgehog pathway, compositions and uses related thereto
AU4698600A (en) 1999-05-05 2000-11-17 Ut-Battelle, Llc Method and apparatus for combinatorial chemistry
US7396905B1 (en) 1999-05-21 2008-07-08 Mckeon Frank Calcipressins: endogenous inhibitors of calcineurin, uses and reagents related thereto
UA81216C2 (en) 1999-06-01 2007-12-25 Prevention and treatment of amyloid disease
WO2000077519A1 (en) * 1999-06-15 2000-12-21 Aventis Pharmaceuticals Products Inc. Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives
NO994873D0 (no) 1999-10-06 1999-10-06 Sinvent As Metode for syntese og analyse av kombinatoriske kjemibiblioteker
AU5077401A (en) 2000-02-08 2001-08-20 Sangamo Biosciences Inc Cells for drug discovery
JP2003523408A (ja) 2000-02-22 2003-08-05 バイオストリーム インク パーキンソン病を診断するための撮像剤
US20030129724A1 (en) 2000-03-03 2003-07-10 Grozinger Christina M. Class II human histone deacetylases, and uses related thereto
US8852937B2 (en) 2000-03-30 2014-10-07 Curis, Inc. Small organic molecule regulators of cell proliferation
US6613798B1 (en) 2000-03-30 2003-09-02 Curis, Inc. Small organic molecule regulators of cell proliferation
US6683108B1 (en) 2000-03-30 2004-01-27 Curis, Inc. Agonists of hedgehog signaling pathways and uses related thereto
US7115653B2 (en) 2000-03-30 2006-10-03 Curis, Inc. Small organic molecule regulators of cell proliferation
EP1276860B1 (en) 2000-04-28 2007-09-26 Sangamo Biosciences Inc. Databases of regulatory sequences; methods of making and using same
AU2001257421A1 (en) 2000-04-28 2001-11-12 Sangamo Biosciences, Inc. Pharmacogenomics and identification of drug targets by reconstruction of signal transduction pathways based on sequences of accessible regions
AU2001255748B2 (en) 2000-04-28 2006-08-10 Sangamo Therapeutics, Inc. Methods for binding an exogenous molecule to cellular chromatin
AU2001257331A1 (en) 2000-04-28 2001-11-12 Sangamo Biosciences, Inc. Methods for designing exogenous regulatory molecules
US7923542B2 (en) 2000-04-28 2011-04-12 Sangamo Biosciences, Inc. Libraries of regulatory sequences, methods of making and using same
AU2001261103B2 (en) 2000-04-29 2007-08-23 University Of Iowa Research Foundation Diagnostics and therapeutics for macular degeneration-related disorders
ATE459367T1 (de) 2000-06-08 2010-03-15 Immune Disease Inst Inc Methoden und verbindungen zur hemmung immunoglobulin-vermittelter reperfusions- verletzungen
US6576472B1 (en) 2000-07-26 2003-06-10 Smithkline Beecham Corporation Chemical constructs for solution phase chemistry
US6584411B1 (en) 2000-07-26 2003-06-24 Smithkline Beecham Corporation Methods to facilitate the calculation of yields of reaction products
US6908732B2 (en) 2000-10-13 2005-06-21 President & Fellows Of Harvard College Compounds and methods for regulating cell differentiation
EP2381116A1 (en) 2000-11-16 2011-10-26 California Institute of Technology Apparatus and methods for conducting assays and high throughput screening
JP4057422B2 (ja) * 2001-01-25 2008-03-05 プレシジョン・システム・サイエンス株式会社 微小物識別装置およびその識別方法
AU2002258100B2 (en) 2001-03-02 2007-03-01 University Of Western Ontario Polymer precursors of radiolabeled compounds, and methods of making and using the same
DE10117274B4 (de) * 2001-04-06 2005-03-03 Hte Ag The High Throughput Experimentation Company Verfahren zur Analyse und Archivierung von wenigstens einer Materialbibliothek
DK2272813T3 (en) 2001-04-24 2017-02-27 Massachusetts Inst Of Tech (Mit) COPPER CATALYST CREATION OF CARBON OXYGEN COMPOUNDS
US7244853B2 (en) 2001-05-09 2007-07-17 President And Fellows Of Harvard College Dioxanes and uses thereof
JP4342934B2 (ja) 2001-06-11 2009-10-14 キセノポート インコーポレーティッド Pept−2輸送体を介した薬剤の投与
WO2002102820A1 (en) 2001-06-20 2002-12-27 Nuevolution A/S Nucleoside derivatives for library preparation
US6974665B2 (en) 2001-09-06 2005-12-13 University Of Nebraska In situ screening to optimize variables in organic reactions
US20050065205A1 (en) 2002-03-07 2005-03-24 Daniel Alkon Methods for Alzheimer's disease treatment and cognitive enhance
US6825229B2 (en) 2002-03-07 2004-11-30 Blanchette Rockefeller Neurosciences Institute Methods for Alzheimer's Disease treatment and cognitive enhancement
CA2478305C (en) 2002-03-11 2012-04-24 Biostream, Inc. Technetium-dipyridine complexes, and methods of use thereof
EP2186897B1 (en) 2002-03-15 2016-02-17 Nuevolution A/S An improved method for synthesising templated molecules
US7655674B2 (en) 2002-04-22 2010-02-02 The Johns Hopkins University Modulators of hedgehog signaling pathways, compositions and uses related thereto
EP2204181A3 (en) 2002-04-30 2010-09-22 Trustees Of Tufts College Protease inhibitors
EP1520040A2 (en) * 2002-06-20 2005-04-06 Nuevolution A/S Microarrays displaying encoded molecules
HUP0202212A2 (hu) * 2002-07-10 2004-04-28 Comgenex Rt. Új kombinatorikus fehérjemarker molekulakönyvtárak, eljárás azok előállítására és alkalmazására
AU2003247266A1 (en) 2002-08-01 2004-02-23 Nuevolution A/S Multi-step synthesis of templated molecules
ES2640279T3 (es) 2002-10-30 2017-11-02 Nuevolution A/S Procedimiento para la síntesis de un complejo bifuncional
TW200509968A (en) 2002-11-01 2005-03-16 Elan Pharm Inc Prevention and treatment of synucleinopathic disease
US8506959B2 (en) 2002-11-01 2013-08-13 Neotope Biosciences Limited Prevention and treatment of synucleinopathic and amyloidogenic disease
WO2004052939A2 (en) 2002-12-09 2004-06-24 Massachusetts Institute Of Technology Ligands for metals and improved metal-catalyzed processes based thereon
ATE450609T1 (de) 2002-12-19 2009-12-15 Nuevolution As Durch quasizufallsstrukturen und funktionen geführte synthesemethode
EP1594969B1 (en) 2003-02-01 2015-05-20 Janssen Sciences Ireland UC Active immunization to generate antibodies to soluble a-beta
US20070026397A1 (en) 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
EP1624901B1 (en) 2003-05-02 2012-07-25 The University Of Western Ontario Prosthetic groups attached to stannylated polymers for the synthesis of radiopharmaceuticals
US20050014932A1 (en) 2003-05-15 2005-01-20 Iogenetics, Llc Targeted biocides
JP4820291B2 (ja) 2003-05-19 2011-11-24 エラン ファーマシューティカルズ,インコーポレイテッド レヴィー小体病におけるαシヌクレインの切断断片
US7358331B2 (en) 2003-05-19 2008-04-15 Elan Pharmaceuticals, Inc. Truncated fragments of alpha-synuclein in Lewy body disease
US20060162014A1 (en) 2003-07-07 2006-07-20 Jaffe Eileen K Alternate morpheeins of allosteric proteins as a target for the development of bioactive molecules
US8153410B2 (en) 2003-07-07 2012-04-10 Fox Chase Cancer Center Alternate morpheein forms of allosteric proteins as a target for the development of bioactive molecules
CA2535971C (en) 2003-08-20 2018-04-10 Biosite, Inc. Methods and compositions for measuring biologically active natriuretic peptides and for improving their therapeutic potential
DK1670939T3 (da) 2003-09-18 2010-03-01 Nuevolution As Fremgangsmåde til opnåelse af strukturel information om et kodet molekyle og fremgangsmåde til udvælgelse af forbindelser
KR101158147B1 (ko) 2003-12-17 2012-07-17 와이어쓰 엘엘씨 Aβ 면역원성 펩티드 캐리어 컨쥬게이트 및 이의 제조방법
KR101157694B1 (ko) 2003-12-17 2012-06-20 와이어쓰 엘엘씨 면역원성 펩티드 캐리어 컨쥬게이트 및 이의 제조 방법
PT1761515E (pt) * 2003-12-20 2009-02-11 Merck Patent Gmbh Derivados de tetra-hidroquinolina 2-(hetero)-aril substituídos
EP1725269B1 (en) 2004-02-24 2012-12-26 The General Hospital Corporation Catalytic radiofluorination
EP1725659B1 (en) 2004-03-01 2011-02-09 Immune Disease Institute, Inc. Natural igm antibodies and inhibitors thereof
TW201206425A (en) 2004-05-18 2012-02-16 Brni Neurosciences Inst Treatment of depressive disorders
DE102004031656A1 (de) * 2004-06-30 2006-01-19 Merck Patent Gmbh Tetrahydrochinoline
US7342093B2 (en) 2004-07-23 2008-03-11 University Of Massachusetts Compounds that inhibit Hsp90 protein-protein interactions with IAP proteins
US7572600B2 (en) 2004-08-04 2009-08-11 Chemocentryx, Inc. Enzymatic activities in chemokine-mediated inflammation
MX2007001679A (es) 2004-08-09 2007-05-23 Elan Pharm Inc Prevencion y tratamiento de la enfermedad sinucleinopatica y amiloidogenica.
US7745389B2 (en) 2005-02-14 2010-06-29 University Of Iowa Research Foundation Methods for treatment of age-related macular degeneration
CN101495116A (zh) 2005-03-22 2009-07-29 哈佛大学校长及研究员协会 蛋白降解病症的治疗
JP2008540549A (ja) 2005-05-09 2008-11-20 ハイドラ バイオサイエンシズ インコーポレイテッド Trpv3機能調節用化合物
US20070054890A1 (en) 2005-07-29 2007-03-08 Alkon Daniel L Protein synthesis required for long-term memory is induced by PKC activation on days preceding associative learning
WO2007030560A2 (en) 2005-09-08 2007-03-15 Philadelphia Health & Education Corporation, D/B/A Drexel University College Of Medicine Identification of modulators of serine protease inhibitor kazal and their use as anti-cancer and anti-viral agents
WO2007044396A2 (en) 2005-10-04 2007-04-19 The Research Foundation Of State University Of New York Fibronectin polypeptides and methods of use
DK3018206T3 (da) 2005-12-01 2021-11-15 Nuevolution As Enzymatic encoding methods for efficient synthesis of large libraries
CN101528679A (zh) 2006-02-14 2009-09-09 哈佛大学校长及研究员协会 组蛋白去乙酰化酶抑制剂
WO2008091349A1 (en) 2006-02-14 2008-07-31 The President And Fellows Of Harvard College Bifunctional histone deacetylase inhibitors
AU2007248656B2 (en) 2006-05-03 2013-04-04 Dana-Farber Cancer Institute, Inc. Histone deacetylase and tubulin deacetylase inhibitors
CA2935516A1 (en) 2006-05-22 2007-12-06 The Board Of Trustees Of The Leland Stanford Junior University Pharmacological treatment of cognitive impairment
WO2008042024A2 (en) 2006-06-01 2008-04-10 Elan Pharmaceuticals, Inc. Neuroactive fragments of app
EP3042668B1 (en) 2006-06-07 2018-09-19 The Board of Trustees of the Leland Stanford Junior University Anti-leukocyte recruitment therapy for the treatment of seizures and epilepsy
US20100297102A1 (en) 2006-06-22 2010-11-25 Hannah Monyer Serotonin 5-ht3a receptors in treatment of neurological and psychiatric disorders
CN101528042A (zh) 2006-08-24 2009-09-09 表面线段公司 药代动力学改进的化合物
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
EP2754448A3 (en) 2007-02-09 2014-12-24 Blanchette Rockefeller Neurosciences, Institute Therapeutic effects of bryostatins, bryologs, and other related substances on head trauma-induced memory impairment and brain injury
KR20090120480A (ko) 2007-02-09 2009-11-24 블랜체트 록펠러 뉴로사이언시즈 인스티튜트 허혈/뇌졸중-유도된 기억 장애 및 뇌 손상에 대한 브리오스타틴, 브리오로그 및 기타 관련된 물질의 치료학적 효과
PT2118300E (pt) 2007-02-23 2015-09-22 Univ California Prevenção e tratamento da doença sinucleinopática e amiloidogénica
PL2583978T3 (pl) 2007-02-23 2016-07-29 Prothena Biosciences Ltd Co Profilaktyka i leczenie chorób synukleinopatycznych i amyloidogennych
EP2167111A4 (en) 2007-06-14 2010-06-09 Univ New York State Res Found POLYPEPTIDES AND METHOD OF USE
WO2009029173A1 (en) 2007-08-23 2009-03-05 The Board Of Trustees Of The Leland Stanford Junior University Modulation of synaptogenesis
EP2231181B1 (en) 2007-12-17 2016-02-17 Marfl AB New vaccine for the treatment of mycobacterium related disorders
SG186689A1 (en) 2007-12-28 2013-01-30 Univ Tennessee Res Foundation Treatment and prophylaxis of amyloidosis
CA2713423A1 (en) 2008-01-18 2009-07-23 North Carolina State University Peptides and methods of use as therapeutics and screening agents
JP5665740B2 (ja) 2008-07-23 2015-02-04 プレジデント アンド フェローズ オブ ハーバード カレッジ デアセチラーゼ阻害剤およびその使用
CN102124104A (zh) 2008-08-18 2011-07-13 财团法人首尔大学校产学协力财团 通过调节赖氨酰tRNA合成酶的细胞水平控制癌症转移或癌细胞移动的方法
EP3211126B1 (en) 2009-02-13 2020-10-21 X-Chem, Inc. Methods of creating and screening dna-encoded libraries
PL2396017T3 (pl) 2009-02-16 2015-12-31 Cerenis Therapeutics Holding Sa Mimetyki apolipoproteiny A-l
EP2443459B1 (en) 2009-06-19 2018-12-26 The Arizona Board of Regents, A Body Corporate Of the State of Arizona acting for and on behalf Of Arizona State University Compound arrays for sample profiling
WO2011019393A2 (en) 2009-08-11 2011-02-17 President And Fellows Of Harvard College Class- and isoform-specific hdac inhibitors and uses thereof
WO2011091435A2 (en) 2010-01-25 2011-07-28 Mount Sinai School Of Medicine Methods of treating liver disease
EP2558577B1 (en) 2010-04-16 2018-12-12 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
EP2714921A4 (en) 2011-05-26 2015-05-13 Univ Michigan EPIGENETIC COREPRESSORS OF THE GAMMA GLOBIN GENE AND METHOD OF USE THEREOF
ES2852073T3 (es) 2011-09-07 2021-09-10 X Chem Inc Métodos para etiquetar bibliotecas codificadas por ADN
WO2013043012A2 (en) 2011-09-22 2013-03-28 Medicinal Bioconvergence Research Center Novel use of leucyl trna synthetase
WO2013044029A1 (en) 2011-09-23 2013-03-28 University Of Louisville Research Foundation, Inc. Methods and compositions for expanding cells and improving engraftment
KR101398079B1 (ko) 2011-10-10 2014-05-27 재단법인 의약바이오컨버젼스연구단 글리실-티알엔에이 합성효소 및 캐드헤린을 이용한 암 예방 또는 치료제의 스크리닝 방법
WO2013078138A1 (en) 2011-11-21 2013-05-30 OSI Pharmaceuticals, LLC Proton nmr spectroscopy for biochemical screening
NZ739931A (en) 2012-07-13 2019-08-30 X Chem Inc Dna-encoded libraries having encoding oligonucleotide linkages not readable by polymerases
WO2014025761A1 (en) 2012-08-07 2014-02-13 Children's Medical Center Corporation Methods to treat neurodegenerative diseases
US9970932B2 (en) 2013-03-15 2018-05-15 Arizona Board Of Regents On Behalf Of Arizona State University Non-covalent patterned chemical features and use thereof in MALDI-based quality control
WO2014145123A2 (en) 2013-03-15 2014-09-18 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State Unversity Peptide array quality control
CA2959045A1 (en) 2014-09-12 2016-03-17 The University Of Washington Wnt signaling agonist molecules
WO2016100857A1 (en) 2014-12-19 2016-06-23 Regeneron Pharmaceuticals, Inc. Stem cells for modeling type 2 diabetes
US10758886B2 (en) 2015-09-14 2020-09-01 Arizona Board Of Regents On Behalf Of Arizona State University Conditioned surfaces for in situ molecular array synthesis
EP3430055B1 (en) 2016-03-17 2020-10-28 Oslo Universitetssykehus HF Fusion proteins targeting tumour associated macrophages for treating cancer
WO2017197158A1 (en) 2016-05-11 2017-11-16 Leuvas Therapeutics Blockade of tim-1 pathways and p-selectin pathways in treatment of neuroinflammatory degenerative disease
WO2017208210A1 (en) 2016-06-03 2017-12-07 Prothena Biosciences Limited Anti-mcam antibodies and associated methods of use
US11747334B2 (en) 2016-06-20 2023-09-05 Cowper Sciences Inc. Methods for differential diagnosis of autoimmune diseases
AU2017281040A1 (en) 2016-06-20 2019-01-24 Healthtell Inc. Methods for diagnosis and treatment of autoimmune diseases
WO2018007979A1 (en) 2016-07-06 2018-01-11 Prothena Biosciences Limited Assay for detecting total and s129 phosphorylated alpha-synuclein
CA3031206A1 (en) 2016-07-29 2018-02-01 Regeneron Pharmaceuticals, Inc. Fibrillin-1 mutations for modeling neonatal progeroid syndrome with congenital lipodystrophy
AU2017342028A1 (en) 2016-10-12 2019-04-11 Janssen Biotech, Inc. Methods for screening for modulators of GDF15-like biological activity
AU2017357818A1 (en) 2016-11-11 2019-05-30 HealthTell, Inc. Methods for identifying candidate biomarkers
CA3061429A1 (en) 2017-05-05 2018-11-08 Inserm (Institut National De La Sante Et De La Recherche Medicale) Microtubule-targeting drugs as immune checkpoint inhibitors and methods of screening novel immune checkpoint inhibitors for the treatment of cancers and infectious diseases
AU2018277083A1 (en) 2017-05-30 2019-12-05 The Board Of Trustees Of The Leland Stanford Junior University Treatment of neuroinflammatory disease
JP7097440B2 (ja) 2017-11-10 2022-07-07 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Slc30a8変異を含む非ヒト動物および使用方法
CA3106833A1 (en) 2018-07-20 2020-01-23 Aicuris Gmbh & Co. Kg Methods for screening and identifying agents that inhibit or modulate the nuclear egress complex of herpesviruses
US20230165976A1 (en) 2019-04-10 2023-06-01 University Of Utah Research Foundation Htra1 modulation for treatment of amd

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4631211A (en) * 1985-03-25 1986-12-23 Scripps Clinic & Research Foundation Means for sequential solid phase organic synthesis and methods using the same
US4755558A (en) * 1986-05-30 1988-07-05 Beckman Instruments, Inc. Using internal marker
AU3869289A (en) * 1988-07-14 1990-02-05 Baylor College Of Medicine Solid phase assembly and reconstruction of biopolymers
US5650489A (en) * 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
US5770358A (en) * 1991-09-18 1998-06-23 Affymax Technologies N.V. Tagged synthetic oligomer libraries
US5677195A (en) * 1991-11-22 1997-10-14 Affymax Technologies N.V. Combinatorial strategies for polymer synthesis
WO1993019205A1 (en) * 1992-03-19 1993-09-30 The Regents Of The University Of California Multiple tag labeling method for dna sequencing
US5573905A (en) * 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US5541061A (en) * 1992-04-29 1996-07-30 Affymax Technologies N.V. Methods for screening factorial chemical libraries
HUT65477A (en) * 1992-05-21 1994-06-28 Recsei Method for complex purification of communal and industrial waste water and apparatus therefor
US5565324A (en) * 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags

Also Published As

Publication number Publication date
NO951230L (no) 1995-03-30
DE69333087D1 (de) 2003-08-14
ES2204910T3 (es) 2004-05-01
HU9500952D0 (en) 1995-05-29
CA2143848A1 (en) 1994-04-14
IL107166A0 (en) 1994-01-25
AU686579B2 (en) 1998-02-12
AU5536994A (en) 1994-04-26
PT665897E (pt) 2003-11-28
WO1994008051A1 (en) 1994-04-14
NO951230D0 (no) 1995-03-30
CA2143848C (en) 2007-09-11
KR100310939B1 (ko) 2002-06-20
DK0665897T3 (da) 2003-10-20
HUT72495A (en) 1996-05-28
DE69333087T2 (de) 2004-05-06
EP0665897B1 (en) 2003-07-09
EP0665897A4 (en) 1995-09-27
JPH08506175A (ja) 1996-07-02
KR950703657A (ko) 1995-09-20
ATE244769T1 (de) 2003-07-15
EP0665897A1 (en) 1995-08-09

Similar Documents

Publication Publication Date Title
IL107166A (en) Complex combinatorial chemical libraries encoded with tags
MX9604719A (es) Bibliotecas quimicas combinatoriales complejas codificadas con marbetes.
Larock Organomercurials in organic synthesis
Nestler et al. A general method for molecular tagging of encoded combinatorial chemistry libraries
Czarnik Encoding methods for combinatorial chemistry
MX9803806A (es) Etiquetas adheridas para usarse en sintensis de quimica combinatoria.
AU7257396A (en) Matrices with memories, sensors with memories and uses thereof
Solinas et al. A cartridge system for organometallic catalysis: sequential catalysis and separation using supercritical carbon dioxide to switch phases
WO1999060007A3 (en) Libraries of oligomers labelled with different tags
Lieto et al. Polymeric supports for catalysts
ATE210496T1 (de) Kodierten partikeln zur verfolgung der verfahrensstufenreihe in der herstellung von bibliotheken aus kombinatorischen verbindungen
CA2309993A1 (en) Carrier-reporter bead assemblies
Yan Detection by ozone-induced chemiluminescence in chromatography
WO2002031501B1 (en) Methods for synthesizing reporter labeled beads
Affleck Solutions for library encoding to create collections of discrete compounds
Rickaby Goldilocks and the three inorganic equilibria: how Earth’s chemistry and life coevolve to be nearly in tune
Lourenço et al. Efficient Depolymerization of Polyester and Polycarbonate Plastic Waste Catalyzed by Commercially Available Homogeneous and Heterogeneous Manganese Catalysts
ATE252416T1 (de) Vorrichtung für eine automatisierte chemische synthese
Sandell et al. VISUALIZATION TECHNIQUE FOR STUDYING IMPINGEMENT MIXING AT REPRESENTATIVE REYNOLDS NUMBERS.
WO1997049653A3 (en) Solid phase tyrphostin library linked to matrices with memories
Morel et al. Heterogeneous reactions in coastal waters
SE9803469D0 (sv) New method
Gogos et al. POLYMER PROCESSING: AN OVERVIEW.
Sydnes Plastic post-Nairobi needs IUPAC involvement
Jui‐Hsiang‐H et al. Enantioface differentiation by chiral polymers having (+)‐5, 6‐exo‐bornanediol moieties, I. Synthesis and polymerization of (+)‐5, 6‐exo‐dihydroxybornyl methacrylate

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
KB Patent renewed
EXP Patent expired