[go: up one dir, main page]

HUT47287A - Process for producing 3,4-dihydro-5h-2,3-benzodiazepine derivatives - Google Patents

Process for producing 3,4-dihydro-5h-2,3-benzodiazepine derivatives

Info

Publication number
HUT47287A
HUT47287A HU863594A HU359486A HUT47287A HU T47287 A HUT47287 A HU T47287A HU 863594 A HU863594 A HU 863594A HU 359486 A HU359486 A HU 359486A HU T47287 A HUT47287 A HU T47287A
Authority
HU
Hungary
Prior art keywords
dihydro
producing
benzodiazepine derivatives
benzodiazepine
derivatives
Prior art date
Application number
HU863594A
Other languages
English (en)
Other versions
HU198494B (en
Inventor
Jenoe Koeroesi
Peter Botka
Ferenc Andrasi
Istvan Elekes
Jozsef Borsy
Tibor Lang
Tamas Hamori
Pal Berzsenyi
Horvath Katalin Goldschmidtne
Tivadarne Lang
Original Assignee
Gyogyszerkutato Intezet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gyogyszerkutato Intezet filed Critical Gyogyszerkutato Intezet
Priority to HU863594A priority Critical patent/HU198494B/hu
Priority to AT0202187A priority patent/ATA202187A/de
Priority to CH3115/87A priority patent/CH673652A5/de
Priority to YU151487A priority patent/YU46223B/sh
Priority to CA000544626A priority patent/CA1284322C/en
Priority to SE8703169A priority patent/SE467357B/sv
Priority to DK424887A priority patent/DK164555C/da
Priority to AU76880/87A priority patent/AU596206B2/en
Priority to BE8700909A priority patent/BE1002415A4/fr
Priority to FI873525A priority patent/FI85706C/fi
Priority to DE19873727226 priority patent/DE3727226A1/de
Priority to SU874203196A priority patent/RU1779251C/ru
Priority to CS876007A priority patent/CS264150B2/cs
Priority to DD87306060A priority patent/DD265627A5/de
Priority to ES8702415A priority patent/ES2004985A6/es
Priority to FR878711578A priority patent/FR2602773B1/fr
Priority to JP62201967A priority patent/JPS6399073A/ja
Priority to IT21667/87A priority patent/IT1222508B/it
Priority to NL8701909A priority patent/NL8701909A/nl
Priority to PL1987267326A priority patent/PL148535B1/pl
Priority to NO873426A priority patent/NO164656C/no
Priority to GB8719265A priority patent/GB2194236B/en
Priority to US07/087,341 priority patent/US4835152A/en
Publication of HUT47287A publication Critical patent/HUT47287A/hu
Publication of HU198494B publication Critical patent/HU198494B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HU863594A 1986-08-15 1986-08-15 Process for producing new 3,4-dihydro-5h-2,3-benzodiazepine derivative and acid addition salts thereof, as well as pharmaceutical compositions comprising same HU198494B (en)

Priority Applications (23)

Application Number Priority Date Filing Date Title
HU863594A HU198494B (en) 1986-08-15 1986-08-15 Process for producing new 3,4-dihydro-5h-2,3-benzodiazepine derivative and acid addition salts thereof, as well as pharmaceutical compositions comprising same
AT0202187A ATA202187A (de) 1986-08-15 1987-08-11 Verfahren zur herstellung von 1-(4-aminophenyl)4-methyl-7,8-methylendioxy-3,4-dihydro-5h-2,3benzodiazepin und seine saeureadditionssalze
CH3115/87A CH673652A5 (hu) 1986-08-15 1987-08-12
YU151487A YU46223B (sh) 1986-08-15 1987-08-13 Postupak za dobivanje 1-/4-aminofenil/-4-metil-7,8-metilendioksi-3,4-dihid ro-5h-2,3-benzodiazepina
CA000544626A CA1284322C (en) 1986-08-15 1987-08-14 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-3,4- dihydro-5h-2,3-benzodiazepine and a process for preparing same
SE8703169A SE467357B (sv) 1986-08-15 1987-08-14 1-(4-aminofenyl)-4-metyl-7,8-metylendioxi-3,4-dihydro-5h-2,3-bensodiazepin, syraadditionssalter daerav samt foerfarande foer framstaellning av desamma
DK424887A DK164555C (da) 1986-08-15 1987-08-14 1-(4-aminofenyl)-4-metyl-7,8-metylendioxy-3,4-dihydro-5h-2,3-benzodiazepin, syreadditionssalte deraf, fremgangsmaade til fremstilling heraf samt farmaceutiske praeparater med cns-stimulerende virkning indeholdende saadanne forbindelser
AU76880/87A AU596206B2 (en) 1986-08-15 1987-08-14 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-3,4-hydro-5h- 2,3- benzodiazepine acid addition salts thereof and process for preparing same
BE8700909A BE1002415A4 (fr) 1986-08-15 1987-08-14 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-3,4-dihydro-5h-2,3-benzodiazepine, ses sels d'addition acides et procede pour les preparer.
FI873525A FI85706C (fi) 1986-08-15 1987-08-14 Foerfarande foer framstaellning av nytt terapeutiskt anvaendbart 1-(4-aminofenyl)-4-metyl -7,8-metylendioxi-3,4-dihydro-5h-2,3-bensodiazepin och syraadditionssalter daerav.
DE19873727226 DE3727226A1 (de) 1986-08-15 1987-08-14 1-(4'-(amino)-phenyl-4-(methyl)-7,8-(methylendioxy)-3,4-di-(hydro)-5h-2,3-benzodiazepin und seine saeureadditionssalze, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
SU874203196A RU1779251C (ru) 1986-08-15 1987-08-14 Способ получени 1-(4-аминофенил)-4-метил-7,8-метилендиокси-3,4-дигидро-5Н-2,3-бензодиазепина или его кислотно-аддитивных солей
CS876007A CS264150B2 (en) 1986-08-15 1987-08-14 Process for preparing new 1-/4-aminophenyl/-4-methyl-7,8-methylendioxy-3,4-dihydro-5h-2,3-benzodiazepine
DD87306060A DD265627A5 (de) 1986-08-15 1987-08-14 Verfahren zur herstellung von 1-(4-aminophenyl)-4-methyl-7,8-methylendioxy-3,4-dihydro-5h-2,3-benzodiazepin
ES8702415A ES2004985A6 (es) 1986-08-15 1987-08-14 Procedimiento de preparacion de 1-4aminofenil-4-metil-7,8-metilendioxi-3,4-dihidro-5h-2,3-benzodiazepina y sus sales de adicion acidas
FR878711578A FR2602773B1 (fr) 1986-08-15 1987-08-14 0- (4-aminophenyl)- 4 -methyl - 7,8 - methylenedioxy- 3,4 -dihydro - 5h - 2,3 - benzodiazepine, ses sels d'addition acides, procede pour les preparer et medicaments les contenant
JP62201967A JPS6399073A (ja) 1986-08-15 1987-08-14 １−（４−アミノフェニル）−４−メチル−７，８−メチレンジオキシ−３，４−ジヒドロ−５ｈ−２，３−ベンゾジアゼピン、その光学活性体およびラセミ体、および前記化合物の酸付加塩、その製造方法、並びに前記化合物を含む薬剤、その製造方法、およびそれによる治療方法
IT21667/87A IT1222508B (it) 1986-08-15 1987-08-14 1-(4-aminofil) 4-metil 7,8-metilendiossi-3,4-diidro-5h-2,3-benzodiazepina,suoi sali di addizione acida e procedimento per la loro preparazione
NL8701909A NL8701909A (nl) 1986-08-15 1987-08-14 1-(4-aminofenyl)-4-methyl-7,8-methyleendioxy-3,4-dihydro-5h-2,3-benzodiazepine, zuur-additiezouten daarvan en werkwijze voor de bereiding ervan.
PL1987267326A PL148535B1 (en) 1986-08-15 1987-08-14 Method of obtaining novel 1-/4-aminophenyl/-4-methyl-7,8-methylenedioxy- 3,4-dihydro-5h-2,3-benzosiazepin and its addition salt with acids
NO873426A NO164656C (no) 1986-08-15 1987-08-14 Analogifremgangsmaate for fremstilling av terapeutisk aktivt 1-(4-amionfenyl)-4-methyl-7,8-methylendioxy-3,4-dihydro-5h-2,3-benzodiazepin.
GB8719265A GB2194236B (en) 1986-08-15 1987-08-14 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-3,4-dihydro-5h-2,3-benzodiazepine, acid addition salts thereof and process for preparing same
US07/087,341 US4835152A (en) 1986-08-15 1987-08-20 1-(4-Aminophenyl)-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzodiazepine and acid addition salts thereof same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU863594A HU198494B (en) 1986-08-15 1986-08-15 Process for producing new 3,4-dihydro-5h-2,3-benzodiazepine derivative and acid addition salts thereof, as well as pharmaceutical compositions comprising same

Publications (2)

Publication Number Publication Date
HUT47287A true HUT47287A (en) 1989-02-28
HU198494B HU198494B (en) 1989-10-30

Family

ID=10964707

Family Applications (1)

Application Number Title Priority Date Filing Date
HU863594A HU198494B (en) 1986-08-15 1986-08-15 Process for producing new 3,4-dihydro-5h-2,3-benzodiazepine derivative and acid addition salts thereof, as well as pharmaceutical compositions comprising same

Country Status (23)

Country Link
US (1) US4835152A (hu)
JP (1) JPS6399073A (hu)
AT (1) ATA202187A (hu)
AU (1) AU596206B2 (hu)
BE (1) BE1002415A4 (hu)
CA (1) CA1284322C (hu)
CH (1) CH673652A5 (hu)
CS (1) CS264150B2 (hu)
DD (1) DD265627A5 (hu)
DE (1) DE3727226A1 (hu)
DK (1) DK164555C (hu)
ES (1) ES2004985A6 (hu)
FI (1) FI85706C (hu)
FR (1) FR2602773B1 (hu)
GB (1) GB2194236B (hu)
HU (1) HU198494B (hu)
IT (1) IT1222508B (hu)
NL (1) NL8701909A (hu)
NO (1) NO164656C (hu)
PL (1) PL148535B1 (hu)
RU (1) RU1779251C (hu)
SE (1) SE467357B (hu)
YU (1) YU46223B (hu)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU219778B (hu) * 1990-12-21 2001-07-30 Gyógyszerkutató Intézet Közös Vállalat Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények
US5639751A (en) * 1990-12-21 1997-06-17 Cyogyszerkutato Intezet Kft N-acyl-2,3-benzodiazepine derivatives for treating acute and chronic neurodegenerative disorders
HU206719B (en) * 1990-12-21 1992-12-28 Gyogyszerkutato Intezet Process for producing 1-/4-acylamino-phenyl/-7,8-methylenedioxy-5h-2,3-benzodiazepine derivatives, acid addicional salts and pharmaceutical compositions containing them
TR199501071A2 (tr) * 1994-08-31 1996-06-21 Lilly Co Eli Dihidro-2,3-benzodiazepin türevlerinin üretilmesi icin stereoselektif islem.
US6329364B1 (en) * 1994-08-31 2001-12-11 Eli Lilly And Company Crystalline form of dihydro-2,3-benzodiazepine derivative
RU2146677C1 (ru) * 1995-03-28 2000-03-20 Эли Лилли Энд Компани Физическая форма (r)-7-ацетил-5-(4-аминофенил)-8,9-дигидро-8-метил-7н-1,3- диоксоло[4,5-h]-[2,3]-бензодиазепина, способ ее получения и фармацевтическая композиция
US5891871A (en) * 1996-03-21 1999-04-06 Cocensys, Inc. Substituted 2,3-benzodiazepin-4-ones and the use thereof
UA67749C2 (uk) * 1997-08-12 2004-07-15 Егіш Дьйодьсердьяр Рт. Похідна 8-заміщеного-9н-1,3-діоксол/4,5-h//2,3/бензодіазепіну з властивостями амра/каїнатного антагоніста, спосіб одержання похідних, фармацевтична композиція (варіанти), спосіб її одержання та спосіб лікування
US6649607B2 (en) * 2001-05-18 2003-11-18 Vela Pharmaceuticals, Inc. Compositions and methods for treating or preventing convulsions or seizures
US6638928B1 (en) 2002-12-03 2003-10-28 Vela Pharmaceuticals, Inc. Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines
US6864251B2 (en) * 2002-12-03 2005-03-08 Vela Pharmaceuticals, Inc. Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines
AU2003303312A1 (en) * 2002-12-03 2004-08-30 Vela Pharmaceuticals, Inc. Pharmaceutical composition of 1-(3-hydroxy-4-methoxyphenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5h-2,3-benzodiazepine and uses therof
US7022700B2 (en) * 2002-12-03 2006-04-04 Vela Pharmaceuticals, Inc. Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines
WO2004050040A2 (en) * 2002-12-03 2004-06-17 Vela Pharmaceuticals, Inc. Pharmaceutical composition of 1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7-methoxy-8-hydroxy-5h-2,3-benzodiazepine and uses thereof
US20040162284A1 (en) * 2003-02-19 2004-08-19 Harris Herbert W. Method of lowering body temperature with (S) tofisopam
US20040224943A1 (en) * 2003-02-19 2004-11-11 Leventer Steven M. Method of lowering body temperature with (R) - 2,3-benzodiazepines
JP4611308B2 (ja) * 2003-05-16 2011-01-12 ヴェラ アクイジション コーポレイション 鏡像的に純粋な（ｒ）２，３−ベンゾジアゼピンを使用する胃腸の機能不全及び関連するストレスの治療
US20070021412A1 (en) * 2003-05-16 2007-01-25 Vela Pharmaceuticals, Inc. Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (S) 2,3-benzodiazepine
US20040254173A1 (en) * 2003-06-13 2004-12-16 Leventer Steven M. Modulation of dopamine responses with substituted (S)-2,3-benzodiazepines
US20050096464A1 (en) * 2003-10-30 2005-05-05 Heikki Heikkila Separation process
EP4197536A1 (en) * 2021-12-20 2023-06-21 Universitat de València Haloperidol for use in the treatment of spinal muscular atrophy

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU186760B (en) * 1981-03-12 1985-09-30 Gyogyszerkutato Intezet Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives
DE3319491A1 (de) * 1982-06-19 1983-10-13 Alps Electric Co., Ltd., Tokyo Papierfuehrungsmechanismus fuer schreibgeraete
HU191698B (en) * 1984-07-27 1987-03-30 Gyogyszerkutato Intezet Process for producing new 1-aryl-5h-2beta-benzodiazepines

Also Published As

Publication number Publication date
HU198494B (en) 1989-10-30
SE8703169L (sv) 1988-02-16
FR2602773B1 (fr) 1990-11-02
YU46223B (sh) 1993-05-28
DK424887D0 (da) 1987-08-14
AU596206B2 (en) 1990-04-26
FR2602773A1 (fr) 1988-02-19
CH673652A5 (hu) 1990-03-30
GB8719265D0 (en) 1987-09-23
NO164656B (no) 1990-07-23
NO164656C (no) 1990-10-31
ES2004985A6 (es) 1989-02-16
FI85706B (fi) 1992-02-14
SE8703169D0 (sv) 1987-08-14
DE3727226A1 (de) 1988-02-18
CS264150B2 (en) 1989-06-13
IT8721667A0 (it) 1987-08-14
CA1284322C (en) 1991-05-21
DK424887A (da) 1988-02-16
NO873426D0 (no) 1987-08-14
IT1222508B (it) 1990-09-05
YU151487A (en) 1988-12-31
SE467357B (sv) 1992-07-06
BE1002415A4 (fr) 1991-02-05
US4835152A (en) 1989-05-30
ATA202187A (de) 1993-06-15
DD265627A5 (de) 1989-03-08
FI873525A0 (fi) 1987-08-14
DK164555B (da) 1992-07-13
RU1779251C (ru) 1992-11-30
NL8701909A (nl) 1988-03-01
FI873525A7 (fi) 1988-02-16
GB2194236A (en) 1988-03-02
AU7688087A (en) 1988-02-18
NO873426L (no) 1988-02-16
GB2194236B (en) 1990-03-21
DK164555C (da) 1992-11-30
JPS6399073A (ja) 1988-04-30
PL148535B1 (en) 1989-10-31
CS600787A2 (en) 1988-08-16
FI85706C (fi) 1992-05-25

Similar Documents

Publication Publication Date Title
HUT43804A (en) Process for producing 3,5-disubstituted pyrochatechol derivatives
HU912420D0 (en) Process for producing 9(11)-dehydro-steroid derivatives
EP0347830A3 (en) Process for producing 1,1,1,2-tetrafluoroethane
HUT45258A (en) Process for producing new condenzed thieno-1,4-diazepines
HUT47287A (en) Process for producing 3,4-dihydro-5h-2,3-benzodiazepine derivatives
HUT45071A (en) Process for producing new cefem derivatives
HUT52050A (en) Process for producing 1,4-disubstituted-piperidinyl-derivatives
HUT45498A (en) Process for producing new, substituted anilide derivatives
HUT46029A (en) Process for producing inosose derivatives
HUT45241A (en) Process for producing naphthothiazepinone derivatives
HUT47074A (en) Improved process for producing 1-amino-indane derivatives
YU136287A (en) Process for preparing new 1,4 benzodiazepines
EP0268820A3 (en) Process for producing 2-acylfuran derivatives
HUT49863A (en) Process for producing 4-amino-1h-1,2,4-triazol-5-one derivatives
HUT55399A (en) Process for producing substituted 3-piperazinyl-1-deoxy-15-deoxo-1,15-epoxyrifamycin derivatives
CZ462688A3 (en) Process for preparing 6,7-diacyl-7-deacetylforscolin derivatives
DE3569366D1 (en) Process for producing 4,4'-dihydroxydiphenyls
HUT47257A (en) Process for producing 3-aryl-5-alkylthio-4h-1,2,4-triazole derivatives
HUT47555A (en) Process for producing 2,3-epoxy-amide derivatives
YU46689A (en) Process for making 1,4-dihydro-pyridinic derivatives
HUT42075A (en) Process for producing 2,2-comma above-bi/1h-imidazol/ derivatives
PT80104A (en) Process for preparing 1,2,4-triazacycloalkadiene derivatives
HU9200020D0 (en) Process for producing 2,4,6 trifluoro-triazine
HUT44533A (en) Process for producing 2,4-diamino-3-oxo-6-piperidyl-pyrimidine
HUT43077A (en) Process for producing 3,7-disubstituted-3-cepheme derivatives

Legal Events

Date Code Title Description
HU90 Patent valid on 900628
HPC4 Succession in title of patentee

Owner name: BIOGAL GYOGYSZERGYAR RT,HU

HMM4 Cancellation of final prot. due to non-payment of fee
HRH9 Withdrawal of annulment decision
HMM4 Cancellation of final prot. due to non-payment of fee