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HUP0002858A1 - Megszakított ATF2-gént tartalmazó élesztőtörzsek és alkalmazásuk - Google Patents

Megszakított ATF2-gént tartalmazó élesztőtörzsek és alkalmazásuk

Info

Publication number
HUP0002858A1
HUP0002858A1 HU0002858A HUP0002858A HUP0002858A1 HU P0002858 A1 HUP0002858 A1 HU P0002858A1 HU 0002858 A HU0002858 A HU 0002858A HU P0002858 A HUP0002858 A HU P0002858A HU P0002858 A1 HUP0002858 A1 HU P0002858A1
Authority
HU
Hungary
Prior art keywords
yeast strains
atf2 gene
interrupted
hydroxysteroids
activity
Prior art date
Application number
HU0002858A
Other languages
English (en)
Inventor
Tilman Achstetter
Gilles Cauet
Eric Degryse
Original Assignee
Hoechst Marion Roussel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel filed Critical Hoechst Marion Roussel
Publication of HUP0002858A1 publication Critical patent/HUP0002858A1/hu
Publication of HUP0002858A3 publication Critical patent/HUP0002858A3/hu
Publication of HU226657B1 publication Critical patent/HU226657B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Botany (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

A találmány tárgya módosított élesztőtörzs, melyben az acetil-koenzim-A-pregnenolon acetil-transzferáz (APAT)-aktivitás ki van küszöbölve azaktivitást kódoló gén módosítása útján, ami a 3b-hidroxi-szteroidokstabilizálódásához vezet. A találmány szerinti élesztőtörzs alkalmasendogén és exogén szterol- és szteroidszubsztrátok, például 3b-hidroxi-szteroidok in vivo oxidációjára. Ó
HU0002858A 1998-02-05 1999-02-04 Yeast strains with modified atf2 gene and uses HU226657B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9801329A FR2774393B1 (fr) 1998-02-05 1998-02-05 Souches de levure ayant le gene atf2 interrompu et leurs applications
PCT/FR1999/000237 WO1999040203A1 (fr) 1998-02-05 1999-02-04 Souches de levure ayant le gene atf2 interrompu et leurs applications

Publications (3)

Publication Number Publication Date
HUP0002858A1 true HUP0002858A1 (hu) 2000-12-28
HUP0002858A3 HUP0002858A3 (en) 2005-11-28
HU226657B1 HU226657B1 (en) 2009-06-29

Family

ID=9522616

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0002858A HU226657B1 (en) 1998-02-05 1999-02-04 Yeast strains with modified atf2 gene and uses

Country Status (30)

Country Link
US (2) US6218139B1 (hu)
EP (1) EP0977868B1 (hu)
JP (1) JP4443636B2 (hu)
KR (1) KR100599346B1 (hu)
CN (1) CN1201008C (hu)
AR (1) AR015225A1 (hu)
AT (1) ATE271610T1 (hu)
AU (1) AU748129B2 (hu)
BR (1) BR9904771A (hu)
CA (1) CA2285686C (hu)
CZ (1) CZ299506B6 (hu)
DE (1) DE69918752T2 (hu)
DK (1) DK0977868T3 (hu)
EA (1) EA004629B1 (hu)
ES (1) ES2221353T3 (hu)
FR (1) FR2774393B1 (hu)
HR (1) HRP990303B1 (hu)
HU (1) HU226657B1 (hu)
ID (1) ID22741A (hu)
IL (1) IL132151A (hu)
ME (1) ME00670B (hu)
PL (1) PL198376B1 (hu)
PT (1) PT977868E (hu)
RS (1) RS49619B (hu)
SI (1) SI0977868T1 (hu)
SK (1) SK286279B6 (hu)
TR (1) TR199902457T1 (hu)
UA (1) UA72438C2 (hu)
WO (1) WO1999040203A1 (hu)
ZA (1) ZA99676B (hu)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2799206A1 (fr) * 1999-10-05 2001-04-06 Transgene Sa Procede de production de steroides modifies par fermentation de levures
FR2812884B1 (fr) * 2000-08-08 2002-11-08 Aventis Pharma Sa Levures modifiees et utilisations, notamment pour la production de derives steroidiens
FR2820145B1 (fr) * 2001-01-31 2004-01-23 Aventis Pharma Sa Souche de levure produisant des steroides de facon autonome
JP5236189B2 (ja) 2003-12-05 2013-07-17 チルドレンズ ホスピタル メディカル センター オリゴ糖組成物および感染症の治療における該組成物の使用
FR2869914B1 (fr) 2004-05-06 2012-11-09 Aventis Pharma Sa Souches de levure produisant du cholesterol et leurs applications
CN102604847B (zh) * 2012-03-23 2013-05-15 天津科技大学 一株含有Lg-ATF1基因的酿酒酵母工程菌

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6447380A (en) * 1987-08-19 1989-02-21 Agency Ind Science Techn Steroid-oxidizing yeast strain
EP0340878B1 (en) * 1988-05-06 2001-05-16 Aventis Pharma S.A. Process for the biochemical oxidation of steroids and genetically engineered cells to be used therefor
FR2678611B1 (fr) 1991-07-04 1995-01-20 Roussel Uclaf Nouveaux esters pyrethrinouides de l'alcool 1,3,4,5,6,7-hexahydro 1,3-dioxo-2h-isoindol-2-yl-methylique, leur procede de preparation et leur application comme pesticides.
JP3363197B2 (ja) * 1992-06-18 2003-01-08 麒麟麦酒株式会社 アルコールアセチルトランスフェラーゼ遺伝子およびその利用
IL116872A (en) * 1995-02-15 2004-12-15 Aventis Pharma Sa Delta-5, 7 sterol reductase from arabidopsis thaliana
JP4093598B2 (ja) * 1995-03-14 2008-06-04 大関株式会社 新規なアルコールアセチルトランスフェラーゼ遺伝子
FR2743829A1 (fr) * 1996-01-19 1997-07-25 Hydroplus Hausse automatique pour ouvrage hydraulique tel que seuil en riviere, deversoir sur un barrage ou sur une digue de protection

Also Published As

Publication number Publication date
DK0977868T3 (da) 2004-11-29
ID22741A (id) 1999-12-09
IL132151A (en) 2006-09-05
JP2001524838A (ja) 2001-12-04
ZA99676B (en) 2000-01-28
US6218139B1 (en) 2001-04-17
HU226657B1 (en) 2009-06-29
ATE271610T1 (de) 2004-08-15
ES2221353T3 (es) 2004-12-16
BR9904771A (pt) 2000-03-21
JP4443636B2 (ja) 2010-03-31
UA72438C2 (uk) 2005-03-15
US20010012630A1 (en) 2001-08-09
SK286279B6 (sk) 2008-06-06
KR100599346B1 (ko) 2006-07-12
PT977868E (pt) 2004-11-30
WO1999040203A1 (fr) 1999-08-12
AR015225A1 (es) 2001-04-18
ME00670B (me) 2007-08-03
HUP0002858A3 (en) 2005-11-28
HRP990303A2 (en) 2000-04-30
EP0977868A1 (fr) 2000-02-09
US6503749B2 (en) 2003-01-07
FR2774393A1 (fr) 1999-08-06
CZ351299A3 (cs) 2000-03-15
AU2171499A (en) 1999-08-23
YU49799A (hu) 2002-08-12
AU748129B2 (en) 2002-05-30
TR199902457T1 (xx) 2000-04-21
EA004629B1 (ru) 2004-06-24
EA199900903A1 (ru) 2000-04-24
SI0977868T1 (en) 2005-02-28
SK133199A3 (en) 2000-05-16
PL336301A1 (en) 2000-06-19
CN1201008C (zh) 2005-05-11
DE69918752D1 (de) 2004-08-26
CA2285686C (fr) 2009-05-26
DE69918752T2 (de) 2005-08-04
HRP990303B1 (en) 2005-04-30
EP0977868B1 (fr) 2004-07-21
CA2285686A1 (fr) 1999-08-12
FR2774393B1 (fr) 2000-03-24
RS49619B (sr) 2007-08-03
PL198376B1 (pl) 2008-06-30
CZ299506B6 (cs) 2008-08-20
IL132151A0 (en) 2001-03-19
KR20010005998A (ko) 2001-01-15
CN1263558A (zh) 2000-08-16

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