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EA199900903A1 - Штаммы дрожжей, содержащие прерванный ген atf2, и их применение - Google Patents

Штаммы дрожжей, содержащие прерванный ген atf2, и их применение

Info

Publication number
EA199900903A1
EA199900903A1 EA199900903A EA199900903A EA199900903A1 EA 199900903 A1 EA199900903 A1 EA 199900903A1 EA 199900903 A EA199900903 A EA 199900903A EA 199900903 A EA199900903 A EA 199900903A EA 199900903 A1 EA199900903 A1 EA 199900903A1
Authority
EA
Eurasian Patent Office
Prior art keywords
yeast strains
strains containing
atf2 gene
containing interrupted
activity
Prior art date
Application number
EA199900903A
Other languages
English (en)
Other versions
EA004629B1 (ru
Inventor
Тильман Ахштеттер
Жилль Коэ
Эрик Дегриз
Original Assignee
Хехст Марион Руссель
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Хехст Марион Руссель filed Critical Хехст Марион Руссель
Publication of EA199900903A1 publication Critical patent/EA199900903A1/ru
Publication of EA004629B1 publication Critical patent/EA004629B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Объектом изобретения является модифицированный штамм дрожжей, лишенный активности ацетил-CoA-прегненолон-ацетилтрансферазы (АРАТ) за счет изменения гена, кодирующего эту активность, что приводит к стабилизации 3β-гидроксистероидов.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900903A 1998-02-05 1999-02-04 ШТАММЫ ДРОЖЖЕЙ, ЛИШЕННЫЕ АЦЕТИЛ-СоА-ПРЕГНЕНОЛОН-АЦЕТИЛТРАНСФЕРАЗНОЙ АКТИВНОСТИ, И СПОСОБЫ ОКИСЛЕНИЯ СТЕРИНОВ И СТЕРОИДОВ ПРИ ИХ ИСПОЛЬЗОВАНИИ EA004629B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9801329A FR2774393B1 (fr) 1998-02-05 1998-02-05 Souches de levure ayant le gene atf2 interrompu et leurs applications
PCT/FR1999/000237 WO1999040203A1 (fr) 1998-02-05 1999-02-04 Souches de levure ayant le gene atf2 interrompu et leurs applications

Publications (2)

Publication Number Publication Date
EA199900903A1 true EA199900903A1 (ru) 2000-04-24
EA004629B1 EA004629B1 (ru) 2004-06-24

Family

ID=9522616

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900903A EA004629B1 (ru) 1998-02-05 1999-02-04 ШТАММЫ ДРОЖЖЕЙ, ЛИШЕННЫЕ АЦЕТИЛ-СоА-ПРЕГНЕНОЛОН-АЦЕТИЛТРАНСФЕРАЗНОЙ АКТИВНОСТИ, И СПОСОБЫ ОКИСЛЕНИЯ СТЕРИНОВ И СТЕРОИДОВ ПРИ ИХ ИСПОЛЬЗОВАНИИ

Country Status (30)

Country Link
US (2) US6218139B1 (ru)
EP (1) EP0977868B1 (ru)
JP (1) JP4443636B2 (ru)
KR (1) KR100599346B1 (ru)
CN (1) CN1201008C (ru)
AR (1) AR015225A1 (ru)
AT (1) ATE271610T1 (ru)
AU (1) AU748129B2 (ru)
BR (1) BR9904771A (ru)
CA (1) CA2285686C (ru)
CZ (1) CZ299506B6 (ru)
DE (1) DE69918752T2 (ru)
DK (1) DK0977868T3 (ru)
EA (1) EA004629B1 (ru)
ES (1) ES2221353T3 (ru)
FR (1) FR2774393B1 (ru)
HR (1) HRP990303B1 (ru)
HU (1) HU226657B1 (ru)
ID (1) ID22741A (ru)
IL (1) IL132151A (ru)
ME (1) ME00670B (ru)
PL (1) PL198376B1 (ru)
PT (1) PT977868E (ru)
RS (1) RS49619B (ru)
SI (1) SI0977868T1 (ru)
SK (1) SK286279B6 (ru)
TR (1) TR199902457T1 (ru)
UA (1) UA72438C2 (ru)
WO (1) WO1999040203A1 (ru)
ZA (1) ZA99676B (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2799206A1 (fr) * 1999-10-05 2001-04-06 Transgene Sa Procede de production de steroides modifies par fermentation de levures
FR2812884B1 (fr) * 2000-08-08 2002-11-08 Aventis Pharma Sa Levures modifiees et utilisations, notamment pour la production de derives steroidiens
FR2820145B1 (fr) * 2001-01-31 2004-01-23 Aventis Pharma Sa Souche de levure produisant des steroides de facon autonome
EP2497478A3 (en) 2003-12-05 2012-11-07 Children's Hospital Medical Center Oligosaccaride compositions and use thereof in the treatment of infection
FR2869914B1 (fr) 2004-05-06 2012-11-09 Aventis Pharma Sa Souches de levure produisant du cholesterol et leurs applications
CN102604847B (zh) * 2012-03-23 2013-05-15 天津科技大学 一株含有Lg-ATF1基因的酿酒酵母工程菌

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6447380A (en) * 1987-08-19 1989-02-21 Agency Ind Science Techn Steroid-oxidizing yeast strain
EP0340878B1 (en) * 1988-05-06 2001-05-16 Aventis Pharma S.A. Process for the biochemical oxidation of steroids and genetically engineered cells to be used therefor
FR2678611B1 (fr) 1991-07-04 1995-01-20 Roussel Uclaf Nouveaux esters pyrethrinouides de l'alcool 1,3,4,5,6,7-hexahydro 1,3-dioxo-2h-isoindol-2-yl-methylique, leur procede de preparation et leur application comme pesticides.
JP3363197B2 (ja) * 1992-06-18 2003-01-08 麒麟麦酒株式会社 アルコールアセチルトランスフェラーゼ遺伝子およびその利用
IL116872A (en) * 1995-02-15 2004-12-15 Aventis Pharma Sa Delta-5, 7 sterol reductase from arabidopsis thaliana
JP4093598B2 (ja) * 1995-03-14 2008-06-04 大関株式会社 新規なアルコールアセチルトランスフェラーゼ遺伝子
FR2743829A1 (fr) * 1996-01-19 1997-07-25 Hydroplus Hausse automatique pour ouvrage hydraulique tel que seuil en riviere, deversoir sur un barrage ou sur une digue de protection

Also Published As

Publication number Publication date
BR9904771A (pt) 2000-03-21
US6503749B2 (en) 2003-01-07
ME00670B (me) 2007-08-03
HUP0002858A1 (hu) 2000-12-28
JP2001524838A (ja) 2001-12-04
EA004629B1 (ru) 2004-06-24
HUP0002858A3 (en) 2005-11-28
AU748129B2 (en) 2002-05-30
SK286279B6 (sk) 2008-06-06
CA2285686C (fr) 2009-05-26
HRP990303B1 (en) 2005-04-30
PL336301A1 (en) 2000-06-19
ID22741A (id) 1999-12-09
ES2221353T3 (es) 2004-12-16
US20010012630A1 (en) 2001-08-09
EP0977868A1 (fr) 2000-02-09
ZA99676B (en) 2000-01-28
CZ351299A3 (cs) 2000-03-15
AR015225A1 (es) 2001-04-18
DE69918752T2 (de) 2005-08-04
IL132151A (en) 2006-09-05
CN1201008C (zh) 2005-05-11
AU2171499A (en) 1999-08-23
UA72438C2 (ru) 2005-03-15
PT977868E (pt) 2004-11-30
TR199902457T1 (xx) 2000-04-21
PL198376B1 (pl) 2008-06-30
CN1263558A (zh) 2000-08-16
RS49619B (sr) 2007-08-03
DK0977868T3 (da) 2004-11-29
YU49799A (ru) 2002-08-12
ATE271610T1 (de) 2004-08-15
SI0977868T1 (en) 2005-02-28
DE69918752D1 (de) 2004-08-26
KR20010005998A (ko) 2001-01-15
SK133199A3 (en) 2000-05-16
KR100599346B1 (ko) 2006-07-12
FR2774393A1 (fr) 1999-08-06
HRP990303A2 (en) 2000-04-30
CZ299506B6 (cs) 2008-08-20
HU226657B1 (en) 2009-06-29
JP4443636B2 (ja) 2010-03-31
US6218139B1 (en) 2001-04-17
FR2774393B1 (fr) 2000-03-24
EP0977868B1 (fr) 2004-07-21
WO1999040203A1 (fr) 1999-08-12
CA2285686A1 (fr) 1999-08-12
IL132151A0 (en) 2001-03-19

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Legal Events

Date Code Title Description
PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU

NF4A Restoration of lapsed right to a eurasian patent

Designated state(s): AZ KG RU

MK4A Patent expired

Designated state(s): RU