HU179983B - Process for preparing nitroimidazole derivatives - Google Patents

Process for preparing nitroimidazole derivatives

Info

Publication number: HU179983B
Authority: HU; Hungary
Prior art keywords: preparing; nitroimidazole derivatives; nitroimidazole; derivatives; preparing nitroimidazole
Prior art date: 1977-08-19

Application number

HU78HO2096A

Other languages

English (en)

Inventor

Carey E Smithen

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-08-19

Filing date

1978-08-18

Publication date

1983-01-28

1978-08-18 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1983-01-28 Publication of HU179983B publication Critical patent/HU179983B/hu

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Tropical Medicine & Parasitology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

HU78HO2096A 1977-08-19 1978-08-18 Process for preparing nitroimidazole derivatives HU179983B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB3490877		1977-08-19
GB1953478		1978-05-15

Publications (1)

Publication Number	Publication Date
HU179983B true HU179983B (en)	1983-01-28

Family

ID=26254111

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU78HO2096A HU179983B (en)	1977-08-19	1978-08-18	Process for preparing nitroimidazole derivatives

Country Status (26)

Country	Link
US (1)	US4241060A (hu)
EP (1)	EP0000928B1 (hu)
JP (1)	JPS5444671A (hu)
AR (3)	AR218325A1 (hu)
AT (1)	AT364829B (hu)
AU (1)	AU516443B2 (hu)
CA (1)	CA1104133A (hu)
DE (2)	DE2860546D1 (hu)
DK (1)	DK155367C (hu)
ES (3)	ES472661A1 (hu)
FI (1)	FI70576C (hu)
FR (1)	FR2400512A1 (hu)
GB (1)	GB2003154A (hu)
GR (1)	GR73055B (hu)
HU (1)	HU179983B (hu)
IE (1)	IE47132B1 (hu)
IL (1)	IL55351A (hu)
IT (1)	IT1098042B (hu)
MC (1)	MC1210A1 (hu)
NL (1)	NL7808597A (hu)
NO (1)	NO151240C (hu)
NZ (1)	NZ188140A (hu)
PH (1)	PH16364A (hu)
PT (1)	PT68441A (hu)
SE (1)	SE7808773L (hu)
YU (1)	YU41317B (hu)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2948884A1 (de) *	1979-12-05	1981-06-11	Basf Ag, 6700 Ludwigshafen	2-hydroxypropylimidazole, verfahren zu ihrer herstellung und verwendung als oelloesliche korrosionsinhibitoren
ZW8781A1 (en) *	1980-05-23	1981-12-16	Hoffmann La Roche	2-nitroimidazoles and preparation thereof
US4494547A (en) *	1981-03-30	1985-01-22	North Carolina Central University	2H-isoindolediones, their synthesis and use as radiosensitizers
US4537969A (en) *	1982-03-18	1985-08-27	Hoffmann-La Roche Inc.	Imidazole derivatives
US4605744A (en) *	1982-03-18	1986-08-12	Hoffmann-La Roche Inc.	Imidazole derivatives
US4581368A (en) *	1982-05-27	1986-04-08	National Research Development Corporation	Aziridino containing nitro imidazoles and pharmaceutical compositions
CA1227211A (en) *	1982-05-27	1987-09-22	Israr Ahmed	Nitro imidazolyl aziridino propanols
US4742050B1 (en) *	1982-08-17	1994-06-28	Alpha Therapeutic Corp	Sensitization of hypoxic tumor cells and control of growth thereof
JPS59501665A (ja) *	1982-08-17	1984-10-04	サン　テツク　インコ−ポレ−テツド	ペルフルオロカ−ボンエマルシヨン、その調製および治療における使用
US4889525A (en) *	1982-08-17	1989-12-26	Adamantech, Inc.	Sensitization of hypoxic tumor cells and control of growth thereof
US5304654A (en) *	1987-06-10	1994-04-19	Yasunori Nishijima	Fluorine-containing nitroimidazole compounds
JP2848602B2 (ja) *	1987-06-24	1999-01-20	京都大学長	新規含フッ素２−ニトロイミダゾールおよびそれを含む放射線増感剤
CA1329206C (en) *	1987-06-10	1994-05-03	Tsutomu Kagiya	Fluorine-containing nitroazole derivatives and radiosensitizer comprising the same
US4797397A (en) *	1987-07-31	1989-01-10	Warner-Lambert Company	2-nitroimidazole derivatives useful as radiosensitizers for hypoxic tumor cells
GB2213150B (en) *	1987-12-04	1991-10-02	Nat Res Dev	Nitro-substituted aromatic or hetero-aromatic compounds for use in cancer treatment
GB8728418D0 (en) *	1987-12-04	1988-01-13	Jenkins T C	Nitro-substituted aromatic/hetero-aromatic compounds for use in cancer treatment
US5086068A (en) *	1988-02-26	1992-02-04	Alberta Cancer Board	Immunochemical detection of hypoxia in normal and tumor tissue
US5194624A (en) *	1988-05-23	1993-03-16	Fujisawa Pharmaceutical Co., Ltd.	Intermediates for the preparation of compounds of antimicrobial activity
JPH02146288A (ja) *	1988-11-25	1990-06-05	Ebara Corp	内部圧縮を持つ容積型圧縮機
US4954515A (en) *	1988-11-25	1990-09-04	Warner-Lambert Company	Haloalkylaminomethyl-2-nitro-1H-imidazoles
US5073639A (en) *	1988-11-25	1991-12-17	Warner-Lambert Company	Process for the synthesis of novel and known nitroimidazoles which are useful as sensitizing agents
US5036089A (en) *	1988-11-25	1991-07-30	Warner-Lambert Company	2-oxazolidinone derivatives of nitroimidazoles and pharmaceutical compositions useful as sensitizing agents
US5036096A (en) *	1988-11-25	1991-07-30	Warner-Lambert Company	Aziridino derivatives of nitroimidazoles and pharmaceutical compositions of selected derivatives
JP2799368B2 (ja) *	1990-01-10	1998-09-17	ポーラ化成工業株式会社	抗原虫剤
GB9127304D0 (en) *	1991-12-23	1992-02-19	Boots Co Plc	Therapeutic agents
MX9304399A (es) *	1992-07-31	1994-02-28	Warner Lambert Co	Proceso novedoso para preparar [[2-bromoetil)-amino]metil]-2-nitro-1h-imidazol-1-etanol quiral y compuestos relacionados.
DE69332741T2 (de) *	1992-11-19	2003-10-02	The University Of Rochester, Rochester	Nachweis von hypoxia
US6855828B1 (en)	1992-11-19	2005-02-15	The Trustees Of The University Of Pennsylvania	Detection of hypoxia
US6252087B1 (en)	1992-11-19	2001-06-26	The Trustees Of The University Of Pennsylvania	Nitroaromatic compounds for the detection of hypoxia
US5741800A (en) *	1993-06-22	1998-04-21	Knoll Aktiengesellachaft	Azolyl-cyclic amine derivates with immunomodulatory activity
GB9312893D0 (en) *	1993-06-22	1993-08-04	Boots Co Plc	Therapeutic agents
US5674693A (en) *	1994-03-18	1997-10-07	Natural Pharmacia International Inc.	Derivatives of 2-nitro-imidazoles as hypoxic cell markers
US5972984A (en) *	1995-06-06	1999-10-26	Merck & Co., Inc.	Inhibitors of farnesyl-protein transferase
US20050026974A1 (en) *	1996-02-08	2005-02-03	Trustees Of The University Of Pennsylvania	Detection of hypoxia
US6331286B1 (en)	1998-12-21	2001-12-18	Photogen, Inc.	Methods for high energy phototherapeutics
US8974363B2 (en)	1997-12-11	2015-03-10	Provectus Pharmatech, Inc.	Topical medicaments and methods for photodynamic treatment of disease
US8557298B2 (en)	1998-08-06	2013-10-15	Provectus Pharmatech, Inc.	Medicaments for chemotherapeutic treatment of disease
US20020001567A1 (en) *	1998-12-21	2002-01-03	Photogen, Inc.	Intracorporeal medicaments for high energy phototherapeutic treatment of disease
US7384623B1 (en)	1998-12-21	2008-06-10	Provectus Pharmatech, Inc.	High energy phototherapeutic agents
US8470296B2 (en) *	1998-12-21	2013-06-25	Provectus Pharmatech, Inc.	Intracorporeal medicaments for high energy phototherapeutic treatment of disease
EP1838305A1 (en) *	2005-01-21	2007-10-03	Richard H. Matthews	Radiosensitizer formulations comprising nitrohistidine derivatives
US9056136B2 (en) *	2006-10-06	2015-06-16	Natural Pharmacia International, Inc.	Weakly basic 2-nitroimidazoles for the non-invasive detection of tissue hypoxia
US7842278B2 (en) *	2006-10-27	2010-11-30	Natural Pharmacia International, Inc.	Hypoxia-selective, weakly basic 2-nitroimidazole delivery agents and methods of use thereof
MD4150C1 (ro) *	2011-10-11	2012-09-30	Институт Химии Академии Наук Молдовы	Procedeu de obţinere a compuşilor coordinativi ai Co(II), Ni(II) şi Zn(II) cu 2-nitro-4,5-difenilimidazol pornind de la 4,5-difenilimidazol şi nitraţii metalelor respective
MD4178C1 (ro) *	2012-02-27	2013-02-28	Институт Химии Академии Наук Молдовы	Procedeu de obţinere a 2-nitro-4,5-difenilimidazolului
KR20160030537A (ko) *	2013-07-16	2016-03-18	코닝 인코포레이티드	얇은 유리를 구부리기 위한 방법 및 기기
CN108203411A (zh) *	2016-12-19	2018-06-26	曾舟华	一种高压合成甲硝唑的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA746007A (en) *		1966-11-08	W. Henry David	1-substituted-2-sulfonyl-5-nitroimidazoles
US3255201A (en) *	1965-04-09	1966-06-07	Hoffmann La Roche	2-nitroimidazoles
US3505349A (en) *	1966-04-18	1970-04-07	Hoffmann La Roche	2-nitro-imidazolyl-1-acetamides
CH512492A (de) *	1966-06-10	1971-09-15	Hoffmann La Roche	Verfahren zur Herstellung von Imidazolderivaten
US3646057A (en) *	1969-04-06	1972-02-29	Hoffmann La Roche	2-nitroimidazoles
FR2260996A1 (en) *	1974-02-15	1975-09-12	Hoffmann La Roche	(2-Nitro-1-imidazolyl)-carbamates - useful as germicides and antiproto-zoal agents
DE2410749A1 (de) *	1974-03-06	1975-09-11	Hoffmann La Roche	2-nitroimidazole
US4038410A (en) *	1974-03-14	1977-07-26	Schering Aktiengesellschaft	Nitroimidazole derivatives and process for the preparation thereof

1978
- 1978-07-20 IE IE1453/78A patent/IE47132B1/en not_active IP Right Cessation
- 1978-08-03 US US05/930,622 patent/US4241060A/en not_active Expired - Lifetime
- 1978-08-14 IL IL55351A patent/IL55351A/xx unknown
- 1978-08-14 NZ NZ188140A patent/NZ188140A/xx unknown
- 1978-08-15 YU YU1953/78A patent/YU41317B/xx unknown
- 1978-08-15 AU AU38915/78A patent/AU516443B2/en not_active Expired
- 1978-08-16 MC MC781318A patent/MC1210A1/xx unknown
- 1978-08-16 IT IT26792/78A patent/IT1098042B/it active
- 1978-08-16 PH PH21502A patent/PH16364A/en unknown
- 1978-08-17 GR GR57019A patent/GR73055B/el unknown
- 1978-08-17 EP EP78100690A patent/EP0000928B1/de not_active Expired
- 1978-08-17 CA CA309,523A patent/CA1104133A/en not_active Expired
- 1978-08-17 DE DE7878100690T patent/DE2860546D1/de not_active Expired
- 1978-08-17 JP JP9958278A patent/JPS5444671A/ja active Granted
- 1978-08-17 DE DE19782836073 patent/DE2836073A1/de not_active Withdrawn
- 1978-08-18 PT PT68441A patent/PT68441A/pt unknown
- 1978-08-18 ES ES472661A patent/ES472661A1/es not_active Expired
- 1978-08-18 DK DK366678A patent/DK155367C/da not_active IP Right Cessation
- 1978-08-18 NO NO782813A patent/NO151240C/no unknown
- 1978-08-18 FI FI782530A patent/FI70576C/fi not_active IP Right Cessation
- 1978-08-18 AR AR273353A patent/AR218325A1/es active
- 1978-08-18 GB GB7833921A patent/GB2003154A/en not_active Withdrawn
- 1978-08-18 AT AT0601078A patent/AT364829B/de not_active IP Right Cessation
- 1978-08-18 FR FR7824132A patent/FR2400512A1/fr active Granted
- 1978-08-18 NL NL7808597A patent/NL7808597A/xx not_active Application Discontinuation
- 1978-08-18 HU HU78HO2096A patent/HU179983B/hu not_active IP Right Cessation
- 1978-08-18 SE SE7808773A patent/SE7808773L/xx unknown
1979
- 1979-02-24 ES ES478051A patent/ES478051A1/es not_active Expired
- 1979-02-24 ES ES478052A patent/ES478052A1/es not_active Expired
- 1979-07-26 AR AR277479A patent/AR220216A1/es active
- 1979-07-26 AR AR277480A patent/AR218553A1/es active

Also Published As

Publication number	Publication date
ES472661A1 (es)	1979-02-16
NO151240C (no)	1985-03-06
ES478052A1 (es)	1979-10-16
AU516443B2 (en)	1981-06-04
FI70576B (fi)	1986-06-06
GR73055B (hu)	1984-01-26
AU3891578A (en)	1980-02-21
PT68441A (hu)	1978-09-01
EP0000928B1 (de)	1981-03-18
JPS6220187B2 (hu)	1987-05-06
SE7808773L (sv)	1979-02-20
DK366678A (da)	1979-02-20
IE781453L (en)	1979-02-19
DE2860546D1 (en)	1981-04-16
AR218553A1 (es)	1980-06-13
YU41317B (en)	1987-02-28
IL55351A0 (en)	1978-10-31
NZ188140A (en)	1981-01-23
IE47132B1 (en)	1983-12-28
FI782530A (fi)	1979-02-20
DK155367B (da)	1989-04-03
FI70576C (fi)	1986-09-24
MC1210A1 (fr)	1979-05-18
AT364829B (de)	1981-11-25
GB2003154A (en)	1979-03-07
YU195378A (en)	1983-01-21
IT1098042B (it)	1985-08-31
IT7826792A0 (it)	1978-08-16
NO782813L (no)	1979-02-20
ES478051A1 (es)	1979-10-16
IL55351A (en)	1982-07-30
PH16364A (en)	1983-09-08
CA1104133A (en)	1981-06-30
ATA601078A (de)	1981-04-15
DE2836073A1 (de)	1979-03-01
US4241060A (en)	1980-12-23
FR2400512A1 (fr)	1979-03-16
AR220216A1 (es)	1980-10-15
JPS5444671A (en)	1979-04-09
NO151240B (no)	1984-11-26
DK155367C (da)	1989-08-14
FR2400512B1 (hu)	1980-07-04
NL7808597A (nl)	1979-02-21
EP0000928A1 (de)	1979-03-07
AR218325A1 (es)	1980-05-30

Publication	Publication Date	Title
HU179983B (en)	1983-01-28	Process for preparing nitroimidazole derivatives
HU177718B (en)	1981-12-28	Process for preparing hydantoin derivatives
YU199478A (en)	1982-10-31	Process for preparing triphenylalkene derivatives
YU216778A (en)	1983-01-21	Process for producing imidazole derivatives
YU177578A (en)	1983-01-21	Process for obtaining imidazo-quinazoline derivatives
CS194833B2 (en)	1979-12-31	Process for preparing azoles
PT68705A (en)	1978-11-01	Process for preparing novel imidazolidine derivatives
YU85778A (en)	1983-01-21	Process for preparing new benzimidazole derivatives
HU174083B (hu)	1979-10-28	Sposob poluchenija novykh proizvodnykh 4-acilamino-fenil-ehtanolamina
YU13478A (en)	1983-01-21	Process for preparing new aminoalkoxyphenyl derivatives
YU40334B (en)	1985-12-31	Process for obtaining isoxazolyl-carbamide derivatives
PT67615B (en)	1980-03-03	Process for preparing oxadiazolopyrimidine derivatives
HU177722B (en)	1981-12-28	Process for preparing 14-amino-morfine derivatives
PT68752A (en)	1978-12-01	Process for preparing novel 2-imino-imidazolidine derivatives
PT68164A (en)	1978-07-01	Process for preparing new nitroso-urea derivatives
PT67614B (en)	1980-03-03	Process for preparing oxadiazolopyrimidine derivatives
HU174219B (hu)	1979-11-28	Sposob poluchenija novykh proizvodnykh tiazolo-izokhinolina
GB1537867A (en)	1979-01-04	Process for preparing 4-acylamino-piperidine derivatives
PT67821A (en)	1978-04-01	Process for preparing quinazoline derivatives
HU178247B (en)	1982-04-28	Process for preparing benzolsulphonyl-carbamide derivatives
HU179711B (en)	1982-11-29	Process for preparing steroid-spiro-oxazolidinone derivatives
PT67635A (en)	1978-03-01	Process for preparing everninomicin derivatives
HU178804B (en)	1982-06-28	Process for preparing 1-hidroxy-aporphine derivatives
JPS53101360A (en)	1978-09-04	Process for preparing benzoheterocyclicglyoxylate derivative
YU40278A (en)	1982-10-31	Process for preparing new pyridyl-piperazine derivatives

Legal Events

Date	Code	Title	Description
1990-06-28	HU90	Patent valid on 900628
1991-08-28	HMM4	Cancellation of final prot. due to non-payment of fee