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HRP20211453T1 - Liječenje amd uporabom aav sflt-1 - Google Patents

Liječenje amd uporabom aav sflt-1 Download PDF

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Publication number
HRP20211453T1
HRP20211453T1 HRP20211453TT HRP20211453T HRP20211453T1 HR P20211453 T1 HRP20211453 T1 HR P20211453T1 HR P20211453T T HRP20211453T T HR P20211453TT HR P20211453 T HRP20211453 T HR P20211453T HR P20211453 T1 HRP20211453 T1 HR P20211453T1
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HR
Croatia
Prior art keywords
raav
wet amd
treatment
vegf
administration
Prior art date
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HRP20211453TT
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English (en)
Inventor
Ian J. Constable
Elizabeth P. Rakoczy
Chooi-may LAI
Thomas W. Chalberg Jr.
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Avalanche Australia Pty Ltd. c/o MPR Group Pty Ltd.
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49584435&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20211453(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Avalanche Australia Pty Ltd. c/o MPR Group Pty Ltd. filed Critical Avalanche Australia Pty Ltd. c/o MPR Group Pty Ltd.
Publication of HRP20211453T1 publication Critical patent/HRP20211453T1/hr

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Claims (8)

1. Rekombinantni adeno-asocirani virus (rAAV) za uporabu u postupku liječenja mokre senilne makularne degeneracije (mokra AMD) kod ljudskog subjekta koji boluje od mokre AMD, pri čemu postupak obuhvaća: i) davanje najmanje jedne doze inhibitora vaskularnog endotelnog faktora rasta (VEGF) odabranog od protu-VEGF protutijela i topljivog VEGF receptora, ili njihovog fuzijskog proteina ili fragmenta, intravitrealnom injekcijom, između 1 i 30 dana prije primjene rAAV ljudskom subjektu; ii) injeciranje, u oko ljudskog subjekta, jedinične doze koja sadrži najmanje 1 x 106, a najviše 1 x 1015 genoma rAAV vektora, i farmaceutski prihvatljiv nosač, pri čemu rAAV sadrži sekvencu nukleinske kiseline koja kodira anti-VEGF protein i pri čemu anti-VEGF protein sadrži ljudski sFLT1 ili njegov funkcionalni fragment; i po izboru iii) primjenu jedne ili dvije doze VEGF inhibitora i) intraokularnim injektiranjem u intervalu od 30 dana nakon primjene rAAV.
2. rAAV za uporabu u postupku liječenja mokreAMD sukladno patentnom zahtjevu 1, pri čemu se injeciranje vrši samo jednom u najmanje 18 meseci.
3. rAAV za uporabu u postupku liječenja mokreAMD sukladno patentnom zahtjevu 1 ili 2, pri čemu jedinična doza sadrži najmanje 1 x 108, a najviše 1 x 1013 genoma vektora.
4. rAAV za uporabu u postupku liječenja mokreAMD sukladno patentnom zahtjevu 1 ili 2, pri čemu jedinična doza sadrži najmanje 1 x 109, a najviše 3 x 1013 genoma vektora.
5. rAAV za uporabu u postupku liječenja mokreAMD sukladno bilo kojem od patentnih zahtjeva od 1 do 4, pri čemu uporaba nadalje obuhvaća mjerenje oštrine vida upotrebom slova Studije rane terapije u dijabetskoj retinopatiji (ETDRS), nakon primjene farmaceutskog pripravka, pri čemu se smanjenje neovaskularizacije zapaža fluoresceinskom angiografijom (FA) nakon primjene farmaceutskog pripravka, ili pri čemu se najbolje korigirana oštrina vida (BCVA) kod ljudskog subjekta smanjuje za manje od 15 slova, što se mjeri uporabom ETDRS slova nakon primjene farmaceutskog pripravka, ili pri čemu se BCVA kod ljudskog subjekta poboljšava za najmanje 1 red, što se mjeri uporabom ETDRS slova nakon primjene jedinične doze.
6. rAAV za uporabu u postupku liječenja mokreAMD sukladno bilo kojem od patentnih zahtjeva od 1 do 5, pri čemu injektiranje obuhvaća subretinalno injektiranje.
7. rAAV za uporabu u postupku liječenja mokreAMD sukladno patentnom zahtjevu 6, koji nadalje obuhvaća uklanjanje staklastog gela prije injektiranja jedinične doze.
8. rAAV za uporabu u postupku liječenja mokreAMD sukladno bilo kojem od patentnih zahtjeva od 1 do 7, pri čemu je VEGF-inhibitor i) odabran iz skupine koju čine bevacizumab, ranibizumab i aflibercept.
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