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HRP20211641T1 - Bispecifična protutijela anti-vegf/anti-ang-2 i njihova primjena u liječenju vaskularnih očnih bolesti - Google Patents

Bispecifična protutijela anti-vegf/anti-ang-2 i njihova primjena u liječenju vaskularnih očnih bolesti Download PDF

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Publication number
HRP20211641T1
HRP20211641T1 HRP20211641TT HRP20211641T HRP20211641T1 HR P20211641 T1 HRP20211641 T1 HR P20211641T1 HR P20211641T T HRP20211641T T HR P20211641TT HR P20211641 T HRP20211641 T HR P20211641T HR P20211641 T1 HRP20211641 T1 HR P20211641T1
Authority
HR
Croatia
Prior art keywords
seq
bispecific antibody
region
antigen binding
binding site
Prior art date
Application number
HRP20211641TT
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English (en)
Inventor
Harald Duerr
Frank Herting
Christian Klein
Joerg Thomas Regula
Matthias Rueth
Kay-Gunnar Stubenrauch
Original Assignee
Roche Glycart Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48783248&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20211641(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Roche Glycart Ag filed Critical Roche Glycart Ag
Publication of HRP20211641T1 publication Critical patent/HRP20211641T1/hr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)

Claims (7)

1. Bispecifično protutijelo ili farmaceutski pripravak koji sadrži navedeno bispecifično protutijelo za primjenu u liječenju vaskularne očne bolesti, gdje su očne vaskularne bolesti dijabetička retinopatija, dijabetički edem makule ili makularna degeneracija povezana sa starošću, gdje bispecifično protutijelo sadrži prvo mjesto za vezivanje antigena koje se specifično vezuje za humani VEGF i drugo mjesto za vezivanje antigena koje se specifično vezuje za humani ANG-2, naznačeno time, da i) navedeno prvo mjesto za vezivanje antigena koje se specifično vezuje za VEGF u varijabilnoj domeni teškog lanca sadrži CDR3H regiju SEQ ID NO: 1, CDR2H regiju SEQ ID NO: 2 i CDR1H regiju SEQ ID NO: 3, a u varijabilnoj domeni lakog lanca sadrži CDR3L regiju SEQ ID NO:4, CDR2L regiju SEQ ID NO:5 i CDR1L regiju SEQ ID NO:6; i ii) navedeno drugo mjesto za vezivanje antigena koje se specifično vezuje za ANG-2 u varijabilnoj domeni teškog lanca sadrži CDR3H regiju SEQ ID NO: 9, CDR2H regiju SEQ ID NO: 10 i CDR1H regiju SEQ ID NO: 11, a u varijabilnoj domeni lakog lanca sadrži CDR3L regiju SEQ ID NO:12, CDR2L regiju SEQ ID NO:13 i CDR1L regiju SEQ ID NO:14, i naznačeno time, da iii) bispecifično protutijelo sadrži konstantnu regiju teškog lanca humanog IgG1 humanog podrijetla i sadrži mutacije I253A, H310A i H435A, koje su numerirane prema Kabatovom EU indeksu.
2. Bispecifično protutijelo ili farmaceutski pripravak koji sadrži navedeno bispecifično protutijelo za uporabu u skladu s patentnim zahtjevom 1, naznačeno time, da konstantna regija teškog lanca potklase IgG1 dalje sadrži mutacije L234A, L235A i P329G, numerirane prema Kabatovom EU indeksu.
3. Bispecifično protutijelo ili farmaceutski pripravak koji sadrži navedeno bispecifično protutijelo za uporabu u skladu s patentnim zahtjevom 1, naznačeno time, da je protutijelo dvovalentno i sadrži aminokiselinske sekvence SEQ ID NO: 25, SEQ ID NO: 26, SEQ ID NO: 27 i SEQ ID NO: 28.
4. Bispecifično protutijelo ili farmaceutski pripravak koji sadrži navedeno bispecifično protutijelo za uporabu u skladu s bilo kojim od patentnih zahtjeva 1 do 3, naznačeno time, da je protutijelo namijenjeno za intravitrealnu primjenu.
5. Bispecifično protutijelo ili farmaceutski pripravak koji sadrži navedeno bispecifično protutijelo za uporabu u skladu s bilo kojim od patentnih zahtjeva 1 do 4, naznačeno time, da je očna vaskularna bolest dijabetička retinopatija.
6. Bispecifično protutijelo ili farmaceutski pripravak koji sadrži navedeno bispecifično protutijelo za uporabu u skladu s bilo kojim od patentnih zahtjeva 1 do 4, naznačeno time, da je očna vaskularna bolest dijabetički makularni edem.
7. Bispecifično protutijelo ili farmaceutski pripravak koji sadrži navedeno bispecifično protutijelo za uporabu u skladu s bilo kojim od patentnih zahtjeva 1 do 4, naznačeno time, da je makularna degeneracija povezana sa starošću (AMD).
HRP20211641TT 2012-07-13 2013-07-11 Bispecifična protutijela anti-vegf/anti-ang-2 i njihova primjena u liječenju vaskularnih očnih bolesti HRP20211641T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12176299 2012-07-13
EP18184973.8A EP3495387B1 (en) 2012-07-13 2013-07-11 Bispecific anti-vegf/anti-ang-2 antibodies and their use in the treatment of ocular vascular diseases

Publications (1)

Publication Number Publication Date
HRP20211641T1 true HRP20211641T1 (hr) 2022-02-04

Family

ID=48783248

Family Applications (2)

Application Number Title Priority Date Filing Date
HRP20181595TT HRP20181595T1 (hr) 2012-07-13 2013-07-11 Bispecifična anti-vegf/anti-ang-2 protutijela i njihova upotreba u liječenju očnih krvožilnih bolesti
HRP20211641TT HRP20211641T1 (hr) 2012-07-13 2013-07-11 Bispecifična protutijela anti-vegf/anti-ang-2 i njihova primjena u liječenju vaskularnih očnih bolesti

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HRP20181595TT HRP20181595T1 (hr) 2012-07-13 2013-07-11 Bispecifična anti-vegf/anti-ang-2 protutijela i njihova upotreba u liječenju očnih krvožilnih bolesti

Country Status (40)

Country Link
US (4) US9695233B2 (hr)
EP (2) EP2872534B1 (hr)
JP (5) JP6154900B2 (hr)
KR (1) KR101774121B1 (hr)
CN (1) CN104428315B (hr)
AR (2) AR092027A1 (hr)
AU (1) AU2013288641B2 (hr)
CA (1) CA2874554C (hr)
CL (2) CL2015000061A1 (hr)
CO (1) CO7151542A2 (hr)
CR (1) CR20140542A (hr)
CY (2) CY1124681T1 (hr)
DK (2) DK3495387T3 (hr)
EA (1) EA032192B1 (hr)
ES (2) ES2896493T3 (hr)
FI (1) FIC20230011I1 (hr)
FR (1) FR23C1010I2 (hr)
HR (2) HRP20181595T1 (hr)
HU (2) HUE056217T2 (hr)
IL (1) IL236292B (hr)
IN (1) IN2014DN11157A (hr)
LT (3) LT3495387T (hr)
MA (1) MA37794B1 (hr)
MX (1) MX361337B (hr)
MY (1) MY183712A (hr)
NL (1) NL301218I2 (hr)
NO (1) NO2023009I1 (hr)
NZ (1) NZ702201A (hr)
PE (1) PE20150361A1 (hr)
PH (1) PH12014502713B1 (hr)
PL (2) PL3495387T3 (hr)
PT (1) PT2872534T (hr)
RS (2) RS62509B1 (hr)
SG (1) SG11201408538PA (hr)
SI (2) SI3495387T1 (hr)
SM (1) SMT202100621T1 (hr)
TW (1) TWI506036B (hr)
UA (1) UA120029C2 (hr)
WO (1) WO2014009465A1 (hr)
ZA (1) ZA201408969B (hr)

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