[go: up one dir, main page]

HRP20201303T1 - Fluidni centripetalni uređaj - Google Patents

Fluidni centripetalni uređaj Download PDF

Info

Publication number
HRP20201303T1
HRP20201303T1 HRP20201303TT HRP20201303T HRP20201303T1 HR P20201303 T1 HRP20201303 T1 HR P20201303T1 HR P20201303T T HRP20201303T T HR P20201303TT HR P20201303 T HRP20201303 T HR P20201303T HR P20201303 T1 HRP20201303 T1 HR P20201303T1
Authority
HR
Croatia
Prior art keywords
fluid
chamber
retention chamber
container
centripetal
Prior art date
Application number
HRP20201303TT
Other languages
English (en)
Inventor
Régis PEYTAVI
Sébastien CHAPDELAINE
Original Assignee
UNIVERSITé LAVAL
Meridian Bioscience, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UNIVERSITé LAVAL, Meridian Bioscience, Inc. filed Critical UNIVERSITé LAVAL
Publication of HRP20201303T1 publication Critical patent/HRP20201303T1/hr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/45—Mixing liquids with liquids; Emulsifying using flow mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/713—Feed mechanisms comprising breaking packages or parts thereof, e.g. piercing or opening sealing elements between compartments or cartridges
    • B01F35/7137—Piercing, perforating or melting membranes or closures which seal the compartments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/71725—Feed mechanisms characterised by the means for feeding the components to the mixer using centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B01L7/525—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/07—Centrifugal type cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00871—Communications between instruments or with remote terminals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/028—Modular arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0631—Purification arrangements, e.g. solid phase extraction [SPE]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B01L2200/147—Employing temperature sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/023—Sending and receiving of information, e.g. using bluetooth
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/043—Hinged closures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0609—Holders integrated in container to position an object
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/069—Absorbents; Gels to retain a fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0803—Disc shape
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • B01L2400/0683—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers mechanically breaking a wall or membrane within a channel or chamber
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/082—Active control of flow resistance, e.g. flow controllers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0325—Cells for testing reactions, e.g. containing reagents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00158—Elements containing microarrays, i.e. "biochip"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465—Separating and mixing arrangements
    • G01N2035/00495—Centrifuges
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N2035/00891—Displaying information to the operator
    • G01N2035/0091—GUI [graphical user interfaces]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0439—Rotary sample carriers, i.e. carousels
    • G01N2035/0451—Rotary sample carriers, i.e. carousels composed of interchangeable sectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/0332—Cuvette constructions with temperature control

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Safety Valves (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Claims (22)

1. Fluidni centripetalni uređaj (1) za ispitivanje komponenti biološkog materijala u fluidu, navedeni fluidni centripetalni uređaj (1) sadrži: oblik prilagođen za prihvaćanje unutar rotirajućeg držača (2); sloj fluidne komponente (3) koja ima fluidna svojstva na barem prednjoj strani, navedena fluidna svojstva uključuju: kanal za ulaz fluida (401); retencijsku komoru (403) za primanje navedenog fluida, navedena retencijska komora je spojena na navedeni kanal za ulaz fluida (401) za primanje fluida iz navedenog kanala za ulaz fluida; spremnik (409) koji se u cijelosti nalazi u navedenoj retencijskoj komori (403), navedeni spremnik sadrži tekući razrjeđivač (410), navedeni spremnik nadalje sadrži prvi osjetljivi materijal s promjenom faze za oslobađanje navedenog razrjeđivača unutar retencijske komore; i sloj donje komponente (4) vezan na navedeni sloj fluidne komponente (3), te sloj fluidne komponente i sloj donje komponente stvaraju fluidnu mrežu za cirkuliranje navedenog fluida, navedeni fluid struji kroz navedenu fluidnu mrežu pod centripetalnom silom.
2. Uređaj prema patentnom zahtjevu 1, naznačen time što je navedeni prvi materijal s promjenom faze materijal koji podnosi toplinu koji ispušta navedeni razrjeđivač na određenoj temperaturi.
3. Uređaj prema patentnom zahtjevu 1 ili 2, naznačen time što navedena retencijska komora (403) obuhvaća spremnik za odvajanje strujanja (406), pri čemu je navedeni spremnik za odvajanje strujanja (406) smješten na vanjskoj strani navedene retencijske komore (403) između kanala za ulaz fluida (401) i unutrašnjosti retencijske komore (403), navedeni spremnik za odvajanje strujanja (406) prekida fluidnu vezu između kanala za ulaz fluida (401) i retencijske komore (403).
4. Uređaj prema patentnom zahtjevu 1 ili 2, naznačen time što navedena retencijska komora (403) sadrži spremnik za odvajanje strujanja (406) smješten na vanjskoj strani navedene retencijske komore (403), te spremnik za odvajanje strujanja sadrži osušeni reagens (408).
5. Uređaj prema patentnom zahtjevu 4, naznačen time što je reagens (408) izoliran od unutrašnjosti retencijske komore (403) drugim osjetljivim materijalom s promjenom faze, pri čemu je navedeni drugi osjetljivi materijal s promjenom faze poželjno materijal koji podnosi toplinu koji ispušta navedeni reagens na određenoj temperaturi.
6. Uređaj prema patentnom zahtjevu 4 ili 5, naznačen time što navedeni spremnik za odvajanje strujanja (406) uključuje osušeni reagens.
7. Uređaj prema bilo kojem od prethodnih patentnih zahtjeva, naznačen time što navedena retencijska komora (403) ima razvodni otvor (405) za navedenu retencijsku komoru (403), navedeni razvodni otvor je smješten na vanjskoj strani navedene retencijske komore, navedeni razvodni otvor je spojen na kanal za distribuciju (604) na unutrašnjoj strani navedenog kanala za distribuciju na prvom kraju navedenog kanala za distribuciju, navedeni kanal za distribuciju ima najmanje jednu kivetu (602) predviđenu na vanjskoj strani navedenog kanala za distribuciju.
8. Uređaj prema patentnom zahtjevu 7, naznačen time što navedena najmanje jedna od navedenih kiveta (602) uključuje najmanje jedno od osušenog reagensa (607) i treći materijal s promjenom faze (608), pri čemu je navedeni treći materijal s promjenom faze poželjno materijal koji podnosi toplinu koji ispušta navedeni reagens na određenoj temperaturi.
9. Uređaj prema patentnom zahtjevu 7 ili 8, naznačen time što je navedena kiveta (602) prilagođena da se optički traži najmanje jedan parametar, pri čemu je navedeni parametar fluorescencija, apsorbancija, i kolorimetrija.
10. Uređaj prema bilo kojem od patentnih zahtjeva 7 do 9, naznačen time što navedeni kanal za distribuciju (604) uključuje komoru za otpad (605) na drugom kraju navedenog kanala za distribuciju.
11. Uređaj prema patentnom zahtjevu 10, naznačen time što navedena komora za otpad (605) uključuje materijal s promjenom faze (612).
12. Uređaj prema patentnom zahtjevu 10 ili 11, naznačen time što su navedeni kanal za distribuciju (604), navedena najmanje jedna kiveta (602) i navedena komora za otpad (605) predviđeni na dijelu navedenog sloja fluidne komponente (3) koji se proteže izvan vanjskog ruba navedenog rotirajućeg držača (2).
13. Uređaj prema bilo kojem od prethodnih patentnih zahtjeva, naznačen time što navedeni sloj fluidne komponente (3) sadrži najmanje dva različita dijela kojima se može kontrolirati temperatura.
14. Uređaj prema bilo kojem od prethodnih patentnih zahtjeva, naznačen time što je navedeni spremnik (409) prilagođen za održavanje navedenog tekućeg razrjeđivača (410) u navedenom spremniku i za oslobađanje navedenog tekućeg razrjeđivača (410) u navedenu retencijsku komoru (403) nakon primjene vanjske sile na navedeni spremnik (409), pri čemu je navedena vanjska sila mehanička, električna, elektromagnetska, toplinska, udarna i zvučna sila, omogućavajući tako fluidnu vezu između navedenog tekućeg razrjeđivača i navedenog fluida u navedenoj retencijskoj komori.
15. Uređaj prema bilo kojem od prethodnih patentnih zahtjeva, naznačen time što navedeni uređaj nadalje sadrži komoru koja se može puniti na dnu (315), pri čemu je navedena komora koja se može puniti na dnu spojena s navedenim ulaznim kanalom (401) za punjenje fluida u retencijsku komoru (403) .
16. Uređaj prema bilo kojem od prethodnih patentnih zahtjeva, naznačen time što nadalje sadrži spremnik (5) za punjenje fluida koji sadrži navedeni biološki materijal.
17. Uređaj prema patentnom zahtjevu 15, naznačen time što navedena komora koja se može puniti na dnu sadrži najmanje jedan element koji se može prenositi koji se premješta unutar navedene komore koja se može puniti na dnu kao odgovor na vanjsko promjenjivo magnetsko polje.
18. Uređaj prema patentnom zahtjevu 15 ili 16, naznačen time što komora koja se može puniti na dnu sadrži najmanje jedan objekt koji ne reagira na promjenjivo magnetsko polje i pri čemu je navedeni objekt najmanje jedan od kuglica, zeolita, čestica, čestica za filtraciju, staklenih kuglica, cirkonijevog zrnca, smole, zrnca i suspenzije smole.
19. Ispitni uređaj (1000) koji koristi fluidni centripetalni uređaj (1) za ispitivanje komponenti biološkog materijala u fluidu, te uređaj sadrži: najmanje jedan navedeni fluidni centripetalni uređaj (1) prema bilo kojem od patentnih zahtjeva 1 do 18; sklop rotora (1003); držač (2) za primanje navedenog najmanje jednog navedenog fluidnog centripetalnog uređaja (1) pomoću navedenog sloja fluidne komponente, pri čemu je navedeni držač povezan s navedenim rotorom; motor (1005) za rotiranje navedenog sklopa rotora; regulator brzine (1008) za navedeni motor za upravljanje najmanje jednim od trajanja i brzine vrtnje navedenog sklopa rotora; podsustav za upravljanje temperaturom (2000) radi kontrole temperature barem dijela navedenog mikro fluidnog centripetalnog uređaja; podsustav za otkrivanje (1009) za otkrivanje karakteristika navedenog fluida; i korisničko sučelje (1006) za primanje korisničke naredbe i za slanje naredbe najmanje jednom od navedenog regulatora brzine, navedenog podsustava za upravljanje temperaturom, navedenog podsustava za pobudu i navedenog podsustava za otkrivanje.
20. Postupak ispitivanja koji koristi fluidni centripetalni uređaj za ispitivanje komponenti biološkog materijala u fluidu, te postupak obuhvaća: osiguravanje ispitnog uređaja (1000) s najmanje jednim navedenim fluidnim centripetalnim uređajem kako je zatraženo u zahtjevu 19; osiguravanje fluida s biološkim materijalom; punjenje navedenog fluida u navedeni spremnik za punjenje navedenog fluidnog centripetalnog uređaja; postavljanje navedenog fluidnog centripetalnog uređaja u navedeni držač (2) navedenog ispitnog uređaja; pružanje korisničke naredbe za započinjanje testne sekvence; rotiranje navedenog sklopa rotora pri prvoj brzini radi prijenosa navedenog fluida iz navedenog spremnika za punjenje u navedenu komoru koja se može puniti na dnu.
21. Postupak ispitivanja prema patentnom zahtjevu 20, naznačen time što je fluid odabran iz skupine koja sadrži krv, nazalnu faringealnu aspiraciju, oralnu tekućinu, tekućinu resuspendiranu iz oralnog brisa, tekućinu resuspendiranu iz brisa za nos, tekućinu resuspendiranu iz analnog brisa, tekućinu resuspendiranu iz vaginalnog brisa, slinu i urin.
22. Postupak ispitivanja prema patentnom zahtjevu 20 ili 21, naznačen time što je za ispitivanje najmanje jedne komponente odabrane iz skupine koja se sastoji od, iona, šećera, metabolita, iona, šećera, metabolita, masnih.
HRP20201303TT 2011-03-08 2020-08-20 Fluidni centripetalni uređaj HRP20201303T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161450373P 2011-03-08 2011-03-08
EP17187723.6A EP3270141B1 (en) 2011-03-08 2012-03-07 Fluidic centripetal device

Publications (1)

Publication Number Publication Date
HRP20201303T1 true HRP20201303T1 (hr) 2021-02-19

Family

ID=46797549

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20201303TT HRP20201303T1 (hr) 2011-03-08 2020-08-20 Fluidni centripetalni uređaj

Country Status (13)

Country Link
US (3) US9562262B2 (hr)
EP (2) EP2684022B1 (hr)
JP (2) JP2014507669A (hr)
CN (1) CN103403521B (hr)
BR (1) BR112013022889B8 (hr)
CA (2) CA3043100C (hr)
DK (1) DK3270141T3 (hr)
ES (2) ES2653916T3 (hr)
HR (1) HRP20201303T1 (hr)
PL (1) PL3270141T3 (hr)
PT (1) PT3270141T (hr)
SI (1) SI3270141T1 (hr)
WO (1) WO2012120463A1 (hr)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102010003223B4 (de) * 2010-03-24 2014-09-18 Albert-Ludwigs-Universität Freiburg Vorrichtung zum Einsetzen in einen Rotor einer Zentrifuge, Zentrifuge und Verfahren zum fluidischen Koppeln von Kavitäten
PT3270141T (pt) 2011-03-08 2020-08-28 Univ Laval Dispositivo centrípeto fluídico
WO2013053077A1 (zh) * 2011-10-10 2013-04-18 保生国际生医股份有限公司 离心式转盘
USD714458S1 (en) 2012-08-20 2014-09-30 Sébastien Chapdelaine Instrument
US20140093980A1 (en) * 2012-10-01 2014-04-03 University Of Washington Through Its Center For Commercialization Dissolvable bridges for manipulating fluid volumes and associated devices, systems and methods
US10197480B2 (en) 2012-11-07 2019-02-05 Sandstone Diagnostics, Inc. Methods and devices for processing samples and counting cells
JP6590697B2 (ja) 2012-11-07 2019-10-16 サンドストーン ダイアグノスティックス インコーポレイテッドＳａｎｄｓｔｏｎｅ Ｄｉａｇｎｏｓｔｉｃｓ，Ｉｎｃ． サンプル処理及び細胞計数のための方法及びデバイス
JP6501714B2 (ja) * 2012-12-05 2019-04-17 ジェネポック・インコーポレイテッドＧｅｎｅｐｏｃ Ｉｎｃ． 光学調査装置
EP2948249A1 (en) 2013-01-22 2015-12-02 University of Washington through its Center for Commercialization Sequential delivery of fluid volumes and associated devices, systems and methods
AU2014214886B2 (en) 2013-02-07 2017-09-07 Laboratory Corporation Of America Holdings Automated sample processing, fluid distribution, and sedimentation assay
AU2013202805B2 (en) 2013-03-14 2015-07-16 Gen-Probe Incorporated System and method for extending the capabilities of a diagnostic analyzer
US9993819B2 (en) * 2014-12-30 2018-06-12 Stmicroelectronics S.R.L. Apparatus for actuating and reading a centrifugal microfluidic disk for biological and biochemical analyses, and use of the apparatus
DE202015008930U1 (de) 2015-01-18 2016-03-09 Christoph Gruß Fixierungsmodul für Eindeckelemente
CN106233818B (zh) * 2015-04-07 2020-10-27 源鉴定私人有限公司 一种直流加热器
CA2991470A1 (en) * 2015-08-07 2017-02-16 Poc Medical Systems, Inc. Microfluidic devices and methods of use thereof
USD799715S1 (en) 2015-10-23 2017-10-10 Gene POC, Inc. Fluidic centripetal device
GB201519565D0 (en) * 2015-11-05 2015-12-23 Alere San Diego Inc Sample preparation device
CN108431609B (zh) * 2015-12-24 2021-11-26 普和希控股公司 试样分析用基板、试样分析装置、试样分析系统和记录介质
CN107398307B (zh) 2016-05-18 2023-07-25 博奥生物集团有限公司 一种集成化微流控芯片
CN109641211B (zh) * 2016-06-27 2022-03-01 硕腾服务有限责任公司 具有经改进的导管的装置
US11364495B2 (en) 2016-12-01 2022-06-21 Novel Microdevices, Llc Automated point-of-care devices for complex sample processing and methods of use thereof
CN108738349A (zh) * 2016-12-28 2018-11-02 达纳福股份有限公司 分析装置
WO2018164686A1 (en) * 2017-03-09 2018-09-13 Sandstone Diagnostics. Inc. Device and method of fluid assay
JP7121244B2 (ja) * 2017-10-23 2022-08-18 国立大学法人山梨大学 分注デバイス、それを用いた分注装置及び方法、並びに検査装置及び方法
JP6950955B2 (ja) * 2017-12-28 2021-10-13 国立研究開発法人産業技術総合研究所 アッセイ装置
CN112654721B (zh) 2018-06-13 2025-01-07 简·探针公司 用于检测b群链球菌核酸的组合物和方法
CN109046477B (zh) * 2018-07-23 2023-12-19 深圳市呈晖医疗科技有限公司 离心微流控装置
JPWO2020032226A1 (ja) * 2018-08-10 2021-08-10 株式会社Ｍｉｒａｉ Ｇｅｎｏｍｉｃｓ 分析装置
MX2021002156A (es) 2018-08-24 2021-04-28 Zoetis Services Llc Metodos para la fabricacion de un dispositivo de rotor microfluidico.
AU2019325342B2 (en) 2018-08-24 2024-12-12 Zoetis Services Llc Microfluidic rotor device
MX2021002159A (es) 2018-08-24 2021-04-28 Zoetis Services Llc Dispositivo de rotor microfluidico.
EP3870369A4 (en) * 2018-10-26 2022-11-09 Neofluidics, LLC FLUID DEVICES HAVING REACTION WELLS AND THROAT CHANNEL AND USES THEREOF
US20220008924A1 (en) * 2018-11-13 2022-01-13 National Research Council Of Canada World-to-chip automated interface for centrifugal microfluidic platforms
CN109735431A (zh) * 2019-02-19 2019-05-10 深圳市刚竹医疗科技有限公司 离心微流控芯片及核酸分析系统
TWI692917B (zh) * 2019-02-22 2020-05-01 恆億電機有限公司 磁鋼組合裝置
CN110029052A (zh) * 2019-04-18 2019-07-19 深圳市刚竹医疗科技有限公司 微流控芯片及分析系统
CA3141433A1 (en) * 2019-05-22 2020-11-26 Citrogene Inc. Apparatus and method for rapid identification of microorganisms
CN110180611B (zh) * 2019-07-05 2024-03-08 宋禹 微流控芯片组件
DE102019212316A1 (de) * 2019-08-16 2021-02-18 varyCELL GmbH Aufbereitungseinrichtung zur Aufbereitung einer Zellsuspension für ein Analyseverfahren, Verfahren zur Aufbereitung einer Zellsuspension für ein Analyseverfahren, Reaktorgehäuse und Verteilergehäuse
DE102019213313A1 (de) * 2019-09-03 2021-03-04 Robert Bosch Gmbh Zentrifugeneinheit für eine mikrofluidische Vorrichtung zur Prozessierung von flüssigen Proben
US10823662B1 (en) * 2020-02-18 2020-11-03 Horiba Instruments, Incorporated Special purpose cuvette assembly and method for optical microscopy of nanoparticle colloids
CN111218395B (zh) * 2020-04-18 2020-08-07 博奥生物集团有限公司 一种全流程生物检测装置
JP1679678S (hr) * 2020-07-02 2021-02-22
DE102020209001B4 (de) 2020-07-17 2024-04-18 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Lyse einer Probe mittels Magnetelementen und rotatorischer Relativbewegung
DE102020210404B4 (de) * 2020-08-14 2022-07-14 SpinDiag GmbH Verfahren zum Betrieb eines Analysegeräts, Verwendung einer Kartusche und Analysegerät
CN112169853B (zh) * 2020-12-01 2021-02-26 南京岚煜生物科技有限公司 一种多功能微流控检测芯片
CN114736787A (zh) * 2022-06-10 2022-07-12 至美时代生物智能科技(北京)有限公司 一种核酸洗脱与检测装置
USD1069156S1 (en) 2023-04-10 2025-04-01 Becton, Dickinson And Company Dispensing device
EP4541461A1 (en) * 2023-10-20 2025-04-23 Direct Analysis Plate of chips for micro-organisms lysing
CN117816264B (zh) * 2024-03-01 2024-05-10 博奥生物集团有限公司 基于离心式微流控的双温区式极速pcr系统及空气压缩式反应芯片

Family Cites Families (143)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5149958Y2 (hr) 1971-05-31 1976-12-02
JPS558709B2 (hr) 1974-03-06 1980-03-05
JPS5810501B2 (ja) 1974-10-23 1983-02-25 ブラザー工業株式会社 テアミキノ キユウシソウチ
US3970245A (en) 1975-05-21 1976-07-20 Dr. Molter Gmbh Universal centrifuge
JPS558709A (en) 1978-07-01 1980-01-22 Chiyouei Takahashi Curve operating device of medical coelom inside inserting tool
DE3044372A1 (de) 1980-11-25 1982-07-08 Boehringer Mannheim Gmbh, 6800 Mannheim Rotoreinheit mit einsatzelementen fuer einen zentrifugalanalysator
FR2579755B1 (fr) 1985-03-26 1988-04-15 Guigan Jean Procede pour la realisation d'analyses medicales d'un echantillon liquide a l'aide de reactifs secs, et dispositif pour la mise en oeuvre du procede
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US5333675C1 (en) 1986-02-25 2001-05-01 Perkin Elmer Corp Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
US5656493A (en) 1985-03-28 1997-08-12 The Perkin-Elmer Corporation System for automated performance of the polymerase chain reaction
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5038852A (en) 1986-02-25 1991-08-13 Cetus Corporation Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
US4923978A (en) 1987-12-28 1990-05-08 E. I. Du Pont De Nemours & Company Process for purifying nucleic acids
USD329902S (en) 1990-05-11 1992-09-29 Kim Young R Microcentrifuge
AU8083891A (en) 1990-06-04 1991-12-31 Abaxis, Inc. Analytical rotors and methods for analysis of biological fluids
US6787338B2 (en) 1990-06-04 2004-09-07 The University Of Utah Method for rapid thermal cycling of biological samples
US7081226B1 (en) 1996-06-04 2006-07-25 University Of Utah Research Foundation System and method for fluorescence monitoring
KR100236506B1 (ko) 1990-11-29 2000-01-15 퍼킨-엘머시터스인스트루먼츠 폴리머라제 연쇄 반응 수행 장치
US6703236B2 (en) 1990-11-29 2004-03-09 Applera Corporation Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control
US5230866A (en) * 1991-03-01 1993-07-27 Biotrack, Inc. Capillary stop-flow junction having improved stability against accidental fluid flow
US5994056A (en) 1991-05-02 1999-11-30 Roche Molecular Systems, Inc. Homogeneous methods for nucleic acid amplification and detection
DE4234086A1 (de) 1992-02-05 1993-08-12 Diagen Inst Molekularbio Verfahren zur bestimmung von in vitro amplifizierten nukleinsaeuresequenzen
US5304348A (en) 1992-02-11 1994-04-19 Abaxis, Inc. Reagent container for analytical rotor
US5591643A (en) 1993-09-01 1997-01-07 Abaxis, Inc. Simplified inlet channels
EP0764266A4 (en) 1994-06-06 1998-08-05 Abay Sa MODIFIED SIPHONE TO IMPROVE DOSING ACCURACY
US5639428A (en) 1994-07-19 1997-06-17 Becton Dickinson And Company Method and apparatus for fully automated nucleic acid amplification, nucleic acid assay and immunoassay
CA2239613A1 (en) * 1995-12-05 1997-06-12 Alec Mian Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics
US6635492B2 (en) 1996-01-25 2003-10-21 Bjs Company Ltd. Heating specimen carriers
EP1179600B1 (en) 1996-06-04 2005-05-11 University Of Utah Research Foundation Monitoring hybridization during PCR
US6143248A (en) 1996-08-12 2000-11-07 Gamera Bioscience Corp. Capillary microvalve
GB9620278D0 (en) 1996-09-28 1996-11-13 Central Research Lab Ltd Apparatus for chemical analysis
US7390668B2 (en) 1996-10-30 2008-06-24 Provectus Pharmatech, Inc. Intracorporeal medicaments for photodynamic treatment of disease
EP2333520B1 (en) 1997-02-28 2014-06-25 Cepheid Heat exchanging, optically interrogated chemical reaction assembly
EP0983504A2 (en) * 1997-05-23 2000-03-08 Gamera Bioscience Corporation Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system
US6632399B1 (en) 1998-05-22 2003-10-14 Tecan Trading Ag Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system for performing biological fluid assays
CA2312102C (en) 1997-12-24 2007-09-04 Cepheid Integrated fluid manipulation cartridge
US6210882B1 (en) 1998-01-29 2001-04-03 Mayo Foundation For Medical Education And Reseach Rapid thermocycling for sample analysis
US7396508B1 (en) 2000-07-12 2008-07-08 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having independent slide heaters
USD415840S (en) 1998-04-09 1999-10-26 Savant Instruments, Inc. Centrifugal vaccum concentrator
US6780617B2 (en) 2000-12-29 2004-08-24 Chen & Chen, Llc Sample processing device and method
US6100084A (en) 1998-11-05 2000-08-08 The Regents Of The University Of California Micro-sonicator for spore lysis
US6431476B1 (en) 1999-12-21 2002-08-13 Cepheid Apparatus and method for rapid ultrasonic disruption of cells or viruses
GB9828785D0 (en) * 1998-12-30 1999-02-17 Amersham Pharm Biotech Ab Sequencing systems
US6391264B2 (en) 1999-02-11 2002-05-21 Careside, Inc. Cartridge-based analytical instrument with rotor balance and cartridge lock/eject system
JP3061414U (ja) 1999-02-12 1999-09-17 禮讚 呂 コンピュ―タディスプレイ用回転台
US6303305B1 (en) 1999-03-30 2001-10-16 Roche Diagnostics, Gmbh Method for quantification of an analyte
US7332326B1 (en) 1999-05-14 2008-02-19 Tecan Trading Ag Centripetally-motivated microfluidics system for performing in vitro hybridization and amplification of nucleic acids
US6485690B1 (en) 1999-05-27 2002-11-26 Orchid Biosciences, Inc. Multiple fluid sample processor and system
US20040200909A1 (en) 1999-05-28 2004-10-14 Cepheid Apparatus and method for cell disruption
US6706519B1 (en) 1999-06-22 2004-03-16 Tecan Trading Ag Devices and methods for the performance of miniaturized in vitro amplification assays
US6884395B2 (en) 2000-05-12 2005-04-26 Gyros Ab Integrated microfluidic disc
US6691041B2 (en) 2000-03-31 2004-02-10 Roche Molecular Systems, Inc. Method for the efficiency-corrected real-time quantification of nucleic acids
US6818435B2 (en) 2000-05-15 2004-11-16 Tecan Trading Ag Microfluidics devices and methods for performing cell based assays
US6720187B2 (en) 2000-06-28 2004-04-13 3M Innovative Properties Company Multi-format sample processing devices
US6627159B1 (en) 2000-06-28 2003-09-30 3M Innovative Properties Company Centrifugal filling of sample processing devices
US6734401B2 (en) 2000-06-28 2004-05-11 3M Innovative Properties Company Enhanced sample processing devices, systems and methods
US6855553B1 (en) 2000-10-02 2005-02-15 3M Innovative Properties Company Sample processing apparatus, methods and systems
DK1201304T3 (da) 2000-10-25 2006-11-13 Boehringer Ingelheim Micropart Mikrostruktureret platform til undersögelse af en væske
US7079468B2 (en) 2000-12-08 2006-07-18 Burstein Technologies, Inc. Optical discs for measuring analytes
GB0105831D0 (en) 2001-03-09 2001-04-25 Toumaz Technology Ltd Method for dna sequencing utilising enzyme linked field effect transistors
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
JP4358618B2 (ja) 2001-07-19 2009-11-04 ジェネオーム サイエンシズ カナダ インコーポレイティド 核酸の放出及びそれらを検出するための細胞を迅速に溶解せしめるための万能な方法及び組成物
EP2269736B1 (en) * 2001-08-28 2013-04-24 Gyros Patent Ab Retaining microfluidic microcavity and other microfluidic structures
US6889468B2 (en) 2001-12-28 2005-05-10 3M Innovative Properties Company Modular systems and methods for using sample processing devices
KR100455293B1 (ko) 2002-05-15 2004-11-06 삼성전자주식회사 친수성 영역과 소수성 영역으로 구성되는 생물분자용어레이 판의 제조방법
US7152616B2 (en) 2002-12-04 2006-12-26 Spinx, Inc. Devices and methods for programmable microscale manipulation of fluids
EP1930635A3 (en) 2002-12-04 2008-08-13 Spinx, Inc. Devices and methods for programmable microscale manipulation of fluids
EP1578533A2 (en) 2002-12-24 2005-09-28 Tecan Trading AG Microfluidics devices and methods for diluting samples and reagents
JP2007502428A (ja) 2003-05-23 2007-02-08 ユィロス・パテント・アクチボラグ 非湿潤性表面に基づく流体機能
US7435381B2 (en) 2003-05-29 2008-10-14 Siemens Healthcare Diagnostics Inc. Packaging of microfluidic devices
US7648835B2 (en) 2003-06-06 2010-01-19 Micronics, Inc. System and method for heating, cooling and heat cycling on microfluidic device
EP1656203A2 (en) 2003-06-19 2006-05-17 Nagaoka & Co., Ltd. Fluidic circuits for sample preparation including bio-discs and methods relating thereto
US7238269B2 (en) 2003-07-01 2007-07-03 3M Innovative Properties Company Sample processing device with unvented channel
EP1673167A2 (en) 2003-09-15 2006-06-28 Tecan Trading AG Microfluidics devices and methods for performing cell based assays
US7322254B2 (en) 2003-12-12 2008-01-29 3M Innovative Properties Company Variable valve apparatus and methods
US20050130177A1 (en) * 2003-12-12 2005-06-16 3M Innovative Properties Company Variable valve apparatus and methods
US20050142571A1 (en) 2003-12-24 2005-06-30 3M Innovative Properties Company Methods for nucleic acid isolation and kits using solid phase material
US7387887B2 (en) 2004-04-20 2008-06-17 University Of Utah Research Foundation Nucleic acid melting analysis with saturation dyes
US20050244837A1 (en) 2004-04-28 2005-11-03 Cepheid Method and device for sample preparation control
WO2005121963A2 (en) 2004-06-07 2005-12-22 Iquum, Inc. Sample multiprocessing
GB2416210B (en) 2004-07-13 2008-02-20 Christofer Toumazou Ion sensitive field effect transistors
WO2006015251A2 (en) 2004-07-29 2006-02-09 The Research Foundation Of State University Of New York System and method for cross-talk cancellation in a multilane fluorescence detector
JP4440857B2 (ja) 2004-09-01 2010-03-24 三星電子株式会社 リアルタイム核酸増幅データから初期核酸濃度を定量化する方法
US20060088844A1 (en) 2004-10-22 2006-04-27 Honeywell International Inc. Real-time PCR microarray based on evanescent wave biosensor
WO2006053588A1 (en) 2004-11-17 2006-05-26 Agilent Technologies, Inc. Supply arrangement with supply reservoir element and fluidic device
US7507575B2 (en) 2005-04-01 2009-03-24 3M Innovative Properties Company Multiplex fluorescence detection device having removable optical modules
US7709249B2 (en) 2005-04-01 2010-05-04 3M Innovative Properties Company Multiplex fluorescence detection device having fiber bundle coupling multiple optical modules to a common detector
EP1874470A1 (en) 2005-04-14 2008-01-09 Gyros Patent Ab Microfluidic device with serial valve
JP5432522B2 (ja) 2005-05-09 2014-03-05 バイオファイアー ダイアグノスティックス，インコーポレイテッド 内蔵型生物学的分析
US20060281192A1 (en) * 2005-06-13 2006-12-14 Harding Philip H Method for mixing fluids in microfluidic systems
WO2007001084A1 (ja) 2005-06-28 2007-01-04 Kabushikikaisya Advance 生化学分析装置及び生化学分析装置用担体
US7754474B2 (en) 2005-07-05 2010-07-13 3M Innovative Properties Company Sample processing device compression systems and methods
US7763210B2 (en) 2005-07-05 2010-07-27 3M Innovative Properties Company Compliant microfluidic sample processing disks
US7323660B2 (en) 2005-07-05 2008-01-29 3M Innovative Properties Company Modular sample processing apparatus kits and modules
USD564667S1 (en) 2005-07-05 2008-03-18 3M Innovative Properties Company Rotatable sample processing disk
US7527763B2 (en) 2005-07-05 2009-05-05 3M Innovative Properties Company Valve control system for a rotating multiplex fluorescence detection device
US20070009382A1 (en) 2005-07-05 2007-01-11 William Bedingham Heating element for a rotating multiplex fluorescence detection device
WO2007006049A2 (en) * 2005-07-06 2007-01-11 The Regents Of The University Of California Apparatuses, systems, and methods for isolating and separating biological materials
US7754148B2 (en) 2006-12-27 2010-07-13 Progentech Limited Instrument for cassette for sample preparation
US7727473B2 (en) 2005-10-19 2010-06-01 Progentech Limited Cassette for sample preparation
JP2007198949A (ja) 2006-01-27 2007-08-09 Matsushita Electric Ind Co Ltd 分析用ディスク、及び分析装置
JP2009530606A (ja) 2006-03-13 2009-08-27 ギロス パテント アーべー 増強型磁気粒子ステアリング
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US8088616B2 (en) 2006-03-24 2012-01-03 Handylab, Inc. Heater unit for microfluidic diagnostic system
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
USD569526S1 (en) 2006-03-27 2008-05-20 Handylab, Inc. Molecular diagnostic instrument
US8900828B2 (en) 2006-05-01 2014-12-02 Cepheid Methods and apparatus for sequential amplification reactions
KR100738113B1 (ko) 2006-05-10 2007-07-12 삼성전자주식회사 상전이형 밸브 및 그 제작방법
KR101422572B1 (ko) 2006-09-05 2014-07-30 삼성전자주식회사 핵산 검출을 위한 원심력 기반의 미세유동장치 및 이를포함하는 미세유동시스템
US7951333B2 (en) * 2006-09-05 2011-05-31 Samsung Electronics Co., Ltd. Centrifugal force-based microfluidic device for protein detection and microfluidic system including the same
US8273310B2 (en) * 2006-09-05 2012-09-25 Samsung Electronics Co., Ltd. Centrifugal force-based microfluidic device for nucleic acid extraction and microfluidic system including the microfluidic device
KR101343034B1 (ko) 2006-09-05 2013-12-18 삼성전자 주식회사 원심력 기반의 단백질 검출용 미세유동 장치 및 이를포함하는 미세유동 시스템
KR20080071786A (ko) * 2007-01-31 2008-08-05 삼성전자주식회사 세포배양 및 세포기반 시험을 위한 원심력 기반의미세유동장치 및 이를 포함하는 미세유동시스템
KR101305976B1 (ko) * 2007-02-12 2013-09-12 삼성전자주식회사 연속희석을 위한 원심력 기반의 미세유동장치 및 이를포함하는 미세유동시스템
US20100129878A1 (en) 2007-04-25 2010-05-27 Parthasarathy Ranjani V Methods for nucleic acid amplification
KR20080107212A (ko) * 2007-06-05 2008-12-10 삼성전자주식회사 유체 컨테이너를 구비한 미세유동 장치
DE102007030347A1 (de) 2007-06-29 2009-01-02 Ducrée, Jens, Dr. Integrierter Rotor
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
KR101335727B1 (ko) * 2007-08-22 2013-12-04 삼성전자주식회사 원심력 기반의 혈액 검사용 디스크형 미세유동장치
WO2009054473A1 (ja) 2007-10-26 2009-04-30 Toppan Printing Co., Ltd. 反応チップ及び反応方法、遺伝子処理装置用温度調節機構及び遺伝子処理装置
CN101779129B (zh) * 2007-10-30 2013-04-03 松下电器产业株式会社 分析用仪器和使用该分析用仪器的分析装置及分析方法
US9182384B2 (en) * 2007-11-08 2015-11-10 Panasonic Healthcare Holdings Co., Ltd. Analyzing device and analyzing method using same
JP4884361B2 (ja) 2007-12-21 2012-02-29 シャープ株式会社 マイクロビーズを利用した化学反応装置
KR100919400B1 (ko) 2008-04-07 2009-09-29 삼성전자주식회사 미세유동장치 및 그 제조방법
KR101102532B1 (ko) * 2008-07-10 2012-01-03 삼성전자주식회사 시약 카트리지, 시약 카트리지를 구비하는 미세유동장치, 그 제조방법, 및 이를 이용한 시료분석방법
USD612276S1 (en) 2008-07-14 2010-03-23 Handylab, Inc. Molecular diagnostic apparatus
KR20100023538A (ko) 2008-08-22 2010-03-04 삼성전자주식회사 고상 시약의 제조방법 및 고상 시약을 수용하는 미세유동장치
USD617909S1 (en) 2008-09-05 2010-06-15 Hitachi Koki Co., Ltd. Centrifuge
KR101099495B1 (ko) * 2008-10-14 2011-12-28 삼성전자주식회사 원심력 기반의 미세유동장치, 이의 제조 방법 및 이를 이용한 시료분석방법
EP2198965A1 (en) 2008-12-19 2010-06-23 Koninklijke Philips Electronics N.V. Integrated device for automated simultaneous detection of multiple specific targets using nucleic acid amplification
JP5508709B2 (ja) 2008-12-22 2014-06-04 株式会社Ｓｏｋｕｄｏ 塗布処理装置および基板処理装置
CA2752760C (en) 2009-04-15 2019-12-24 Biocartis Sa Optical detection system for monitoring rtpcr reaction
JP5423200B2 (ja) * 2009-07-21 2014-02-19 東レ株式会社 分析チップおよび検体の分析方法
US8303911B2 (en) * 2009-10-19 2012-11-06 The Regents Of The University Of California Centrifugal microfluidic system for nucleic acid sample preparation, amplification, and detection
JP5149958B2 (ja) 2009-12-25 2013-02-20 楽天株式会社 商品受注装置、商品受注方法、商品受注プログラム、及びそのプログラムを記録するコンピュータ読取可能な記録媒体
KR101722548B1 (ko) 2010-01-29 2017-04-03 삼성전자주식회사 원심력기반의 미세유동장치 및 이를 이용한 유체시료 내 분석대상물질 검출방법
KR101519379B1 (ko) 2010-04-29 2015-05-12 삼성전자 주식회사 원심력 기반의 미세유동장치 및 이를 이용한 면역분석방법
USD663041S1 (en) 2010-05-03 2012-07-03 Thermo Electron Led Gmbh Centrifuge
PT3270141T (pt) 2011-03-08 2020-08-28 Univ Laval Dispositivo centrípeto fluídico
USD689193S1 (en) 2012-04-02 2013-09-03 Panasonic Corporation Biochemical analyzer
USD705437S1 (en) 2012-12-28 2014-05-20 Meso Scale Technologies, Llc. Instrument

Also Published As

Publication number Publication date
ES2653916T3 (es) 2018-02-09
CN103403521A (zh) 2013-11-20
EP3270141A3 (en) 2018-05-02
PL3270141T3 (pl) 2021-04-19
US10427158B2 (en) 2019-10-01
EP3270141B1 (en) 2020-05-20
WO2012120463A1 (en) 2012-09-13
JP6105644B2 (ja) 2017-03-29
ES2827293T3 (es) 2021-05-20
SI3270141T1 (sl) 2021-03-31
US20200061607A1 (en) 2020-02-27
US11123730B2 (en) 2021-09-21
US20170056878A1 (en) 2017-03-02
EP2684022A1 (en) 2014-01-15
BR112013022889B1 (pt) 2020-10-06
CA2827614C (en) 2019-07-02
US9562262B2 (en) 2017-02-07
BR112013022889A2 (pt) 2017-07-25
JP2015092182A (ja) 2015-05-14
BR112013022889B8 (pt) 2022-12-20
EP3270141A2 (en) 2018-01-17
CA3043100C (en) 2022-03-01
CA3043100A1 (en) 2012-09-13
EP2684022B1 (en) 2017-09-27
DK3270141T3 (da) 2020-08-24
PT3270141T (pt) 2020-08-28
US20130344496A1 (en) 2013-12-26
JP2014507669A (ja) 2014-03-27
CN103403521B (zh) 2016-08-10
EP2684022A4 (en) 2014-08-20
CA2827614A1 (en) 2012-09-13

Similar Documents

Publication Publication Date Title
HRP20201303T1 (hr) Fluidni centripetalni uređaj
JP2015092182A5 (hr)
US10583433B2 (en) Nucleic acid amplification disk apparatus using temperature sensitive polymer synthesis and the analysis method using the same
CN106660040B (zh) 用于处理和分析生物样品的可旋转盒
US10307757B2 (en) Rotatable cartridge with a metering chamber for analyzing a biological sample
US10016758B2 (en) Rotatable cartridge for analyzing a biological sample
KR101963721B1 (ko) 샘플 처리 장치 상의 밸빙을 위한 시스템 및 방법
CN101817495A (zh) 微流控芯片及其制备方法和应用
US8931331B2 (en) Systems and methods for volumetric metering on a sample processing device
CN105738638A (zh) 用于分析仪的保温壳
CN206193012U (zh) 用于分析仪的保温壳
CN205720261U (zh) 用于分析仪的液体加热传输装置
CN205749536U (zh) 分析仪
KR102424845B1 (ko) 미세 유동 장치