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HRP20150987T1 - UPORABA sGC STIMULATORA, sGC AKTIVATORA, SAMOSTALNO I U KOMBINACIJAMA S INHIBITORIMA PDE5 ZA LIJEÄŚENJE SISTEMSKE SKLEROZE (SSc) - Google Patents

UPORABA sGC STIMULATORA, sGC AKTIVATORA, SAMOSTALNO I U KOMBINACIJAMA S INHIBITORIMA PDE5 ZA LIJEÄŚENJE SISTEMSKE SKLEROZE (SSc) Download PDF

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Publication number
HRP20150987T1
HRP20150987T1 HRP20150987TT HRP20150987T HRP20150987T1 HR P20150987 T1 HRP20150987 T1 HR P20150987T1 HR P20150987T T HRP20150987T T HR P20150987TT HR P20150987 T HRP20150987 T HR P20150987T HR P20150987 T1 HRP20150987 T1 HR P20150987T1
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Croatia
Prior art keywords
systemic sclerosis
image
treatment
ssc
prevention
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HRP20150987TT
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English (en)
Inventor
Claudia Hirth-Dietrich
Peter Sandner
Johannes-Peter Stasch
Andreas Knorr
Georges Von Degenfeld
Michael Hahn
Markus Follmann
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Adverio Pharma Gmbh
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Priority claimed from DE102010021637A external-priority patent/DE102010021637A1/de
Application filed by Adverio Pharma Gmbh filed Critical Adverio Pharma Gmbh
Publication of HRP20150987T1 publication Critical patent/HRP20150987T1/hr

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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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Claims (18)

1. Spojevi prema formulama (1) do (27) [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] naznačeni time da su za uporabu za prevenciju i/ili liječenje sistemske skleroze (SSc).
2. Spojevi prema formulama (1), (2), (3), (4), (5), (6), (7) i (27) naznačeni time da su za uporabu za prevenciju i/ili liječenje sistemske skleroze (SSc).
3. Spoj prema formuli (3) naznačen time da je za uporabu za prevenciju i/ili liječenje sistemske skleroze.
4. Najmanje jedan spoj prema zahtjevu 1 do 3 naznačen time da je u kombinaciji s barem jednim inhibitorom PDE5 odabranim iz skupine koja sadrži: Tadalafil ((6R,12aR)-2,3,6,7,12,12a-Heksahidro-2-metil-6-(3,4-metilen - dioksifenil)pirazino(1',2':1,6)pirido(3,4-b)indol-1,4-dion), Vardenafil (2-(2-Etoksi-5-(4-etilpiperazin-1-il-1-sulfonil)fenil)-5-metil-7-propil-3H-imidazo (5,1-f) (1,2,4)triazin-4-on), Sildenafil (3-[2-etoksi-5-(4-metilpiperazin-1-il)sulfonil-fenil]-7- metil- 9-propil-2,4,7,8-tetrazabiciklo [4.3.0]nona -3,8,10-trien-5-on), Udenafil 5-[2-propiloksi-5-(1-metil-2-pirolidiniletilamidosulfonil)fenil]-metil-3-propil-1,6-dihidro-7H-pirazolo(4,3-d)pirimidin-7-on, Dasantafil 7-(3-Bromo-4-metoksibenzil)-1-etil-8-[[(1,2)-2-hidroksiciklopentil]amino]-3-(2-hidroksietil)-3,7-dihidro-1-purin-2,6-dion, Avanafil 4-{[(3-kloro-4-metoksifenil)metil]amino}-2-[(2S)-2-(hidroksimetil)pirolidin-1-il]-N-(pirimidin-2-ilmetil)pirimidin-5-karboksamid, Mirodenafil, Lodenafil, UK 369.003, UK 371.800, SLx 2101 od tvrtke Surface Logix, LAS 34179 Triazolo[1,2-]ksantin,6-metil-4-propil-2-[2-propoksi-5-(4-metilpiperazino)sulfonil]fenil ili soli, hidrati ili hidrati soli naznačen time da je za uporabu za prevenciju i/ili liječenje sistemske skleroze (SSc).
5. Najmanje jedan spoj prema zahtjevu 1 do 3 u kombinaciji sa sildenafilom ili vardenafilom naznačen time da je za uporabu za prevenciju i/ili liječenje sistemske skleroze (SSc).
6. Spojevi prema zahtjevu 1 do 5 su za uporabu za prevenciju i/ili liječenje sistemske skleroze (SSc), difuzne sistemske skleroze (dSSc), ograničene sistemske skleroze (lSSc), preklapajućeg tipa sistemske skleroze, nediferenciranog tipa sistemske skleroze, sistemske skleroze bez sklerodermije, fibroze kože, sklerodermije, nefrogene fibrozne dermopatije (NFD), nefrogene sistemske fibroze (NSF), stvaranja keloida.
7. Spojevi prema zahtjevu 1 do 5 naznačeni time da su za uporabu za prevenciju i/ili liječenje sistemske skleroze SSc uz popratnu fibrozu unutrašnjih organa, koji obuhvaćaju crijeva, pluća, bubrege i krvne žile.
8. Spojevi prema formulama (3), (4), (6), i/ili (7) naznačeni time da su za uporabu za prevenciju i/ili liječenje sistemske skleroze SSc.
9. Najmanje jedan spoj prema formulama (3), (4), (6) i/ili (7) u kombinaciji s vardenafilom ili sildenafilom naznačen time da je za uporabu za prevenciju i/ili liječenje sistemske skleroze SSc.
10. Uporaba spoja prema zahtjevima 1-9 naznačena time da je za proizvodnju lijeka za prevenciju i/ili liječenje sistemske skleroze (SSc) koji sadrži učinkovitu količinu spoja prema zahtjevima 1 do 9.
11. Uporaba spoja prema zahtjevima 1-9 naznačena time da je za proizvodnju lijeka za prevenciju i/ili liječenje sistemske skleroze (SSc), difuzne sistemske skleroze (dSSc), ograničene sistemske skleroze (lSSc), preklapajućeg tipa sistemske skleroze, nediferenciranog tipa sistemske skleroze, sistemske skleroze bez sklerodermije, fibroze kože, sklerodermije, nefrogene fibrozne dermopatije (NFD), stvaranja keloida, koji sadrži učinkovitu količinu spoja prema zahtjevima 1 do 9.
12. Uporaba spoja prema zahtjevima 1-9 naznačena time da je za proizvodnju lijeka za prevenciju i/ili liječenje sistemske skleroze SSc uz popratnu fibrozu unutrašnjih organa, koji obuhvaćaju crijeva, pluća, bubrege i krvne žile koji sadrži učinkovitu količinu spoja prema zahtjevima 1 do 9.
13. Farmaceutska formulacija koja sadrži barem jedan spoj ili jednu kombinaciju prema zahtjevima 1 do 9 naznačena time da je za uporabu za prevenciju i/ili liječenje sistemske skleroze (SSc).
14. Farmaceutska formulacija koja sadrži barem jedan spoj ili jednu kombinaciju prema zahtjevima 1 do 9 naznačena time da je za uporabu za prevenciju i/ili liječenje sistemske skleroze (SSc), difuzne sistemske skleroze (dSSc), ograničene sistemske skleroze (lSSc), preklapajućeg tipa sistemske skleroze, nediferenciranog tipa sistemske skleroze, sistemske skleroze bez sklerodermije, fibroze kože, sklerodermije, nefrogene fibrozne dermopatije (NFD), stvaranja keloida.
15. Farmaceutska formulacija koja sadrži barem jedan spoj ili jednu kombinaciju prema zahtjevima 1 do 9 naznačena time da je za uporabu za prevenciju i/ili liječenje sistemske skleroze SSc uz popratnu fibrozu unutrašnjih organa, koji obuhvaćaju crijeva, pluća, bubrege i krvne žile.
16. Komplet koji sadrži najmanje jedan stimulator i/ili aktivator sGC prema zahtjevima od 1 do 3 ili kombinacija prema zahtjevima od 4 do 5 naznačen time da je za uporabu za prevenciju i/ili liječenje sistemske skleroze (SSc).
17. Komplet prema zahtjevu 16 naznačen time da je za uporabu za prevenciju i/ili liječenje sistemske skleroze (SSc), difuzne sistemske skleroze (dSSc), ograničene sistemske skleroze (lSSc), preklapajućeg tipa sistemske skleroze, nediferenciranog tipa sistemske skleroze, sistemske skleroze bez sklerodermije, fibroze kože, sklerodermije, nefrogene fibrozne dermopatije (NFD), stvaranja keloida.
18. Komplet prema zahtjevima 16 i 17 naznačen time da je za uporabu za prevenciju i/ili liječenje sistemske skleroze SSc uz popratnu fibrozu unutrašnjih organa, koji obuhvaćaju crijeva, pluća, bubrege i krvne žile.
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