CN103038232A - 单独的和与PDE5抑制剂相组合的sGC刺激剂、sGC活化剂用于治疗系统性硬化症(SSc)的用途 - Google Patents
单独的和与PDE5抑制剂相组合的sGC刺激剂、sGC活化剂用于治疗系统性硬化症(SSc)的用途 Download PDFInfo
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Abstract
Description
a)博来霉素 + 媒介物 | b)博来霉素 + 1 mg/kg实施例27 | c)博来霉素 + 3mg/kg实施例27 | ||
真皮厚度 | 1.70 | 1.37 | 1.19 | |
胶原含量 | 1.31 | 1.19 | 1.11 | |
肌成纤维细胞计数 | 3.72 | 3.23 | 1.90 |
a)博来霉素 + 媒介物 | b)博来霉素 + 1.0 mg/kg 实施例3 | c)博来霉素 + 0.3 mg/kg 实施例6 | d)博来霉素 + 1 mg/kg 实施例6 | e)博来霉素 + 3 mg/kg 实施例6 | |
真皮厚度 | 1.71 | 1.38 | 1.41 | 1.24 | 1.19 |
胶原含量 | 1.56 | 1.38 | 1.41 | 1.28 | 1.20 |
肌成纤维细胞计数 | 3.86 | 2.55 | 3.13 | 2.05 | 1.49 |
b)博来霉素 6周 | c)博来霉素6周 + 3周实施例27 | d)博来霉素3周 + 3周NaCl | ||
真皮厚度 | 1.57 | 1.26 | 1.40 | |
肌成纤维细胞计数 | 3.87 | 1.68 | 3.50 |
Tsk-1 + 媒介物 | Tsk-1 + 1 mg/kg实施例27 | Tsk-1 + 3mg/kg实施例27 | ||
真皮厚度 | 5.03 | 3.46 | 2.88 | |
胶原含量 | 2.46 | 1.61 | 1.67 | |
肌成纤维细胞计数 | 2.64 | 2.12 | 1.70 |
Claims (17)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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DE102010021637.2 | 2010-05-26 | ||
DE102010021637A DE102010021637A1 (de) | 2010-05-26 | 2010-05-26 | Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung |
EP10170413 | 2010-07-22 | ||
EP10170413.8 | 2010-07-22 | ||
PCT/EP2011/058433 WO2011147810A1 (en) | 2010-05-26 | 2011-05-24 | THE USE OF sGC STIMULATORS, sGC ACTIVATORS, ALONE AND COMBINATIONS WITH PDE5 INHIBITORS FOR THE TREATMENT OF SYSTEMIC SCLEROSIS (SSc). |
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CN103038232A true CN103038232A (zh) | 2013-04-10 |
CN103038232B CN103038232B (zh) | 2016-01-20 |
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US (1) | US10189856B2 (zh) |
EP (1) | EP2576548B1 (zh) |
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CN (1) | CN103038232B (zh) |
AU (1) | AU2011257336B2 (zh) |
CA (2) | CA2800709C (zh) |
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CR (1) | CR20120597A (zh) |
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EA (1) | EA030735B9 (zh) |
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HU (1) | HUE025162T2 (zh) |
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ME (1) | ME02207B (zh) |
MX (1) | MX2012013574A (zh) |
MY (1) | MY170094A (zh) |
NZ (1) | NZ603799A (zh) |
PH (1) | PH12012502322A1 (zh) |
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PT (1) | PT2576548E (zh) |
RS (1) | RS54261B1 (zh) |
SG (1) | SG185690A1 (zh) |
SI (1) | SI2576548T1 (zh) |
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
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CN105658621A (zh) * | 2013-10-15 | 2016-06-08 | 东亚荣养株式会社 | 4-氨甲基苯甲酸衍生物 |
CN107580495A (zh) * | 2015-05-06 | 2018-01-12 | 拜耳制药股份公司 | 单独和与PDE5抑制剂组合的sGC刺激剂、sGC活化剂用于治疗伴随系统性硬化症(SSc)的指溃疡(DU)的用途 |
CN108690016A (zh) * | 2017-04-11 | 2018-10-23 | 广东东阳光药业有限公司 | 吡唑并吡啶类化合物及其用途 |
CN111638329A (zh) * | 2020-06-09 | 2020-09-08 | 南方医科大学 | 一种用于检测布鲁氏菌病elispot检测试剂盒及其应用 |
CN115160312A (zh) * | 2022-06-29 | 2022-10-11 | 常州制药厂有限公司 | 一种维立西呱关键中间体及其制备方法 |
CN115697978A (zh) * | 2020-06-16 | 2023-02-03 | 阿德弗里奥药品有限责任公司 | 制备甲基{4,6-二氨基-2-[5-氟-1-(2-氟苄基)-1H-吡唑并[3,4-b]吡啶-3-基]嘧啶-5-基}氨基甲酸酯的方法 |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10189856B2 (en) | 2010-05-26 | 2019-01-29 | Adverio Pharma Gmbh | Use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc) |
DE102010021637A1 (de) * | 2010-05-26 | 2011-12-01 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung |
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