EA200800920A1 - Производные пиразоло[4,3-d]пиримидин-5-ила, применяемые в качестве ингибиторов фосфодиэстеразы 5 (pde5) - Google Patents
Производные пиразоло[4,3-d]пиримидин-5-ила, применяемые в качестве ингибиторов фосфодиэстеразы 5 (pde5)Info
- Publication number
- EA200800920A1 EA200800920A1 EA200800920A EA200800920A EA200800920A1 EA 200800920 A1 EA200800920 A1 EA 200800920A1 EA 200800920 A EA200800920 A EA 200800920A EA 200800920 A EA200800920 A EA 200800920A EA 200800920 A1 EA200800920 A1 EA 200800920A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- pde5
- pyrazolo
- phosphodiesterrase
- ila
- pyrimidine
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 102000011016 Type 5 Cyclic Nucleotide Phosphodiesterases Human genes 0.000 abstract 2
- 108010037581 Type 5 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- IQZQWPRZFLHJFI-UHFFFAOYSA-N 1-[1-(2-ethoxyethyl)-3-ethyl-7-[(4-methylpyridin-2-yl)amino]pyrazolo[4,3-d]pyrimidin-5-yl]piperidine-4-carboxylic acid Chemical compound C=12N(CCOCC)N=C(CC)C2=NC(N2CCC(CC2)C(O)=O)=NC=1NC1=CC(C)=CC=N1 IQZQWPRZFLHJFI-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000010189 synthetic method Methods 0.000 abstract 1
Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract
Настоящее изобретение включает (I) 1-(1-(2-этоксиэтил)-3-этил-7-(4-метилпиридин-2-иламино)-1Н-пиразоло[4,3-d]пиримидин-5-ил)пиперидин-4-карбоновую кислоту и ее соли. Изобретение также включает фармацевтические композиции, способы лечения и способы синтеза, относящиеся к соединениям формулы (I). Соединения формулы (I) применяют для ингибирования фермента фосфодиэстеразы 5 (PDE5).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73532005P | 2005-11-10 | 2005-11-10 | |
| PCT/IB2006/003132 WO2007054778A1 (en) | 2005-11-10 | 2006-10-31 | Pyrazolo[4,3-d]pyrimidin-5-yl)derivative used as pde5 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA200800920A1 true EA200800920A1 (ru) | 2008-10-30 |
Family
ID=37685872
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200800920A EA200800920A1 (ru) | 2005-11-10 | 2006-10-31 | Производные пиразоло[4,3-d]пиримидин-5-ила, применяемые в качестве ингибиторов фосфодиэстеразы 5 (pde5) |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US20090156618A1 (ru) |
| EP (1) | EP1948661B1 (ru) |
| JP (1) | JP4208959B1 (ru) |
| KR (1) | KR101012592B1 (ru) |
| CN (1) | CN101305007B (ru) |
| AP (1) | AP2008004437A0 (ru) |
| AR (1) | AR057885A1 (ru) |
| AT (1) | ATE435865T1 (ru) |
| AU (1) | AU2006313486B2 (ru) |
| BR (1) | BRPI0618284A2 (ru) |
| CA (1) | CA2629339C (ru) |
| CR (1) | CR9966A (ru) |
| DE (1) | DE602006007728D1 (ru) |
| DK (1) | DK1948661T3 (ru) |
| DO (1) | DOP2006000248A (ru) |
| EA (1) | EA200800920A1 (ru) |
| EC (1) | ECSP088441A (ru) |
| ES (1) | ES2326919T3 (ru) |
| IL (1) | IL190456A (ru) |
| MA (1) | MA29943B1 (ru) |
| NL (1) | NL2000291C2 (ru) |
| NO (1) | NO20082593L (ru) |
| PE (1) | PE20070764A1 (ru) |
| RS (1) | RS20080197A (ru) |
| TN (1) | TNSN08209A1 (ru) |
| TW (1) | TW200738723A (ru) |
| UY (1) | UY29909A1 (ru) |
| WO (1) | WO2007054778A1 (ru) |
| ZA (1) | ZA200803173B (ru) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2011001259A (es) * | 2008-08-01 | 2011-03-15 | Biocryst Pharm Inc | Derivados de piperidina como inhibidores jak3. |
| WO2010043633A1 (en) * | 2008-10-15 | 2010-04-22 | Palau Pharma, S. A. | 2h-pyrazolo [4,3-d]pyrimidin-5-amine derivatives as h4 histamine receptor antagonists for the treatment of allergic, immunological and inflammatory diseases |
| KR101377178B1 (ko) * | 2010-04-05 | 2014-03-26 | 에스케이케미칼주식회사 | Ｐｄｅ5 억제제를 함유하는 피부 주름 개선용 조성물 |
| US20140072557A1 (en) * | 2011-02-28 | 2014-03-13 | National Cerebral And Cardiovascular Center | Medicinal agent for suppressing malignant tumor metastasis |
| PE20140928A1 (es) | 2011-04-21 | 2014-08-24 | Origenis Gmbh | Pirazolo[4,3-d]pirimidinas utiles como inhibidores de cinasas |
| US9637491B2 (en) | 2012-10-19 | 2017-05-02 | Origenis Gmbh | Pyrazolo[4,3-D]pyrimidines as kinase inhibitors |
| MX2015005004A (es) * | 2012-10-23 | 2015-07-17 | Pfizer | Uso de un compuesto de pirazolo[4,3-d]pirimidina tetrasubstituida para tratar la nefropatia diabetica. |
| WO2016025100A2 (en) | 2014-08-12 | 2016-02-18 | Mezzion Pharma Co., Ltd. | Methods of improving myocardial performance in fontan patients using udenafil compositions |
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| IL127873A0 (en) | 1996-07-08 | 1999-10-28 | Du Pont Pharm Co | Amidinoindoles amidinoazoles and analogs thereof as inhibitors of factor xa and of thrombin |
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| GB9822238D0 (en) * | 1998-10-12 | 1998-12-09 | Pfizer Ltd | Process for preparation of pyrazolo[4,3-D]pyrimidin-7-ones and intermediates thereof |
| AU5995699A (en) | 1998-10-23 | 2000-05-15 | Bunnage, Mark Edward | Pyrazolopyrimidinone cgmp pde5 inhibitors for the treatment of sexual dysfunction |
| DE19942474A1 (de) | 1999-09-06 | 2001-03-15 | Merck Patent Gmbh | Pyrazolo[4,3-d]pyrimidine |
| TWI306859B (en) | 2000-04-28 | 2009-03-01 | Acadia Pharm Inc | Muscarinic agonists |
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| BRPI0409903A (pt) * | 2003-04-29 | 2006-04-25 | Pfizer Ltd | 5,7-diamino-pirazol[4,3-d]pirimidina úteis no tratamento de hipertensão |
| EA012279B1 (ru) | 2003-05-22 | 2009-08-28 | Никомед Гмбх | Композиция, включающая ингибитор pde4 и ингибитор pde5 |
| CA2545340A1 (en) | 2003-11-10 | 2005-05-26 | Synta Pharmaceuticals, Corp. | Fused heterocyclic compounds |
| GB0327323D0 (en) * | 2003-11-24 | 2003-12-31 | Pfizer Ltd | Novel pharmaceuticals |
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| US7569572B2 (en) * | 2004-04-07 | 2009-08-04 | Pfizer Inc | Pyrazolo[4,3-D]pyrimidines |
| AU2005270068B2 (en) | 2004-07-02 | 2012-04-19 | Exelixis, Inc. | C-Met modulators and method of use |
| EP1809632A2 (en) * | 2004-10-28 | 2007-07-25 | Pharmacia & Upjohn Company LLC | Pyrazolo[4,3-d]pyrimidine derivatives useful as pde-5 inhibitors |
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