HRP20080618T3 - Methods for making 3-o-protected morphinones and 3-o-protected morphinone dienol carboxylates - Google Patents

Methods for making 3-o-protected morphinones and 3-o-protected morphinone dienol carboxylates

Info

Publication number: HRP20080618T3
Authority: HR; Croatia
Prior art keywords: protected; making; methods; morphinones; morphinone dienol
Prior art date: 2004-02-06

Application number

HR20080618T

Other languages

English (en)

Croatian (hr)

Inventor

Stumpf Andreas

Original Assignee

Euro-Celtique S.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-02-06

Filing date

2008-11-26

Publication date

2009-01-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34860329&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20080618(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-11-26 Application filed by Euro-Celtique S.A. filed Critical Euro-Celtique S.A.

2009-01-31 Publication of HRP20080618T3 publication Critical patent/HRP20080618T3/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pain & Pain Management (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Catalysts (AREA)
Saccharide Compounds (AREA)
Steroid Compounds (AREA)

HR20080618T 2004-02-06 2008-11-26 Methods for making 3-o-protected morphinones and 3-o-protected morphinone dienol carboxylates HRP20080618T3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US54271104P	2004-02-06	2004-02-06
PCT/US2005/003390 WO2005077957A2 (en)	2004-02-06	2005-02-04	Methods for making 3-o-protected morphinones and 3-o-protected morphinone dienol carboxylates

Publications (1)

Publication Number	Publication Date
HRP20080618T3 true HRP20080618T3 (en)	2009-01-31

Family

ID=34860329

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
HR20080618T HRP20080618T3 (en)	2004-02-06	2008-11-26	Methods for making 3-o-protected morphinones and 3-o-protected morphinone dienol carboxylates
HR20100123T HRP20100123T1 (hr)	2004-02-06	2010-03-05	Postupci za pripravljanje 3-o-zaštićenih morfinona i 3-o-zaštićenih morfinon dienol karboksilata

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
HR20100123T HRP20100123T1 (hr)	2004-02-06	2010-03-05	Postupci za pripravljanje 3-o-zaštićenih morfinona i 3-o-zaštićenih morfinon dienol karboksilata

Country Status (34)

Country	Link
US (6)	US8003793B2 (no)
EP (3)	EP1864987B1 (no)
JP (1)	JP4963968B2 (no)
KR (4)	KR100921695B1 (no)
CN (1)	CN1918168B (no)
AP (1)	AP2006003716A0 (no)
AT (2)	ATE451374T1 (no)
AU (1)	AU2005212258B2 (no)
BR (1)	BRPI0506607B8 (no)
CA (2)	CA2555215C (no)
CR (1)	CR8590A (no)
CY (2)	CY1108506T1 (no)
DE (2)	DE602005018265D1 (no)
DK (2)	DK1711502T3 (no)
EA (2)	EA016062B1 (no)
EC (1)	ECSP066824A (no)
ES (2)	ES2313299T3 (no)
GE (1)	GEP20084454B (no)
HK (2)	HK1103071A1 (no)
HR (2)	HRP20080618T3 (no)
IL (2)	IL177281A (no)
MA (1)	MA28346A1 (no)
MX (1)	MXPA06008931A (no)
NO (2)	NO20063989L (no)
NZ (2)	NZ565355A (no)
PL (2)	PL1711502T3 (no)
PT (2)	PT1711502E (no)
RS (2)	RS50663B (no)
SG (1)	SG150500A1 (no)
SI (2)	SI1864987T1 (no)
TN (1)	TNSN06248A1 (no)
UA (2)	UA88646C2 (no)
WO (1)	WO2005077957A2 (no)
ZA (1)	ZA200606252B (no)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2005077957A2 (en)	2004-02-06	2005-08-25	Euro-Celtique S.A.	Methods for making 3-o-protected morphinones and 3-o-protected morphinone dienol carboxylates
JP2010504325A (ja) *	2006-09-20	2010-02-12	マリンクロットインコーポレイテッド	置換モルフィナン−６−オン、並びにその塩および中間体の調製
CN101781303A (zh) *	2007-03-06	2010-07-21	马林克罗特公司	季n-烷基吗啡喃生物碱盐的制备方法
US9040726B2 (en) *	2007-03-06	2015-05-26	Mallinckrodt Llc	Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
PL2896614T3 (pl)	2008-05-27	2018-02-28	Mallinckrodt Llc	Sposoby i związki do wytwarzania normorfinanów
WO2010028004A2 (en)	2008-09-03	2010-03-11	Mallinckrodt Inc.	Substituted berbines and processes for their synthesis
BR112012028656A2 (pt)	2010-05-10	2016-08-09	Euro Celtique Sa	combinação de grânulos carregados ativos com ativos adicionais
SE1251371A1 (sv)	2010-05-10	2012-12-27	Euro Celtique Sa	Farmaceutiska kompositioner innefattande hydromorfon och naloxon
EP2568968B1 (en)	2010-05-10	2017-07-12	Euro-Celtique S.A.	Manufacturing of active-free granules and tablets comprising the same
US9814710B2 (en)	2013-11-13	2017-11-14	Euro-Celtique S.A.	Hydromorphone and naloxone for treatment of pain and opioid bowel dysfunction syndrome
JP6888550B2 (ja) *	2015-09-30	2021-06-16	富士フイルム和光純薬株式会社	有機化合物の製造方法

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US2654756A (en)	1949-10-20	1953-10-06	Mallinckrodt Chemical Works	Process of preparing codeinone, dihydrocodeinone, and dihydromorphinone
DE902257C (de)	1951-07-17	1954-01-21	Knoll Ag	Verfahren zur Herstellung von Acylderivaten der Enolform des Codeinons
GB1495271A (en) *	1974-04-10	1977-12-14	Macfarlan Smith Ltd	Dehydrohalogenation of codeinone derivatives
US4472253A (en)	1981-08-17	1984-09-18	The Florida Board Of Regents On Behalf Of The Florida State University	Process for the preparation of an N-substituted 3-O-alkyl-14-hydroxynormorphinone derivative
US5112975A (en)	1984-03-27	1992-05-12	Mallinckrodt Specialty Chemicals Company	Preparation of noroxymorphone from morphine
SE9003665D0 (sv)	1990-11-16	1990-11-16	Kabivitrum Ab	Morphine prodrugs
GB9116909D0 (en)	1991-08-06	1991-09-18	Salford Ultrafine Chem & Res	Morphine derivatives
US5821374A (en)	1995-11-21	1998-10-13	Hoffmann-La Roche Inc.	Process for the oxidation of alcohols
US5869669A (en)	1996-07-26	1999-02-09	Penick Corporation	Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
GB9713703D0 (en) *	1997-06-30	1997-09-03	Johnson Matthey Plc	Preparation of opiates
US6177567B1 (en) *	1999-10-15	2001-01-23	Boehringer Ingelheim Chemicals, Inc.	Method for preparing oxycodone
US6596877B2 (en)	2001-10-17	2003-07-22	Novartis Ag	Accelerated process for preparing O-methyl phenols, N-methyl heteroaromatic compounds, and methylated aminophenols
WO2005077957A2 (en)	2004-02-06	2005-08-25	Euro-Celtique S.A.	Methods for making 3-o-protected morphinones and 3-o-protected morphinone dienol carboxylates

2005
- 2005-02-04 WO PCT/US2005/003390 patent/WO2005077957A2/en active Application Filing
- 2005-02-04 RS RSP-2008/0553A patent/RS50663B/sr unknown
- 2005-02-04 EP EP07014411A patent/EP1864987B1/en not_active Expired - Lifetime
- 2005-02-04 SI SI200530925T patent/SI1864987T1/sl unknown
- 2005-02-04 CA CA2555215A patent/CA2555215C/en not_active Expired - Lifetime
- 2005-02-04 AT AT07014411T patent/ATE451374T1/de active
- 2005-02-04 AU AU2005212258A patent/AU2005212258B2/en not_active Expired
- 2005-02-04 EA EA200801811A patent/EA016062B1/ru not_active IP Right Cessation
- 2005-02-04 GE GEAP20059608A patent/GEP20084454B/en unknown
- 2005-02-04 NZ NZ565355A patent/NZ565355A/en unknown
- 2005-02-04 PL PL05712726T patent/PL1711502T3/pl unknown
- 2005-02-04 KR KR1020077025206A patent/KR100921695B1/ko active IP Right Grant
- 2005-02-04 CA CA2808199A patent/CA2808199C/en not_active Expired - Lifetime
- 2005-02-04 PL PL07014411T patent/PL1864987T3/pl unknown
- 2005-02-04 AT AT05712726T patent/ATE406372T1/de active
- 2005-02-04 EA EA200601394A patent/EA012905B1/ru not_active IP Right Cessation
- 2005-02-04 PT PT05712726T patent/PT1711502E/pt unknown
- 2005-02-04 EP EP05712726A patent/EP1711502B1/en not_active Expired - Lifetime
- 2005-02-04 DK DK05712726T patent/DK1711502T3/da active
- 2005-02-04 RS RSP-2010/0064A patent/RS51317B/sr unknown
- 2005-02-04 ES ES05712726T patent/ES2313299T3/es not_active Expired - Lifetime
- 2005-02-04 SI SI200530468T patent/SI1711502T1/sl unknown
- 2005-02-04 SG SG200900838-4A patent/SG150500A1/en unknown
- 2005-02-04 DE DE602005018265T patent/DE602005018265D1/de not_active Expired - Lifetime
- 2005-02-04 DE DE602005009321T patent/DE602005009321D1/de not_active Expired - Lifetime
- 2005-02-04 BR BRPI0506607A patent/BRPI0506607B8/pt active IP Right Grant
- 2005-02-04 DK DK07014411.8T patent/DK1864987T3/da active
- 2005-02-04 KR KR1020077025207A patent/KR20070108956A/ko not_active Application Discontinuation
- 2005-02-04 CN CN2005800040830A patent/CN1918168B/zh not_active Expired - Lifetime
- 2005-02-04 NZ NZ548786A patent/NZ548786A/en unknown
- 2005-02-04 JP JP2006552236A patent/JP4963968B2/ja not_active Expired - Lifetime
- 2005-02-04 UA UAA200704105A patent/UA88646C2/uk unknown
- 2005-02-04 ES ES07014411T patent/ES2338054T3/es not_active Expired - Lifetime
- 2005-02-04 EP EP09015220A patent/EP2194059A3/en not_active Withdrawn
- 2005-02-04 KR KR1020097016500A patent/KR101011460B1/ko active IP Right Grant
- 2005-02-04 PT PT07014411T patent/PT1864987E/pt unknown
- 2005-02-04 MX MXPA06008931A patent/MXPA06008931A/es active IP Right Grant
- 2005-02-04 US US10/588,637 patent/US8003793B2/en active Active
- 2005-02-04 AP AP2006003716A patent/AP2006003716A0/xx unknown
- 2005-04-02 UA UAA200609622A patent/UA87833C2/uk unknown
2006
- 2006-07-28 ZA ZA200606252A patent/ZA200606252B/en unknown
- 2006-08-03 IL IL177281A patent/IL177281A/en active IP Right Grant
- 2006-08-04 MA MA29240A patent/MA28346A1/fr unknown
- 2006-08-04 TN TNP2006000248A patent/TNSN06248A1/fr unknown
- 2006-09-01 CR CR8590A patent/CR8590A/es unknown
- 2006-09-05 EC EC2006006824A patent/ECSP066824A/es unknown
- 2006-09-05 KR KR1020067018113A patent/KR100921696B1/ko active IP Right Grant
- 2006-09-06 NO NO20063989A patent/NO20063989L/no not_active Application Discontinuation
2007
- 2007-04-18 HK HK07104100.2A patent/HK1103071A1/xx not_active IP Right Cessation
- 2007-04-18 HK HK08106459.3A patent/HK1119160A1/xx not_active IP Right Cessation
2008
- 2008-11-12 CY CY20081101295T patent/CY1108506T1/el unknown
- 2008-11-26 HR HR20080618T patent/HRP20080618T3/xx unknown
2010
- 2010-02-25 CY CY20101100178T patent/CY1109838T1/el unknown
- 2010-03-05 HR HR20100123T patent/HRP20100123T1/hr unknown
- 2010-05-06 IL IL205596A patent/IL205596A/en active IP Right Grant
2011
- 2011-07-22 US US13/189,228 patent/US8198444B2/en not_active Expired - Lifetime
2012
- 2012-05-15 US US13/472,227 patent/US8685996B2/en not_active Expired - Lifetime
2014
- 2014-02-24 US US14/188,430 patent/US8975257B2/en not_active Expired - Lifetime
2015
- 2015-03-02 NO NO20150276A patent/NO339083B1/no unknown
- 2015-03-03 US US14/637,129 patent/US9670218B2/en not_active Expired - Fee Related
2017
- 2017-05-04 US US15/587,118 patent/US20170233400A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EA200601394A1 (ru)	2006-12-29
TNSN06248A1 (fr)	2007-12-03
NZ565355A (en)	2008-09-26
AU2005212258A1 (en)	2005-08-25
MA28346A1 (fr)	2006-12-01
CA2555215A1 (en)	2005-08-25
US20120225902A1 (en)	2012-09-06
BRPI0506607B1 (pt)	2018-01-16
US20140171643A1 (en)	2014-06-19
JP2007520563A (ja)	2007-07-26
BRPI0506607B8 (pt)	2021-05-25
AP2006003716A0 (en)	2006-08-31
IL205596A (en)	2011-11-30
EP2194059A3 (en)	2010-09-22
ES2338054T3 (es)	2010-05-03
ECSP066824A (es)	2006-12-29
KR100921696B1 (ko)	2009-10-15
EA016062B1 (ru)	2012-01-30
KR20070026401A (ko)	2007-03-08
CA2808199C (en)	2015-10-27
PL1864987T3 (pl)	2010-05-31
EP2194059A2 (en)	2010-06-09
GEP20084454B (en)	2008-08-10
EP1864987A3 (en)	2008-02-20
MXPA06008931A (es)	2007-01-26
EA200801811A1 (ru)	2008-12-30
ATE451374T1 (de)	2009-12-15
IL177281A (en)	2012-02-29
NO20063989L (no)	2006-10-31
CA2808199A1 (en)	2005-08-25
ES2313299T3 (es)	2009-03-01
US9670218B2 (en)	2017-06-06
US20170233400A1 (en)	2017-08-17
SG150500A1 (en)	2009-03-30
RS50663B (sr)	2010-06-30
HK1119160A1 (en)	2009-02-27
ZA200606252B (en)	2007-11-28
CR8590A (es)	2007-07-19
EP1711502B1 (en)	2008-08-27
CY1109838T1 (el)	2014-09-10
NZ548786A (en)	2008-08-29
DE602005018265D1 (de)	2010-01-21
CA2555215C (en)	2013-05-21
US8198444B2 (en)	2012-06-12
EP1711502A2 (en)	2006-10-18
HRP20100123T1 (hr)	2010-04-30
US8975257B2 (en)	2015-03-10
IL177281A0 (en)	2006-12-10
US8003793B2 (en)	2011-08-23
DK1711502T3 (da)	2008-12-01
KR20070117701A (ko)	2007-12-12
ATE406372T1 (de)	2008-09-15
US20150239898A1 (en)	2015-08-27
US20120022259A1 (en)	2012-01-26
PL1711502T3 (pl)	2009-02-27
PT1864987E (pt)	2010-03-09
KR100921695B1 (ko)	2009-10-15
UA88646C2 (uk)	2009-11-10
KR20090089486A (ko)	2009-08-21
US8685996B2 (en)	2014-04-01
PT1711502E (pt)	2008-11-20
CN1918168A (zh)	2007-02-21
EP1864987A2 (en)	2007-12-12
AU2005212258B2 (en)	2008-05-22
US20080146804A1 (en)	2008-06-19
CY1108506T1 (el)	2014-04-09
WO2005077957A2 (en)	2005-08-25
EA012905B1 (ru)	2010-02-26
KR20070108956A (ko)	2007-11-13
NO20150276L (no)	2006-10-31
KR101011460B1 (ko)	2011-01-28
UA87833C2 (uk)	2009-08-25
WO2005077957A3 (en)	2006-05-04
DK1864987T3 (da)	2010-04-12
SI1864987T1 (sl)	2010-04-30
RS51317B (sr)	2010-12-31
DE602005009321D1 (de)	2008-10-09
HK1103071A1 (en)	2007-12-14
CN1918168B (zh)	2011-04-27
JP4963968B2 (ja)	2012-06-27
SI1711502T1 (sl)	2009-02-28
BRPI0506607A (pt)	2007-05-02
EP1864987B1 (en)	2009-12-09
NO339083B1 (no)	2016-11-14

Publication	Publication Date	Title
HRP20080618T3 (en)	2009-01-31	Methods for making 3-o-protected morphinones and 3-o-protected morphinone dienol carboxylates
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