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CY1109838T1 - Μεθοδος δια παρασκευη 3-ο-προστατευμενων μορφινονων και καρβοξυλικων αλατων διενολης 3-ο-προστατευμενης μορφινονης - Google Patents

Μεθοδος δια παρασκευη 3-ο-προστατευμενων μορφινονων και καρβοξυλικων αλατων διενολης 3-ο-προστατευμενης μορφινονης

Info

Publication number
CY1109838T1
CY1109838T1 CY20101100178T CY101100178T CY1109838T1 CY 1109838 T1 CY1109838 T1 CY 1109838T1 CY 20101100178 T CY20101100178 T CY 20101100178T CY 101100178 T CY101100178 T CY 101100178T CY 1109838 T1 CY1109838 T1 CY 1109838T1
Authority
CY
Cyprus
Prior art keywords
preparation
protected morphinones
morphinones
protected
diavol
Prior art date
Application number
CY20101100178T
Other languages
English (en)
Inventor
Andreas Stumpf
Original Assignee
Euro-Celtique S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34860329&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1109838(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Euro-Celtique S.A. filed Critical Euro-Celtique S.A.
Publication of CY1109838T1 publication Critical patent/CY1109838T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Η παρούσα εφεύρεση σχετίζεται με μια μέθοδο για παρασκευή μιας ένωσης του τύπου (II):
CY20101100178T 2004-02-06 2010-02-25 Μεθοδος δια παρασκευη 3-ο-προστατευμενων μορφινονων και καρβοξυλικων αλατων διενολης 3-ο-προστατευμενης μορφινονης CY1109838T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54271104P 2004-02-06 2004-02-06
EP07014411A EP1864987B1 (en) 2004-02-06 2005-02-04 Methods for making 3-O protected morphinones and 3-O-protected morphinone dienol carboxylates

Publications (1)

Publication Number Publication Date
CY1109838T1 true CY1109838T1 (el) 2014-09-10

Family

ID=34860329

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20081101295T CY1108506T1 (el) 2004-02-06 2008-11-12 Μεθοδος δια thn παρασκευην 3-ο-προστατευμενων μορφινονων και καρβοξυλικων αλατων διενολης 3-ο-προστατευμενης μορφινονης
CY20101100178T CY1109838T1 (el) 2004-02-06 2010-02-25 Μεθοδος δια παρασκευη 3-ο-προστατευμενων μορφινονων και καρβοξυλικων αλατων διενολης 3-ο-προστατευμενης μορφινονης

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20081101295T CY1108506T1 (el) 2004-02-06 2008-11-12 Μεθοδος δια thn παρασκευην 3-ο-προστατευμενων μορφινονων και καρβοξυλικων αλατων διενολης 3-ο-προστατευμενης μορφινονης

Country Status (34)

Country Link
US (6) US8003793B2 (el)
EP (3) EP1711502B1 (el)
JP (1) JP4963968B2 (el)
KR (4) KR101011460B1 (el)
CN (1) CN1918168B (el)
AP (1) AP2006003716A0 (el)
AT (2) ATE406372T1 (el)
AU (1) AU2005212258B2 (el)
BR (1) BRPI0506607B8 (el)
CA (2) CA2808199C (el)
CR (1) CR8590A (el)
CY (2) CY1108506T1 (el)
DE (2) DE602005009321D1 (el)
DK (2) DK1864987T3 (el)
EA (2) EA012905B1 (el)
EC (1) ECSP066824A (el)
ES (2) ES2338054T3 (el)
GE (1) GEP20084454B (el)
HK (2) HK1103071A1 (el)
HR (2) HRP20080618T3 (el)
IL (2) IL177281A (el)
MA (1) MA28346A1 (el)
MX (1) MXPA06008931A (el)
NO (2) NO20063989L (el)
NZ (2) NZ548786A (el)
PL (2) PL1711502T3 (el)
PT (2) PT1711502E (el)
RS (2) RS50663B (el)
SG (1) SG150500A1 (el)
SI (2) SI1864987T1 (el)
TN (1) TNSN06248A1 (el)
UA (2) UA88646C2 (el)
WO (1) WO2005077957A2 (el)
ZA (1) ZA200606252B (el)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005077957A2 (en) 2004-02-06 2005-08-25 Euro-Celtique S.A. Methods for making 3-o-protected morphinones and 3-o-protected morphinone dienol carboxylates
WO2008036172A1 (en) * 2006-09-20 2008-03-27 Mallinckrodt Inc. Preparation of substituted morphinan-6-ones and salts and intermediates thereof
CA2707757C (en) * 2007-03-06 2017-01-03 Peter X. Wang Process for the preparation of quaternary n-alkyl morphinan alkaloid salts
US9040726B2 (en) 2007-03-06 2015-05-26 Mallinckrodt Llc Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
EP2285780B1 (en) * 2008-05-27 2015-08-26 Mallinckrodt LLC Processes and compounds for the preparation of normorphinans
WO2010028004A2 (en) 2008-09-03 2010-03-11 Mallinckrodt Inc. Substituted berbines and processes for their synthesis
WO2011141490A1 (en) 2010-05-10 2011-11-17 Euro-Celtique S.A. Combination of active loaded granules with additional actives
BR112012028773A2 (pt) 2010-05-10 2016-07-19 Euro Celtique Sa composições farmacêuticas compreendendo hidromorfona e naloxona
EP2568968B1 (en) 2010-05-10 2017-07-12 Euro-Celtique S.A. Manufacturing of active-free granules and tablets comprising the same
CN112716955A (zh) 2013-11-13 2021-04-30 欧洲凯尔特公司 用于治疗疼痛和阿片样物质肠功能障碍综合征的氢吗啡酮和纳洛酮
US10351512B2 (en) 2015-09-30 2019-07-16 Fujifilm Wako Pure Chemical Corporation Method of producing organic compound

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2654756A (en) 1949-10-20 1953-10-06 Mallinckrodt Chemical Works Process of preparing codeinone, dihydrocodeinone, and dihydromorphinone
DE902257C (de) 1951-07-17 1954-01-21 Knoll Ag Verfahren zur Herstellung von Acylderivaten der Enolform des Codeinons
GB1495271A (en) * 1974-04-10 1977-12-14 Macfarlan Smith Ltd Dehydrohalogenation of codeinone derivatives
US4472253A (en) 1981-08-17 1984-09-18 The Florida Board Of Regents On Behalf Of The Florida State University Process for the preparation of an N-substituted 3-O-alkyl-14-hydroxynormorphinone derivative
US5112975A (en) 1984-03-27 1992-05-12 Mallinckrodt Specialty Chemicals Company Preparation of noroxymorphone from morphine
SE9003665D0 (sv) 1990-11-16 1990-11-16 Kabivitrum Ab Morphine prodrugs
GB9116909D0 (en) 1991-08-06 1991-09-18 Salford Ultrafine Chem & Res Morphine derivatives
US5821374A (en) 1995-11-21 1998-10-13 Hoffmann-La Roche Inc. Process for the oxidation of alcohols
US5869669A (en) 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
GB9713703D0 (en) * 1997-06-30 1997-09-03 Johnson Matthey Plc Preparation of opiates
US6177567B1 (en) 1999-10-15 2001-01-23 Boehringer Ingelheim Chemicals, Inc. Method for preparing oxycodone
US6596877B2 (en) 2001-10-17 2003-07-22 Novartis Ag Accelerated process for preparing O-methyl phenols, N-methyl heteroaromatic compounds, and methylated aminophenols
WO2005077957A2 (en) 2004-02-06 2005-08-25 Euro-Celtique S.A. Methods for making 3-o-protected morphinones and 3-o-protected morphinone dienol carboxylates

Also Published As

Publication number Publication date
KR20090089486A (ko) 2009-08-21
NO20150276L (no) 2006-10-31
AU2005212258A1 (en) 2005-08-25
DK1711502T3 (da) 2008-12-01
WO2005077957A3 (en) 2006-05-04
WO2005077957A2 (en) 2005-08-25
CA2808199C (en) 2015-10-27
US8003793B2 (en) 2011-08-23
US20170233400A1 (en) 2017-08-17
EA016062B1 (ru) 2012-01-30
DE602005009321D1 (de) 2008-10-09
BRPI0506607B1 (pt) 2018-01-16
KR20070026401A (ko) 2007-03-08
NZ548786A (en) 2008-08-29
UA88646C2 (uk) 2009-11-10
CA2555215C (en) 2013-05-21
MA28346A1 (fr) 2006-12-01
EA012905B1 (ru) 2010-02-26
BRPI0506607B8 (pt) 2021-05-25
AP2006003716A0 (en) 2006-08-31
HK1119160A1 (en) 2009-02-27
GEP20084454B (en) 2008-08-10
KR100921695B1 (ko) 2009-10-15
DK1864987T3 (da) 2010-04-12
JP4963968B2 (ja) 2012-06-27
KR101011460B1 (ko) 2011-01-28
AU2005212258B2 (en) 2008-05-22
US8685996B2 (en) 2014-04-01
ES2313299T3 (es) 2009-03-01
PL1711502T3 (pl) 2009-02-27
NZ565355A (en) 2008-09-26
PL1864987T3 (pl) 2010-05-31
US9670218B2 (en) 2017-06-06
CR8590A (es) 2007-07-19
HRP20100123T1 (hr) 2010-04-30
US8198444B2 (en) 2012-06-12
RS50663B (sr) 2010-06-30
CA2808199A1 (en) 2005-08-25
BRPI0506607A (pt) 2007-05-02
US20120225902A1 (en) 2012-09-06
SG150500A1 (en) 2009-03-30
US20140171643A1 (en) 2014-06-19
CN1918168B (zh) 2011-04-27
KR20070117701A (ko) 2007-12-12
EP1711502A2 (en) 2006-10-18
UA87833C2 (uk) 2009-08-25
HRP20080618T3 (en) 2009-01-31
IL177281A0 (en) 2006-12-10
ATE406372T1 (de) 2008-09-15
MXPA06008931A (es) 2007-01-26
JP2007520563A (ja) 2007-07-26
ECSP066824A (es) 2006-12-29
NO339083B1 (no) 2016-11-14
EA200801811A1 (ru) 2008-12-30
US8975257B2 (en) 2015-03-10
KR20070108956A (ko) 2007-11-13
CY1108506T1 (el) 2014-04-09
SI1864987T1 (sl) 2010-04-30
US20120022259A1 (en) 2012-01-26
CA2555215A1 (en) 2005-08-25
ES2338054T3 (es) 2010-05-03
SI1711502T1 (sl) 2009-02-28
ZA200606252B (en) 2007-11-28
RS51317B (sr) 2010-12-31
EP1864987A3 (en) 2008-02-20
EP1864987B1 (en) 2009-12-09
TNSN06248A1 (fr) 2007-12-03
EA200601394A1 (ru) 2006-12-29
DE602005018265D1 (de) 2010-01-21
EP2194059A3 (en) 2010-09-22
IL177281A (en) 2012-02-29
US20080146804A1 (en) 2008-06-19
KR100921696B1 (ko) 2009-10-15
US20150239898A1 (en) 2015-08-27
PT1711502E (pt) 2008-11-20
ATE451374T1 (de) 2009-12-15
EP2194059A2 (en) 2010-06-09
EP1711502B1 (en) 2008-08-27
EP1864987A2 (en) 2007-12-12
CN1918168A (zh) 2007-02-21
PT1864987E (pt) 2010-03-09
HK1103071A1 (en) 2007-12-14
IL205596A (en) 2011-11-30
NO20063989L (no) 2006-10-31

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